北京若生智能科技有限公司
Drug Database
AV

avapritinib

✓ Approved

Genetron Health · PDGFRA · 辅助诊断

什么是 avapritinib？

avapritinib 是一种辅助诊断，由Genetron Health研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

公司Genetron Health
药物类别辅助诊断
分子靶点PDGFRA
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Genetron Health

作用机制

分子靶点

avapritinib 作用于 1 个分子靶点：

PDGFRAplatelet derived growth factor receptor alpha (PDGFR-2, CD140A)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

avapritinib 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

相关研究文献

PubMedCells2026-10-26

Triterpenoid Exposure and HO-1 Blockade Sensitize Neoplastic Mast Cells Against Midostaurin and Avapritinib.

John Max Vincent MV, Filik Schüppler Yüksel Y, Witzeneder Nadine N, Schneeweiss-Gleixner Mathias M et al.

Advanced systemic mastocytosis (advSM), including aggressive SM (ASM), SM with an associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL), are rare, mostly KIT D816V-driven malignancies with a poor prognosis. KIT D816V-targeting drugs, such as midostaurin or avapritinib, can induce hematologic responses in most patients with advSM. However, relapses may occur. Therefore, current research focuses on novel drugs and drug combinations to improve outcomes in advSM. We here describe that the synthetic triterpenoids bardoxolone methyl and omaveloxolone suppress proliferation in various human MCL-like cell lines expressing or lacking KIT D816V, with IC50 values of 0.2-0.4 µM. Growth-inhibitory effects were accompanied by induction of apoptosis, decreased surface expression of CD44, CD71 and KIT, and downregulation of cytoplasmic AKT. Antiproliferative effects of bardoxolone methyl and omaveloxolone were also observed in primary neoplastic cells obtained from patients with advSM. Moreover, both synthetic triterpenoids were found to cooperate with midostaurin and avapritinib in suppressing the proliferation of HMC-1 and MCPV-1 cells. However, bardoxolone methyl and omaveloxolone also augmented expression of heme oxygenase-1 (HO-1), a mediator of cell survival and drug resistance in these cells. The HO-1 inhibitor SMA-ZnPP was subsequently applied and found to sensitize neoplastic mast cells against synthetic triterpenoids and KIT D816V-targeting drugs. Together, application of bardoxolone methyl and omaveloxolone, as single agents or in drug combinations involving HO-1 blockers and/or KIT D816V-targeting drugs, may be a suitable strategy to improve therapy and to overcome resistance in advSM. The clinical value of this combination approach remains to be assessed in clinical trials.

PMID 42929870
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PubMedCells2026-10-26

Stem Cell-Based Therapies in Companion Animals: Molecular Mechanisms, Clinical Applications, and Translational Perspectives.

Liu Weina W, Wang Yu Y, An Wei W, Wang Zhenlong Z et al.

Stem cell-based therapies, as regenerative and immunomodulatory strategies, show substantial potential in companion animals through tissue repair, functional recovery, and immune modulation. Despite advances in human stem cell research, veterinary clinical translation remains constrained by small sample sizes, short follow-up periods, and non-standardized cell dosing regimens and delivery protocols. The expanding repertoire of stem cell-based modalities and technologies-including mesenchymal stem cells, induced pluripotent stem cells, extracellular vesicles, and tissue engineering-provides promising avenues for clinical application. This review summarizes recent progress in stem cell-based therapies across multiple disease systems in dogs and cats, with particular attention to the molecular mechanisms underlying regenerative and immunomodulatory effects, cross-species translational strategies, current challenges, and combinatorial therapeutic approaches in companion animals. By examining mechanistic findings alongside preclinical and early clinical evidence, this review highlights the limitations of current knowledge and identifies research priorities for evaluating the safety and efficacy of stem cell-based therapies in dogs and cats.

PMID 42929856
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PubMedVeterinary medicine international2026-10-26

Zoonotic Potential of Non-Helicobacter pylori Helicobacter Species Associated With Dogs and Cats in Human Infections: A Systematic Review.

Al-Gburi Nagham Mohammed NM

Non-Helicobacter pylori Helicobacter (NHPH) spp. are clinically relevant organisms found in humans and several animal hosts. Dogs and cats are natural hosts of multiple gastric and enterohepatic NHPH spp. and may represent potential sources of human exposure. This systematic review aimed to synthesize the clinical, epidemiological, and molecular evidence concerning human infections involving dog- and cat-associated NHPH spp. and to evaluate the evidence for a possible epidemiological association with companion animals. PubMed and Scopus databases were searched for studies published from 2000 through the final search on April 15, 2026. Eligible studies reported human infection with NHPH spp. involving H. heilmannii sensu stricto (s.s), H. felis, H. bizzozeronii, H. salomonis, or H. canis. The following information was extracted: study and patient characteristics, NHPH species, human samples, diagnostic techniques, molecular confirmation, immunological state, clinical results, and exposure to dogs and/or cats. The risk of bias was evaluated using the Joanna Briggs Institute (JBI) critical appraisal checklist appropriate for each study design. Of 350 records identified, 51 studies met the inclusion criteria. The evidence consisted predominantly of case reports. H. heilmannii-related organisms were the most frequently reported, followed by H. canis, H. felis, H. bizzozeronii, and H. salomonis. Gastric NHPH infections were predominantly associated with gastric disease, while H. canis was mainly associated with systemic and extragastric infections, especially in immunocompromised or clinically vulnerable patients. Molecular confirmation was reported in 66.7% of studies (34/51), with one additional study providing molecular confirmation for only 2 of 22 cases. Dog and/or cat exposure was documented in 41.2% of studies (21/51). Although several studies identified the same NHPH spp. in humans and companion animals, paired strain-level molecular evidence remained limited and was insufficient to establish the direction of transmission. Numerous gastrointestinal and systemic infections in humans have been linked to NHPH spp. found in dogs and cats. According to available data, dogs and cats may act as reservoirs or sources of human NHPH infection, given the recognized zoonotic potential of these pathogens. However, direct animal-to-human transmission and its direction have not been conclusively established. This is largely due to the limited availability of strain-level molecular comparisons and paired human-animal sampling. To clarify transmission routes and improve integrated One Health surveillance, consistent molecular identification and comparative genomic studies are therefore required.

