ApicHope Pharmaceutical · 多肽类 · 多肽类
cerebroprotein hydrolysate for injection (III) 是一种多肽类，由ApicHope Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。
| 公司 | ApicHope Pharmaceutical |
| 药物类别 | 多肽类 |
| 给药途径 | Injectable (Others) |
| 状态 | Approved |
cerebroprotein hydrolysate for injection (III) 针对 3 个适应症，涉及 3 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Nervous system disorders | Amnesia | ✓ Approved |
| Injury, poisoning and procedural complications | Craniocerebral injury | ✓ Approved |
| Psychiatric disorders | Attention deficit hyperactivity disorder | ✓ Approved |
Adding the mRNA-based individualized neoantigen vaccine intismeran autogene to the PD-1 inhibitor pembrolizumab following surgery for melanoma reduced the risk of disease recurrence or death by 42%, according to the results of the phase III INTerpath-0001 trial. The data were presented at the ESMO Congress 2026, held October 23-27, in Madrid, Spain.
Parvini Mojdeh M, Ghasemian Fatemeh F, Salimy Siamak S
Azoospermia is a severe form of male fertility characterized by the absence of sperm in the ejaculate. Sphingolipids regulate essential cellular processes, including differentiation and apoptosis, with ceramide and sphingosine functioning as key bioactive signaling molecules. This study investigated sphingosine levels and ceramide subtype profiles in the testicular tissue of mice across distinct spermatogenic states, including immature, normal mature, and azoospermic conditions. In this experimental study, 24 NMRI mice were randomly allocated into three equal groups (n=8): i. Immature (2 weeks old), ii. Normal mature (8 weeks old), and iii. Azoospermic (8 weeks old), the latter induced by a single intraperitoneal injection of busulfan (40 mg/kg). Following histopathological evaluation, sphingosine and ceramide concentrations in testicular tissue were quantified using high-performance liquid chromatography (HPLC). Statistical analysis was performed using one-way analysis of variance (ANOVA), followed by appropriate posthoc tests for group comparisons. Significant differences in sphingosine and ceramide concentrations were observed among the experimental groups. Sphingosine levels were highest in normal mature mice, followed by azoospermic and immature groups (P<0.001). A similar overall pattern was observed for most ceramide subtypes (Cer14, Cer18, and Cer20), which were significantly elevated in normal mature mice compared with the other groups. In contrast, Cer16 showed a distinct pattern, with reduced levels in azoospermic mice compared with immature animals (P<0.001). Alterations in specific sphingolipid metabolites are associated with spermatogenic status and may contribute to the pathophysiology of male infertility. Disruption of sphingosine and ceramide homeostasis may impair reproductive function, supporting their potential utility as biomarkers and therapeutic targets in azoospermia..
Zhang Xiaoxiang X, Zhang Yu Y
Loft Matthew M, Gibbs Peter P
Zhang Guanchao G, Jia Lei L, Xu Bing B
The accurate detection of liver cancer-associated microRNAs (miRNAs) remains challenging due to their low abundance and high sequence homology. Herein, we report a colorimetric biosensor integrating Exo-III-assisted target recycling with a cyclization-functional DNAzyme walker for sensitive and highly specific miRNA detection. Notably, the assay incorporates two distinct miRNA recognition events: first, the target miRNA hybridizes with a stem-loop probe to trigger Exo-III-mediated cyclic cleavage; second, the released initiator strand activates the DNA walker on magnetic beads, where the miRNA must hybridize with a specific binding site on the tracker strand to reconstitute the split DNAzyme catalytic core. This dual-recognition mechanism dramatically enhances specificity, enabling the sensor to discriminate single- and double-nucleotide mismatches with high reliability. Coupled with Ag+-aptamer-mediated signal transduction, the platform produces a visible color change for naked-eye readout. With cascade amplification, the assay achieves a detection limit of 2.7 fM and a linear range of 5 fM to 100 pM. Successful spike-recovery tests in human serum (96.2-104.4%) suggest its potential for clinical application. This portable, visual colorimetric strategy offers a promising solution for early liver cancer screening.
Ghosh Rajashri R, Rashid Ambreen A, Dey Anik Kumar AK, Pramanik Sourav S et al.
Inorganic phosphates and polyphosphates are vital to biological function, and their dysregulation is linked to metabolic and renal disorders, driving the need for selective, sensitive, and reversible luminescent probes for their detection. Here, we report three bis-heteroleptic Ir(III) complexes (IC1-IC3) bearing imidazole-functionalized ancillary ligands that show selective "switch-on" emission toward phosphate (H2PO4-) and pyrophosphate (HP2O73-) over competing anions, driven by C-H···O hydrogen bonding between imidazole donors and phosphate oxygens. Variable-temperature studies (80-300 K) reveal long-lived phosphorescence (τ = 1.4 μs at 80 K) governed by restricted intramolecular motion and a large singlet-triplet gap. Emission analysis shows mixed 3MLCT character for IC1/IC2, while nitro-substituted IC3 displays combined 3MLCT/3LLCT character. The interaction of IC1 with H2PO4- gives a 1:2 binding stoichiometry (K = 8.0 × 105 M-1) and detection limits of 35.4 nM and 16.3 nM for H2PO4- and HP2O73-, respectively. NMR and DLS studies indicate that phosphate binding triggers hydrogen-bond-mediated supramolecular aggregation, rigidifying the excited state and enhancing emission, while Zn2+ reversibly quenches this response, enabling switch-on/switch-off behavior applicable to molecular logic gate. Phosphate binding extends IC1's excited-state lifetime from 91.68 to 357.66 ns. These Ir(III) complexes thus emerge as a tunable platform for selective, reversible phosphate sensing.
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