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BF-611 (Turkadon / heparin, LMW, Fidia)

✓ Approved

Fidia · SERPINC1

什么是 BF-611？

BF-611 是一种治疗药物，由Fidia研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Turkadon, heparin, LMW, Fidia
公司Fidia
分子靶点SERPINC1, F2, F10
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Fidia

作用机制

分子靶点

BF-611 作用于 3 个分子靶点：

SERPINC1serpin family C member 1 (ATIII, AT3D)
F2coagulation factor II, thrombin (THPH1, PT)
F10coagulation factor X (FXA, FX)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

BF-611 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved

相关研究文献

PubMedUrogynecology (Philadelphia, Pa.)2026-10-26

Breastfeeding and Genitourinary Symptoms: A Prospective Cohort Study.

Illston Jana D JD, McMinn Erin K EK, McIlwraith Claire A CA, McGraw Margeaux R MR et al.

Understanding genitourinary effects of breastfeeding allows for proactive treatments and quality-of-life improvements. The objective of this study was to estimate the effect of breastfeeding on genitourinary symptoms. This prospective cohort study of breastfeeding (BF) versus non-breastfeeding (NB) primiparous women characterized genitourinary symptoms after singleton delivery at ≥34 weeks of gestation. Validated measures included the Urinary Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7), Most Bothersome Symptom questionnaire (MBS), and Pelvic Organ Prolapse Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR). Questionnaires were completed at baseline, 6 weeks, 3 months, and 6 months postpartum. The primary outcome was the UDI-6 score at 3 months. Multivariable linear and logistic regression models were evaluated for group differences. UDI-6 scores at 3 months were not different between groups (5.6±11.8 BF, 7±12 NB, P=0.43). Differences in IIQ-7 scores were not statistically significant (4.9±7.4 BF, 13.5±25.2 NB, P=0.07). Multivariable analysis for those not sexually active revealed better partner-related scores in the BF group (β, -0.85; 95% CI, -1.58, -0.12, P=0.024). Among those sexually active, the BF group had worse condition impact scores (β, 0.29; 95% CI, 0.11, 0.47, P=0.002). The three-month MBS revealed nearly a threefold likelihood of experiencing vaginal dryness in BF (adjusted odds ratio, 2.82; 95% CI, 1.19, 6.66, P=0.018). At 6 months, vaginal dryness was no longer different, but breastfeeding continued to affect sexual function. At 3-months postpartum, there were no differences in lower urinary tract symptom severity between BF versus NB women. The BF group had increased bothersome vaginal symptoms and a mixed effect on sexual function. Awareness of these findings should lead to proactive assessment of symptoms and timely treatments.

PMID 42929799
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PubMedJournal of functional morphology and kinesiology2026-10-25

Anthropometric Profiling, Somatotype Differentiation, and Methodological Discrepancies in Body Fat Estimation Across Combat Sports: A Comparative Multi-Equation Analysis.

Monterrosa-Quintero Armando A, Ojeda-Aravena Alex A, Guzmán-Sanchez Adriana A, Becerra-Patiño Boryi A BA et al.

Objectives: To evaluate kinanthropometric profiles, somatotypes, Phantom z-scores, and methodological discrepancies among nine body fat percentage (%BF) equations relative to the Katch & McArdle comparator equation across combat sports. Methods: Sixty-seven elite male athletes (Brazilian Jiu-Jitsu: n = 17, Muay Thai: n = 16, Wrestling: n = 16, Taekwondo: n = 18) underwent complete ISAK profiling. Differences across disciplines were assessed via ANOVA, while inter-equation agreement was evaluated using repeated-measures ANOVA, Bland-Altman metrics, Lin's concordance correlation coefficient (ρc), and principal component analysis (PCA). Results: Striking and grappling disciplines exhibited distinct morphological profiles, with Taekwondo displaying an ecto-mesomorphic habitus versus the endo-mesomorphic profile of grappling combat sports. Substantial systematic differences and proportional biases were observed across %BF equations (p < 0.001). Withers demonstrated the highest agreement with the comparator equation, whereas Durnin & Womersley showed a marked positive bias. PCA ordination (accounting for 71.78% of variance) successfully separated morphological robusticity from linearity. Conclusions: Anthropometric %BF equations produce substantial systematic discrepancies and should not be considered interchangeable when monitoring combat athletes. External validation against an independent criterion method is required before establishing absolute body fat values.