PMID 42928729
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PubMedBiosensors2026-10-26

Development of a One-Pot MIRA-CRISPR/Cas12b Fluorescence Biosensing Platform for Rapid Detection of Brucella canis.

Huo Suxin S, Zhu Yinchu Y, Ji Congyun C, Fan Fu F et al.

Brucellosis is an important zoonotic disease worldwide, and Brucella canis (B. canis) is an emerging concern in companion animal health. Rapid and reliable detection of B. canis in dogs is essential for disease control. Herein, we developed a one-pot MIRA CRISPR/Cas12b fluorescence biosensing platform targeting the conserved omp31 gene. The platform integrates MIRA mediated isothermal amplification with CRISPR/Cas12b-based target recognition and collateral cleavage. After optimization, the assay achieved a detection limit of 5 copies/reaction within 20 min, comparable to qPCR. No cross reactivity was observed with seven common canine pathogens. Among 128 clinical blood samples, the biosensor showed complete agreement with qPCR, achieving 100% sensitivity and 100% specificity. These findings demonstrate that the biosensor provides a rapid, sensitive, and specific approach for B. canis detection, with potential for decentralized veterinary testing through its endpoint visual fluorescence readout and applications in One Health surveillance.

PMID 42930125
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PubMedJournal of evaluation in clinical practice2026-10-26

Medicine's Unfinished Revolution. Part 1-The Case for Change: Systems Thinking and the Soul of Medicine.

Sturmberg Joachim J

Medicine has historically progressed by addressing anomalies that its prevailing conceptual framework could not explain, subsequently expanding that framework to incorporate them. This essay, the first of two, contends that the current anomalies confronting medicine-chronic multimorbidity and suffering arising from the interactions between conditions and lived experiences-are fundamentally different. These challenges cannot be resolved by merely broadening a framework designed to isolate components, as they represent anomalies of interconnection and interdependence. What is needed is not an expanded biomedical frame, but an entirely new conceptual approach. Drawing on systems and complexity sciences, this essay differentiates four phenomena that medicine often conflates-health, illness, dis-ease, and disease-and introduces the somato-psycho-socio-semiotic (SPSS) model, which conceptualises health as a dynamic equilibrium rather than simply the absence of pathology. The consultation is redefined as the fundamental unit of care, and the health system is reconceptualised as a purpose-driven organisation, described as a health care vortex, centred on the patient's experience of health. The argument is illustrated through the case of a single, representative patient and concludes by identifying unfinished work at three levels: the physician, medical education, and medicine's social license. A companion essay addresses the common objections to this argument.

PMID 42929744
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PubMedEuropean journal of investigation in health, psychology and education2026-10-26

Mental Well-Being Among Emerging Adults With and Without SLD/ADHD During War.

Alon Raaya R, Harel-Gadassi Ayelet A

Emerging adulthood is marked by increasing independence and responsibility across educational, occupational, and social domains. During wartime, disruptions to daily routines, security, and perceived control may threaten mental well-being, understood as positive emotional, social, and psychological functioning. These challenges may be particularly salient for individuals with specific learning disabilities (SLD) and/or attention deficit hyperactivity disorder (ADHD), who may experience difficulties in executive functioning and maintaining everyday routines. This study examined differences in mental well-being between emerging adults with and without SLD and/or ADHD and assessed the contributions of executive functioning, health-promoting daily activities, psychological capital, and perceived social support during wartime. Participants were 317 Israeli emerging adults aged 18-28 years. Among the 316 participants with valid diagnostic-group classification, 115 reported SLD and/or ADHD and 201 reported neither condition. Emerging adults with SLD and/or ADHD reported lower mental well-being, greater executive functioning difficulties, and lower engagement in health-promoting daily activities than those without SLD and/or ADHD. Mental well-being was positively associated with psychological capital, health-promoting daily activities, and perceived social support, and negatively associated with executive functioning difficulties. In the hierarchical regression, diagnostic-group status was initially associated with mental well-being but was no longer significant after psychological capital, health-promoting daily activities and executive functioning were entered; perceived social support made a small additional contribution. The final model explained 37.2% of the variance in mental well-being. These findings highlight the relevance of cognitive-functional, psychological, occupational, and social factors to mental well-being during a prolonged national crisis.

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