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CTC-111 (Anact C)

✓ Approved

Meiji Holdings · PROC

什么是 CTC-111？

CTC-111 是一种治疗药物，由Meiji Holdings研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Anact C
公司Meiji Holdings
分子靶点PROC
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Meiji Holdings

作用机制

分子靶点

CTC-111 作用于 1 个分子靶点：

PROCprotein C, inactivator of coagulation factors Va and VIIIa (APC, PROC1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

CTC-111 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved
Skin and subcutaneous tissue disordersPurpura fulminans✓ Approved

相关研究文献

PubMedAnalytical methods : advancing methods and applications2026-07-27

Smartphone-based fluorescence sensing platform for tetracycline determination based on a high quantum yield europium metal-organic framework with a dual-ligand strategy.

Cheng Shuang S, Song Jintian J, Wen Yue Y, Xu Yijia Y et al.

Ultrasensitive and visual detection of tetracyclines (TCs) is of great significance to public health and environmental safety. Herein, we synthesized a dual-ligand europium metal-organic framework (Eu-phen-MOF) via a one-step solvothermal method for the fluorescence detection of TCs. Compared with the Eu-MOF without 1,10-phenanthroline, Eu-phen-MOF exhibits superior stability, lower LOD and higher quantum yield. It delivers superior TC sensing performance and anti-interference, enabling high-accuracy detection with limits of 152.0 nmol L-1, 249.4 nmol L-1, 171.0 nmol L-1 and 277.7 nmol L-1 for tetracycline (TC), oxytetracycline (OTC), doxycycline hydrochloride (DOX), and chlortetracycline (CTC), respectively. Eu-phen-MOF was used for the quantitative detection of TC, OTC, DOX, and CTC in real samples (milk, eggs, and river water) and recoveries ranging from 94.64% to 105.37% were achieved. Finally, a portable fluorescence sensing platform integrating a smartphone and the Eu-phen-MOF fluorescent hydrogel was constructed, enabling convenient, rapid, and low-cost detection of TCs. This work not only highlights the significance of the dual-ligand strategy for fabricating an efficient TC sensor, but also develops a rapid and visual method for TC detection.

PMID 42504902
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PubMedACS nano2026-07-27

Tuning Competing Electronic Phases in Monolayer VSe2 via Interface Hybridization.

Pushkarna Ishita I, Pásztor Árpád Á, Lupi Greta G, Fumega Adolfo O AO et al.

Competing electronic phases in two-dimensional transition metal dichalcogenides constitute a fertile platform for uncovering emergent ground states and elucidating the control parameters that govern the correlated electron phases. Among these materials, vanadium diselenide is particularly compelling: while the bulk hosts a well-established charge density wave (CDW), monolayers exhibit markedly different electronic behavior. Here, we identify three distinct electronic regimes in mechanically exfoliated VSe2 flakes on Au(111) substrates, where interfacial hybridization, charge transfer, and strain act as primary tuning parameters of electronic order. Monolayers strongly coupled to gold show complete suppression of the CDW, accompanied by the emergence of moiré modulations. In contrast, bilayers preserve the in-plane 4a × 4a CDW characteristic of the bulk limit. Strained, electronically decoupled monolayers formed in suspended membrane and bubble regions stabilize a √3a × √7a CDW phase, underscoring the reversible role of substrate interaction and hybridization.

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PubMedJournal of agricultural and food chemistry2026-07-27

Machine Learning-Enabled Quantification of Fucosylated Human Milk Oligosaccharides in Human Breast Milk by Benchtop 1H NMR Spectroscopy.

Hu Zhiyan Z, Jiang Jiaxi J, Abe Jun J, Thumrongtaradol Thanawat T et al.

Human milk oligosaccharides (HMOs) are bioactive components of human breast milk (HBM), but their concentrations vary with maternal secretor phenotype and lactation stage, making individual HMO quantification analytically demanding. Here, we present a reference-guided benchtop 60 MHz NMR workflow integrating chemometrics and machine learning to quantify major fucosylated HMOs in HBM. A total of 111 HBM samples from 37 donors across lactation stages were analyzed. Using 800 MHz NMR-derived concentrations as references, predictive models were developed from benchtop NMR spectra for 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), and lacto-N-fucopentaose I (LNFP-I). Unlike conventional peak-fitting-based NMR quantification, this workflow recovered HMO-specific quantitative information from highly overlapped 60 MHz carbohydrate signals that were not directly resolvable in authentic HBM. Elastic Net yielded practical models, particularly for lower-abundance 3-FL and LNFP-I. These results support benchtop NMR combined with machine learning as an accessible platform for HMO screening.

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PubMedCureus2026-07-27

Periportal Right Colic Artery Arising From the Ventral Aspect of the Superior Mesenteric Artery With Associated Vascular Anomalies: A Case Report.

