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estradiol valerate + MPA (Divina / E2V + MPA, Orion / Klimalet)

✓ Approved

HyundaiPharm · ESR1 · 小分子

什么是 estradiol valerate + MPA？

estradiol valerate + MPA 是一种小分子，由HyundaiPharm研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Divina, E2V + MPA, Orion, Klimalet
公司HyundaiPharm
药物类别小分子
分子靶点ESR1
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, HyundaiPharm

作用机制

分子靶点

estradiol valerate + MPA 作用于 1 个分子靶点：

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

estradiol valerate + MPA 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresHormone replacement therapy✓ Approved

相关研究文献

PubMedThe Journal of craniofacial surgery2026-07-27

Finite Element Analysis of Conventional and Patient-Specific Fixation Systems in Large Maxillary Repositioning.

Gürlek Gündüz Can GC, Çubuk Seçil S, Yenigün Ekin E

This study evaluated the biomechanical performance of 3 fixation systems-L-shaped miniplates, prebent plates, and a single-piece patient-specific plate (PSP)-for maxillary stabilization following Le Fort I osteotomy using finite element analysis. A three-dimensional finite element model of the maxilla was constructed from computed tomography data of a patient with maxillary deficiency. Simulated Le Fort I osteotomies included 5 mm maxillary advancement and 6 mm downgrafting, with iliac bone grafts placed between the segments. Fixation was achieved using 4 L-shaped miniplates, 2 prebent plates, or a single-piece PSP. Vertical (500 N) and oblique (250 N) masticatory loads were applied. Von Mises stress on plates and screws, maximum principal stress in bone and graft, and total segment displacement were assessed. The prebent plate model exhibited the highest von Mises stress on fixation plates under vertical loading (135.596 MPa). The single-piece PSP demonstrated the lowest displacement values in all directions, indicating superior segmental stability. Although slightly higher screw (88.379 MPa) and bone stress (14.835 MPa) values were observed in the PSP model, all stresses remained below physiological and material safety thresholds. Graft stress values were comparable to those of surrounding bone under both oblique (6.229-6.621 MPa) and vertical loading (8.385-9.127 MPa). All fixation systems provided adequate mechanical performance; however, the single-piece PSP showed more favorable stress distribution and stability, supporting its use as a biomechanically advantageous fixation option in orthognathic surgery.

PMID 42507388
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PubMedOrbit (Amsterdam, Netherlands)2026-07-27

Innovative orbital rim repositioning with mortise-tenon joints: a fusion of modern surgery and traditional Chinese woodcraft.

Lei Chaoyu C, Zhang Shuo S, Sun Jing J, Zhang Ningbin N et al.

Orbital rim repositioning is a pivotal step in lateral orbitotomy. This study aims to introduce a novel mortise-tenon joint fixation (MTF) technique inspired by traditional Chinese woodcraft for lateral orbital rim reconstruction. This retrospective case series analyzed outcomes in patients with thyroid eye disease (TED) undergoing balanced orbital decompression surgery using MTF. The clinical outcomes, the number of surgical implants used, and hospitalization costs were analyzed. Additionally, an orbital model of the same laterality, derived from another patient treated with titanium plate-and-screw fixation (PSF), was selected as the comparator for the three-dimensional finite element analysis. Analysis was conducted with masseter muscle fixation and the application of occlusal force on the masseter muscle. Nine TED patients (12 orbits) undergoing MTF reconstruction were enrolled. A mean proptosis reduction of 5.3 ± 0.9 mm was achieved. No complications such as severe hemorrhage, vision loss, or orbital rim displacement were observed. Finite element analysis showed that maximum stress was lower with MTF than with PSF: 8.59 MPa vs. 91.33 MPa (masseter muscle fixation) and 16.33 MPa vs. 91.20 MPa (force applied). Maximum displacement was also lower for MTF: 0.010 mm vs. 0.014 mm (masseter muscle fixation) and 0.026 mm vs. 0.033 mm (force applied). Implant material expenses in hospitalization costs decreased by $288.43-$412.00, representing an approximate 84.3% reduction compared to PSF. In summary, the MTF technique demonstrates safety, effectiveness, and biomechanical advantages for orbital rim repositioning during lateral orbitotomy. It also reduces patient costs, offering a promising alternative to traditional fixation methods.

PMID 42504687
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PubMedJournal of functional biomaterials2026-07-27

Thickness-Tunable Bilayer PBAT Nanofibrous Scaffolds for Enhancing r-AdMSCs' Tenogenic Commitment in Supraspinatus Tendon Regeneration.

Akbulut Serdar Onat SO, Konuk Tokak Elvan E, Gültan Tuğçe T, Gümüşderelioğlu Menemşe M

