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tuberculosis vaccine (Mw) (Immuvac / Cadi05 / Sepsivac)

✓ Approved

Cadila Pharmaceuticals Ltd. · 细胞治疗 · 细胞治疗

什么是 tuberculosis vaccine (Mw)？

tuberculosis vaccine (Mw) 是一种细胞治疗，由Cadila Pharmaceuticals Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intradermal Injection。

药物档案

商品名Immuvac, Cadi05, Sepsivac
公司Cadila Pharmaceuticals Ltd.
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Intradermal Injection
状态Approved
来源： ClinicalTrials.gov, Cadila Pharmaceuticals Ltd.

治疗适应症

tuberculosis vaccine (Mw) 针对 10 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsLeprosy✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-small cell lung cancer stage IV✓ Approved
Infections and infestationsSepsis✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-small cell lung cancer metastatic✓ Approved
Infections and infestationsSystemic infection✓ Approved

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相关研究文献

PubMedFrontiers in cardiovascular medicine2026-09-10

Myocardial function recovery in peripartum cardiomyopathy: the role of global longitudinal strain and myocardial work.

Ilardi Federica F, Carusone Federica F, D'Alconzo Dario D, Manzo Rachele R et al.

Peripartum cardiomyopathy (PPCM) occurs during the peripartum period or shortly thereafter and is characterised by left ventricular (LV) systolic dysfunction. Although some women achieve recovery of LV ejection fraction (LVEF), others develop persistent systolic impairment. Data on myocardial mechanics and contractile performance after the acute phase are limited. We aimed to evaluate whether global longitudinal strain (GLS) and myocardial work (MW) indices could provide a more comprehensive assessment of myocardial performance and identify subtle abnormalities associated with incomplete myocardial recovery in PPCM. We retrospectively analysed 22 women (mean age 42.1 ± 8.9 years) with PPCM, evaluated ≥6 months after the acute phase, enrolled in the Italian Multicentre Observational PPCM Registry (NCT05878041). Myocardial mechanics were assessed using GLS, global work index, global constructive work, global wasted work, and global work efficiency (GWE). Patients were stratified by LVEF into Group A (<50%) and Group B (≥50%) and compared with 21 age-matched healthy women (Group C). LV recovery was observed in 16 women (72.7%). Compared with controls, Groups A and B displayed larger LV diameters and volumes (p < 0.001), impaired tricuspid annular plane systolic excursion (p = 0.007), and left atrial strain (p < 0.001). Group A exhibited significantly worse GLS and MW parameters (p < 0.001 for all), consistent with the impairment of LVEF. Despite LVEF recovery, Group B still showed reduced GLS (18.0 ± 3.1% vs. 21.8 ± 1.7%, p < 0.001) and GWE (92.6 ± 6.0 vs. 95.9 ± 2.0%, p = 0.023) compared with controls. GLS and MW indices enable a refined assessment of myocardial performance in PPCM. Persistent abnormalities despite normalised LVEF suggest residual subclinical dysfunction and support their potential role as sensitive markers of myocardial impairment beyond conventional measures of systolic function.

PMID 42719012
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PubMedACS omega2026-09-10

Tucuma Fat-Based Nanostructured Lipid Carriers: Physical Stability and Antifungal Activity.

Aguiar Gomes Antônio Taylon AT, Pereira Rayanne Rocha RR, Ferreira Lindalva Maria de Meneses Costa LMMC, da Cruz Naila Ferreira NF et al.

This study aimed to obtain and characterize NLCs from tucuma fat and evaluate them against fungal cultures. The NLCs were obtained by high-pressure homogenization of tucuma fat and carnauba wax as the oil phase and were evaluated for encapsulation efficiency (EE), drug loading (DL), zeta potential, particle size, and in vitro release kinetics over a 70-day period. Four formulations (NLC1, NLC2, NLC3, and NLC4) were prepared, showing particle size variation between 109.7 and 241.1 nm, PDI ranging from 0.16 to 0.41, and zeta potential between -12.7 mW and -27.5 mW. Only two of the four formulations were loaded with ketoconazole, presenting encapsulation efficiencies between 43.55% (NLC3) and 80.97% (NLC4), while drug loading values ranged from 2.18% (NLC3) to 4.03% (NLC4). After 70 days of storage at 8 and 28 °C, they maintained their physical characteristics (particle size, zeta potential, and PDI). The release kinetics of NLC3 and NLC4 were explained by the Korsmeyer-Peppas mathematical model. Finally, the antifungal activity of ketoconazole was improved 8-fold in NLC3 and NLC4. Finally, tucuma NLCs showed physical stability and biological efficacy.

PMID 42719824
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PubMedFrontiers in immunology2026-09-10

A bivalent oral yeast vaccine displaying Nocardia seriolae FHA and LMBV MCP confers protection in largemouth bass (Micropterus salmoides).