PMID 42924714
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PubMedACS omega2026-10-25

Analysis and Modeling of Iron Ore Reduction and Melting Behavior under Blast Furnace Ore-Coke Coupling Conditions.

Wu Mingxin M, Li Jinbo J, Li Tingle T, Wang Qi Q et al.

The efficiency of blast furnace (BF) ironmaking, a predominant method for pig iron production, is profoundly influenced by the reduction-contraction behavior and melting reduction mechanism of iron ore within the cohesive zone. These factors are critical for optimizing BF operations and energy utilization, yet remain incompletely understood, particularly under ore-coke coupling conditions. This study introduces a novel methodology to investigate the complex interactions between iron ore and coke, focusing on oxygen and carbon transfer during high-temperature reduction processes. Results demonstrate that the contraction rate of the iron ore layer is positively correlated with the direct reduction rate prior to melting, whereas inversely related trends emerge during the melting process. Postmelting, the contraction rate is governed by the dripping behavior of slag and molten iron permeating through the coke layer. The melting reduction mechanism is delineated into two distinct stages: the initial stage involves direct reaction between FeO and coke, while the subsequent stage is characterized by carbon monoxide production from the reaction of coke with CO2, which subsequently permeates into the iron layer, establishing a gas film (CO and CO2) at the coke-iron interface. This research provides fundamental insights into the thermal behavior and modeling of iron ore reduction and melting in BFs, offering a robust theoretical foundation for enhancing iron ore and coke utilization efficiency while reducing carbon emissions.

PMID 42924153
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PubMedJournal of health economics and outcomes research2026-10-25

Clinical and Economic Outcomes of Transcutaneous Afferent Patterned Stimulation for Essential Tremor.

Dai Dingwei D, Lu Chiahao C, Rosenbluth Kathryn H KH, Fernandes Joaquim J

TAPS® therapy (Cala Health) delivers transcutaneous afferent patterned stimulation through a noninvasive, wrist-worn neuromodulation device for the treatment of hand tremor in patients with essential tremor (ET). Although previous studies have demonstrated its effectiveness and safety, real-world evidence regarding its long-term clinical outcomes and economic impact remains limited. To evaluate the long-term clinical effectiveness and the healthcare resource utilization and cost impact of TAPS in patients with ET treated in real-world settings. Patients who completed a 1-month randomized pragmatic phase comparing TAPS with standard of care entered 12 months of open-label home use. Clinical outcomes were assessed via device-based motion sensors and the Bain & Findley Activities of Daily Living (BF-ADL) upper-limb scale at baseline and every 3 months. Healthcare resource utilization and costs over the 12-month TAPS treatment period were compared with those during the 12 months before TAPS initiation and with a propensity-score-matched external control arm (ECA) derived from a large US commercial and Medicare Advantage claims database. Among 225 patients who used TAPS therapy for 12 months, daily functioning improved, with the mean BF-ADL score decreasing from 17.2 to 15.8 (P < .003). Device-measured tremor power decreased by more than 50% (P < .001). No serious device-related adverse events were reported. In the ECA analysis, 153 TAPS-treated patients were matched to 306 ECA patients. Compared with baseline, TAPS-treated patients experienced significant reductions in ET-related healthcare costs ($440 decrease; P < .0001), ET-related medication use (15% fewer patients; P < .01), and ambulatory and office visits (~0.3 fewer each; P < .05). These reductions were significantly greater than those observed in the ECA (all P < .05). This is the largest and longest prospective ET study to jointly assess tremor severity, daily function, and healthcare economic outcomes. The sustained clinical benefits observed with TAPS therapy, together with reductions in ET-related healthcare utilization and costs, support TAPS as a noninvasive treatment option for adults with ET. Over 12 months of real-world use, TAPS reduced tremor severity, improved daily functioning, and lowered ET-related healthcare resource utilization and costs.

