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ammonium lactate

✓ Approved

Bristol-Myers Squibb · 小分子 · 小分子

什么是 ammonium lactate？

ammonium lactate 是一种小分子，由Bristol-Myers Squibb研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Bristol-Myers Squibb
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Bristol-Myers Squibb

治疗适应症

ammonium lactate 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersIchthyosis✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved
General disorders and administration site conditionsXerosis✓ Approved

相关研究文献

PubMedFrontiers in cell and developmental biology2026-10-26

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance.

Hu Xiaosong X, Yang Li L, Hu Yanghao Y, Cui Hongjuan H

Glioma is characterized by profound metabolic reprogramming and sustained lactate accumulation; however, the mechanisms by which lactate-rich metabolic stress is translated into stable malignant phenotypes remain incompletely understood. Lysine lactylation (Kla), a recently identified post-translational modification, has emerged as a critical nexus linking lactate metabolism to durable epigenetic and protein-state adaptations. In glioma, accumulating evidence indicates that Kla contributes to multiple dimensions of tumor biology, including oncogenic transcriptional activation, glioma stem-like cell (GSC) maintenance, immunosuppressive remodeling, and therapeutic resistance. Mechanistically, histone Kla rewires metabolic stress-responsive transcriptional programs, whereas non-histone Kla executes rapid, transcription-independent responses by directly modifying key regulatory proteins involved in DNA repair, signal transduction, and metabolic adaptation. This review systematically summarizes current progress on the lactate-Kla axis in glioma, encompassing the basis of lactate metabolism, the molecular regulatory network of Kla, and the distinct yet coordinated functions of histone and non-histone lactylation. We further discuss how Kla contributes to temozolomide (TMZ) resistance, radioresistance, and chemoradiotherapy adaptation, and outline a hierarchical therapeutic framework targeting this pathway. Despite rapid advances, important areas requiring further investigation include subtype-specific variation in lactate-Kla biology and the potential crosstalk between Kla and other post-translational modifications. A better understanding of these issues will help define the biological significance of the lactate-Kla axis and guide the future development of lactylation-based therapeutic strategies in glioma.

PMID 42928918
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PubMedClinics and practice2026-10-26

Inflammatory and Metabolic Biomarkers Associated with Chronic Subdural Hematoma Recurrence: A Single-Center Retrospective Cohort Study.

Ertuğrul Bilal B, Kömürcü Harun H

Background: Chronic subdural hematoma (CSDH) recurs in 5-20% of patients despite surgical treatment, and readily accessible biomarkers associated with recurrence remain limited. This study evaluated perioperative hematological, biochemical, and metabolic biomarkers associated with CSDH recurrence, focusing on preoperative lactate and the lactate-to-albumin ratio (LAR). Methods: This retrospective single-center cohort study included 163 adults who underwent burr-hole evacuation for CSDH between January 2021 and December 2025. All patients underwent saline irrigation without placement of a postoperative subdural drain, in accordance with the institutional surgical protocol. Clinical, radiological, laboratory, and perioperative arterial blood gas data were analyzed. Recurrence was defined as symptomatic re-expansion requiring repeat surgery within six months. Receiver operating characteristic (ROC) analysis and multivariable logistic regression were used to assess discrimination and associations with recurrence. Results: Postoperative recurrence occurred in 22 patients (13.5%). Recurrence was associated with higher preoperative lactate, LAR, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index, as well as lower serum albumin. LAR showed moderate discrimination (AUC 0.758, 95% CI 0.652-0.864), while lactate had an AUC of 0.744. Increased LAR (OR 1.42 per 0.1-unit increase, 95% CI 1.15-1.76; p = 0.001), bilateral hematoma (OR 2.91, 95% CI 1.08-7.84; p = 0.035), and mixed-density hematoma (OR 2.64, 95% CI 1.01-6.89; p = 0.047) were independently associated with recurrence in the fitted model. The age × lactate interaction did not reach conventional statistical significance (p = 0.058) and was considered exploratory. Conclusions: Higher preoperative LAR was associated with CSDH recurrence and showed moderate discriminative performance in this cohort. These findings are exploratory and require independent validation before LAR or the combined model can be considered for clinical risk prediction.

PMID 42930378
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PubMedAntibodies (Basel, Switzerland)2026-10-26

Purification of Bioactive Natural Antibodies to PD-1 Known as Regulatory Rheumatoid Factor from Human Blood Plasma.