Sharma Vinay V, Panchal Padamjeet P, Babu Cs Ramesh CR

The right colic artery (RCA) classically arises from the right convex surface of the superior mesenteric artery (SMA), crossing the superior mesenteric vein (SMV) anteriorly or posteriorly. We report a previously undescribed combination of three concurrent vascular anomalies identified during routine cadaveric dissection: an RCA arising from the ventral SMA surface with a periportal course producing visible indentation of the anterior SMV wall; an aberrant middle colic artery (MCA) arising from the ventral-left SMA surface with immediate bifurcation into right and left branches, the latter running along the inferior pancreatic border; and bifid middle colic venous drainage without a common trunk, with left tributaries draining to the splenic vein and right tributaries draining independently to the SMV. The periportal RCA lies directly within the D3 (third level lymph node dissection) field, the central lymphadenectomy zone extending from the ileocolic artery (ICA) root to the MCA root along the SMA, where the surgeon skeletonizes the SMV and ligates colic vessels at their origins during laparoscopic right hemicolectomy with complete mesocolic excision (CME) and central vascular ligation (CVL). Unlike a standard anteriorly crossing RCA, which maintains a tissue plane between itself and the SMV, this periportal variant contacts the anterior SMV wall directly at the outset of central dissection, creating an unannounced risk of inadvertent SMV laceration during the medial-to-lateral approach. The independent venous drainage to the splenic vein cannot be controlled by standard middle colic vein (MCV) ligation. Preoperative high-resolution computed tomography colonography-angiography (CTC-A) is essential for anticipating such variants. This case demonstrates that right colonic vascular anomalies may occur in complex combinations affecting both the arterial and venous systems. Detailed preoperative vascular mapping is strongly recommended before complete mesocolic excision/central lymphadenectomy to minimize the risk of catastrophic intraoperative hemorrhage.

PMID 42504329
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PubMedACS nano2026-07-27

Reproducible Synthesis of 6-Inch Adlayer-Free Graphene Single Crystals via Interfacial Chemical Potential Engineering.

Zhang Dapeng D, Yang Bo B, Xu Shining S, Xie Fan F et al.

Chemical vapor deposition (CVD) synthesis of monolayer graphene single crystals on Cu(111) substrates has been regarded as a promising route toward controlled batch production. However, the widespread use of CVD-derived graphene remains hindered by the unavoidable formation of adlayers, which compromises thickness uniformity and property homogeneity. Current adlayer elimination strategies still suffer from narrow process windows, limiting scalability and reproducibility. Here, we identify the carbon chemical potential as a key factor determining adlayer formation and develop an interfacial chemical potential engineering strategy for the reproducible growth of 6-inch adlayer-free graphene single crystals. By constructing a symmetric dual-catalytic confinement, the chemical potential of active carbon species is effectively regulated, enlarging the tolerance for adlayer-free growth. Using this approach, twenty 6-inch monolayer graphene wafers are produced in a single batch with an expanded reaction window and a 4-orders-of-magnitude reduction in adlayer density. Furthermore, the effective elimination of adlayers improves the transfer intactness and electrical uniformity of as-received graphene, demonstrating an average carrier mobility of ∼8461 cm2 V-1 s-1 at room temperature and a sheet resistance of 401 ± 12 Ω sq-1 across the entire wafer. This work provides an effective strategy for adlayer suppression and establishes a reliable and scalable pathway toward wafer-scale monolayer graphene single crystals.

PMID 42503801
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An optimization-embedded simulation approach for quantifying the operational impacts of right-sizing prenatal care.

Ghrayeb Leena L, Cohn Amy A, Jiang Ruiwei R, Peahl Alex A

The United States spends approximately $111 billion annually on maternity care but has the worst maternal mortality rate among peer high-income nations. Recent studies suggest that outdated prenatal care guidelines may be a cause for this. In response to the growing need for modernized prenatal care standards, national prenatal care stakeholders are moving away from the traditional "one-size-fits-all" prenatal care pathways and have proposed new "tailored" appointment pathways. To study the operational impacts of adopting this new paradigm, we propose a discrete-event simulation model, which captures patient-related heterogeneity, with a mixed-integer linear programming model embedded within it, to schedule patients on a weekly basis. The objectives are to minimize patient delays, patient rescheduling, and overbooking. We use this model to quantify the operational impacts of adopting the new tailored care paradigm and to draw insights about varying scheduling policies. We apply our model to a case study of a single prenatal care clinic within a large academic health center. Our results suggest that tailoring care significantly reduces delays, rescheduling, and overbooking. This additional flexibility may allow a clinic to accommodate more patients, or to better adapt to social risk factors and/or unexpected complications that require additional care. We also find that scheduling appointments one at a time, rather than by trimester or the entirety of the pathway, yields schedules with minimal delays and overbooking.

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