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transdermal DDS (Latitude / transdermal DDS, 3M / TDDS)

✓ Approved

3M Pharmaceuticals · 小分子 · 小分子

什么是 transdermal DDS?

transdermal DDS 是一种小分子,由3M Pharmaceuticals研发。该药已获批,用于治疗相关适应症,给药途径:Transdermal。

药物档案

商品名Latitude, transdermal DDS, 3M, TDDS
公司3M Pharmaceuticals
药物类别小分子
给药途径Transdermal
状态Approved

治疗适应症

transdermal DDS 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

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Reimagining Dental Education, Licensure, and Workforce Development.

Subramanian Gayathri G, Quek Samuel Y P SYP

Three key challenges confront the dental profession-a growing oral healthcare workforce shortage, escalating costs of dental education, and a need to re-evaluate the relevance of dental license examinations. Solutions proposed thus far address these issues individually and may inadvertently either compromise patient access to care or augment dental student burden. An integrated approach is needed to address these challenges optimally. To propose a novel dental education and licensure model that reduces educational costs, enhances workforce distribution, and optimizes practice readiness, while preserving public trust and patient safety. A narrative review and analysis of current challenges identified above was undertaken. Factors such as existing educational models, including accelerated oral healthcare professional training, residency-based licensure alternatives, and rural workforce development, were evaluated to inform the development of the proposed educational framework. A post-high school "2+4+1" dental education model is proposed. This framework includes 2 years of integrated pre-professional undergraduate education, a traditional 4-year DDS/DMD curriculum, and a seventh year dedicated to supervised rural or underserved service, or alternatively, a CODA-accredited residency training program. Dental graduates would receive a limited permit for practice-under-supervision upon completion of dental school, with full licensure contingent upon completion of the seventh year/residency. This model could potentially reduce education costs/debt, enhance clinical experience, improve access to care in underserved communities, and facilitate standardizing practice readiness. This model draws on successful elements of pharmacy education and rural workforce initiatives including the University of Washington RIDE program.

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PubMedGels (Basel, Switzerland)2026-10-26

Engineering Smart Hydrogels Through Dynamic Polymer Networks for Controlled Drug Delivery.

Choi Chanju C, Seo Dongseong D, Kim Taeho T, Park Jonghyun J et al.

Smart hydrogels are increasingly explored as adaptive platforms for controlled drug delivery because their polymer networks can respond dynamically to chemical, biological, and physical cues. Among these systems, dynamic polymer networks formed through reversible covalent and noncovalent interactions provide a unique means of coupling molecular-scale bond exchange with time-dependent changes in hydrogel structure, mechanics, degradation, and therapeutic transport. This review presents an integrated framework linking dynamic crosslink chemistry, exchange kinetics, network properties, and drug-release behavior. Dynamic covalent, supramolecular, metal-ligand, and hybrid network strategies are compared with particular emphasis on how crosslink lifetime, mesh accessibility, swelling, viscoelasticity, stress relaxation, and degradation govern therapeutic cargo loading, retention, diffusion, and release. Representative release mechanisms and kinetic models are discussed together with cargo-specific design considerations for small molecules, proteins and peptides, nucleic acids, and nanoparticle-based therapeutics. Biomedical applications are further considered according to therapeutic requirements and administration routes, including injectable local depots, topical and transdermal delivery, and regenerative systems. Finally, key translational challenges involving physiological complexity, biocompatibility, reproducibility, scale-up, sterilization, and storage stability are critically assessed. By connecting molecular interaction dynamics with network-level behavior and therapeutic performance, this review provides design principles for developing more predictable, programmable, and clinically translatable dynamic hydrogel drug-delivery systems.

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PubMedACS omega2026-10-25

α‑Lipoic Acid and Deferoxamine Restore Redox-Metallomic Homeostasis in Dapsone Toxicity: Integrated Biochemical, Histological, and Molecular Modeling Evidence.