Menshikova Daria D, Terentiev Alexey A, Ivanov Pavel P, Cherednichenko Alexandr A et al.

Regulatory rheumatoid factor (regRF) is a recently discovered population of natural anti-idiotypic antibodies carrying a shared paratope specific to the PD-1 molecule. Normally, regRF exerts a cytotoxic effect on PD-1-expressing T lymphocytes, including autoreactive ones, thereby controlling their expansion. The specificity for PD-1 indentifies regRF as a promising therapeutic agent for suppressing autoimmune reactions via the PD-1 pathway. The aim of this study was to develop gentle methods for regRF isolation from healthy blood plasma, which would preserve the bioactivity of regRF. Ammonium sulfate precipitation was used for crude regRF purification. A search for suitable affinity sorbents was carried out. The purified regRF was tested for its bioactivity. Ammonium sulfate precipitation at 35% saturation, followed by extraction with 28% saturated ammonium sulfate solution, allowed the separation of regRF from a portion of non-target IgG and high-molecular-weight fibrinogen. RegRF showed high affinity for Cibacron Blue and no binding to Protein A. Sequential affinity chromatography on immobilized Cibacron Blue and Protein A enabled the purification of regRF from non-target immunoglobulins and low-molecular-weight fibrinogen. The purified regRF samples showed binding to PD-1 and reduced the PD-1+CD4+ T lymphocyte count in vitro. Thus, we have identified sorbents and conditions for the purification of biologically active regRF.

PMID 42930040
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PubMedMicrobiology spectrum2026-10-26

Purification, identification, and characterization of a bacterioferritin from the anammox bacterium Kuenenia stuttgartiensis.

Claret Fernández Laura L, Lindhoud Simon S, Berben Tom T, Mesman Rob R et al.

Anaerobic ammonium-oxidizing (anammox) bacteria convert ammonium and nitrite to nitrogen gas, with nitric oxide and hydrazine as intermediates. The anammox reaction takes place inside a dedicated cell compartment called the anammoxosome and is proposed to be coupled to energy conversion via a proton motive force over the anammoxosome membrane. This anammox energy metabolism is for a large part carried out by heme-containing enzymes, which depend on readily available iron for synthesis and proper functioning. Bacterioferritins are multimeric iron storage proteins. The genome of the model anammox species Kuenenia stuttgartiensis contains two putative bacterioferritin genes: KSMBR1_0066 and KSMBR1_0230. Here, we isolated and characterized K. stuttgartiensis bacterioferritin KSMBR1_0066 (KsBfr) and investigated the distribution of bacterioferritin homologs in anammox genomes. KsBfr was purified from K. stuttgartiensis cells and identified as KSMBR1_0066. A search for putative Bfr homologs in anammox Brocadiales genomes showed that most contain either one or two homologs and that these cluster in two distinct groups: bfr1 and bfr2. KSMBR1_066 clustered with bfr2. Purified KsBfr had an 18-kDa monomer size, consisted of 14-nm-wide particles with a 6-nm electron-dense core, and contained heme b with absorption maxima at 423, 527, and 557 nm when reduced. As-isolated KsBfr could be unloaded and subsequently reloaded with iron. We propose that KsBfr is involved in iron storage in K. stuttgartiensis cells and speculate that anammox bacterioferritins could play a role in iron storage for use and reuse of iron in heme biosynthesis.IMPORTANCEAnaerobic ammonium-oxidizing (anammox) bacteria contribute to the global nitrogen cycle by removing fixed nitrogen from the environment. They do so via the anaerobic oxidation of ammonium to dinitrogen gas, with nitrite as terminal electron acceptor and nitric oxide and hydrazine as free intermediates. This anammox energy metabolism is carried out by heme-containing enzymes, most of which are unique to anammox bacteria (i.e., hydrazine synthase and hydrazine dehydrogenase). The heme-containing enzymes rely on the availability of iron for their synthesis and functioning. Iron storage is thus expected to play an important role in anammox bacteria. Here we purify, identify, and characterize a bacterioferritin, an iron storage protein, from the anammox bacterium Kuenenia stuttgartiensis. We propose and discuss that bacterioferritin could play an important role in iron storage in K. stuttgartiensis and other anammox bacteria for potential use and reuse of iron in heme biosynthesis.

