北京若生智能科技有限公司
Drug Database
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OLipHEX delivery system

✓ Approved

PR Pharmaceuticals · 治疗药物

什么是 OLipHEX delivery system？

OLipHEX delivery system 是一种治疗药物，由PR Pharmaceuticals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司PR Pharmaceuticals
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, PR Pharmaceuticals

治疗适应症

OLipHEX delivery system 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedTranslational vision science & technology2026-10-26

A Robotic Tele-Laser System for Remote Visualization and Nd:YAG Laser Triggering: A Preclinical Feasibility Study.

Xu Andi A, Huang Yining Y, Lian Zhangkai Z, Yu Naiji N et al.

To evaluate the technical feasibility and short-term procedural safety of a remotely operated robotic tele-laser platform for anterior-segment neodymium-doped yttrium aluminum garnet (Nd:YAG) laser delivery in rabbit models. A remotely operated, robotic tele-laser platform integrating a customizable finger robot, stereoscopic visualization, and a Nd:YAG laser device was developed to enable ophthalmologists to remotely perform laser treatments. Twenty-four rabbits were allocated into two predefined experimental cohorts: a posterior capsular opacification (PCO) cohort (n = 12) and a laser peripheral iridotomy (LPI) cohort (n = 12). Within each cohort, animals were assigned into remotely operated and on-site subgroups. Outcome measures included technical completion, laser-delivery duration, laser parameters, engineering performance, and postoperative findings. All 24 procedures were technically completed. For capsulotomy, median laser-delivery duration was 285.0 seconds (interquartile range [IQR], 161.5-793.5) in the remotely operated group and 214.0 seconds (IQR, 173.25-441.0) in the on-site group (P = 0.589). Intraocular lens (IOL) pitting within the central 3-mm optical zone occurred in four of six eyes and in three of six eyes, respectively. For LPI, no statistically significant between-group differences were detected in laser-delivery duration, laser parameters, or change from baseline at postoperative day 1 in intraocular pressure (IOP). Mean targeting errors were 0.0380 ± 0.0174 mm in the remotely operated procedure and 0.0341 ± 0.0230 mm on site (P = 0.053). Mean glass-to-glass video latency and button-to-laser activation latency were 258.6 ± 10.2 ms and 522.7 ± 29.3 ms, respectively. This controlled preclinical study demonstrates the feasibility of a remotely operated robotic tele-laser platform for anterior-segment laser delivery. The platform enabled remote completion of capsulotomy and LPI workflows under controlled experimental conditions and provides a foundation for further engineering and translational validation. This study demonstrates the preliminary feasibility of a remotely operated robotic tele-laser platform in a preclinical animal model. This platform enables remote expert participation in laser treatment workflows and provides a foundation for future tele-laser applications. Further engineering optimization, safety validation, and clinical studies are required before translation into human ophthalmic practice.

PMID 42929704
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome-Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury.

Hu Zhenxin Z, Wang Haoli H, Huang Jing J, Zhou Junhua J et al.

Excessive accumulation and insufficient clearance of apoptotic cells following spinal cord injury (SCI) are key factors contributing to persistent injury. Macrophage efferocytosis is essential for resolving injury but is compromised by mitochondrial dysfunction and lysosomal overload. Maintaining mitochondrial functional homeostasis is therefore crucial for preserving the acidic lysosomal environment, alleviating the cellular lysosomal burden, and sustaining efferocytosis. Common mitochondrial quality control (MQC) pathways such as mitophagy increase the lysosomal burden. Here, we investigated how polo-like kinase 1 (PLK1) regulates macrophage efferocytosis and elucidated the underlying mechanism of migrasome-mediated mitocytosis. We demonstrate that PLK1 regulates TSPAN4-dependent migrasome formation, which drives the selective extrusion of damaged mitochondria, alleviates the lysosomal burden, and increases efferocytic capacity. To enable targeted PLK1 delivery, we engineered macrophage membrane-coated, reactive oxygen species (ROS)-responsive nanocomplexes encapsulating PLK1 plasmids (MM-NPs@PLK1). This biomimetic nanoplatform preferentially accumulates in the injured spinal cord, promotes macrophage-associated PLK1 delivery, enhances mitocytosis and efferocytosis, supports neural tissue repair, and significantly improves locomotor recovery in SCI mice. In summary, our study reveals a PLK1-regulated MQC mechanism that sustains macrophage efferocytosis through migrasome-mediated mitocytosis, providing a promising therapeutic strategy for SCI.

