北京若生智能科技有限公司
Drug Database
N-

N-1037

✓ Approved

Bausch Health Companies Inc. · 小分子 · 小分子

什么是 N-1037？

N-1037 是一种小分子，由Bausch Health Companies Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Others、Inhaled、Topical。

药物档案

公司Bausch Health Companies Inc.
药物类别小分子
给药途径Others, Inhaled, Topical
状态Approved
来源： ClinicalTrials.gov, Bausch Health Companies Inc.

治疗适应症

N-1037 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Eye disordersConjunctivitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

相关研究文献

PubMedFrontiers in plant science2026-09-10

Controlled-release fertilization reshapes maize yield through plant-soil synchrony: shifting from nitrogen supply intensity to synchronization-driven vegetative remobilization.

Ma Hongyu H, Li Xianyue X, De Feudis Mauro M, Hu Qi Q et al.

Nitrogen (N) management in maize systems is constrained by low fertilizer use efficiency and substantial environmental losses, particularly in arid irrigated regions where soil N heterogeneity disrupts plant uptake and allocation. Controlled-release fertilizers (CRFs) offer a promising approach to coordinate soil N supply with crop N demand and regulate internal N cycling during yield. To elucidate the mechanisms by which CRF enhances N utilization and coordinates N allocation, field experiments were conducted in western Inner Mongolia, China from 2022 to 2024. This study to evaluate their impact on N accumulation (NA), tissue-specific N partitioning and N remobilization, leaf N remobilization efficiency (NREleaf), stem N remobilization efficiency (NREstem), supply-demand synchrony index (SDI), supply-plant N requirement synchronization (SPNR), soil nitrate dynamics, and maize yield throughout the growing season. The results showed CRF markedly enhanced N remobilization, with NREleaf and NREstem increasing by 12.3% and 24.8%. Notably, CRFs also improved overall N supply-demand synchronization: average SDI values for CF3 and CF2 were 0.77 and 0.86, compared with 0.61 for regular fertilizer (RF), representing a 26-41% increase. Building on this, structural equation modeling revealed that the mechanism regulating yield shifted from N supply intensity under RF (R2= 0.74) to synchronization-driven control under CRF (R2 = 0.79), in which SPNR coordinated N allocation and remobilization (>0.8 contribution) to determine grain NA and final yield. These findings demonstrate that optimizing N supply-demand synchronization, rather than increasing N inputs, fundamentally reshapes maize yield formation by coordinating internal N cycling. CRFs, particularly at moderate N rates, offer a pathway for improving N use efficiency while reducing environmental risk, providing actionable insights for sustainable maize production in N-limited, arid irrigated systems.

PMID 42719657
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PubMedBMC plant biology2026-09-10

Root traits are strongly associated with nitrogen uptake efficiency in contrasting rapeseed genotypes.

Guo Xiao X, Dai Tingting T, Luo Ji J, Luo Qian Q et al.

Screening the higher nitrogen (N) uptake efficiency (NUpE) rapeseed (Brassica napus L.) genotype (N-efficient-genotype) and exploring the N efficient uptake mechanism could be an ideal way to meet the environmentally use of valuable N and the increasing demand for edible oils. In this study, we selected a N-efficient-genotype and a N-inefficient-genotype to dissect the differences in root physiological indexes under a pot experiment and a hydroponic culture. Results showed that during the high and low N levels, root biomass was the main factor affecting NUpE at the pot experiment. Compared to the N-inefficient-genotype, N-efficient-genotype displayed respectively 39.72%, 31.52%, 39.94%, 41.28% and 54.80% higher root biomass, N content, root length, root surface area and Vmax, along with 36.86%,48.68%, 134.14%, 72.71%, nitrate reductase (NR), glutamine synthetase (GS), catalase (CAT) and glutathione (GSH) activity. These were accompanied by a significant increase (P < 0.05) in BnNRT1.1 (7.04 fold), BnNRT1.5 (4.66 fold), BnNRT2.1 (8.63 fold) and BnNRT2.5 (12.13 fold), which may result in the greater N uptake ability than did the N-inefficient-genotype under the hydroponic culture. Our results indicate that higher root indexes for the N-efficient-genotype could uptake more N to support the photosynthesis sustained and seed development, and would achieve the larger NUpE and NUE in rapeseed genotypes.

PMID 42717318
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PubMedPlant, cell & environment2026-09-10

Long-Term Warming Suppresses Nitrogen-Fixation Gene Transcription in the Rhizosphere of Invasive Plant Solidago canadensis.

Li Min M, Zhou Xiaohui X, Yang Han H, Wang Dungang D et al.

Climate warming can enhance the growth performance of invasive plants, potentially increasing their nitrogen (N) demand. However, whether this additional demand is supported by free-living N fixation remains unclear. Here, we used a 12-year warming experiment to determine how warming affected diazotrophic abundance, community composition, and nifH transcription in the roots and rhizosphere of the invasive plant Solidago canadensis during the growing and flowering stages. While warming increased plant biomass, it did not increase diazotrophic abundance or nifH transcription in either roots or rhizosphere soil. In the rhizosphere, warming even suppressed nifH transcription during flowering, which coincided with pronounced shifts in the rhizosphere metabolome and diazotrophic community composition, particularly among Bradyrhizobium-affiliated taxa. By contrast, these associations were weak or absent during the growing stage, indicating that plant developmental stage and concurrent seasonal variation modulate the responses of diazotrophs to climate warming. Overall, given the relatively high N availability at our study site, warming-enhanced growth of S. canadensis was unlikely to be supported by increased inputs of newly fixed N. Instead, S. canadensis may have met its increased N demand primarily through morphological and physiological adjustments that favour more efficient uptake and use of existing N pools, as indicated by higher specific root length and increased leaf N-use efficiency under warming. Future studies that directly quantify N fixation rates across gradients of N availability are warranted to validate our findings, especially in N-limited conditions where biological N fixation may contribute more substantially to plant N acquisition.

