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influenza vaccine (MonoGrippol Neo)

✓ Approved

Npo Petrovax Pharm · 疫苗 · 疫苗

什么是 influenza vaccine？

influenza vaccine 是一种疫苗，由Npo Petrovax Pharm研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

商品名MonoGrippol Neo
公司Npo Petrovax Pharm
药物类别疫苗, 大分子
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Npo Petrovax Pharm

相关研究文献

PubMedNature communications2026-10-26

Extended dosing intervals enhance the durability of a self-amplifying mRNA vaccine against pandemic H5N1 influenza: a randomized, observer-blind, dose-finding Phase I study.

Pragalos Antoinette A AA, Pacciarini Filippo F, Jin Hongfan H, Hopkins Terri T et al.

Avian influenza poses a persistent pandemic threat, yet traditional vaccines face production delays. Self-amplifying mRNA (sa-mRNA) technology offers potential advantages, including rapid development, dose sparing, and enhanced, durable immunity. We evaluated ARCT-2304, a bicistronic sa-mRNA vaccine encoding H5N1 hemagglutinin (HA) and neuraminidase (NA), in a Phase 1 randomized, observer-blind trial (NCT06602531). Healthy adults (N = 212) received two doses of ARCT-2304 (1.5, 5, or 12 mcg) or control/placebo on a 4- or 8-week schedule. Primary outcomes evaluated safety and reactogenicity (solicited/unsolicited/serious adverse events [AEs]) and immunogenicity (HA inhibition and NA enzyme-linked lectin assays 28 days post-second dose). Immunogenicity results were benchmarked using serum from a prior study supporting licensure of an H5N1 vaccine. ARCT-2304 was well-tolerated, displaying mostly mild-to-moderate, transient, dose-dependent solicited AEs, with no safety concerns identified. Two doses elicited robust HA and NA humoral responses. An 8-week interval yielded higher magnitude and greater durability than a 4-week schedule, with neutralizing and anti-NA antibodies remaining significantly elevated 6-7 months post-second dose. ARCT-2304 also induced dose-dependent, Th1-polarized T-cell responses peaking at Day 29. These findings support advancing sa-mRNA platforms for pandemic influenza preparedness.

PMID 42928290
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PubMedEpidemiology and infection2026-10-26

An investigation into post-pandemic ethnic group and deprivation inequalities in influenza and COVID-19 hospitalizations.

Scott Meg M, Browning Lucy L, Roberts Tirion T, De Boer Jessica J et al.

Health system decision-makers need evidence on how modifiable factors contribute to inequalities to inform effective interventions. We examined ethnic group and deprivation inequalities in influenza and COVID-19 hospitalizations in England (2023-2024) among vaccine-eligible individuals, using causal mediation analysis to assess the roles of deprivation, vaccination uptake and comorbidities. For influenza, hospitalization odds were highest among Pakistani and Bangladeshi groups, compared with White British individuals. Deprivation mediated 26% of the total ethnic group effect for the Pakistani group and 41% for the Bangladeshi group, whilst comorbidities contributed little. Ethnic group differences in COVID-19 hospitalizations were minimal in this post-pandemic period. For both infections, the most deprived group had disproportionately high hospitalization compared to the least deprived. For influenza, vaccination uptake mediated 17%-26% of deprivation effects, whilst for COVID-19, there were no meaningful residual deprivation inequalities after including vaccination uptake and comorbidities. Vaccination uptake and deprivation mediate a substantial proportion of inequalities in hospitalization for influenza and COVID-19 in the vaccine-eligible cohort. Improving vaccination coverage in under-vaccinated groups should remain a public health priority.

PMID 42929057
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PubMedNature communications2026-10-26

Reoviridae-derived short trimerization domain for stabilizing homo-trimerization of vaccine immunogens and therapeutic proteins.

Wei Min M, Bu Qingfang Q, Xiao Jin J, Yuan Lunzhi L et al.

Trimerization motifs play pivotal roles in structural biology and therapeutic protein engineering. Here, we describe a short trimerization motif (rFd1303) derived from the Reoviridae family reovirus σ1 protein. Compared with the widely used T4-Foldon, the rFd1303 increased recombinant protein yields. The rFd1303-fused immunogens of SARS-CoV-2 spike and influenza hemagglutinin elicited antibody responses comparable to T4-Foldon-fused controls in mice. Using this tag, we engineered a trimeric ACE2-Ig fusion protein (TriACE2-Ig) that remained stable after 30 days at room temperature and neutralized a broad range of ACE2-utilizing sarbecoviruses, including 19 SARS-CoV-2 variants, SARS-CoV, and pangolin coronaviruses GD and GX, with higher potency than monomeric ACE2-Ig. In the hamster model challenged with various SARS-CoV-2 variants, our data demonstrated that intranasal TriACE2-Ig administration markedly reduced viral loads, virus-induced body-weight loss, lung pathology, and decreased within-cage virus transmission. These findings highlight rFd1303 as a versatile trimerization platform for vaccine and therapeutic protein development.

PMID 42928093
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PubMedCells2026-10-26

Decoding Cell-Cell Interactions in Neurovascular Unit Co-Cultures Through Molecular Vibrational Spectroscopy and Biology.

Pragnąca Aleksandra A, Borkowska Agata A, Antolak Anna A, Leśniak Monika M et al.

