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estradiol valerate + MPA (Divina / E2V + MPA, Orion / Klimalet)

✓ Approved

HyundaiPharm · ESR1 · 小分子

什么是 estradiol valerate + MPA？

estradiol valerate + MPA 是一种小分子，由HyundaiPharm研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Divina, E2V + MPA, Orion, Klimalet
公司HyundaiPharm
药物类别小分子
分子靶点ESR1
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, HyundaiPharm

作用机制

分子靶点

estradiol valerate + MPA 作用于 1 个分子靶点：

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

estradiol valerate + MPA 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresHormone replacement therapy✓ Approved

相关研究文献

PubMedMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2026-10-27

Association between Plasma Short-Chain Fatty Acids and Hypertensive Disorders of Pregnancy: A Nested Case-Control Study.

Wang Dandan D, Wu Lei L, Feng Pei P, Sun Yexiu Y et al.

To investigate the associations between plasma short-chain fatty acids (SCFAs) and hypertensive disorders of pregnancy (HDP). A nested case-control study was conducted comprising 387 pairs of HDP cases and non-HDP controls. The HDP group included 291 cases of gestational hypertension (GH) and 96 of preeclampsia (PE) or chronic hypertension (CH) with superimposed PE (PE/CH-PE). Seven plasma SCFA levels were assayed at gestational weeks 16-20, before HDP onset. The individual effects of the seven SCFAs on HDP risk were analyzed using logistic regression, with false discovery rate (FDR) correction applied to calculate adjusted P-values in multivariate analysis. The joint effects of the seven SCFAs were evaluated using weighted quantile sum (WQS) regression. HDP cases exhibited significantly lower median (interquartile range) valerate levels than controls (9 (5-14) vs. 10 (6-18) ng/mL, P = 0.001). Among the seven analyzed SCFAs, isobutyrate and isovalerate demonstrated the highest correlation coefficient at 0.85 (P < 0.001). Each interquartile range increase in valerate content was associated with a low risk of HDP, yielding an adjusted odds ratio (aOR) of 0.699 (95% confidence interval (CI): 0.516-0.946, FDR-corrected P = 0.047). Isobutyrate and hexanoate were also inversely associated with HDP after multivariate adjustment and FDR correction (both P = 0.047), with aORs of 0.899 (95% CI: 0.826-0.980) and 0.686 (95% CI: 0.508-0.927), respectively. WQS regression revealed that joint SCFA exposure was associated with a decreased risk of HDP (aOR: 0.230, 95% CI: 0.105-0.506) and GH (aOR: 0.740, 95% CI: 0.571-0.933). Plasma levels of valerate, isobutyrate, and hexanoate are inversely associated with HDP risk. Furthermore, the combined effect of these SCFAs is linked to a lower incidence of both HDP and GH. These findings suggest that circulating SCFAs may serve as potential early biomarkers for HDP.

PMID 42936818
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PubMedMaterials (Basel, Switzerland)2026-10-27

Combined Use of Sodium Bentonite and Recycled Aggregates in Concrete: Microstructural Characterization and Mechanical Performance.

Morales-Beltrán Hugo H, Gálvez Edelmira E, Salinas-Rodríguez Eleazar E, Saldana Manuel M et al.

The reuse of construction and demolition waste (CDW) and supplementary aluminosilicate materials can reduce the environmental impact of concrete. This study evaluated two formulations produced with fine and coarse recycled CDW aggregates: a control with 0 wt% sodium bentonite and an experimental mixture with 5 wt% sodium bentonite as a partial Portland cement replacement (ACI 211.1-91, target 19.61 MPa at 28 days). Two independent control batches achieved 19.833 MPa (202.24 kg/cm2) and 19.788 MPa (201.78 kg/cm2) (mean 19.810 MPa, 101.01% of target). The 5 wt% bentonite mixture achieved a mean of 15.353 MPa (156.55 kg/cm2, SD 0.060 MPa, CV 0.391%, 95% CI, 15.290-15.416 MPa, n = 6), equivalent to 78.29% of the target strength and 22.50% lower than the control mean. The six specimens containing 5 wt% bentonite were technical replicates obtained from a single batch, whereas control values correspond to two independent batches (one specimen each); therefore, confidence intervals are presented descriptively. Characterization of the 5 wt% formulation at 28 days was performed by XDR, SEM, and EDS. XRD identified calcite, ettringite, quartz, and signals compatible with calcium silicate hydrate (C-S-H) products and tobermorite. SEM reveals a heterogeneous matrix with acicular morphologies compatible with C-S-H and densified regions. EDS showed O 54.8 wt%, Ca 27.8 wt%, Si 10.2 wt%, and Al 2.8 wt% with heterogeneous distribution of Ca, Si, and Al without marked segregation at the observation scale. Characterization was limited to the 5 wt% formulation at 28 days; therefore, observed phases and morphologies cannot be attributed exclusively to bentonite.