PMID 42929517
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PubMedInternational journal of fertility & sterility2026-10-26

Granulosa Cell Conditioned Medium Enhanced In Vitro Maturation and Developmental Potential of Mice Oocytes by Improving Mitochondrial Function, ATP Synthesis, and REDOX System.

Zamanikia Romina R, Fazli Mohaddese M, Hajiaghalou Samira S, Dalman Azam A et al.

The aim of this study was to compare the effects of base medium supplemented with knock-out serum replacement (KSR; BMK group) or foetal bovine serum (FBS; BMF group) and granulosa cell conditioned medium (GCCM) prepared with KSR (CMK group) or FBS (CMF group) on in vitro maturation (IVM) of immature murine oocytes. In this experimental study, the BMF, BMK, CMF, and CMK media were assessed for lactate and pyruvate content, and total antioxidant capacity (TAC). Immature oocytes were cultured with these IVM media. Maturation rate [proportion of oocytes at metaphase II (MII) stage], mitochondrial membrane potential (MMP), ATP content, reactive oxygen species (ROS), and embryonic development following in vitro fertilisation (IVF) were evaluated in the cultured oocytes. Immature oocytes cultured with BMK had the highest degeneration and lowest maturation rate (68.16% of MII-stage oocytes). The resultant in vitro-matured oocytes had the worst embryonic development (8.47% of blastocyst- stage embryos, P<0.05), which might be due to the low lactate content of this medium. Immature oocytes cultured in media that contained GCCM (CMF and CMK) had superior maturation rates (81.18 and 82.24% of MII-stage oocytes, respectively). The resultant in vitro-matured oocytes had higher mitochondrial activity and ATP, lower ROS and greater embryonic development (42.62 and 35.59% of blastocyst-stage embryos, respectively, P<0.05). This finding was probably related to the higher lactate content and antioxidant capacity of GCCM versus base medium. KSR was recognized as an unsuitable nutrient supplement for IVM of oocytes in mice, probably due to its lack of lactate. GCCM supplementation of IVM medium improved maturation rate, quality, and developmental potential of the in vitro-matured oocytes.

PMID 42929004
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PubMedCureus2026-10-26

Persistent Type B Hyperlactataemia as a Diagnostic Clue to Occult Diffuse Large B-cell Lymphoma-Associated Haemophagocytic Lymphohistiocytosis.

Hassan Nasiba N, Khatib Kavish K

Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory disorder characterised by excessive immune activation. It may be primary or secondary, with secondary HLH associated with a range of triggers; the most common are infections, autoimmune and autoinflammatory conditions, haematological malignancies and other immune‑dysregulatory states. We present a case of a man in his 70s who presented with a two-week history of exertional dyspnoea, profound fatigue and anorexia. Initial investigations demonstrated marked hyperferritinaemia, thrombocytopenia, mild anaemia, cholestatic liver dysfunction and disproportionately elevated lactate without acidosis. Despite intravenous fluids, lactate remained persistently elevated, consistent with type B hyperlactataemia. Computed tomography (CT) of the abdomen and pelvis demonstrated appearances suggestive of hepatitis but no organomegaly, significant lymphadenopathy or biliary obstruction. Despite empirical antibiotics and fluid resuscitation, he developed progressive pancytopenia, worsening liver dysfunction and rising lactate. Further investigations supported secondary HLH, with an HScore of 186, hypertriglyceridaemia and markedly elevated lactate dehydrogenase. Initial treatment with corticosteroids and anakinra resulted in limited response. An autoimmune trigger was initially considered given his Raynaud's phenomenon and ongoing connective tissue disease investigation. However, bone marrow biopsy subsequently confirmed diffuse large B-cell lymphoma (DLBCL). Reduced-dose rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone (R-mini-CHOP) was commenced, resulting in the resolution of hyperlactataemia, normalisation of blood counts and liver function and improvement in performance status. PET-CT after two cycles demonstrated a complete metabolic response. This case highlights the importance of considering secondary HLH in patients with unexplained cytopenias, hyperferritinaemia, liver dysfunction and persistent hyperlactataemia. Persistent hyperlactataemia despite adequate fluid resuscitation should prompt the consideration of systemic causes beyond tissue hypoperfusion. Bone marrow biopsy is crucial for identifying occult malignancy when conventional imaging fails to show overt malignancy. The early recognition of HLH and investigation for an underlying aetiology may facilitate timely definitive treatment.

PMID 42928750
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