Lu Jianfei J, Gu Boge B, Yu Pengzhen P, Chen Jiong J

Largemouth bass ranavirus (LMBV) and Nocardia seriolae are major pathogens affecting largemouth bass (Micropterus salmoides), causing significant economic losses. In this study, recombinant yeasts expressing the fibronectin-binding protein A (FHA) of N. seriolae or the major capsid protein (MCP) of LMBV were constructed using the yeast surface display (YSD) system. Based on these recombinant strains, a bivalent oral yeast-based vaccine was developed and its protective efficacy was systematically evaluated. Oral administration of the vaccine induced specific antibodies against FHA and MCP in serum, as well as increased the transcription levels of adaptive immune genes (IgM, IgT, MHC-II) and innate immune genes (IL-1β, TNF-α, IFN-1, Mx2) in the hindgut, liver, and spleen. Importantly, the bivalent oral vaccine provided significant protection against both pathogens in largemouth bass, with relative percent survival (RPS) values of 56.7% against N. seriolae and 63.3% against LMBV. Meanwhile, the oral vaccine reduced pathogen loads and alleviated histopathological lesions. In summary, these findings suggest that the bivalent oral vaccine developed in this study could serve as a promising strategy for controlling N. seriolae and LMBV infections in largemouth bass aquaculture.

PMID 42718698
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PubMedClinical case reports2026-09-10

Laparoscopy and Peritoneal Biopsy in the Diagnosis of Peritoneal Tuberculosis: A Case Report.

Gundapaneni Sri Ram Charan SRC, Divity Shravani S, Banka Amulya Varshini AV, Burri Rithwik Goud RG et al.

A 48-year-old male was initially diagnosed with pulmonary tuberculosis (TB) based on presenting symptoms, abdominal complications, and systemic symptoms, despite anti-TB treatment. Diagnostic laparoscopy and histopathological examination of biopsy samples confirmed peritoneal TB, leading to an adjusted anti-TB regimen and significant clinical improvement over six months.

PMID 42719061
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PubMedRSC medicinal chemistry2026-09-10

Development of macrocyclic peptide inhibitors of Mycobacterium tuberculosis MurF via mRNA display with genetic reprogramming.

Carlos Patrick W PW, Franck Charlotte C, Clarke-Shepperson Caitlin E CE, Strong Emily J EJ et al.

The development of new antibacterials for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains critical due to the continued global burden of disease and the emergence of multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains. The MurF enzyme, which catalyses the ATP-dependent ligation of d-Ala-d-Ala to a UDP-MurNAc-tripeptide precursor in peptidoglycan biosynthesis, represents a promising therapeutic target. In this work, random non-standard peptide integrated discovery (RaPID) mRNA display with genetic reprogramming of a non-canonical uracil-derived amino acid was applied to Mtb MurF, leading to the identification of several high-affinity thioether-linked cyclic peptide ligands, several of which also inhibited the catalytic activity of the Mtb MurX enzyme.

PMID 42719787
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PubMedAngewandte Chemie (International ed. in English)2026-09-10

All-in-One Stretchable Flexible Zinc-Air Battery Enabled by Eutectogel-Derived Electrolyte and Electrodes.

Zheng Yafen Y, Wang Tao T, Wu Dongling D, Ren Pengxu P et al.

Flexible zinc-air batteries (FZABs) draw attention for flexibility and high energy density, yet developing integrated ones with stable electrode/electrolyte interfaces and stretchability remains challenging. Herein, lactic acid/ethylene glycol-polyvinyl alcohol (LA/EG-PVA) eutectogel is rationally designed to simultaneously act as the electrolyte, zinc anode, and catalyst cathode matrix for the fabricating fully stretchable, self-healing, all-in-one FZABs. The carboxyl (─COOH) and hydroxyl (─OH) groups of LA form numerous hydrogen bonds with EG and PVA, creating a dense cross-linked structure in the eutectogel. This gives the eutectogel excellent adhesion for robust electrode/electrolyte contact and significantly enhances its liquid retention and ionic conductivity. Furthermore, the ─COOH and ─OH in LA molecules effectively immobilize water molecules via forming hydrogen bonds, which mitigates hydrogen evolution and corrosion side reactions. Simultaneously, the strong electrostatic interaction between LA and Zn(OH)4 2- induces uniform zinc deposition, thereby suppressing dendritic growth and passivation. The all-in-one FZAB with eutectogel-derived electrolyte/electrodes delivers a peak power density of 65.4 mW cm-2, retains 44.5 mW cm-2 under 100% tensile strain, self-heals to function under stretching after cutting, and operates from -40 to 100°C. This integrated eutectogel design approach offers a new avenue for stretchable FZABs and holds promise for more stretchable energy storage devices.

PMID 42720210
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