PMID 42941018
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PubMedJournal of conservative dentistry and endodontics2026-10-27

Effect of placement technique on the push-out bond strength of three modern root repair materials: A multi-level in vitro analysis.

Parikh Hetvi H, Bharatiya Rajendra R, Ujariya Urvashi U, Kothari Anjali A et al.

The aim of the study is to evaluate and compare the push-out bond strength (POBS) of three root repair materials (RRMs) - mineral trioxide aggregate (MTA), Biodentine, and Bio-C Repair - placed using two distinct techniques (sectional and full-root placement) at coronal, middle, and apical dentin levels. Forty-eight extracted mandibular premolars were prepared and divided into three material groups (n = 16), each further subdivided into sectional placement (Group S) and full-root placement (Group F). Standardized 1-mm slices were obtained from each root level, i.e., coronal, middle, and apical. After 24 h of incubation at 37°C, POBS was determined using a universal testing machine. Data were statistically analyzed using the Shapiro-Wilk test, analysis of variance (ANOVA), and independent t-tests (α =0.05). Biodentine demonstrated the highest POBS values in all regions. In Group S, mean values ranged from 4.57 to 4.97 MPa for MTA, 5.13 to 5.46 MPa for Biodentine, and 2.99 to 3.40 MPa for Bio-C Repair. Group F showed consistently lower values: MTA - 3.93-4.17 MPa, Biodentine - 4.27-4.54 MPa, and Bio-C Repair - 2.48-2.75 MPa. Group S exhibited significantly greater POBS than Group F for all materials (P < 0.05). POBS of RRMs was significantly influenced by both material type and placement technique. Sectional placement produced greater dislodgement resistance than full-root placement, while Biodentine demonstrated the highest bond strength among the tested materials.

PMID 42936832
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PubMedPolymers2026-10-27

Effect of Polymer Matrix Type and Particle-Size Distribution on the Mechanical, Microstructural, and Thermal Behavior of Waste Tire Rubber Composites.

Mohabbi Mehrzad M, Sahin Canan Kaya CK

Recycling ground tire rubber (GTR) into polymer-matrix composites requires accounting for both matrix formulation and rubber particle-size distribution. Here, polyurethane, epoxy, novolac-hexamine, and unsaturated polyester systems were compared using four gradations of the same rubber source (16 formulations). A common main-resin-to-rubber mass ratio of 20% was used; differences in required auxiliary components and curing conditions were explicitly considered. The 28-day reference compression results ranged from 1.22 to 1.35 MPa for the polyester formulations to 8.21 MPa for epoxy-K1; epoxy-K1 also reached 2.21 MPa in flexure, whereas polyurethane-K4 reached 6.29 MPa in compression and 1.94 MPa in flexure. Thirteen available compression curves were reprocessed using the 70 × 50 mm loaded face and 70 mm loading length; derived deformation and work-density parameters are apparent, machine-displacement-based measures. Binder-specific UPV trends were exploratory (four gradations per binder). Selected SEM/EDS, ATR-FTIR, and representative TGA/DTG data supplied complementary evidence without establishing interfacial chemical bonding, cure inhibition, or fire performance. The results indicate formulation-dependent strength-deformation trade-offs within the tested materials rather than a universal optimum matrix or gradation.