PMID 42929182
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-26

A Glycan Key Unlocks Microglia Targeting and Reprogramming to Promote Functional Recovery After Spinal Cord Injury.

Liu Ting T, Du Liangchao L, Ma Wanrong W, Long Ge G et al.

Spinal cord injury (SCI) triggers uncontrolled neuroinflammation driven by dysfunctional microglia and pro-inflammatory-biased reprogramming, yet precise therapeutic strategies remain limited. Here, we report a novel glycan-targeted nanoparticle system (ICT@APD) designed to enhance the microglia-reprogramming potential of icaritin (ICT) while overcoming its inherent narrow therapeutic window. By functionalizing nanoparticles with 2,5-anhydro-D-mannitol (2,5-AM), a high-affinity ligand for the microglia-specific transporter GLUT5, ICT@APD achieves selective microglial uptake and amplifies the capacity of ICT to reprogram microglia toward an anti-inflammatory phenotype. The targeted reprogramming consequently creates a positive microenvironment that promotes axon regeneration, neuronal survival, and synaptic reconstruction, leading to significantly improved locomotor recovery after SCI. Our findings establish a novel glycan-mediated microglial targeting and reprogramming strategy for SCI repair, which may extend to other central nervous system disorders and provide a referenceable platform for the delivery of other therapeutic agents with a narrow therapeutic window.

PMID 42929058
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PubMedDiseases (Basel, Switzerland)2026-10-26

Advanced Therapies for Diabetic Kidney Disease: A Critical Review of Gene-, RNA-, and Cell-Based Strategies to Address Residual Risk.

Kitaeva Kristina V KV, Solovyeva Valeriya V VV, Rizvanov Albert A AA

Diabetic kidney disease (DKD) can progress despite contemporary kidney-protective treatment, motivating the development of additional mechanism-based interventions. This critical narrative review evaluates whether gene-, RNA-, and cell-based strategies are ready to address this residual risk and identifies the evidence required for clinical translation. A targeted literature verification and update was undertaken for the revision, with emphasis on primary intervention studies, contradictory findings, and the distinction between target validation and product efficacy. Mechanistic and model system background is considered in relation to therapeutic selection. Adeno-associated viral vectors offer potentially durable expression but face species-dependent renal tropism, immunity, and limited control after administration. RNA therapeutics permit time-limited modulation, although productive renal delivery and compartment-specific effects remain unresolved. Mesenchymal stromal cells and extracellular vesicles provide broader paracrine activity, with challenges in potency definition, biodistribution, and manufacturing. Autologous renal cell products have entered clinical testing but require individualized production and invasive delivery. Most gene and RNA evidence is preclinical; cell therapy trials provide feasibility or exploratory efficacy signals rather than definitive kidney protection. Thus, at present, progress toward routine DKD use requires reproducible renal target engagement, validated manufacturing, and confirmation of clinical benefit in randomized trials.

PMID 42930010
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PubMedBMC proceedings2026-10-26

Meeting report of the fifth symposium organized by the coalition to strengthen the HPV immunization community (CHIC): Nairobi, Kenya - advancing sustainable HPV vaccination programs in Africa.

Bolio Ana A, Jennings Mary Carol MC, Burdier Ricardo R, Jindal Sakshi S et al.

