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estradiol valerate + MPA (Divina / E2V + MPA, Orion / Klimalet)

✓ Approved

HyundaiPharm · ESR1 · 小分子

什么是 estradiol valerate + MPA？

estradiol valerate + MPA 是一种小分子，由HyundaiPharm研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Divina, E2V + MPA, Orion, Klimalet
公司HyundaiPharm
药物类别小分子
分子靶点ESR1
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, HyundaiPharm

作用机制

分子靶点

estradiol valerate + MPA 作用于 1 个分子靶点：

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

estradiol valerate + MPA 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresHormone replacement therapy✓ Approved

相关研究文献

PubMedFrontiers in dental medicine2026-09-10

Phytic acid and grape seed extract in dentin biomodification: effects on bond strength and interface integrity.

Gomes Astrid Ana AA, Devadiga Darshana D, M Roma R, Chandramouli Darshan Madihalli DM et al.

Hybrid layer degradation, driven by residual matrix metalloproteinase (MMP) activity and hydrolytic attack at the resin-dentin interface, remains a primary cause of adhesive restoration failure. Dentin biomodification using natural cross-linking agents represents a promising strategy to enhance collagen stability and inhibit enzymatic degradation of the bonded interface. To evaluate and compare the effect of collagen cross linking agents, phytic acid (IP6) and grape seed extract (GSE), to reinforce the shear bond strength (SBS) of resin composite to dentin. Enamel of 34 human maxillary premolars was eliminated and each tooth was sectioned to make a total sample size of 68 which was divided into four groups (n = 17) for surface treatment: G1-PA:37% Phosphoric acid (control), G2-IP6:1% phytic acid, G3-PA + GSE:37% phosphoric acid+6.5% GSE and G4-IP6 + GSE:1% phytic acid+6.5% GSE. A hybrid resin composite material was bonded and subjected to 1,000 cycles of thermocycling followed by SBS testing and analysis of fracture mode by Scanning Electron Microscopy. The data was statistically analysed using one-way Analysis of Variance (ANOVA) followed by Tukey's Honestly Significant Difference (HSD) post hoc test. G4-IP6 + GSE showed the highest SBS (23.44 ± 4.28 MPa), followed by G2-IP6 (21.51 ± 6.00 MPa) and G3-PA + GSE (21.01 ± 4.35 MPa), while G1-PA had the lowest values of 15.40 ± 4.60 MPa. FTIR analysis showed that phytic acid exhibited a broad peak at 3311.77 cm⁻1 while GSE showed peaks 3266.37 cm⁻1 and 1602.93 cm⁻1 corresponding to hydroxyl and carbonyl functional groups. Phytic acid and grape seed extract significantly improved the composite-dentin shear bond strength of dentin. Their application appears to enhance the structural integrity of demineralized collagen at the resin-dentin interface, thereby supporting their potential incorporation into adhesive restorative protocols as a promising strategy to enhance dentin bond strength.

PMID 42718430
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PubMedCureus2026-09-10

Influence of Dentin Desensitizer Pretreatment on the Shear Bond Strength of Composite Resin Using Three Adhesive Systems: An In Vitro Study.

Jhansi M M, Chandrababu K S KS, C Sunilkumar S, Krishna N Vamsee V et al.

Dentin desensitizers are used to reduce postoperative sensitivity but may influence the bonding performance of adhesive systems. The effect of dentin desensitizers on different generations of dentin bonding agents requires further evaluation. To compare and evaluate the shear bond strength of composite resin using fifth-, seventh-, and eighth-generation bonding agents with and without the application of a dentin desensitizer. Sixty extracted human permanent molars were randomly divided into six groups (n = 10). Composite restorations were performed using three generations of bonding agents with or without Prevest Shield Activ (Prevest DenPro, Jammu, India) dentin desensitizer. Shear bond strength was evaluated using a Universal Testing Machine (Instron®, Norwood, MA, USA). Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's post hoc test for multiple group comparisons. Statistical analysis was set at p<0.05. The fifth-generation adhesive without desensitizer demonstrated the highest shear bond strength (24.75 ± 1.15 MPa), whereas the seventh-generation adhesive with desensitizer showed the lowest (14.52 ± 0.61 MPa). Significant intergroup differences were observed (F = 167.516, p<0.001). Application of the dentin desensitizer reduced bond strength in all adhesive systems. The fifth-generation adhesive exhibited superior shear bond strength. Pretreatment with dentin desensitizer reduced bond strength in all groups, with the greatest reduction observed in the seventh-generation adhesive. Careful selection of adhesive systems is recommended when dentin desensitizers are used clinically.

PMID 42719205
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PubMedAnnals of translational medicine2026-09-10

A comprehensive longitudinal study quantifying the systemic effects associated with ovariectomy and high-dose corticosteroids in a sheep model of osteoporosis.

Bisazza Katie T KT, Nelson Brad B BB, Anthony Russell V RV, Goodrich Laurie R LR et al.

