北京若生智能科技有限公司
Drug Database
N-

N-1037

✓ Approved

Bausch Health Companies Inc. · 小分子 · 小分子

什么是 N-1037？

N-1037 是一种小分子，由Bausch Health Companies Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Others、Inhaled、Topical。

药物档案

公司Bausch Health Companies Inc.
药物类别小分子
给药途径Others, Inhaled, Topical
状态Approved
来源： ClinicalTrials.gov, Bausch Health Companies Inc.

治疗适应症

N-1037 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Eye disordersConjunctivitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

相关研究文献

PubMedBJPsych open2026-10-26

Eating disorders and exercise therapy: scoping review on outcome measures used in eating disorder and exercise research.

McMahen Caleb C, Kramer Ben B, Schweizer Kai K, Wright Kemi K et al.

Exercise is increasingly utilised as a complementary therapy within eating disorder treatment because of the emerging evidence for the psychological and physical benefits of exercise in eating disorders. Despite this, there is currently limited guidance on assessment within exercise therapy and eating disorders. This review aimed to (a) outline outcome assessments used in the exercise and eating disorder literature, including interventional and cross-sectional studies; and (b) provide an overview of the general impacts of exercise intervention trials in eating disorders. A scoping review was employed with searches on databases PsycINFO, Medline and EMBASE, with terms related to eating disorders, exercise and health outcomes. Data extraction included study and intervention characteristics, assessments and outcome change. Twenty-six intervention and cross-sectional studies were included, consisting of anorexia nervosa (n = 27%), binge eating disorder (n = 19%), bulimia nervosa (n = 4%) and mixed diagnostic populations (n = 50%). Body composition assessment was conducted with the greatest frequency of included studies (n = 26), followed by eating disorder psychopathology (n = 21), subjective physical activity level (n = 13) and exercise assessment (n = 11), including strength assessment (n = 6) and cardiorespiratory fitness testing (n = 6). No adverse events were reported in the included studies. The results of this review outline that comprehensive assessment within exercise interventions and eating disorders, including strength and cardiorespiratory fitness exercise tests, are safe when conducted in appropriate contexts and may offer additional insight into patient health and function beyond current standard practice. The results of this review may guide future exercise professionals in eating disorder services on relevant assessment as part of exercise therapy.

PMID 42929080
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PubMedDentistry journal2026-10-26

Fracture Resistance and Stress Distribution of Weakened Bovine Roots Restored with Different Glass Fiber Post Systems.

Moura Felipe Bernardo de FB, Andrade Guilherme G, Borges Alexandre A, Carvalho Cláudio C

Background/Objectives: The restoration of structurally weakened roots remains a clinical challenge. This in vitro study evaluated the fracture resistance, failure pattern, and stress distribution of weakened bovine roots restored with two glass fiber post systems under different remaining root dentin thicknesses. Methods: Sixty bovine incisor roots were divided into six groups (n = 10): G1, 2 mm of remaining root dentin without a post; G2, 3 mm without a post; G3, 2 mm with an Exacto post; G4, 3 mm with an Exacto post; G5, 2 mm with a Splendor-SAP post; and G6, 3 mm with a Splendor-SAP post. Specimens underwent root canal treatment and standardized restoration, followed by 1,200,000 mechanical cycles at 88 N and 3.8 Hz and fracture testing at 45°. Finite element models were subjected to an 88 N oblique load. Fracture resistance was analyzed using Welch's one-way ANOVA followed by Games-Howell post hoc comparisons, whereas failure patterns were analyzed using the Fisher-Freeman-Halton exact test. Results: Fracture resistance differed significantly among groups (p < 0.001). G1 (88.7 N) and G2 (95.6 N) showed the lowest and statistically similar values; G3 (670.9 N) and G5 (691.9 N) showed intermediate and statistically similar values; and G4 (786.2 N) and G6 (784.8 N) showed the highest and statistically similar values. Failure-pattern distribution was not significantly associated with the experimental groups (p = 0.582). Finite element analysis showed stress concentration predominantly in the cervical region of the root, with G5 showing the highest maximum principal stress in root dentin. Conclusions: Glass fiber posts substantially increased the fracture resistance of weakened roots. Among post-restored specimens, roots with 3 mm of remaining dentin showed higher fracture resistance than those with 2 mm, whereas no significant difference was observed between the Exacto and Splendor-SAP systems under the same remaining-dentin condition.

