北京若生智能科技有限公司
Drug Database
CL

clobetasol (DFD06 / DFD06 Cream / DFD 06)

✓ Approved

Encore Dermatology, Inc. · NR3C1 · 类固醇

什么是 clobetasol？

clobetasol 是一种类固醇，由Encore Dermatology, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名DFD06, DFD06 Cream, DFD 06
公司Encore Dermatology, Inc.
药物类别类固醇, 小分子
分子靶点NR3C1
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Encore Dermatology, Inc.

作用机制

分子靶点

clobetasol 作用于 1 个分子靶点：

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

clobetasol 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

相关研究文献

PubMedDentistry journal2026-10-26

Influence of Continuous Chelation on Root Dentin: A Laboratory Study.

Correia Eva E, Ferreira Inês I, Lopes Maria Ascensão MA, Braga Ana Cristina AC et al.

Background/Objectives: Continuous chelation has emerged as an alternative to conventional sequential irrigation by combining sodium hypochlorite (NaOCl) with weak chelators in a single irrigant solution. This study evaluated and compared the effects of different final irrigation protocols on root dentin microhardness, chemical composition, and irrigant surface tension. Methods: Sixty extracted human canines were standardized for root length and canal lumen. Root dentin discs obtained from the middle third were randomly assigned to five groups according to the irrigation protocol: 3% NaOCl (total exposure time, 24 min), 17% EDTA (3 min), 3% NaOCl-DR HEDP (total exposure time, 24 min), 3% NaOCl/17% EDTA (NaOCl total exposure time, 24 min; EDTA 3 min), and 3% NaOCl/17% EDTA/3% NaOCl (NaOCl total exposure time, 24 min; EDTA 3 min). Dentin microhardness was assessed before and after treatment using the Vickers hardness test. Chemical composition was analyzed by energy-dispersive X-ray spectroscopy, and surface tension was measured using the pendant drop method. Data were analyzed using one-way ANOVA and Tamhane's T2 post hoc test (α = 0.05). Results: Dentin microhardness decreased by approximately 4.0% with NaOCl-DR HEDP, 4.1% with EDTA alone, 14.3% with NaOCl, 16.9% with NaOCl/EDTA/NaOCl, and 39.7% with NaOCl/EDTA. Post hoc analysis showed that NaOCl/EDTA resulted in significantly greater reductions in dentin microhardness than EDTA alone, continuous chelation with NaOCl-DR HEDP, and the NaOCl/EDTA/NaOCl protocol (p < 0.05). EDTA and NaOCl-DR HEDP exhibited the smallest reductions in microhardness and did not differ significantly from each other. Regarding chemical composition, NaOCl-DR HEDP induced intermediate changes in organic and inorganic components. NaOCl alone yielded the lowest carbon content, while EDTA and NaOCl/EDTA sequence showed the lowest calcium and phosphorus levels. Surface tension was highest for the H2O-HEDP solution, followed by 3% NaOCl-DR HEDP and 17% EDTA, and lowest for 3% NaOCl. Conclusions: Despite its higher surface tension, the continuous chelation protocol with NaOCl-DR HEDP preserved dentin microhardness to a similar extent as EDTA alone and promoted more moderate changes in dentin chemical composition than the conventional final irrigation protocols, particularly NaOCl/EDTA, suggesting a conservative effect on root dentin.

PMID 42930394
阅读全文 →
PubMedEpidemiologia (Basel, Switzerland)2026-10-26

Characteristics and Treatment Outcomes of Patients with Drug-Resistant Tuberculosis in Selected Facilities of O.R. Tambo District Municipality, Eastern Cape, South Africa: A Retrospective Cohort Study.