PMID 42717422
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PubMedThe journal of physical chemistry letters2026-09-10

O2 Adsorption on AunRh+ (n = 3-8) Clusters: A Distinctive δ-like Bonding Interaction at Rh Sites.

Huang Lulu L, Zhao Zhongpu Z, Liu Wen W, Liu Qingyu Q et al.

We investigated reactions of AunRh+ (n = 3-20) with O2 using mass spectrometry and density functional theory calculations. The results reveal a structural transition from surface Rh sites with high spin density to encapsulated ones with quenched spin. For n = 3-8, O2 adsorption on surface Rh involves a distinctive face-to-face interaction between Rh 4d and O2 π* orbitals, resembling a δ-like bond. The abrupt reactivity quenching at n = 9 arises from an inert, high-coordination, half-encapsulated Rh, while for n > 9 it stems from an inert, fully encapsulated Rh, both exhibiting negligible spin density. These findings demonstrate that surface Rh atoms on gold with low coordination numbers can activate O2 into a nondissociative side-on configuration, offering mechanistic insights for the rational design of Rh-Au catalysts for low-temperature oxidation.

PMID 42720339
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PubMedPediatric blood & cancer2026-09-10

Interventions to Reduce Financial Toxicity of Childhood, Adolescent, and Young Adult Cancer Survivors: A Scoping Review.

Ndungu Rorah W RW, Buchman Ross L RL, Anandarajah Akila A, Rice Hannah E HE et al.

Financial toxicity (FT) worsens health outcomes and quality of life for childhood, adolescent, and young adult (CAYA) cancer survivors. This scoping review examines interventions designed to alleviate FT among CAYA cancer survivors and identifies the levels of influence within the multilevel framework that these interventions target (i.e., patient, family/caregiver, provider, organization, policy, and society levels). Additionally, this review analyzes how current interventions align with National Comprehensive Cancer Network (NCCN) Recommendations for Supportive Care Services/Interventions for Socioeconomic Issues. We included English-language studies mentioning cost or adjacent terms that analyzed the effectiveness/efficacy of interventions designed to address FT in CAYA populations. Thirteen studies met the inclusion criteria. Most (n = 11, 84.6%) studies were conducted in the United States and addressed multiple levels of influence, primarily targeting the individual (n = 13, 100%), organizational (n = 7, 53.8%), and provider (n = 7, 53.8%) levels. Regarding NCCN recommendations, interventions most frequently addressed the integration of financial assistance into survivorship care plans (n = 8, 61.5%) and the establishment of financial support programs (n = 7, 53.8%). Extant literature focuses primarily on the individual level, financial assistance, and support programs. Future research should elucidate complex parameters defining multilevel interventions and prioritize gaps in current interventions according to NCCN guidelines.

PMID 42720420
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PubMedJournal of spine surgery (Hong Kong)2026-09-10

Clinical burden and treatment pathways of early deep surgical site infection after lumbar spine surgery: a Vietnamese single-center descriptive study.

Nguyen Vu Hoang VH, Nguyen Ngoc Quyen NQ

Early deep surgical site infection (SSI) after lumbar spine surgery is uncommon, but management may require repeated surgery, negative-pressure wound therapy, prolonged antimicrobial treatment, and complex implant-related decisions. We aimed to characterize the clinical course, treatment pathways, and major treatment-burden events among affected patients. This retrospective descriptive study screened 1,923 patients who underwent primary lumbar spine surgery at a single tertiary center between October 2018 and October 2023. Sixteen patients met an operational definition adapted from Centers for Disease Control and Prevention/National Healthcare Safety Network criteria for early deep incisional or organ/space SSI within 90 days. Analyses were descriptive; an exploratory comparison of cumulative infection-related inpatient days was summarized without predictive inference. Sixteen early deep SSIs were identified [crude institutional incidence, 0.83%; 95% confidence interval (CI), 0.48-1.35%]. Diagnosis occurred a median of 14.5 days after surgery [interquartile range (IQR), 6.8-20.8; range, 4-70]. Fourteen patients underwent 52 spinal reoperations; 10 required vacuum-assisted closure with 37 foam changes. Two required intensive care, two were readmitted, and no deaths occurred. Cultures yielded methicillin-susceptible Staphylococcus aureus (n=6), methicillin-resistant S. aureus (n=2), Escherichia coli (n=3), Enterococcus faecium (n=1), and Enterobacter cloacae (n=1); one culture was negative and two patients were not cultured. Eight patients experienced a major treatment-burden event: infection-related adverse outcomes (n=4), an unplanned small-bowel injury during revision (n=1), or implant-removal source-control procedures (n=3). Median cumulative infection-related inpatient duration was 46.5 days with an event and 23.0 days without an event. Early deep SSI was uncommon in this single-center series but imposed considerable procedural and inpatient burden among affected patients. The findings support early recognition, microbiological confirmation when feasible, careful revision planning, and coordinated multidisciplinary infection management, while avoiding causal or predictive conclusions from this small descriptive cohort.

PMID 42718861
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