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quinidine bisulfate (Kiditard)

✓ Approved

Adare Pharma Solutions · SCN5A · 小分子

什么是 quinidine bisulfate？

quinidine bisulfate 是一种小分子，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Kiditard
公司Adare Pharma Solutions
药物类别小分子
分子靶点SCN5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Adare Pharma Solutions

作用机制

分子靶点

quinidine bisulfate 作用于 1 个分子靶点：

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

quinidine bisulfate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersArrhythmia✓ Approved

相关研究文献

PubMedJournal of dairy science2026-10-23

Controlling ammonia concentrations in calf hutches with sodium bisulfate.

Casper David P DP, Robbins Randall D RD

Neonatal calves are susceptible to respiratory irritation and lung damage via elevated ammonia concentrations in calf facilities. The study objective evaluated the addition of Sodium Bisulfate (SBS; SurpHace; Jones-Hamilton) to reduce ammonia concentrations in calf hutches. Ninety Holstein male calves were blocked by body weight (BW) and randomly assigned to 1 of 2 treatments starting on June 4, 2025. Treatments were 1): Control: no SBS applied to calf hutch wheat straw bedding and 2): 454 g of SBS applied twice per week on Tuesday and Saturday mornings after feeding. SBS was applied with a Scotts WIZZ grass seeder to achieve even distribution of SBS in the hutches. Fresh chopped straw was added again on July 7 and ground soyhulls were added on July 14 and July 21 with the experiment ending on July 30. Ammonia readings were collected weekly starting wk 3 on Thursday mornings following feeding using a single personal NH3 gas detector (Model FD-80A (Forensics Detectors, Rolling Hills Estates, CA). The use of SBS reduced (P < 0.01) ammonia concentrations by approximately 85% (10.5 and 1.63 mg/kg for Control and SBS, respectively). There was a treatment by week interaction with the greatest reductions occurring during wk 7 and 8. Calves with SBS added to their bedding had increased (P < 0.02) BW gain (30.3 and 33.9 kg) and average daily gains (ADG; 541 and 605 g/d) approximately 12%. There was a tendency for increased calf starter consumption (0.63 and 0.73 kg/d) and a tendency for a treatment by week interaction demonstrating increased calf starter intake during wk 6, 7, and 8 for calf hutches receiving SBS compared with Control hutches. Feed conversions (0.495 and 0.511 kg/kg) were similar among both hutch treatments. Heart girth gain (12.5 and 14.5 cm) was improved for calves housed in hutches receiving SBS compared with Control hutches while remaining frame measurements were similar among calves housed in hutches without or with SBS. Scour scores were similar among calves housed in both hutch treatments. SBS was effective in reducing calf hutch ammonia concentrations by 85%, which supported improved BW gains, ADG, calf starter intake, and heart girth gains.

PMID 42913828
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PubMedEnvironmental research2026-10-22

Reconciling competing objectives in carbonated MSWI fly ash washing: Dechlorination, calcium retention, and heavy metal stabilization.

He Xuyang X, Wang Jincheng J, Zhang Dingyuan D, Li Weihua W et al.

The resource utilization of MSW incineration fly ash is constrained by its high chloride content, calcium loss during washing, and the environmental risk of residual heavy metals. This study proposes a multistage pretreatment integrating carbonation, ball milling, ultrasonication, and CO2-coupled washing to balance dechlorination, calcium retention, and heavy metal stabilization. Citric acid (CA), ammonium bisulfate (AB), and ethylenediaminetetraacetic acid (EDTA) were selected as washing agents and evaluated on carbonated fly ash. For the investigated fly ash, results demonstrated that carbonation provided the foundational calcium fixation, while ball milling physically disrupted particle agglomerates to expose encapsulated chlorides, with 60 min selected as the milling duration. Ultrasonication for 10 min further reduced soluble chloride contents in heavily carbonated fly ash residues to 0.72%, 0.79%, and 0.81%, respectively, with calcium loss rates of 14.30%, 10.81%, and 12.08%. However, EDTA washing caused severe remobilization of Pb, Zn, Cu, and Cd. Further coupling ball milling and ultrasonication with in-situ CO2 sparging (20 min for CA and 10 min for AB) improved the overall treatment performance. The lowest soluble chloride content (0.71%) was obtained with CA, whereas AB achieved the lowest calcium loss (8.87%). All heavy metal leaching concentrations in CA and AB residues met the regulatory limits. Risk assessment code analysis indicated that AB generally resulted in lower environmental risks than CA, although Cd remained the primary residual concern. Overall, the coupled treatment alleviated the trade-offs among chloride removal, calcium retention, and heavy metal stabilization, thereby improving the resource recovery potential of treated fly ash.