HPV vaccination coverage across Africa has improved substantially in recent years but remains below elimination thresholds, with persistent gaps in reaching hard-to-reach populations and growing uncertainty around future financing. This report summarizes proceedings from the fifth regional symposium of the Coalition to Strengthen the HPV Immunization Community (CHIC), held in Nairobi, Kenya, in October 2025 in collaboration with Kenya's Ministry of Health. The three-day symposium convened over 100 participants from 22 African countries, including national immunisation program managers, ministry officials, researchers, civil society representatives, and global partners (WHO, UNICEF, Gavi, PATH, the Gates Foundation). The agenda, developed through stakeholder interviews and prior scientific and advisory input, centered on six subthemes related to program sustainability. Plenary sessions addressed epidemiological trends, national policy updates including Kenya's transition to a single-dose schedule, and implications of Gavi's upcoming consolidated funding model (Gavi 6.0). Country snapshot presentations and service-delivery case studies facilitated cross-country peer learning. On day three, though an electronic poll of helped to prioritize 12 candidate implementation themes, which structured subsequent round table working groups. Countries then developed individual action plans identifying priority challenges, responsible stakeholders, and implementation timelines. Sustainable service delivery, financing, and data systems emerged as the highest-priority implementation themes. Country action plans most frequently targeted data systems strengthening, communication and community engagement, sustainable service delivery, and financing mechanisms, with additional attention to service integration, hard-to-reach populations, and target population expansion. Cross-cutting synthesis identified recurring concerns regarding HPV vaccination for people living with HIV, fragmented data systems, the role of program integration, financing sustainability under evolving donor models, and underrecognized risks from misinformation, including emerging AI-generated content. The symposium reinforced CHIC's role as a platform for peer-to-peer learning across countries at varying stages of HPV vaccine introduction, surfacing shared structural barriers to sustainability alongside country-specific action plans. Findings underscore the need for sustained political commitment, financing transition planning, digital system strengthening, and multisectoral integration to support the WHO goal of cervical cancer elimination by 2030.

PMID 42928213
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PubMedGels (Basel, Switzerland)2026-10-26

pH-Responsive Chitosan-Alginate Hydrogel Beads Co-Encapsulating Jujube Polysaccharides and cAMP: Enhanced Antioxidant Activity and Gastrointestinal Controlled Release.

Zhao Guanghui G, Han Chi C, Wang Weihua W, Lu Jiankang J et al.

Jujube polysaccharides (ZJPA) and cyclic adenosine monophosphate (cAMP) are bioactive compounds with antioxidant and health-promoting potential, and their combination exhibits enhanced antioxidant activity. However, their limited stability and susceptibility to gastrointestinal environmental stresses restrict their applications in functional foods. In this study, a pH-responsive composite hydrogel bead delivery system was developed using chitosan (CS) and sodium alginate (SA) as wall materials to co-encapsulate ZJPA and cAMP, aiming to protect these bioactive compounds during gastrointestinal digestion while maintaining their enhanced functionality. The hydrogel beads were fabricated via the ionotropic gelation method, and the formulation parameters were optimized using single-factor experiments combined with response surface methodology (RSM). The optimized hydrogel beads were obtained under the conditions of calcium chloride concentration of 3%, CS concentration of 0.5%, SA concentration of 3%, and core-to-wall ratio of 1:6, with a cAMP microencapsulation yield (MEY) of 97.79%. Structural characterization confirmed that ZJPA and cAMP were successfully incorporated into the CS-SA network through electrostatic interactions and intermolecular hydrogen bonding without the formation of new covalent bonds. Furthermore, the hydrogel beads exhibited distinct pH-responsive swelling and gastrointestinal release behaviors, providing effective protection under acidic gastric conditions and enabling sustained release under intestinal conditions. Importantly, the DPPH radical scavenging assay demonstrated that the co-encapsulation strategy preserved the enhanced antioxidant activity between ZJPA and cAMP. Overall, this study establishes a multifunctional hydrogel bead delivery strategy integrating enhanced bioactivity preservation, gastrointestinal protection, and controlled release, providing new opportunities for the application of jujube-derived bioactive compounds in functional foods.

PMID 42929926
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