The blood-brain barrier (BBB) is a coordinated multicellular interface in which intercellular communication shapes responses to injury and metabolic stress. However, the contributions of individual cell types to collective stress adaptation remain poorly understood. Here, we examined molecular and metabolic responses of 2D neurovascular unit (NVU) co-culture models comprising endothelial cells, astrocytes, and pericytes exposed to hypoxia or sublethal HgCl2 toxicity. An integrated platform combining gene and protein expression profiling, label-free vibrational spectroscopic imaging, and machine-learning-based analysis was used to assess stress-induced changes in cell-cycle regulation and metabolism across mono- and co-culture configurations. Hypoxia broadly suppressed G1/S and G2/M regulators, inducing cell-cycle arrest with limited cell death, consistent with an adaptive response. HgCl2 caused heterogeneous, model-dependent changes in viability and proliferative capacity. Spectroscopic phenotyping revealed that the triple co-culture exhibited spectral features resembling those of pericyte monocultures, although the contributions of cell-cell interactions and differences in culture conditions could not be distinguished. Fluorescence imaging further revealed mitochondria-associated signals at cell-cell contact sites, suggesting a possible association of mitochondrial material with regions of close cellular interaction. The presence of pericytes was associated with a more stress-resistant cellular phenotype in the investigated co-culture configurations. The developed spectroscopic-molecular platform provides a label-free framework for characterizing cellular communication and stress responses in multicellular NVU co-culture models.

PMID 42929844
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PubMedCells2026-10-26

A Novel Bioengineering Approach to Breast Cancer Invasion In Vitro Through Enhancing the Value of Existing Breast Cancer Epithelial Lineages.

Webb Ethan E, Goncalves Kirsty K, Przyborski Stefan S

Breast cancer incidence is rising globally. The emerging literature implicates cancer cell interactions with their surrounding microenvironment as a clinically significant driver of cell migration and metastasis. Current in vitro modelling approaches often rely on basic two-dimensional culture practices, a microenvironment far removed from the native tissue. This simplicity fails to recapitulate key aspects of the tumour environment that are critical to disease progression. This study has built upon three-dimensional culture technology to describe a breast cancer invasion assay with enhanced complexity compared with standard approaches. Three key breast epithelial cell lines, namely MCF-10A, MCF-7 and MDA-MB-231, representative of increasing invasiveness, were applied to in vitro systems of varying complexity. Through enhancing the geometry of the culture system, and inclusion of stromal populations, we have successfully improved breast cancer invasion modelling in vitro, exemplified by a demonstrated response to a test compound. The incorporation of a tissue-specific stromal foundation, upon which each epithelial cell lines were cultured, allowed for interaction between neosynthesised extracellular matrix and stromal and epithelial cells, whilst providing a dense physical network for cancer cells to migrate through. This has introduced several microenvironmental factors consistent with the native tissue but lacking in other more simplistic culture systems and has enhanced the value of commonplace cancer cell lines. This novel bioengineered culture system also lends itself to in-depth fundamental mechanistic insights into aspects of cancer cell biology, including interactions with the tissue environment and the role of cancer-associated fibroblasts in disease progression.

PMID 42929854
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PubMedVeterinary world2026-10-26

Preclinical evaluation of a live attenuated bivalent Trichophyton vaccine for prophylaxis and post-infection treatment of dermatophytosis in rabbits.

Umitzhanov Mynbay M, Bakirov Nurbol N, Sansyzbay Abylay A, Nurpeisova Ainur A et al.

Bovine trichophytosis is a contagious zoonotic dermatophytosis that adversely affects animal health and livestock productivity and poses an occupational risk to people in contact with infected cattle. Although live attenuated vaccines have contributed to disease control, evidence for bivalent formulations targeting multiple Trichophyton species remains limited. This study evaluated the prophylactic activity and post-infection outcomes of a live attenuated bivalent vaccine candidate containing Trichophyton verrucosum and a member of the Trichophyton mentagrophytes species complex in an experimental rabbit model. Thirty-three clinically healthy rabbits were allocated to a prophylactic group (Group I, n = 10), therapeutic group (Group IIa, n = 10), infected untreated histopathology subgroup (Group IIb, n = 3), and intact control group (Group III, n = 10). Group I received two intramuscular vaccinations 14 days apart and was challenged 21 days after the second vaccination, whereas Group IIa was experimentally infected before therapeutic vaccination. Clinical manifestations, body weight, rectal temperature, hematological parameters, mycological culture, and histopathological changes were evaluated. Clinical and histopathological assessments were descriptive and non-blinded. Following experimental challenge, no clinically visible dermatophytosis lesions occurred in prophylactically vaccinated rabbits (0/10), whereas all infected untreated reference rabbits developed lesions (3/3; two-sided Fisher's exact test, p = 0.0035), supporting prophylactic activity. Therapeutically vaccinated rabbits showed progressive regression of visible crusting and hair regrowth; however, the absence of a longitudinal untreated infected group and positive treatment comparator precluded attribution of recovery specifically to vaccination. Dermatophyte growth was recovered from challenged skin after 5-7 days, although species-specific identification and quantitative fungal burden were not determined. Hematological indices showed limited descriptive variation. Histopathology demonstrated inflammatory and degenerative cutaneous lesions in untreated infected rabbits and nonspecific reactive lymphoid changes in vaccinated animals. The live attenuated bivalent vaccine candidate demonstrated promising prophylactic activity against experimental dermatophytosis in rabbits. Post-infection clinical improvement provides preliminary evidence warranting further investigation but cannot establish therapeutic efficacy. Controlled studies in the target host should incorporate adequate comparator groups, standardized lesion scoring, quantitative and species-specific mycology, immunological endpoints, and comprehensive vaccine quality control and stability assessments before field application.

PMID 42928825
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