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synth conjugated estrogens (Enjuvia)

✓ Approved

Teva Pharmaceutical Industries Ltd. · ESR1

什么是 synth conjugated estrogens?

synth conjugated estrogens 是一种治疗药物,由Teva Pharmaceutical Industries Ltd.研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名Enjuvia
公司Teva Pharmaceutical Industries Ltd.
分子靶点ESR1
给药途径Oral (PO)
状态Approved

作用机制

分子靶点

synth conjugated estrogens 作用于 1 个分子靶点:

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

synth conjugated estrogens 针对 3 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersAtrophic vulvovaginitis✓ Approved
Surgical and medical proceduresHormone replacement therapy✓ Approved
Reproductive system and breast disordersMenopausal symptoms✓ Approved

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Developing highly sensitive, efficient, stable, and low-cost viral antigen detection strategies suitable for primary healthcare settings is of great significance for the early diagnosis and treatment of viral infections. Herein, we report a highly efficient fluorescent immunoassay strategy for the detection of hepatitis B envelope antigen (HBeAg) based on aggregation-induced emission (AIE) molecule-encoded fluorescent nanospheres. Three AIE luminogens (TPE-Br4, TPE-O2, and TPE-O3) were encapsulated into carboxyl-functionalized nanospheres via an ultrasonic swelling method, yielding uniform and well-dispersed multicolor fluorescent nanospheres. Among them, the red-emitting nanospheres, exhibiting superior photostability, were selected as signal output units. Anti-hepatitis B envelope antibodies were subsequently conjugated onto their surfaces to construct fluorescent nanobioprobes. By integrating these nanobioprobes with a sandwich-type enzyme-linked immunosorbent assay, specific capture and recognition of HBeAg were successfully achieved. The proposed method demonstrated a linear detection range of 0.01-1 ng mL-1 and an ultra-low limit of detection (LOD) of 9 pg mL-1. In addition, it exhibited excellent specificity and robust anti-interference performance in spiked fresh mouse serum samples. Overall, this work presents a sensitive, convenient, and cost-effective sensing platform for HBeAg detection, showing great potential for rapid and on-site screening of viral antigens in clinical applications.

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Exploring high-performance birefringent crystals holds paramount significance in modern optics, yet traditional candidates generally struggle to reconcile substantial birefringence with broad spectral transparency. To circumvent this long-standing bottleneck, a synergistic multifunctional-group assembly strategy has been devised to guide the rational design of birefringent crystals. Correspondingly, driven by lanthanide coordination and hydrogen bonding, two kinds of π-conjugated units were successfully incorporated into a new birefringent crystal, Ce(2,2'-bipyridyl)3(SCN)3. Synthesized via a facile solution evaporation method, Ce(2,2'-bipyridyl)3(SCN)3 was characterized by a large birefringence of 0.18@546 nm, broad transmission windows (nearly spanning 0.445-25 μm), and moderate thermal stability (up to 270 °C), making it favorable for practical applications.

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