北京若生智能科技有限公司
Drug Database
OM

omeprazole

✓ Approved

Santarus, Inc. · ATP4A · 小分子

什么是 omeprazole？

omeprazole 是一种小分子，由Santarus, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Santarus, Inc.
药物类别小分子
分子靶点ATP4A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Santarus, Inc.

作用机制

分子靶点

omeprazole 作用于 1 个分子靶点：

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

omeprazole 针对 3 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved
Gastrointestinal disordersGastrooesophageal reflux disease✓ Approved

相关研究文献

PubMedChemistry & biodiversity2026-10-26

Phytochemical Profiling, Molecular Docking Study, and Gastroprotective Effect of Matricaria chamomilla L. Aqueous Extract in Ethanol-Induced Gastric Ulcer in Mice.

Bouhadjar Meroua M, Naimi Dalila D, Cheriet Mouna M, Barros Lillian L et al.

While Matricaria chamomilla L. is renowned for its medicinal properties, most research has focused on its essential oils or organic extracts, neglecting the traditionally used aqueous preparation. This study investigated the chemical composition and the molecular interactions of phenolic compounds in chamomile aqueous extract (CAE), focusing on its unique water-soluble components. CAE, prepared from dried chamomile flowers, was analyzed by UHPLC-DAD-ESI-MS, revealing 19 phenolic constituents dominated by flavonoids and phenolic acids. In silico studies of the major compounds -trans-3,5-di-O-caffeoylquinic acid, myricetin-3-O-glucoside, and 4-O-caffeoylquinic acid, showed high binding affinities (-7.5 to -10.4 kcal/mol) via hydrogen bonding with the catalytic residues of cyclooxygenase-2, metalloproteinase-9, and gastric H+/K+ ATPase, providing a mechanistic of analytical findings. These computational findings were supported by in vitro antioxidant and anti-inflammatory assays and in vivo evaluation in ethanol-induced gastric ulcer mouse models. CAE treatment provided exceptional protection (99% at 500 mg/kg) and reduced the ulcer index from 4.5 to 0.24, significantly outperforming conventional omeprazole treatment. Histopathology confirmed improved mucosal integrity and reduced tissue damage. This work represents the first study combining phytochemical profiling of chamomile aqueous extract with multi-target molecular docking and in vivo validation of its gastro-protective efficacy.

PMID 42928570
阅读全文 →
PubMedNature communications2026-10-26

Record stack durability in industrial solid oxide steam electrolysis through operational control.

Bilalis Vasileios V, Sloth Olivia Fjord OF, Smitshuysen Thomas Erik Lyck TEL, Beyrami Javid J et al.

Solid oxide steam electrolysis offers the highest electrical efficiency for hydrogen production, yet wide-scale deployment remains constrained by durability. Here, we show that long-term stack durability can be strongly influenced by operating strategy, achieving 25,000 h of steam electrolysis operation in a full 70-cell solid oxide electrolysis cell stack under frequency-dependent electrochemical operation (AC:DC). This experiment represents, to our knowledge, the longest and lowest degradation operation reported for a full stack. The stack enters a stabilized regime with an average voltage degradation rate of 0.05 % kh⁻¹ (0.65 mV kh⁻¹ per cell) sustained for 22,000 h after initial conditioning. The behavior is evaluated against initial DC operation, prior full-stack benchmarks, impedance evolution, and post-test microstructural signatures. Periodic polarity inversion between electrolysis and fuel-cell modes modulates electrochemical polarization and heat generation, consistent with mitigating thermal and electrochemical gradients that develop during sustained DC electrolysis. Stack-level impedance evolution and post-mortem microstructural analysis demonstrate stabilization of electrochemical performance and suppression of degradation signatures commonly observed under DC operation, indicating that key degradation pathways are not activated under AC:DC operation. By shifting durability control from materials to operational strategy, AC:DC operation offers a scalable pathway toward long-lived solid oxide electrolysis for economically competitive green hydrogen production.

PMID 42928371
阅读全文 →
PubMedBiomimetics (Basel, Switzerland)2026-10-26

Thermal-Fluid-Solid Coupling Analysis of Enhanced Heat Transfer and Thermal Stress in Shark Skin Micro-Rib Tubes.

Jiang Zhengkai Z, Sun Jichen J, Xiao Hongguang H, Li Muzhen M

A multi-field coupled numerical model integrating fluid flow, convective heat transfer, and thermal stress is established for a shark-skin-inspired V-shaped micro-rib heat exchange tube. Using the shear stress transport (SST) k-ω model, its thermal-hydraulic performance is compared with a smooth tube, revealing the mechanism of vortex-induced thermal boundary layer disturbance. Based on an L32 orthogonal array and range analysis, the sensitivity of seven geometric parameters to pressure drop and heat transfer power is quantified. A one-way thermal-fluid-solid coupling technique maps the non-uniform temperature field onto the solid domain and solves thermal strain and stress via thermoelastic constitutive equations. Results indicate that the shark skin structure induces dense prismatic vortices, improving the heat transfer coefficient by 21.7% while incurring a 245.4% increase in pressure drop. Among the parameters, hrib/P exerts the most significant influence. Thermal stress concentration occurs at the rib-root junctions. Under specific nuclear power plant seawater heat exchanger conditions, the maximum thermal stress is about 42 MPa, far below the TA2 (Grade 2 titanium alloy) yield strength, ensuring the design remains within the linear elastic safety range without plastic yielding.