Acute or chronic rotator cuff tears are major causes of shoulder dysfunction, motivating the development of scaffolds with tailored thickness and mechanics for supraspinatus tendon regeneration. This study aimed to investigate the effect of bilayer poly(butylene adipate-co-terephthalate) (PBAT) scaffold thickness on the tenogenic differentiation of rat adipose mesenchymal stem cells (r-AdMSCs) and supraspinatus tendon regeneration. Aligned fibers with a diameter of approximately 476 nm were deposited onto randomly oriented layers at different times (4 h; 4S, 6 h; 6S, 8 h; 8S), and scaffolds with increasing thicknesses from 441 µm (4S) to 1132 µm (8S) were produced. Mechanical testing showed comparable tensile strength for 4S and 6S (≈1.9-2.0 MPa) and modulus (5.5-7.3 MPa), while 8S exhibited markedly reduced stiffness (0.5 MPa) and hyper elastic deformation. Mechanical performance across degradation conditions remained strongly thickness-dependent: thinner scaffolds retained integrity and strengthened, with modulus increases during hydrolytic and enzymatic degradation, whereas thicker matrices showed limited remodeling and instability. Rat-AdMSCs' were cultured on the scaffolds for 21 days. Cell-free and cell-laden mechanical responses further reflected thickness effects: cell-free samples stiffened due to media-induced passive matrix tightening, whereas cell-laden scaffolds showed extracellular matrix (ECM)-driven reinforcement, most prominently in 4S, which reached 2.1 MPa tensile strength with improved elasticity and balanced deformation. The 4S scaffold exhibited the highest tensile strength and significantly increased collagen-1 (col1), tenomodulin (tnmd) and scleraxis (scx) expression compared with the other groups. In conclusion, among all groups, 4S scaffolds demonstrated the most favorable mechanical and biological performance, suggesting that scaffold thickness plays a critical role in regulating tendon regeneration and will become even more suitable when matured in bioreactors.

PMID 42506536
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Welding-Induced Heterogeneity Promotes Gradient Nanostructuring in Laser-Welded 304 Stainless Steel Joints.

Zhao Tianzhang T, Zhu Junping J, Deng Hongchuan H, Wang Chuanchen C et al.

Laser-welded stainless steel joints usually suffer from strain localization and premature failure in the weld metal (WM) due to microstructural heterogeneity introduced during welding. In this work, surface mechanical rolling treatment (SMRT) was applied to laser-welded 304 stainless steel plates to enhance the mechanical performance of the welded joints. Laser welding introduced multiple heterogeneous features in the WM, including local Ni compositional fluctuations, nanoscale oxide particles and heterogeneous grain structures. Among them, the local fluctuation of Ni concentration is considered to play a dominant role by locally modifying the stability of γ-austenite and promoting strain-induced martensitic transformation during SMRT. As a result, the WM exhibited more severe grain refinement and a stronger gradient nanostructure than base metal (BM) under identical processing conditions. The near-surface hardness of the WM reached ~500 Hv, which was noticeably higher than that of the BM. Uniaxial tensile tests revealed that the yield strength increased from ~350 MPa to ~700 MPa, while the ultimate tensile strength reached ~1000 MPa with ~40% elongation. More importantly, the fracture location shifted from the WM to the BM after SMRT. The enhanced martensitic transformation and gradient nanostructure effectively suppressed strain localization and improved the mechanical reliability of the welded joint.

PMID 42506493
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PubMedThe Review of scientific instruments2026-07-27

A high-temperature and high-pressure optical cell for oil-water separation with porous materials.

Zhu Gang G, Chen Hao H, Zhang Yan Y, Zhao Xuezhi X et al.

Some industrial oil-water separations require in situ separation under high-temperature and high-pressure (HTHP) conditions. Although porous materials are promising for this purpose, dedicated optical cells capable of evaluating their separation performance under controlled HTHP environments remain scarce. Here, an HTHP optical cell was engineered using a 316L stainless-steel framework integrated with quartz-glass windows to enable direct visualization and performance assessment of porous materials under precisely regulated thermal and pressure conditions. The apparatus operates at up to 160 °C and 2 MPa. In representative static-holding and steady-injection validation tests, the system exhibited excellent stability, with maximum recorded deviations of 0.2 °C/0.012 MPa and 0.1 °C/0.003 MPa from the respective mean values, and no anomalous fluctuations were detected. The setup was validated using three distinct porous media, including a sponge, a membrane, and a packed powder bed, to demonstrate its broad applicability. With integrated real-time differential pressure monitoring, the system enables steady-state pressure-drop acquisition across varying flow rates, providing quantitative insight into fluid permeability resistance. It further supports flux-dependent demulsification assessment through continuous collection of the filtrate and subsequent water content analysis. By combining direct optical access with controlled thermophysical extremes, the developed cell offers a practical, robust, and versatile platform for quantitative benchmarking of porous materials in oil-water separation processes under realistic HTHP injection scenarios.

PMID 42505108
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PubMedGels (Basel, Switzerland)2026-07-27

Research on Adhesion Performance of Silicone Gel for Power Module Packaging Regulated by Crosslink Structure and Interfacial Connection.

An Xiangze X, He Dongxin D, Zheng Xiaobin X, Li Tinghui T et al.

Silicone gel for high-voltage power module packaging is prone to interfacial failure due to poor intrinsic adhesion, which seriously threatens the reliability of devices. This study explores ways to improve the adhesion performance of silicone gel from the two aspects of crosslink network structure and interfacial connection. The crosslink structure is regulated by adjusting the ratio of side-hydrogen-containing silicone oil to terminal-hydrogen-containing silicone oil, and interface adhesion is improved by adding three different contents of silane coupling agents (KH560, KH570, A171). The adhesion strength is evaluated by lap shear experiments. The results show that when the ratio of side-hydrogen to terminal-hydrogen is 16:24, the adhesion strength reaches a peak value of 0.0921 MPa. Among the coupling agents, KH560 shows the most significant enhancement, with the adhesion strength reaching 0.1356 MPa at 4% addition and a 47% improvement over the baseline, KH570 is only effective at low addition levels, and A171 shows the weakest effect due to vinyl interference in the crosslink network. Breakdown tests confirm that all three modification schemes do not seriously damage insulation performance. This study provides a feasible strategy and basis for the adhesion reliability design of silicone gel for power module packaging.

PMID 42505329
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