PMID 42906668
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PubMedJACC. Clinical electrophysiology2026-10-20

Long-Term Outcome Following Idiopathic Ventricular Fibrillation and Potential Emerging Etiologies.

Haïssaguerre Michel M, Benali Karim K, de Groot Natasja N, Eckardt Lars L et al.

Unexplained cardiac death and cardiac arrest associated with idiopathic ventricular fibrillation (IVF) are heterogeneous pathologies responsible for significant mortality in young people. This retrospective multicenter cohort study evaluated the natural history of a large cohort of IVF survivors including recurrence burden, emerging etiologies, and long-term management. This study included IVF patients from 46 tertiary centers and followed for at least 5 years. Patients over the age of 15 years who had documented ventricular fibrillation and extensive negative investigations supporting the diagnosis of IVF were included. Patients were followed in each center with their outcome being established on data collection from subsequent clinical records, new investigations, genetic results, and implanted defibrillator recordings. Recurrent arrhythmias and mortality were assessed. Diagnoses were graded as definite (direct evidence) or probable (indirect criteria). A total of 825 patients (37% women; age 35.7 ± 12 years) were followed for a median duration of 120 months (Q1-Q3: 78-180 months). Death occurred in 27 patients (3.3%) from cardiac (n = 10; 1.2%), noncardiac (n = 9; 1.1%), and unknown (n = 8; 1%) causes, and few patients (4.5%) developed overt cardiomyopathy. Overall arrhythmia recurrence increased steadily over 2 decades, reaching 52.7% of patients, with a median time to first recurrence of 20 months (Q1-Q3: 5-48 months) and a similar incidence in men and women. Emergent etiologies occurred in 68.8% of the total population, and were associated with new information during recurrences, structural changes, genetic results, and mapping procedures. They included reclassified inherited arrhythmia conditions in 73 (8.8%), focal sources in 272 (33.0%), and definite or probable microstructural myocardial alterations (MiCMs) with normal imaging in 223 (27.0%), while no diagnosis was identified in 257 (31.2%). Compared with MiCM, focal IVF included more women, occurred more frequently at rest/sleep, and was associated with narrow QRS complexes (90.1 ± 12 milliseconds vs 104.8 ± 16 milliseconds; P < 0.001). Quinidine appeared effective in preventing focal IVF (68.3%) whereas beta-blockers appeared effective (49.3%) in MiCM-IVF. Catheter ablation was performed in 181 patients with no recurrence observed in 75.7%. This multicenter long-term cohort study of IVF survivors shows low cardiac mortality, a persistent risk of arrhythmia recurrences over time, and identifies potential emerging etiologies.

PMID 42900029
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PubMedHeart, lung & circulation2026-10-16

Angry Purkinje Syndrome: A Review of Short-Coupled Polymorphic Ventricular Tachycardia with Quinidine Treatment.