PMID 42927135
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PubMedDialogues in health2026-10-24

Financial counselling gaps in Alzheimer's care: Patient out-of-pocket expenses and physician barriers in a regional German cross-sectional pilot study.

Tabi Younes Adam YA, Meyer Eva Christina EC, Tabi Abdelati A, Rave Julius J et al.

Alzheimer's disease (AD) is associated with substantial societal and household costs, but patient-level direct out-of-pocket expenses and perceived financial counselling needs in routine memory-clinic care remain insufficiently characterised. We conducted a regional exploratory mixed-methods cross-sectional pilot survey in Schleswig-Holstein, Germany, including 38 patients recruited from a single university memory clinic and 136 responding outpatient physicians (general practitioners and neurologists; 8.8% response rate). Patients reported direct out-of-pocket expenses, perceived financial impact, and information/counselling needs. Physicians reported counselling practices, perceived burden, and barriers, complemented by brief free-text responses analysed using inductive qualitative content analysis informed by Grounded Theory coding principles. In this patient sample, 34% reported increased out-of-pocket expenses, most commonly medication co-payments and transportation costs. Nearly 40% reported insufficient information about financial implications and 32% expressed a strong desire for more financial counselling. Bayesian Kendall analyses indicated that higher household income was associated with better perceived health (τ = 0.39, 95% CrI [0.13, 0.58], BF₁₀ = 28.68) and perceived health with quality of life (τ = 0.80, 95% CrI [0.51, 0.90], BF₁₀ = 5.62 × 108). Longer time since symptom onset was associated with lower perceived health (τ = -0.33, 95% CrI [-0.52, -0.08], BF₁₀ = 8.40) and quality of life (τ = -0.38, 95% CrI [-0.56, -0.13], BF₁₀ = 25.64), whereas evidence for an association with total out-of-pocket expense category was inconclusive (τ = 0.20, 95% CrI [-0.04, 0.40], BF₁₀ = 0.86). Among responding physicians, 64% reported rarely or never discussing financial aspects of AD care. Free-text responses described time constraints, limited training/resources, and uncertainty about professional role boundaries. Thus, modest direct out-of-pocket expenses in this local sample coexisted with substantial perceived information and counselling needs. Because of the single-clinic patient sample and low physician response rate, these findings are exploratory and should not be interpreted as representative of German AD care.

PMID 42920727
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PubMedDiscover mental health2026-10-23

Breastfeeding as a protective factor of maternal depression: a multi-country analysis from Africa and South Asia.

Khalid Amna A, Qaisar Rizwan R, Hussain Azhar A

The association between breastfeeding (BF) and maternal mental health remains underexplored in low- and middle-income countries (LMICs). This study examined the relationship between BF and depressive symptoms among mothers in selected LMICs across Africa and South Asia. We conducted a secondary analysis of nationally representative Demographic and Health Survey (DHS) data from Lesotho (n = 793; 2023-2024), Mozambique (n = 5092; 2022-2023), Bangladesh (n = 4971; 2022), and Nepal (n = 1401; 2022). The pooled sample comprised 12,257 mothers aged 15-49 years with complete data on BF status and depressive symptoms. Depression was assessed using DHS items adapted from the Patient Health Questionnaire (PHQ), applying a dichotomous cut-off score of ≥ 10. BF was categorized as ever versus never. Country-specific and pooled logistic regression models were estimated, adjusting for maternal age, education, and household wealth. Breastfeeding prevalence was high across countries (Lesotho: 92.3%; Mozambique: 96.3%; Bangladesh: 95.7%; Nepal: 98.9%), while the prevalence of depressive symptoms ranged from 4.0 to 7.6%. BF was associated with lower depressive symptoms in unadjusted analyses but reached significance only in Bangladesh (β = -0.861, p < .001) and the pooled sample (β = -0.449, p < .01) in the adjusted model. Overall, mothers who never breastfed showed a consistently higher risk of depression than those who had breastfed. This multi-country analysis provides evidence of an inverse association between BF and maternal depressive symptoms in LMICs, with significant effects observed primarily in Bangladesh. Integrating maternal mental health support into BF promotion programs may be beneficial. Longitudinal studies with more detailed BF measures are needed to clarify causal pathways.

PMID 42918969
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