PMID 42942720
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PubMedMicromachines2026-10-27

Thermomechanically Coupled Modeling and Process-Parameter Analysis of Laser-Field-Assisted Hybrid Milling of GH4096 Superalloy.

Yan Hongyang H, Lei Hongqin H, Liang Ping P, Zhao Haodi H et al.

GH4096 is a Chinese nickel-based disk superalloy used for disks and shafts in advanced gas-turbine engines, where creep, fatigue, corrosion resistance, and microstructural stability are service-critical. These requirements are associated with high deformation resistance and thermomechanical loading during milling. However, laser-assisted milling (LAM) of GH4096 has not yet been systematically investigated. This study addresses that material-process gap through a three-dimensional thermomechanically coupled finite-element analysis based on a GH4096 constitutive-damage description. Johnson-Cook (JC) plasticity and damage parameters are calibrated using quasi-static, high-strain-rate, elevated-temperature, and stress-state-dependent data, while displacement-based damage evolution is used after damage initiation. A moving Gaussian surface heat source reproduces localized preheating and coupled material removal. The model quantifies the effects of laser power, spot radius, cutting depth, feed speed, and spindle speed on milling force, the transient temperature field and surface von Mises equivalent stress. Intermittent force peaks occur in all three directions, with the largest local peaks arising mainly from axial RF3 loading. Feed speed produces the largest peak-force variation relative to the baseline case (73.0%), followed by cutting depth (65.6%). Laser power, spot radius, and spindle speed produce variations of 29.7%, 28.8%, and 28.2%, respectively. Force peaks respond non-monotonically to laser power, spot radius, and spindle speed. Maximum surface von Mises equivalent stress also varies non-monotonically with all five parameters. Feed speed produces the largest fluctuation, peaking at 623.56 MPa at 20 mm/s before decreasing to 529.32 MPa at 30 mm/s. Cutting depth yields a minimum of 502.88 MPa at 0.5 mm and a maximum of 580.90 MPa at 0.9 mm. Surface von Mises equivalent stress peaks at 619.75 MPa at 400 W and decreases to 550.89 MPa at a 2.2 mm spot radius. It increases sharply at 2.4-2.6 mm and reaches 573.14 MPa at 10,000 r/min before declining. These results establish a bounded basis for coordinating optical and mechanical parameters in GH4096 LAM within the investigated model and parameter ranges.

PMID 42943923
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PubMedLangmuir : the ACS journal of surfaces and colloids2026-10-27

Effects of Reservoir Pressure and Temperature on CO2-Brine Wettability in Low-Permeability Sandstone: Implications for CO2-Enhanced Oil Recovery and Geological Storage.

Chen Nuo N, Fu Guo-Tao GT, Zheng Zi-Gang ZG, Li Mei M et al.

Wettability is a key interfacial property affecting CO2-enhanced oil recovery and geological CO2 storage in reservoirs. However, experimental data on the wettability of CO2-brine-rock systems remain limited for low-permeability sandstone, a major lithology in unconventional oil reservoirs. In this study, low-permeability sandstone samples (∼1 mD) from the Chang 7 Member of the Ordos Basin, China, were used to measure the contact angle (CA) and interfacial tension (IFT) of the CO2-brine-sandstone system at 25-125 °C and 0.1-20 MPa. Results show that the measured CA increases with pressure, although its pressure dependence becomes weaker above approximately 7-8 MPa. Pressure and temperature exerted statistically significant but opposing effects on CA. At 85 °C, CO2-brine IFT decreases from 49.85 to 29.65 mN·m-1 as pressure increases from 3 to 20 MPa, with a gradual-transition region near 8-11 MPa, while its temperature response exhibits a clear pressure dependence. For the sandstone samples studied, an empirical power-law relationship between surface roughness and permeability was established, while the roughness-induced apparent CA differences progressively diminished at 17-20 MPa. To support practical interpretation, an interfacial capillary term was introduced to combine CA and IFT, thus providing a first-order interfacial reference for capillary behavior relevant to CO2-enhanced oil recovery and geological CO2 storage in low-permeability sandstone systems.

PMID 42937629
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