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octreotide

✓ Approved

TTY Biopharm · SSTR2 · 小分子

什么是 octreotide？

octreotide 是一种小分子，由TTY Biopharm研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司TTY Biopharm
药物类别小分子, 多肽类
分子靶点SSTR2, SSTR5
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, TTY Biopharm

作用机制

分子靶点

octreotide 作用于 2 个分子靶点：

SSTR2somatostatin receptor 2 (SST2)
SSTR5somatostatin receptor 5 (SST5, SS-5-R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

octreotide 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersAcromegaly✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Pancreatic neuroendocrine tumour metastatic✓ Approved

相关研究文献

PubMedBiosensors2026-10-26

Multiscale Microparticle Trapping Through Tapered-Fiber Structures and Refractive-Index Modulation.

Chen Xiaoyue X, Xiong Yubin Y, Zhu Hanbing H, Su Yinhong Y et al.

Tapered optical fibers reshape optical fields in confined spaces, enabling versatile microparticle trapping. This study establishes a continuous framework spanning near-field confinement, far-field extension, and environmental modulation by comparing flame-tapered and machine-pulled fibers. Flame tapering produces sharp tips with micrometer-scale foci; taper angles of 24°, 40°, and 60° yield focal positions of 0.2, 5.1, and 7.0 µm, respectively. A 980 nm laser is used, and stable trapping and probe-guided transport of 20 µm polystyrene microspheres were achieved at a threshold of 84 mW, with dual-particle trapping demonstrated via microlens-induced secondary potential wells. In contrast, machine-assisted tapering generates smooth end faces and long transition regions, extending working distances to 67, 122, and 163 µm. A long-transition probe further produced dual axial potential wells that stably confined 5 µm microspheres at 143 and 286 µm at powers above 500 mW. Environmental modulation revealed that increasing the external refractive index from 1.33 to 1.36 shifted the simulated focal positions from 40 to 55 µm, while ethanol-water evaporation experimentally reduced the trapping distances from 353 to 236 µm. These results show that fiber geometry defines the trapping range, whereas refractive index tunes the precise trapping position, offering a compact platform for multiscale manipulation with potential applications in cell positioning and sorting in liquid environments.

PMID 42930105
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PubMedWater research2026-10-25

Enhancing oil-water separation in hydrocyclones using superhydrophobic/superoleophilic fiber microspheres.

Zhang Lian L, Lu Zhaojin Z, Gu Shen S, Bai Zhishan Z

To overcome the separation scale limit of conventional hydrocyclones for microfine oil droplets, multiphase/multi-field coupling has emerged as a frontier in enhancing oil-water separation. In this paper, a novel modified fiber microsphere-coupled hydrocyclone (MFMCHC) for enhanced separation was proposed. The modified fiber microspheres with superhydrophobic and superoleophilic properties were successfully fabricated via electrospinning, electrospraying, and a one-step solvent immersion. The microspheres were systematically characterized. The effects of reaction time, dopamine, and octadecylamine concentration on surface wettability were investigated, along with the influence of operating parameters on separation efficiency. Results showed that after modification, the microspheres changed from milky white to black, with the formation of micro-nano rough structures on the surface and enhanced thermal stability. Wettability tests revealed a maximum water contact angle of 166° in air and an underwater oil contact angle of 0°, with complete oil spreading achieved in 1.9 s under optimal conditions. The modified microspheres also showed good stability under high-speed shear and prolonged water immersion. Separation experiments demonstrated that the modified microspheres significantly promoted oil droplet coalescence and growth, increasing the volume average diameter at the oil outlet from 35.63 μm to 50.60 μm. The coupled separator improved separation efficiency by 10.0%-23.1% over the conventional hydrocyclone. The separation efficiency increased with the overflow split ratio and inlet oil concentration, and the modified coupled separation system exhibited superior performance compared with the unmodified one across different inlet flow rates. This work offers theoretical and technical guidance for multiphase-coupled hydrocyclone design in oily wastewater treatment.

PMID 42925757
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PubMedFrontiers in bioengineering and biotechnology2026-10-25

From formation history to intra-articular service: coupling network evolution, fatigue, degradation, and drug release in adaptive hydrogel microspheres.

Gu Yang Y, Jiao Fude F, Fang Yuqin Y, Zhang Jun J et al.

Hydrogel microspheres intended for intra-articular delivery are commonly compared by particle size, encapsulation efficiency, equilibrium modulus, static degradation, and cumulative drug release. These endpoints do not recover the specimen's life-cycle history. Crosslinker transport, reaction kinetics, washing, storage, reconstitution, and needle passage can leave gradients in crosslink density, water content, residual functionality, cargo distribution, and relaxation. In the joint, that hidden state evolves under compression, shear, friction, and wear, while reversible adaptation competes with defect accumulation, bond loss, degradation, and erosion. Each process can alter transport pathways and local exposure. This Mini Review examines evidence linking formation history to intra-articular service, emphasizing hydrogel microspheres rather than bulk injectable gels. Direct end-to-end evidence remains sparse: only one particle-containing study identified here compared release after repeated compression, and tribology, injection, storage, release, and pharmacokinetics are usually tested separately. We integrate findings from external gelation, dynamic networks, hydrogel fatigue, mechanically modulated release, synovial-fluid interfaces, and joint pharmacokinetics. A service-aware framework follows initially matched particles through storage, reconstitution, injection, relaxation, cyclic loading, wear, degradation, release, and repeat administration. The critical design variable is the measurable network state inherited from manufacture and altered by use, not a bond label or initial modulus alone.