Somjobo Yanga Y, Faye Lindiwe Modest LM, Hosu Mojisola Clara MC

Background: Tuberculosis (TB) remains a major global health concern, particularly in low- and middle-income countries, due to its high prevalence, mortality, and economic impact. The emergence of drug-resistant tuberculosis (DR-TB) has intensified this burden, posing significant challenges to disease control and management. Understanding the epidemiology of DR-TB is crucial for improving prevention strategies, guiding treatment interventions, and informing public health policies aimed at reducing its spread and impact. Methods: A retrospective cohort study was conducted using medical records of patients diagnosed with DR-TB between January 2020 and December 2024 at decentralized DR-TB clinics in the O.R. Tambo District Municipality, Eastern Cape, South Africa. Treatment outcomes were collected from available records through August 2025. Data on demographic, clinical, and treatment outcome variables were collected using a structured abstraction tool. Data was analyzed using SPSS version 30 (IBM Corp., Armonk, NY, USA). Results: A total of 385 participants were included in the study, with a mean age of 38.6 years. Males accounted for 62.3% of cases. Most participants (94.3%) resided in rural areas, and 62% were HIV-coinfected. Rifampicin-resistant TB was the most common type (51%), followed by MDR-TB (38%). A significant association was observed between age and HIV status (p = 0.001). Treatment outcomes showed that 40.8% of patients were cured, while 11.7% died, with mortality highest among older and HIV-positive patients. Comorbidities reported included hypertension and diabetes mellitus. Conclusions: Most patients included in this facility-based cohort were males, aged 25-39 years, rural residents, living with HIV, with suboptimal treatment outcomes and a substantial comorbidity burden. Strengthened integrated TB/HIV care, early diagnosis, and targeted interventions are needed to improve DR-TB outcomes in this setting.

PMID 42930325
阅读全文 →
PubMedNature communications2026-10-26

DR-GEM enables self-supervised machine learning for single-cell embeddings and annotations.

Yeh Christine Yiwen CY, Sun Min Woo MW, Zhu Dixian D, Jerby Livnat L

Dimensionality reduction and clustering are instrumental to single-cell and spatial genomics data analysis. Here we show that existing methods tend to fit oversampled classes and miss more unique signals and patterns, such as rare cell types and states. We find that the problem in such cases is not primarily data scarcity per se, but the model equating abundance with importance. Addressing this, we present "Distributionally Robust and latent Group-AwarE consensus Machine learning" or DR-GEM, a self-supervised meta-algorithm that uses the reconstruction error to reorient the model attention to patterns it initially missed and applies balanced consensus learning to increase robustness and filter low-quality data. We apply DR-GEM to synthetic and real-world single-cell, spatial transcriptomics, and Perturb-seq datasets and demonstrate that it outperforms existing methods in obtaining reliable embeddings, recovering rare cell types, filtering noise, mitigating cell-level and patient-level underrepresentation, and uncovering held-out genetic and spatial features. We thus surface and address an underappreciated problem and present a self-supervised framework to help support AI-based and data-driven discoveries.

PMID 42928257
阅读全文 →
PubMedTranslational vision science & technology2026-10-26

Association Between Systemic Arterial Stiffness and Choroidal Vascular Resistance Assessed by Laser Speckle Flowgraphy in Diabetic Retinopathy.

Fujioka Naoki N, Tanaka Kazufumi K, Nunose Moe M, Imai Sara S et al.

This study aimed to investigate the association between peripapillary choroidal hemodynamics, as measured by laser speckle flowgraphy (LSFG), and systemic arterial stiffness, indicated by the cardio-ankle vascular index (CAVI), in patients with diabetic retinopathy (DR). In this retrospective cross-sectional study, 72 eyes from 72 patients with type 2 diabetes across DR stages were analyzed. Choroidal parameters, including mean blur rate (MBR; indicating blood flow), beat strength (BS; reflecting pulsatility), and the BS/MBR ratio (BOM; a resistance-related waveform index), were quantified in both temporal and nasal peripapillary regions. A stepwise multiple regression analysis was conducted to identify independent predictors of CAVI, considering age, sex, and LSFG parameters. In univariate analyses, higher CAVI was significantly associated with increased choroidal pulsatility and resistance (P < 0.05). In the final exploratory stepwise multivariable model, age remained significantly associated with higher CAVI (β = 0.048, P = 0.020), while temporal BOM showed a borderline positive trend with CAVI (β = 2.719, P = 0.055). The model was statistically significant overall (adjusted R² = 0.326, P < 0.001). In patients with DR, age was the most robust determinant of CAVI. The retention of regional choroidal BOM parameters in the final exploratory stepwise model suggests a possible association whereby systemic pulsatile stress may influence choroidal hemodynamics, although these findings are exploratory and hypothesis-generating. LSFG-derived choroidal resistance (BOM) may help explore the ocular-systemic vascular connection in diabetes management.

PMID 42929703
阅读全文 →
PubMedBMC ophthalmology2026-10-26

Comparative detection of diabetic retinopathy microvascular lesions using single-capture ultrawide-field swept-source OCT angiography versus widefield colour fundus photography.