PMID 42930417
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PubMedInorganic chemistry2026-10-26

Crystal Morphology of Luminescent Microcrystals Based on Eu(III) Coordination Polymers Changed by Surfactant Solutions.

Enokido Masaki M, Wang Mengfei M, Kitagawa Yuichi Y, Hasegawa Yasuchika Y

The morphological control of Eu(III) coordination polymers with intermolecular interactions between polymer chains was demonstrated with surfactants as molecular modulators. [Eu(hfa)3(m-dpb)]n coordination polymers (hfa; hexafluoroacetylacetonate, m-dpb; 1,3-bis(diphenylphosphoryl)benzene) showed crystal growth in CTAB/SDS solution (CTAB, cetyltrimethylammonium bromide; SDS, sodium dodecyl sulfate). The crystal morphology of [Eu(hfa)3(m-dpb)]n was changed under the synthetic conditions with various types of cationic surfactants (N+(CH3)3CnH2n+1; n = 8, 12, and 16). The Eu(III) coordination polymer crystals were observed as plates and slender rod shapes. Their crystal morphologies suggest that the crystal growth along the chain growth direction is faster than that along the chain stacking direction.

PMID 42929628
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PubMedCureus2026-10-26

Perceptions of Planetary Health and Sustainability Among Canadian Radiation Oncology Professionals: A National Survey.

Quon Stephanie S, Wong Philip P, Kassam Zahra Z, Rozanec Natalie N et al.

Climate change poses increasing risks to human health and healthcare delivery, including increased cancer burden, treatment disruptions, and exacerbation of comorbidities. Despite growing international attention to sustainable cancer care, Canadian data on professional perceptions, institutional practices, and priorities for action within radiation oncology remain limited. This study aimed to assess perceptions, knowledge, and workplace practices related to planetary health and sustainability among Canadian radiation oncology professionals. A cross-sectional electronic survey was distributed to Canadian radiation oncology professionals and trainees through the Canadian Association of Radiation Oncology (CARO) membership email list and departmental distribution across cancer centers. The 27-item questionnaire was developed based on previously validated climate perception and sustainability surveys, including SASSY and CHANT, and assessed perceptions of climate change and health impacts, workplace sustainability practices, and priorities for action. Responses were anonymous and analyzed using descriptive statistics. A total of 108 respondents completed the survey, including radiation oncologists, therapists, physicists, nurses, and trainees from nine provinces. Climate change was rated as a personal priority by 73% (n = 79/108) of respondents, and 75% (n = 81/108) agreed that it would increase cancer incidence. Support for prioritizing low-carbon, low-waste cancer care was high (77%; n = 83/108). However, only 34% (n = 37/108) reported the presence of a sustainability initiative at their cancer center, and 62% (n = 67/108) felt sustainability was not a workplace priority. Strong support was expressed for CARO-led initiatives, including member education on planetary health (77%; n = 83/108), sustainability recommendations for clinical practice (76%; n = 82/108), and evaluation of radiation oncology's carbon footprint (69%; n = 75/108). Interest in reducing CARO ASM emissions was high, with 58% (n = 63/108) supporting at least a 30% reduction. While Canadian radiation oncology professionals recognize the relevance of climate change to cancer care and support action in sustainability, institutional implementation remains limited. Future work should evaluate strategies to engage broader professional groups and increase awareness and participation in sustainability initiatives in radiation oncology.

PMID 42928945
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PubMedInorganic chemistry2026-10-26

Synthesis, Cytotoxicity, and Mechanistic Evaluation of Thiazolium-Based Gold(I) Bis-N-Heterocyclic Carbene Complexes.

Hoffmann Melanie E ME, Haas Lisa C LC, Marques Fernanda F, Sarwary Sarah S et al.