The sheep is a common preclinical model for osteoporosis in humans and allows for robust longitudinal studies. Appropriate characterization of large animal models is necessary prior to selection for preclinical studies. We sought to comprehensively characterize the process of bone loss in a 12-month sheep model of osteoporosis, and report on the sheep clinical pathologies throughout osteoporosis model development. We induced osteoporotic bone loss in 10 sheep via ovariectomy and corticosteroid administration. Over a 12-month period, we performed serial bone density scanning, bone biopsy for microarchitecture and histomorphometry assessment, clinical assessments, and evaluated systemic levels of steroid hormones, as well as hematological and biochemical values. Statistical analysis was performed to compare the outcomes of osteoporotic sheep to healthy age-matched control sheep over time. We successfully induced osteoporotic-like bone loss in the experimental group by observing decreased bone density in the lumbar spine and tibia by 6 months, including changes to bone microarchitecture (i.e., trabecular thinning, decreasing bone volume) and histomorphometry (i.e., decreased trabecular bone ratio) indicative of bone remodeling disruption. We also reported comprehensive systemic changes in the same animals over time. Compared to control animals, we observed a significant disruption to clinical pathology parameters and steroid hormone production in osteoporotic sheep. Osteoporotic model development induced hematological and serological disruptions at 3 months, including neutrophilia, immune cell suppression, electrolyte and protein imbalances, hyperphosphatemia, and elevated liver enzymes. Additionally, administration of corticosteroids appeared to suppress cortisol production over the course of model development, followed by a surge of endogenous cortisol following cessation of corticosteroid treatment. Estradiol surprisingly did not drop to significantly lower levels than controls for the duration of the experiment, suggesting that there are extragonadal sources of estradiol production or dietary sources of phytoestrogens in the sheep differing from humans. Bone loss was induced in sheep within 3-6 months, and the most significant systemic disruptions appear to correlate with timing of high-dose corticosteroids. These findings offer a detailed characterization of the sheep model of osteoporosis, enabling investigators to distinguish the effects of treatment administration from those arising solely from model development.

PMID 42718873
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Topological Structuring of Adhesive Layers to Enhance Resistance against Interfacial Fracture.

Arai Shunto S

The reliable bonding of dissimilar materials is crucial for lightweighting and energy saving. However, their interface is often susceptible to fracture, impeding the widespread adoption of composites. While tough adhesion relying only on intermolecular interactions has been effective for specific adherends, fracture strength is significantly impaired depending on the adhesive selection. Alternatively, it is also widely used to improve the bonding strength through mechanical interlocking (anchor effect) via surface structuring. However, this approach has problems in energy consumption and environmental considerations associated with etching and surface cleaning procedures. Here, we introduce an alternative/hybrid approach that combines chemical affinity with structural interlocking. We produce a porous layer strongly interacting with one adherend using a solution-based technique. This porous architecture templates a robust mechanical interlock with the other adherend, without using conventional adhesives. By tuning pore geometry, this method enables a detachment strength of over 7 MPa, showing significant improvement compared with unstructured interfaces. Experiments and simulations reveal that the fracture toughness stems from a stiffness difference within the interlocked structure, suppressing crack propagation. This structural design strategy offers a rational route to engineering durable interfaces, enabling advanced composites of various materials.

PMID 42717766
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PubMedACS applied materials & interfaces2026-09-10

Microenvironment Engineering with Supercritical CO2 for Selective CO2-to-CH4 Electrocatalysis.

Yang Suilin S, Yang Chen C, Bai Penghui P, Yu Yang Y et al.

Supercritical carbon dioxide (ScCO2), characterized by its high diffusivity, tunable density, and unique solvent properties, presents a novel opportunity to manipulate the local environment in electrocatalytic reactions. This study demonstrates the efficacy of ScCO2 as a reaction medium to dramatically enhance the selectivity of the electrocatalytic CO2 reduction reaction (ECO2RR) toward methane (CH4) on a Pd-decorated porous CuZn (CuZn@Pd) catalyst. Under optimized ScCO2 conditions (50 °C, 16 MPa, -1.2 V vs Pt), the Faradaic efficiency (FE) for CH4 reaches a remarkable 65%, a substantial increase from the 33% FE observed under ambient aqueous conditions. Concurrently, the competing hydrogen evolution reaction (HER) is effectively suppressed, with the H2 FE plummeting to only 3%. Comprehensive characterization and electrochemical analysis reveal that the ScCO2 medium enhances CO2 mass transport, increases its local concentration at the catalyst surface, and modifies the interfacial environment. Density functional theory (DFT) calculations provide atomic-level insight, showing that ScCO2 facilitates the key *CO to *COH step at Pd sites, reducing the reaction energy barrier and steering the pathway selectively toward CH4. This work establishes supercritical fluid medium engineering as a powerful strategy for controlling product selectivity in electrocatalysis.

PMID 42720129
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PubMedInnovation (Cambridge (Mass.))2026-09-10

Wear-resistant, moldable mineral hydroplastics via nonsolvent-induced phase separation for adaptive architectural applications.

Chen Junqing J, Wang Shanshan S, Lizundia Erlantz E, Yu Le L et al.

The development of sustainable plastic alternatives derived from natural components, such as biopolymers and minerals, represents a promising strategy to mitigate the escalating problem of plastic pollution. Here, by employing a nonsolvent-induced phase separation (NIPS) strategy, a hydro-processable mineral-dominated structural material, called "mineral hydroplastic" (M-Hydroplastic), is developed. High-mineral-content (up to 75 wt %) hydrogels are fabricated through in situ polymerization of specific monomers and shaped under mild conditions through polymer chain rearrangement triggered by nonsolvent exposure. Further pressing-assisted desolvation optimizes the orientation of mineral sheets, yielding hydro-processable high-mineral-content plastics with combined features of mineral (flexural strength, 90.6 MPa; hardness, 0.23 GPa; and flame retardancy) and plastic (low density of ∼1.5 g cm-3 and facile moldability). Combined experimental and computational analyses reveal that strong intercomponent hydrogen bonding and a nacre-like micro-structure underpin the material's exceptional mechanical performance. This versatile strategy is applicable to various minerals, producing a family of robust hydroplastics with tunable optical, thermal, and radiative properties. Such adaptability enables the design of multifunctional, flame-retardant materials for multi-scenario energy-efficient building applications. This work reconciles ceramic-like mechanical properties with polymer-like processability, providing crucial insights into designing next-generation plastic alternatives for engineering applications.

PMID 42719301
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