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BF-611 (Turkadon / heparin, LMW, Fidia)

✓ Approved

Fidia · SERPINC1

什么是 BF-611？

BF-611 是一种治疗药物，由Fidia研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Turkadon, heparin, LMW, Fidia
公司Fidia
分子靶点SERPINC1, F2, F10
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Fidia

作用机制

分子靶点

BF-611 作用于 3 个分子靶点：

SERPINC1serpin family C member 1 (ATIII, AT3D)
F2coagulation factor II, thrombin (THPH1, PT)
F10coagulation factor X (FXA, FX)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

BF-611 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved

相关研究文献

PubMedNature2026-09-10

TRI-611, a selective, brain-penetrant molecular glue degrader of ALK.

Conery Andrew R AR, La Daniel S DS, Alekseyenko Artyom A AA, Marcoux David D et al.

Tyrosine kinase inhibitors (TKIs) targeting anaplastic lymphoma kinase (ALK) have transformed the treatment landscape of ALK fusion-positive non-small-cell lung carcinoma (ALK-positive NSCLC), but the limited options for patients who progress on approved TKIs highlight a continued need for an orthogonal therapeutic approach1,2. TRI-611 is a potent, brain-penetrant molecular glue degrader of ALK fusion proteins with the potential to address this need. TRI-611 promotes the proximity of the ALK kinase domain and CRL4 substrate adaptor CRBN through a unique degron interface distal from the kinase active site. The unique binding interface of TRI-611 leads to selectivity across the proteome including known CRBN neosubstrates and other kinases. TRI-611 treatment induces degradation of all forms of ALK fusion proteins, including wild-type and ALK TKI-resistant versions, leading to regression of cell line and patient-derived subcutaneous and intracranial tumour models of ALK-positive NSCLC. TRI-611 can be combined with orthosteric ALK TKIs, achieving synergistic and durable tumour regressions. TRI-611 represents to our knowledge the first clinical-stage molecular glue degrader targeting an oncogenic gene fusion and has the potential to expand the arsenal of therapeutic options for patients with ALK-positive NSCLC .

PMID 42717093
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PubMedFrontiers in psychiatry2026-09-10

Comparative efficacy and cognitive safety of bifrontal versus bitemporal electroconvulsive therapy in adolescents with major depressive disorder: a retrospective cohort study.

Chen Xiaolu X, Liu Ke K, Shen Xiaoshan X, Yang Yifan Y et al.

Electroconvulsive therapy (ECT) remains a rapid and highly effective treatment for severe, treatment-resistant depression in adolescents, particularly when immediate suicide risk is present. However, its clinical utilization in the pediatric population is still low, largely restricted by pervasive concerns regarding cognitive impairment. While randomized trials in adults suggest that bifrontal (BF) electrode placement offers a superior cognitive safety profile compared to the standard bitemporal (BT) placement, comparative evidence specifically regarding the developing adolescent brain remains scarce. We conducted a retrospective cohort study at the Department of Psychiatry in a tertiary general hospital, analyzing 217 adolescents (aged 12-18 years) diagnosed with major depressive disorder (MDD) who underwent a course of ECT between January 2018 and June 2024. Patients were categorized into the BF group (n = 111) or BT group (n = 106) based on the electrode placement utilized. The primary efficacy outcomes were the response rate (≥50% reduction in 24-item Hamilton Depression Rating Scale (HAMD-24) scores) and remission rate (HAMD-24 score ≤8). Secondary outcomes included the reduction in suicidal ideation (Beck Scale for Suicide Ideation (BSSI) scores), the incidence of subjective memory complaints, and post-ictal recovery time. Multivariate logistic regression was performed to identify independent predictors of subjective memory complaints, adjusting for baseline severity and concurrent medications. Baseline demographic and clinical characteristics, including severity of depression and suicidality, were well-balanced between groups. The BF group achieved a numerically higher response rate (85.6%) compared to the BT group (82.1%), although this difference did not reach statistical significance (p = 0.478; odds ratio [OR] = 1.29, 95% CI 0.64-2.42). Remission rates were also comparable (33.3% vs. 33.0%; p = 0.963). Both groups showed equal efficacy in reducing suicidal ideation (p > 0.05). While efficacy outcomes were similar, the two modalities showed notable differences in two specific safety-related endpoints that are relevant to daily clinical practice: the incidence of subjectively reported memory complaints (28.8% in the BF group compared with 67.9% in the BT group; p < 0.001; OR = 0.20, 95% CI 0.11-0.36) and the objectively measured post-ictal recovery time (23.7 ± 7.7 min for BF compared with 33.4 ± 9.9 min for BT; p < 0.001; Cohen's d = 1.12). After adjusting for age, baseline HAMD-24 scores, and concurrent use of benzodiazepines and antipsychotics, BF placement remained a significant independent protective factor against subjective memory complaints (adjusted OR = 0.21, 95% CI: 0.11-0.39, p < 0.001). In adolescents with MDD, bifrontal ECT showed short-term antidepressant and anti-suicidal outcomes comparable to those of bitemporal ECT in this retrospective cohort. BF ECT appeared to be associated with fewer subjective memory complaints (as assessed by spontaneous patient reports and daily physician inquiries) and shorter post-ictal recovery time. These two endpoints, while clinically relevant in routine practice, do not capture the full spectrum of cognitive function; standardized neuropsychological assessment would be required for a comprehensive comparison. Given the retrospective design and non-random treatment allocation, these findings should be interpreted cautiously and confirmed in prospective controlled studies.