Fang Qing Yi QY, Somma Vincenzo V, Lee Geoffrey G, Anderson Robert D RD

Polymorphic ventricular tachycardia (VT) mediated by short-coupled premature ventricular complexes in patients with recent myocardial infarction is termed 'Angry Purkinje Syndrome'. These arrhythmias are typically refractory to conventional antiarrhythmic therapy but may respond to quinidine. We present a case series of patients with short-coupled polymorphic VT occurring 2-8 days after acute myocardial infarction and coronary revascularisation. All three patients had recurrent polymorphic VT episodes that were consistently initiated by ventricular ectopy with a short coupling interval of 360 milliseconds. All three patients experienced arrhythmic storms requiring multiple cardioversions and were refractory to amiodarone, procainamide, lignocaine, and isoprenaline. Quinidine led to sustained suppression of ventricular arrhythmias, with marked reduction in premature ventricular contraction burden within 24 hours. Two patients were successfully extubated 4 days after arrest, and the third was decannulated from extracorporeal membrane oxygenation 4 days after quinidine initiation. 'Angry Purkinje Syndrome' is an uncommon but important cause of polymorphic VT in patients with coronary disease not related to acute myocardial ischaemia. Quinidine appears to provide effective suppression of Purkinje-mediated polymorphic VT and may represent an important therapeutic option in this setting.

PMID 42888107
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PubMedEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2026-10-16

Translational evaluation of in vitro-to-in vivo extrapolation techniques for brain penetration using open flow microperfusion and microdialysis in rats.

Murata Yukiko Y, Hogan Janita J, Al-Majdoub Zubida M ZM, Cheong Jonathan J et al.

There is a growing need to leverage mathematical models of the central nervous system (CNS) with translational approaches employing in vitro-in vivo extrapolation (IVIVE) approaches. As a benchmark of brain penetration, unbound brain partitioning (Kp,uu), and subsequently a combination of cerebral Open Flow Microperfusion (cOFM) and microdialysis (MD) were evaluated in rats. Additionally, a six-compartment physiologically-based pharmacokinetic (PBPK) model of the CNS was developed in rats using six drugs with varying affinities to the P-glycoprotein (P-gp) transporter to learn and verify the in vivo studies. Active and passive drug efflux and permeability parameters derived from two P-gp overexpressing cell lines (MDCK-I and LLC-PK1) were scaled using proteomics-informed methods. Model predictions were evaluated with data obtained from terminal brain-to-plasma partition coefficient from both rat cOFM and MD experiments. In correcting for loss of drug in both the cOFM and MD equipment, a relative recovery (RR) showed significantly higher recovery in cOFM compared to MD experiments; for phenytoin, quinidine, and verapamil these were 0.53/0.063, 0.73/0.46, and 0.16/0.04 (cOFM/MD), respectively. Notably, higher P-gp efflux obtained from experiments with MDCK-I-transfected cells resulted in simulated lower drug concentrations in brain compartments. Overall, the CNS-IVIVE-PBPK model tended to overpredict brain drug concentrations, especially using data obtained from transfected LLC-PK1 cells. However, there is better agreement between the model predictions and the observed data for whole-brain concentrations obtained from terminal studies. We also demonstrated the feasibility of an IVIVE framework that integrates cell line derived passive and active drug parameters to estimate brain concentrations.

PMID 42887679
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PubMedScience advances2026-10-14

Bisulfate-mediated selective methane oxidation under mild aqueous conditions.

Lu Shike S, Wen Shao-Chun SC, Liu Wenxuan W, Li Haonan H et al.

The selective oxidation of methane under mild conditions remains a formidable challenge because of the inert C─H bond and the ease of over-oxidation. Here we report a facile strategy that enables methane conversion at room temperature and ambient pressure using molecular O2 and commercially available Cu powder in dilute aqueous H2SO4. The reaction is capable of proceeding with only trace CO2 formation, producing methyl bisulfate and methanol as the primary partial oxidation products. In situ Raman spectroscopy indicates that an in situ O2-derived Cu2O surface is the reaction-relevant phase associated with C─H bond activation. The observed selectivity arises from bisulfate adsorption on this Cu2O surface, which suppresses methanol over-oxidation, together with the interception of surface-generated methyl intermediates to form oxidation-resistant methyl bisulfate. This Cu/O2-H2SO4 system demonstrates that methane can be selectively oxidized under mild aqueous conditions and provides mechanistic insight into Cu/O2-mediated oxidation, suggesting a bisulfate-assisted approach to suppressing over-oxidation that may be applicable to other substrates.

PMID 42873888
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