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ammonium lactate

✓ Approved

Bristol-Myers Squibb · 小分子 · 小分子

什么是 ammonium lactate？

ammonium lactate 是一种小分子，由Bristol-Myers Squibb研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Bristol-Myers Squibb
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Bristol-Myers Squibb

治疗适应症

ammonium lactate 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersIchthyosis✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved
General disorders and administration site conditionsXerosis✓ Approved

相关研究文献

PubMedAndrology2026-09-10

Lactate-Responsive Glycogen Dynamics Are Associated With Bull Sperm Motility and Fertilization Under Glucose-Limited Conditions.

Miraz Md Faizul Hossain MFH, Yamanaka Takahiro T, Umehara Takashi T, Akter Shahrina S et al.

Mammalian sperm need to undergo hyperactivation, capacitation, and acrosome reaction to achieve fertilization competence. However, the female reproductive tract presents contrasting metabolic environments. The uterus is glucose-rich, and the oviduct is lactate-rich and glucose-limited. Furthermore, our previous study reported that lactate plays a regulatory role in glucose metabolism through suppressing glucose uptake and glycolysis. How bull sperm maintain glycolysis-associated functions when exogenous glucose is limited remains unclear. To characterize lactate-responsive changes in sperm glycogen content and determine whether CP91149-sensitive processes are associated with glycolysis-related sperm functions and cleavage after in vitro fertilization (IVF) under glucose-limited conditions. Fresh bull ejaculates were incubated in substrate-free HTF medium to deplete the stored energy. The energy-depleted sperm were treated with lactate, followed by lactate withdrawal and subsequent incubation with glycogen phosphorylase inhibitor (CP91149) in the presence or absence of glucose. Sperm motility, kinematics, acrosome integrity, metabolic flux, glycogen level, and cleavage were evaluated in vitro. Lactate pretreatment prolonged sperm motility under substrate depletion. Lactate withdrawal increased a hyperactivated-like motility subpopulation. Flow cytometry showed that the lactate withdrawal increased membrane permeability of sperm and elevated the percentage of acrosome-reacting sperm. Glycolytic activity of sperm was increased after withdrawal, but the induction was suppressed by the glycogen phosphorylase inhibitor CP91149. Lactate increased sperm glycogen content, which declined after withdrawal. Immunoblotting and immunofluorescence detected proteins associated with gluconeogenesis and glycogen metabolism in bull sperm. CP91149 reduced motility after lactate withdrawal in a dose-dependent manner, and glucose supplementation restored motility. Under glucose-free IVF conditions, CP91149 reduced the post-IVF functional outcome, which was restored by glucose supplementation. These findings show lactate-responsive changes in sperm glycogen content and a CP91149-sensitive phenotype affecting glycolytic activity, motility, and the post-IVF functional outcome. The data are consistent with a contribution of endogenous glycogen-derived substrates to sperm function under glucose-limited conditions.

PMID 42717699
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PubMedBioEssays : news and reviews in molecular, cellular and developmental biology2026-09-10

Lactate Metabolism: Separating Correlation From Causation.

Blaze Bhavya B, Cluntun Ahmad A AA

Lactate is among the most frequently measured metabolites in physiology and medicine, yet it remains one of the most persistently misunderstood. Long regarded as a metabolic waste product, a marker of anaerobic metabolism, or a direct cause of acidosis and fatigue, lactate remains burdened by misconceptions that obscure its true biological roles. Recent advances in metabolic flux analysis, isotope tracing, hyperpolarized magnetic resonance spectroscopy, and cellular imaging have revised this view and established lactate as a central intermediary in energy metabolism, redox homeostasis, and interorgan metabolic communication. Here, we re-examine common myths surrounding lactate biology and clarify the distinction between correlation and causation in its interpretation. By reframing lactate as a dynamic indicator and, in some contexts, a regulator, of metabolic state rather than a toxic by-product, this review improves experimental reasoning and clinical interpretation across diverse physiological and pathological contexts.

PMID 42717640
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PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-09-10

Carboxylate-Probase Catalyzed Favorskii Reaction.

Bannykh Anton A, Stenfors Sanna M SM, Nechaev Anton A, Fiskari John M JM et al.

An O-silylative carboxylate-catalyzed Favorskii reaction for terminal alkynes with aldehydes, ketones or α-ketoesters is described, using a quaternary ammonium carboxylate catalyst and silylating agent, bis(trimethylsilyl)acetamide as the probase system. A wide range of alkynes and carbonyl electrophiles are tolerated as substrates, providing the propargylic alcohol products in up to 96% yield under metal-free, catalytic conditions. Chiral cinchona alkaloid-derived quaternary ammonium catalysts afforded moderate enantioselectivity (up to 73:27 er). Mechanistic studies with p-substituted aryl alkynes and α-keto ester electrophiles provided additional evidence for a mechanism that involves the turnover-determining deprotonation to give quaternary ammonium ion - acetylide ion pairs, which then react with the electrophiles in the chemo- and enantioselectivity-determining step.

PMID 42717632
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Nanopore and Self-Assembled Monolayer Engineering of l-Lactate Oxidase Gold Electrodes for Enhanced l-Lactate Biosensing.

Sušac Mislav M, Graf Samuel S, Novak Lara-Marie LM, Hengge Elisabeth E et al.