PMID 42719568
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PubMedInternational journal of biological macromolecules2026-09-09

Improvement in the freeze-thaw stability and in vitro protein digestibility of beef patties using κ-carrageenan-locust bean gum emulsion gel.

Woo Minkyung M, Kim Soeun S, Han Seokhee S, Choi Yun-Sang YS et al.

This study evaluated the freeze-thaw stability and in vitro digestion behavior of beef patties by replacing beef fat with a κ-carrageenan (κCAR)-locust bean gum (LBG)-based emulsion gel. LBG addition to κCAR-based emulsion gels reduced drip loss under all freezing temperatures (P < 0.05). Patties were prepared using three treatments: beef fat (BF), canola oil (CO), and κCAR-LBG emulsion gel (EG). EG batter exhibited less coalescence and significantly lower drip loss than BF and CO after freeze-thawing (P < 0.05). Additionally, unlike CO which hardened significantly (P < 0.05), BF and EG maintained stable hardness after freeze-thawing (P > 0.05). In an in vitro gastrointestinal digestion, CO and EG had higher α-amino groups than BF, and EG had the highest <3 kDa protein content (P < 0.05). Consequently, κCAR-LBG emulsion gel is effective beef fat substitute in beef patties, offering better freeze-thaw stability than canola oil and improved in vitro protein digestion than beef fat.

PMID 42716160
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PubMedFrontiers in immunology2026-09-09

Comparative analysis of immune escape and BCR repertoire remodeling after Omicron BF.7 and JN.1 infections.

Lin Luanfeng L, Yang Luxuan L, Sun Yulei Y, Li Jiayan J et al.

SARS-CoV-2 Omicron evolution continues to erode antibody-mediated immunity, but whether infection with antigenically distinct lineages simply amplifies pre-existing memory or redirects humoral recognition toward newly evolved antigenic space remains unclear. Here, we analyzed paired early- and convalescent-phase plasma and whole-blood samples from individuals with sequencing-confirmed BF.7 or JN.1 infection. Integrated neutralization profiling, antigenic cartography, and bulk B cell receptor (BCR) repertoire analysis revealed lineage-associated humoral trajectories. Both breakthrough infections increased cross-variant neutralization, but their updated humoral profiles were not equivalent. BF.7 breakthrough infection broadly boosted neutralization from a BA.5-related background, whereas JN.1 breakthrough infection produced greater gains against BA.2.86, JN.1, and KP.2 and shifted humoral recognition toward late-Omicron antigenic space. Neutralization remained branch-structured, with BQ.1.1 and KP.2 acting as persistent escape nodes within the BA.2/BA.5-related and BA.2.86/JN.1-related branches, respectively. This humoral updating paralleled changes in IGH clonotype counts, repertoire diversity, V/J gene usage, isotype composition, and V-J pairing, whereas major CDR3 length distributions and sequence-logo patterns remained largely conserved. Overall, these findings indicate that antigenically distinct Omicron breakthrough infections generate non-equivalent humoral recall trajectories: BF.7 exposure preferentially reinforced BA.5-related antibody recognition, whereas JN.1 exposure more effectively redirected recognition toward BA.2.86/JN.1-derived variants.