PMID 42920797
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PubMedExperimental physiology2026-10-25

Diet-induced obesity enhances the glycaemic response to glucagon in male C57BL/6J mice.

Reynolds Thomas H TH, Saxena Smriti S, Maher Gillian G, Zhang Jin J

Although the impact of obesity on the action of insulin has been studied extensively, little is known about how obesity affects the action of its counter-regulatory hormone, glucagon. The purpose of this study was to determine whether diet-induced obesity alters in vivo glucagon responsiveness, independent of insulin action. To study diet-induced obesity, C57BL/6J male mice were fed a normal chow diet or a Western diet for 16 weeks. Glucagon responsiveness was determined by assessing the blood glucose response to glucagon (25 µg/kg) while insulin secretion was inhibited by octreotide (1 mg/kg). Body composition was assessed by nuclear magnetic resonance spectroscopy. Insulin sensitivity was assessed by an insulin-assisted glucose tolerance test. As expected, the Western diet resulted in an increase in adiposity and a decrease in insulin sensitivity. Contrary to our initial hypothesis, diet-induced obesity increased glucagon responsiveness, as evidenced by significantly higher blood glucose levels following glucagon administration, resulting in a greater area under the curve in mice fed a Western diet compared with mice fed a normal chow diet. In a preclinical model of obesity and insulin resistance, our study indicates that the glycaemic response to glucagon is enhanced when insulin secretion is inhibited with octreotide, arguing against the idea of impaired glucagon responsiveness. Future studies can use this approach to identify alterations in glucagon signalling that might explain the enhanced glucose response to glucagon.

PMID 42927671
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-25

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1-Dependent Immune Priming in Hepatocellular Carcinoma.

Yang Jiakun J, Yang Nailin N, Ji Shuangshuang S, Meng Siping S et al.

Hepatocellular carcinoma (HCC) imposes a major global health burden, with current ablation techniques limited by invasiveness and post-treatment recurrence. Here, size-controllable, polylactic acid/iron oxide magnetic microspheres containing 30% Fe3O4 (P@Fe30 MSs) were fabricated via shirasu porous glass membrane emulsification for transarterial magnetic thermal ablation (MTA). The optimized microspheres exhibit superior magnetothermal performance under an alternating magnetic field, effectively killing tumor cells and triggering immunogenic cell death (ICD). Mechanistically, MTA-induced tumor disruption cooperates with the TLR9 agonist CpG ODN to accelerate dendritic cell maturation and promote a tumor-TDLN immune-priming cascade, featuring CD103+ cDC1 enrichment and CCR7-associated cDC1 migration dynamics, functional CD8+ T-cell activation, and systemic memory-associated immune remodeling. Crucially, direct evaluation of CpG timelines reveals that early post-MTA CpG administration significantly outperforms delayed delivery, validating a transient post-ablation immune-priming window. Furthermore, experiments in Batf3-/- mice confirm that this systemic antitumor immunity strictly depends on a cDC1- mediated priming pathway. Finally, preclinical validation in an orthotopic rabbit VX2 liver tumor model demonstrates excellent transarterial feasibility, localized metabolic tumor suppression via 18F-FDG PET imaging, and a favorable safety profile. This work establishes a remotely activated transarterial ablation platform that coordinates with temporal innate immunotherapy to drive systemic cDC1-dependent antitumor responses.

PMID 42921859
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PubMedACS omega2026-10-25

Hollow Silica/PUU Composites for Flame Retardancy and Blast Mitigation: From Shock Tube to In Vivo Protection.

Huang Deming D, Xu Jintao J, Huang Zeng Z, Du Juan J et al.

Blast shock waves and the resulting thermal burns from secondary fires are among the primary causes of casualties in explosions, underscoring the significance of developing protective materials that simultaneously deliver efficient shock wave attenuation and flame retardancy. Herein, a flame-retardant polyurethane-urea (PUU) elastomer was synthesized via molecular structure engineering and subsequently reinforced with hollow silica microspheres (HSM), yielding PUU composites. The PUU matrix attained a limiting oxygen index of 31.15%, demonstrating self-extinguishing capability. Shock tube tests revealed that the PUU composite with 10 wt % HSM (PUU10S) achieved an attenuation rate of 75%, the excellent attenuation performance originates from continuously distributed impedance mismatch interfaces established by the microspheres, coupled with microsphere debonding and wave path redirection under shock loading. Rat blast protection evaluation directly confirmed the protective efficacy, as the PUU10S-protected group exhibited a reduction in pulmonary injury area from 91.03% to 33.94%, recovery of the lung wet-to-dry ratio from 6.91 to 4.70, and a decrease in 6 h mortality from 50% to 8.3% relative to the unprotected cohort. This study provides a promising strategy for reconciling flame retardancy and blast resistance in a single polyurea-based material: the intrinsically flame-retardant PUU matrix retains its self-extinguishing character upon HSM incorporation, albeit with a moderate reduction in tensile strength and toughness, while the hollow-microsphere architecture delivers a reduction in transmitted peak pressure and a marked reduction of blast-induced pulmonary injury in rats, establishing a foundation spanning materials design to biological protective validation for next-generation high-performance composite protective materials.

PMID 42924125
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