Mesquita da Silva Rana Karen RK, Monteiro Amanda Caroline Dos Santos ACDS, Freitas Sara Kerolim Figueiredo SKF, Santana Ana Paula Holanda APH et al.

Dapsone (DDS), a sulfone antibiotic widely used in the treatment of leprosy and autoimmune diseases, is associated with hematotoxicity and hepatotoxicity due to its metabolic conversion into hydroxylamine derivatives that promote methemoglobinemia, iron dysregulation, oxidative stress, and tissue injury. In addition to CYP-mediated bioactivation, DDS may contribute to lysosomal stress-associated iron imbalance and oxidative propagation. Conventional antioxidants or iron-chelating therapies alone may provide only partial protection against these interconnected mechanisms. This study evaluated the protective effects of α-lipoic acid (ALA) and deferoxamine (DFO), administered individually or in combination, against DDS-induced oxidative and hematological disturbances using integrated in vivo and in silico approaches. Male Swiss mice received DDS (40 mg/kg, gavage) for 5 days, followed by treatment with ALA (25 mg/kg, gavage), DFO (40 mg/kg, i.p.), or their combination for an additional 5 days. Methemoglobin (MetHb), reduced glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), and plasma iron levels were evaluated. Histopathological analysis and molecular docking studies involving cytochrome P450 isoforms (CYP2C9, CYP2C19, CYP3A4, and CYP2E1) and hemoglobin were performed to investigate potential mechanisms underlying DDS-induced toxicity and the protective effects of ALA and DFO. DDS markedly increased MetHb, nitric oxide, malondialdehyde, and plasma iron levels, accompanied by depletion of GSH and hepatocellular degeneration. ALA and DFO individually attenuated oxidative and iron-related disturbances, whereas combined treatment effectively reduced methemoglobin formation and preserved hepatic architecture; however, plasma ferric iron levels remained comparable to those in DDS-treated animals. Molecular docking suggested preferential interactions of DDS with CYP2E1 and CYP3A4, supporting the biological plausibility of their involvement in oxidative bioactivation pathways, whereas DFO showed predicted interactions with CYP2C9, CYP2E1, and hemoglobin-associated iron sites. Collectively, these findings indicate that ALA and DFO each attenuate DDS-induced hepatotoxicity and hematotoxicity through distinct but complementary antioxidant, iron-chelating, and redox-modulating mechanisms. Combined treatment effectively improved selected endpoints, including methemoglobin formation and hepatic architecture, although its protective effects were endpoint-dependent. The molecular modeling results provide supportive mechanistic insights and should be interpreted as hypothesis-generating evidence complementary to the in vivo findings.

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PubMedNeuropsychiatric disease and treatment2026-10-25

Acylation Modifications at the Crossroads of Metabolism and Epigenetics: Unraveling the Neuroplasticity and Therapeutic Landscape of Depressive Disorders (Review).

Zhang Han H

Depressive disorders (DDs) are heterogeneous neuropsychiatric conditions arising from complex interactions among genetic susceptibility, environmental stress, metabolic disturbances, neuroinflammation and impaired neuroplasticity. Increasing evidence suggests that metabolic-epigenetic crosstalk contributes to DD pathophysiology. Protein acylation, which couples metabolite-derived acyl groups to histone and non-histone proteins, provides a potential molecular interface between cellular metabolism and the regulation of gene expression, protein function and intracellular signaling. The present review summarizes current evidence implicating major acylation modifications, including acetylation, crotonylation, succinylation, β-hydroxybutyrylation, lactylation, palmitoylation and myristoylation, in DDs. The current study discusses how dysregulated acylation may influence neuroplasticity and neuroimmune responses, and examines the roles of key regulatory enzymes in DDs. Furthermore, the present review summarizes that deacylases HDACs play a central, pivotal regulatory role in the pathological progression of DDs. Finally, it discusses emerging experimental and therapeutic strategies for DDs, including spatially resolved acyl-proteomics, single-cell analysis and targeted modulation of acylation-regulating enzymes. These approaches may clarify the cell-type- and brain-region-specific functions of acylation, and may facilitate the development of mechanism-based biomarkers and personalized therapeutic interventions for biologically defined subgroups of DDs. However, clinical translation remains challenging because causal evidence is still limited, acylation effects are highly cell- and context-specific, peripheral biomarkers may not reliably reflect brain alterations, and pharmacological targeting of acylation enzymes may be constrained by limited selectivity and off-target effects. Addressing these challenges may clarify the mechanistic significance of acylation in DDs and support the development of more precise biomarkers and mechanism-informed therapeutic strategies.