PMID 42930264
阅读全文 →
PubMedThe Review of scientific instruments2026-10-26

Coincidence counting of double-shell shot solid debris.

Rusev G G, Crowell A S AS, Finch S W SW, Fry C C et al.

In support of Los Alamos National Laboratory's double shell program and the radiochemical diagnostic of mix, a study of the coincidence γ rays was carried out at the tandem accelerator of the Triangle Universities Nuclear Laboratory. A tungsten foil was irradiated with 13 MeV deuterium beams, and coincidence γ rays with multiplicity up to five were observed with a dual high-purity germanium detector system. The level schemes of 182W and 184W were constructed from the identified coincidence γ rays. Many of these γ rays were confirmed by coincidence counting of two solid radiochemical collection diagnostic foils from a recent tungsten-capsule double shell shot N260124 at the National Ignition Facility. Measuring the decay curve of the tungsten characteristic γ rays revealed a new model-independent method for estimating the effect of mix.

PMID 42929710
阅读全文 →
PubMedSmall methods2026-10-26

Polarity-Mediated β-Phase Reconstruction and Dual-Salt Synergy for Fast Li+ Transport in Solid-State Li Metal Batteries.

Liu Yan Y, Yan Yongle Y, Chang Yuying Y, Zhang Bo B et al.

Solid polymer electrolytes (SPEs) based on poly(vinylidene fluoride) (PVDF) hold great promise for safe Li metal batteries but are hindered by low ionic conductivity and insufficient salt dissociation. Here, we propose a molecular polarity-mediated synergistic strategy that integrates tetracyanoethylene (TCNE)-induced β-phase reconstruction with dual-salt chemistry to simultaneously optimize ion transport kinetics and interfacial stability. In this strategy, the strongly electron-withdrawing cyano groups of TCNE engage in dipole interactions with PVDF chains, triggering a nonpolar α-to-polar β-phase transition, which facilitates salt dissociation and shortens the Li+ migration pathway; the dual-salt system further ensures fast Li+ conduction while constructing a robust, LiF/boron-rich interphase via LiDFOB. The resulting TCNE-modified PVDF electrolyte (PTDL) delivers a high ionic conductivity of 9.32 × 10- 4 S cm- 1, a high Li+ transference number of 0.76, and a wide electrochemical window of 4.8 V. Thus, the symmetric cells can maintain a low overpotential over 1000 h at 0.2 mA cm- 2, and full cells with LiFePO4 cathode can run stably for 1000 cycles at 10 C. This work provides a new path for designing high-performance PVDF-based SPEs.

PMID 42929095
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Bioengineered Stroma-Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity.

Zhang Ziqi Z, Luo Jing J, Zhang Mengdi M, Zhuang Jingying J et al.

The cooperative upregulation of IDO1 and the immune checkpoint CD276 in solid tumors establishes a dual immunosuppressive circuit that depletes tryptophan, accumulates kynurenines, and silences T-cells. We engineered fibroblast-mimetic nanovesicles (AM@UIO-BMS/DOX) that uniquely integrate stromal-camouflaged tumor accumulation, CD276 checkpoint blockade, and co-delivery of doxorubicin with the clinical IDO1 inhibitor BMS-986205. The fibroblast-derived membrane coating promotes accumulation in fibroblast-rich tumor regions, while surface-anchored anti-CD276 scFv enables precision tumor specific targeting and concurrent checkpoint neutralization. Within the tumor microenvironment, doxorubicin elicits immunogenic cell death, and BMS-986205 metabolically recalibrates the tryptophan-kynurenine equilibrium, relieving the metabolic suppression that otherwise blunts T-cell priming. In syngeneic tumor models, this bioengineered platform profoundly remodeled the immune microenvironment, as evidenced by a tripartite shift: enhanced dendritic cell maturation and cross-presentation, expansion of Granzyme B+ cytotoxic CD8+ T lymphocytes, and selective depletion of CD25+FoxP3+ regulatory T cells. This concerted action effectively converted immunologically "cold" tumors into an inflamed phenotype, overcoming intrinsic chemoresistance and adaptive immune evasion. Collectively, our findings establish that bioengineered stroma-camouflaged nanovesicles disrupt the dual IDO1/CD276 immunosuppressive circuit, enhancing antitumor immunity and offering a promising strategy to surmount chemo-immunotherapy resistance in advanced solid tumors.

PMID 42928435
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多omeprazole