Nanoporous architectures offer unique opportunities to spatially organize biocatalysts while preserving efficient interfacial charge transfer. Here, we introduce a tiered enzyme-electrode interface based on nanoporous gold (np-Au) that enables high-density, activity-retaining immobilization of lactate oxidase for sensitive l-lactate detection. The np-Au scaffold, prepared by controlled dealloying of Ag-Au, exhibits average pore diameter of ∼170 nm, providing geometric confinement compatible with the tetrameric structure of Aerococcus viridans l-lactate oxidase (LOx). A mixed self-assembled monolayer composed of 1-thioglycerol and Ni2 +-nitrilotriacetic acid-terminated 12-thiododecaneamide establishes a bifunctional interface that combines hydrophilic-antifouling properties with site-directed immobilization of N-terminal His-tagged LOx. This architecture affords high immobilization yield (64%), elevated surface loading (7.44 mg m- 2; ∼9 mg g-1), and superior retention of enzymatic activity. Electrochemical impedance spectroscopy reveals controlled modulation of interfacial charge-transfer resistance upon sequential SAM formation and enzyme coupling, confirming the formation of a structurally defined biointerface. The resulting bioelectrode exhibits stable and sensitive amperometric l-lactate detection with a linear dynamic range of 0.12 - 3.0 mM and a sensitivity of 75 µA mM-1 cm- 2, covering clinically relevant concentrations in saliva and blood. The presented tiered design strategy establishes a modular platform for high-performance nanoporous metal bioelectrodes with controlled enzyme orientation and enhanced operational stability.

PMID 42720216
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PubMedNeuro-oncology advances2026-09-10

A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate.

Dirain Carolyn O CO, Grossman Stuart A SA, Ye Xiaobu X, Sambasivan Priya P et al.

Glioblastomas are characterized by the Warburg effect, driven by upregulation of pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase complex (PDC), leading to lactate accumulation. Dichloroacetate (DCA) is a potent and safe PDK inhibitor that crosses the blood-brain barrier, reverses Warburg metabolism, and reduces lactate levels. This trial (RO1FD007271) evaluated the pharmacodynamics and pharmacokinetics of oral DCA in recurrent glioblastoma patients requiring surgical debulking. The primary endpoint was decreased PDC phosphorylation (p-PDHA1) in resected tumors. Patients received either 1 week of DCA or no DCA prior to surgery. All patients received DCA postoperatively. Enhancing and non-enhancing tumor tissue, and serial plasma DCA and lactate levels were analyzed. 37 patients were enrolled (median age = 60 years). In DCA-treated patients, the contrast-enhancing tumor had lower p-PDHA1, PDK4, HIF1-α, VEGF-α, and PGK1 expression (all P < .05) than non-DCA-treated patients. In non-enhancing tumors, p-PDHA1 and PDK 1-3 expression were not different, but PDK4, PCNA, and PGK1 levels were reduced, and ERK1/2 was increased in DCA-treated patients (all P ≤ .01). At surgery, DCA-treated patients had lower plasma lactate (P = .004) than untreated patients. Postoperatively when all patients received DCA, plasma lactate fell dramatically (P < .001). DCA was well-tolerated but did not delay tumor recurrence. In recurrent glioblastomas, DCA was safe, well-tolerated, and promoted aerobic respiration. It reduced markers of tumor cell proliferation and lowered plasma lactate. Although no clinical benefit was noted, further studies of combination therapy are indicated, given the known association between poor cancer outcomes and elevated PDK expression and lactate levels.

PMID 42719375
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PubMedJournal of phycology2026-09-10

Macroalgae respond to consumer-mediated nutrient cycling in a temperate ecosystem.

Lim Em G EG, Attridge Claire M CM, Kattler Kiara R KR, Spriel Brittnie B et al.

Primary production in coastal upwelling regions has often been presumed to be supported primarily by allochthonous nutrients, but inconsistent nutrient delivery and the metabolic cost of nitrate assimilation can leave producers nitrogen limited during the growing season. As a potential supplement for insufficient allochthonous supply, nutrient provisioning through the metabolic wastes of animals, termed consumer-mediated nutrient cycling (CNC), provides easily assimilated nitrogen in the form of ammonium. Although it has been suggested that CNC sustains macroalgal growth on the west coast of North America, experimental fertilization experiments, especially on kelps, are lacking. Here, we measured the growth rates of winged kelp (Alaria marginata) and sea lettuce (Ulva sp.) under ammonium levels that varied experimentally in the laboratory as well as naturally across sites in the wild. We observed evidence that in the field, a regionally high-nitrate environment, elevated ammonium was associated with 1.4× higher growth and 1.2× higher percent nitrogen content in A. marginata. Using in situ mesocosms, we observed that Ulva grew 3.8× faster and had 1.4× higher internal nitrogen concentration when exposed to nitrogen-rich excretion from red rock crabs (Cancer productus). Our study suggests kelps growing in low ammonium but higher nitrate conditions may be nitrogen limited, suggesting that nitrates from allochthonous sources may not meet the nutrient requirements of macroalgae in this moderate upwelling ecosystem. Therefore, nutrient regeneration by animals may be an important source of nitrogen across varying levels of allochthonous nitrate supply.

PMID 42717852
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