Imidazole- and benzimidazole-based Au(I) N-heterocyclic carbene (NHC) complexes show great potency as anticancer agents. However, other NHC scaffolds are only sparsely explored. Four gold(I) NHC complexes featuring thiazolium-based ligands (NHCthia) with varying N-substituents were synthesized and evaluated for their biological activity. The complexes containing aromatic N-substituents demonstrate higher stability, higher TrxR inhibition, and activity against breast (MDA-MB-231 and MCF-7) and ovarian (A2780) cancer cell lines, compared to the tested alkyl N-substituted complexes. Specifically, mesityl-substituted complex 1 exhibits high activity with IC50 values in the nanomolar range, exceeding the potency of auranofin in MDA-MB-231 cells. Mechanistic studies in leukemia cells (Nalm-6) revealed that complex 1 induces ROS formation, activates BAX and BAK, and causes mitochondrial membrane potential loss, initiating intrinsic apoptosis. Notably, the ligand precursor L1 shows no significant cytotoxicity, confirming that the gold(I) moiety drives the activity. Additionally, complex 1 can overcome resistance to etoposide and prednisolone without affecting healthy leukocytes, making Au(I) bis-NHCthia complexes a compelling class of antiproliferative agents.

PMID 42929613
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PubMedCureus2026-10-26

Association of Glycaemic Control and Blood Pressure With Clinical Outcomes of Acute Pancreatitis in Obese Adult Men.

Isaq Amel A, Fida Asim A, Ullah Sahar Hidayat SH, Majeed Mona M et al.

Background In obese adults, acute pancreatitis is often complicated by metabolic abnormalities, and suboptimal glycaemic control and hypertension may be linked to worse clinical outcomes and severity of disease. Objective To evaluate the association of glycaemic control and blood pressure status on clinical outcomes of acute pancreatitis in obese adult men. Methodology A prospective observational study was conducted at Pakistan Institute of Medical Sciences (PIMS), Islamabad, over one year (January 2025-December 2025). A total of 394 obese adult male patients with acute pancreatitis were enrolled using consecutive sampling. Clinical characteristics, laboratory parameters, glycaemic status, blood pressure, radiological findings, and clinical outcomes were assessed. HbA1c was categorized as <7% or ≥7% to characterize glycaemic status, while blood pressure was categorized as controlled or uncontrolled based on repeated inpatient measurements according to the prespecified threshold. Clinical outcomes were compared according to glycaemic and blood pressure status using Pearson chi-square tests. Multivariable logistic regression was performed to identify factors independently associated with severe acute pancreatitis, with adjusted odds ratios (AORs) and 95% confidence intervals (CIs) reported. Results Among 394 patients, 243 (61.68%) had HbA1c ≥7%, while 151 (38.32%) had HbA1c <7%. Uncontrolled blood pressure was observed in 222 (56.35%) patients compared with 172 (43.65%) with controlled blood pressure. Poor glycaemic status was associated with higher frequencies of severe acute pancreatitis (n=49; 20.16% vs. n=10; 6.62%), ICU admission (n=58; 23.87% vs. n=14; 9.27%), and in-hospital mortality (n=25; 10.29% vs. n=5; 3.31%) (all p<0.05). Uncontrolled blood pressure was associated with higher frequencies of severe acute pancreatitis (n=44; 19.82% vs. n=15; 8.72%), but the difference in in-hospital mortality was not statistically significant (n=22; 9.91% vs. n=8; 4.65%; p=0.051). In multivariable analysis, poor glycaemic control (AOR=2.84, 95% CI: 1.61-5.02, p<0.001) and uncontrolled blood pressure (AOR=2.31, 95% CI: 1.34-3.98, p=0.003) were independently associated with higher odds of severe acute pancreatitis. Conclusion Poor glycaemic control and uncontrolled blood pressure were associated with adverse clinical outcomes among obese adult men with acute pancreatitis. Poor glycaemic control and uncontrolled blood pressure were also independently associated with higher odds of severe acute pancreatitis in the final adjusted model. These findings support the clinical value of assessing metabolic characteristics in obese patients with acute pancreatitis, but the observational design does not establish causality or demonstrate that modifying these factors would improve outcomes. Further multicenter prospective and interventional studies are warranted to confirm these associations and determine whether targeted metabolic management can improve clinical outcomes.

PMID 42928754
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