Asad Yusra Y, Paniharam Pavan P, Goh Ser Koon SK, Jayakrishnan Ayush A et al.

To compare the detection and quantification of intraretinal microvascular abnormalities (IRMAs) and neovascularization (NV) between widefield colour fundus photography (WF CFP) and single-capture ultrawide-field swept-source OCT angiography (UWF SS-OCTA) across diabetic retinopathy (DR) severity stages, and to evaluate whether paired multimodal review enhances lesion detection and disease classification. Eyes of different DR stages were imaged using 133° WF CFP and 150° UWF OCTA imaging modalities. Images were independently graded by masked, trained graders for the presence and quantification of NVs and IRMAs. Paired multimodal review was then performed bidirectionally for WF CFP and UWF OCTA to assess whether lesion detection could be improved by cross-referencing the corresponding image from the other modality. Intergrader agreement and inter-modality agreement during independent and paired multimodal review were assessed using intraclass correlation coefficients (ICC). A total of 120 eyes were analysed (NPDR: 64.6%; PDR: 35.4%). Under independent grading, UWF OCTA detected significantly more lesions than WF CFP across all DR stages (all p < 0.001), with poor inter-modality agreement. Paired multimodal review significantly increased WF CFP lesion counts across all groups (all p < 0.001), while UWF OCTA counts remained unchanged or showed no significant increase. Inter-modality agreement improved after paired review (mild-moderate NPDR IRMA ICC: 0.219; severe NPDR IRMA ICC: 0.334; PDR NV ICC: 0.726), however, UWF OCTA continued to detect significantly more lesions (all p < 0.001). Inter-grader agreement for both NV and IRMA grading was higher for UWF OCTA than WF CFP (NV ICC: 0.974 vs. 0.694; IRMA ICC: 0.635 vs. 0.420). In an exploratory finding, 12 eyes (10%) were reclassified from NPDR to PDR following multimodal review. Single-capture UWF OCTA detects significantly more IRMAs and NV than WF CFP, with superior reproducibility. Multimodal review enhances lesion recognition on WF CFP but does not eliminate inter-modality discrepancies. These findings highlight the potential of UWF OCTA to refine DR staging and influence clinical decision-making, supporting its complementary role alongside fundus photography in specialised diabetic eye care.

PMID 42928188
阅读全文 →
PubMedCurrent oncology (Toronto, Ont.)2026-10-26

Societal and Healthcare Costs of Post-IDFS Events Following Adjuvant Ribociclib Plus an Aromatase Inhibitor (AI) Versus AI Alone in Pre- and Postmenopausal Women with Early HR+/HER2- Breast Cancer in Canada.

Soliman Dina D, Brezden-Masley Christine C, Sehdev Sandeep S, Sabater Anaya Natalia N et al.

Recent advancements in early breast cancer (EBC) for high-risk populations have significantly improved invasive disease-free survival (IDFS). While cost-effectiveness has been assessed, the broader societal impact of improved IDFS remains unstudied. A non-homogeneous semi-Markov model was developed to estimate total healthcare and societal costs after first-line treatment with ribociclib plus an aromatase inhibitor (AI) or, alternatively, AI alone in patients with hormone-receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) EBC. Using an incidence-based approach, the model calculated total expected annual societal costs of disease-related events after cessation of adjuvant treatment with ribociclib plus AI or AI alone for HR+/HER2- EBC. The model includes five states: IDFS, non-metastatic recurrence (NMR), distant recurrence (DR), secondary primary malignancy (SPM) and death, with a one-year cycle length, and a new cohort entering each year. Health state transition probabilities are based on a previously published cost-effectiveness model (CEM). Costs are tallied only after IDFS (after cessation of adjuvant treatment) and include direct costs of medical care as well as indirect costs related to employment, productivity, and wage loss. At the 4-year NATALEE data cut-off (April 2024), ribociclib plus AI reduced the risk of an IDFS event by 28.5% versus AI alone (HR 0.715), corresponding in the model to 23% fewer non-fatal events (NMR, DR, and SPM), 18% lower mortality, 23% lower total direct costs (-$957,471,465), and 24% lower indirect costs (-$448,542,692) from the period of cessation of adjuvant therapy until death. Healthcare savings were driven primarily by fewer distant recurrences and deaths, while societal savings were largely due to reduced caregiver costs. Treatments that reduce disease recurrence and mortality can significantly lower societal costs and alleviate burden on the healthcare system.

PMID 42930162
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多clobetasol