Pharmaprojects No. 3498

Conservatively Managed Osteochondral Lesion of the Talus With a Subchondral Cyst: A Case Report.

Kiribayashi Toshiaki T, Seki Hayato H, Ueno Taiki T, Yoshimoto Takuma T et al.

Osteochondral lesions of the talus (OLT) are increasingly recognized as resulting from trauma in a broad sense, including repetitive microtrauma, yet detailed reports of lesions accompanied by a subchondral bone cyst that are managed conservatively alone remain scarce, and no consensus exists regarding their optimal management. We report the case of a 59-year-old woman with chronic right ankle pain that had not improved despite prior follow-up and who had no clear history of trauma. Examination revealed no swelling, tenderness, or pain on supination. Plain radiography and MRI demonstrated a subchondral cystic lesion with bone marrow edema on the medial talar dome, corresponding to a Scranton stage V, Anderson stage IIA osteochondral lesion. Given tolerable symptoms, small cyst size, and absence of cartilage damage on MRI, conservative management with outpatient observation was planned; however, the patient did not return for scheduled follow-up. She re-presented after a prolonged interval, and follow-up radiography showed no significant progression of the lesion. Although follow-up imaging in this case showed no significant progression of the lesion, prior literature indicates that radiographic progression can occur even in patients with favorable clinical symptoms, underscoring the importance of sustained clinical and radiographic follow-up in patients with OLT managed conservatively, even when early symptoms and imaging appear reassuring.

Association Between Patient Body Mass Index and Preferred Interpersonal Distance From Pharmacists.

Yamagiwa Haruno H, Gocho Saori S, Miyagi Yukina Y, Miyachi Yuka Y et al.

Appropriate interpersonal distance is an important element of nonverbal communication during medication counseling by pharmacists. Although interpersonal distance can be influenced by several factors such as sex, age, and psychological condition, the relationship between patients' body mass index (BMI) and their preferred interpersonal distance from pharmacists remains unclear. This study aimed to examine the association between patients' BMI and their preferred interpersonal distance from pharmacists. A total of 95 outpatients receiving anticancer drug therapy at the Nagoya Ekisaikai Hospital participated in this study. The preferred interpersonal distance was measured using both approach and withdrawal methods. The participants were divided into two groups according to their BMI: < 25 kg/m² and ≥ 25 kg/m². The preferred interpersonal distances of the two groups were then compared. Additional analyses were conducted to examine the combined effects of BMI, sex, and age. No significant difference in the preferred interpersonal distance was found between the two BMI groups. The combined analysis of sex and BMI also showed no statistically significant differences, although a possible trend was observed among the groups (p = 0.06). Similarly, no significant differences were identified in the combined analysis of age and BMI. No statistically significant association between BMI and preferred interpersonal distance was identified in this sample. However, the possible relationship between sex and BMI should be examined further in studies with larger sample sizes.

Contrast-enhanced mammography in a man with mixed invasive lobular and no-special-type breast carcinoma.

Rudnicki Wojciech W, Szpor Joanna J, Popiela Tadeusz T, Hodorowicz-Zaniewska Diana D et al.

Informing Your Future Clozapine Patients of the Mortality Risk: Fear of Agranulocytosis vs. Pharmacovigilance Fatal Outcomes.

de Leon Jose J, Ruan Can-Jun CJ, Schoretsanitis Georgios G, Sanz Emilio J EJ et al.

No abstract present.