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PubMedWaste management (New York, N.Y.)2026-10-25

Precision sorting of municipal solid waste using dynamic disc screen.

Oberoi Akashdeep S AS, Zhang Yu Y, Ding Ling L, Lin Yingqian Y et al.

Municipal solid waste (MSW) represents a large, low-cost biomass resource for bioenergy and bioproduct production. However, its heterogeneity and compositional variability limit its direct use as a conversion-ready feedstock. This study evaluated three mechanical pre-screening technologies vibratory screening, trommel screening, and a dynamic disc screen (DDS) for the recovery of the organic fraction of MSW (OFMSW), and removal of plastic contaminants from unprocessed black bag MSW. All systems separated MSW into fines and overs fractions based on particle size and density, with compositional analysis confirming enrichment of biodegradable organics in the fines and preferential concentration of plastics in the overs. Vibratory screening produced an organic fines fraction with 45.6% purity and 63.1% OFMSW recovery, whereas trommel screening achieved higher purity (70.5%) but substantially lower recovery (20.6%) on a dry basis. In contrast, DDS screening produced high-purity fines, with OFMSW purity ranging from 77.8% to 99.0% and OFMSW recovery varying between 25.3% and 99.1% across five batches. Across all DDS batches, plastic decontamination efficiency remained high (85.7-95.5%), demonstrating robust contaminant removal over a range of feed compositions and operating conditions. Extended operation using a larger waste mass (∼1,672 kg) further demonstrated the operational stability of the DDS under the tested conditions. The higher motor-speed condition was associated with lower OFMSW recovery in the fines fraction, suggesting a potential influence of motor speed on DDS separation performance. Overall, DDS-based mechanical pre-screening offers a scalable and effective approach for producing high-purity, low-contaminant OFMSW with the potential for downstream biochemical valorization and sustainable MSW management.

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PubMedACS omega2026-10-25

Design and Tunability of Thermochromic Polymers Based on Dye-Developer-Solvent Systems: Toward Non-Toxic Materials.

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Thermochromic polymers have had significant development over the years through consistent research. Specifically, polymers that involve an embedded ternary thermochromic compound, which consists of a dye, color developer, and cosolvent, have garnered a lot of attention for the tunability of their color-changing properties. These compounds exhibit color changes through the mechanism of proton transfer between the dye and developer species, and the presence of a solvent is crucial to facilitating this phenomenon. By manipulating the type of each component within the dye-developer-solvent (DDS) compound, the color, direction of color change, and phase transition temperature can be adjusted. The fabrication of thermochromic polymers with DDS compounds can be done through encapsulation, impregnation into a porous material, coating, or a combination of encapsulation and compounding with a polymer matrix. Potential applications of temperature-sensitive polymers include temperature sensors and heat regulators in packaging, clothing, medical devices, and architecture. Research efforts are being continuously made on DDS compounds to make them safer and more eco-friendly with the replacement of conventional components with biobased materials. This review provides a comprehensive overview of the working principle of ternary thermochromic DDS compounds, the tunability of the thermochromic properties, the current progress of research on utilizing DDS compounds in polymers, and the prospects in developing nontoxic thermochromic polymers for food packaging and medical applications.

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