PMID 42712620
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PubMedJournal of physics. Condensed matter : an Institute of Physics journal2026-09-09

Critical Role of Quantum and Electrical Double Layer Capacitance in 2D Electrode/Ionic-Liquid Electrolyte Based Supercapacitors.

Mohanty Kalyani K, Prabhu Amritha A, Panjikallu Ashwath Subrahmanya Subrahmanya ASS, Ray Subhasmita S et al.

This work examines graphene and MXene electrodes integrated with three imidazolium-based ionic liquid electrolytes for supercapacitor applications. Quantum capacitance and electric double-layer capacitance were systematically analyzed to evaluate electrode-electrolyte performance. MXenes exhibited nearly an order of magnitude higher quantum capacitance than multilayer graphene, highlighting their superior suitability. Among the electrolytes, EMIM-TCB showed limited applicability with peak capacitance confined to zero potential. In contrast, BMIM-PF 6 and BMIM-BF 4 displayed strong compatibility, particularly with MXenes, delivering enhanced capacitance across a wide potential range due to favorable structural and electrostatic interactions. Overall, the MXene-BMIM-PF 6 combination emerges as a promising candidate for high-performance supercapacitors, while the study emphasizes the critical role of interfacial engineering in the design of next-generation energy storage systems.

PMID 42716094
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PubMedChinese journal of cancer research = Chung-kuo yen cheng yen chiu2026-09-09

A CT-based deep learning model with biological interpretation for predicting early recurrence after neoadjuvant therapy in gastric cancer.

Weng Caiming C, Zhong Qing Q, Chen Lihong L, Sun Yuqin Y et al.

To achieve accurate prediction of early recurrence (ER) in locally advanced gastric cancer (LAGC) patients after neoadjuvant therapy (NAT) and surgery, we constructed a deep learning fusion model integrating preoperative computed tomography (CT) imaging and perioperative clinicopathological features. We retrospectively enrolled 611 LAGC patients who received NAT from four tertiary teaching hospitals, including a training cohort (TC), an internal validation cohort (IVC), and an external validation cohort (EVC). ER was defined as recurrence occurring within 2 years post-surgery. Based on preoperative 2.5D CT images, we constructed a deep learning signature (DLS) using a ResNet50 architecture. In parallel, a clinical signature (CLIS) was developed through logistic regression analyses. To further improve predictive performance, a deep learning fusion signature (DLFS) was constructed by integrating the DLS and CLIS. Model performance was evaluated by discrimination, calibration, and clinical utility. Kaplan-Meier analysis was used to evaluate prognostic differences across risk groups. Bulk and single-cell transcriptomic analyses explored biological features. Compared with the DLS and CLIS, the DLFS demonstrated superior performance in predicting ER, with area under the curve (AUC) values of 0.884 in the TC, 0.828 in the IVC, and 0.748 in the EVC. Calibration curves exhibited good agreement, and decision curve analysis indicated a higher net benefit. Risk stratification based on DLFS showed worse overall survival (OS) in the high-risk group (3-year OS: TC, 35.36% vs. 77.99%; IVC, 22.90% vs. 73.88%; EVC, 36.01% vs. 63.35%; all P<0.001). Moreover, proliferation-related pathways were enriched in the high-DLFS subgroup, accompanied by an increased proportion of malignant epithelial cells in single-cell analysis. The DLFS model, integrating preoperative CT imaging and perioperative clinicopathological variables, effectively predicts ER and survival in LAGC patients after NAT. Thus, it can serve as a useful tool to optimize prognostic monitoring.

PMID 42712826
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