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parathyroid hormone (Natpara / NPSP558 / SHP634)

✓ Approved

AstraZeneca UK Limited · PTH1R · 重组蛋白

什么是 parathyroid hormone？

parathyroid hormone 是一种重组蛋白，由AstraZeneca UK Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Natpara, NPSP558, SHP634
公司AstraZeneca UK Limited
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, AstraZeneca UK Limited

作用机制

分子靶点

parathyroid hormone 作用于 1 个分子靶点：

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

parathyroid hormone 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersHypoparathyroidism✓ Approved
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedFrontiers in medicine2026-09-10

Primary hyperparathyroidism in pregnancy: a case report and review of the literature.

Hao Li L, Chen Yalin Y, Lu Yumei Y, Wang Rui R

Primary hyperparathyroidism during pregnancy represents an exceedingly rare clinical entity. Its early manifestations are frequently subtle and easily masked by physiological adaptations of gestation, frequently leading to diagnostic delay. Persistent hypercalcemia carries substantial hazards to both maternal and fetal wellbeing, while relevant clinical literature remains limited. Herein, we present an advanced maternal age patient with recurrent pregnancy loss complicated by second-trimester persistent nausea and vomiting. Serum biochemistry demonstrated marked hypercalcemia and elevated parathyroid hormone, cervical ultrasonography identified a hypoechoic nodule within the right parathyroid gland. The combined biochemical and imaging findings were consistent with pregnancy-associated primary hyperparathyroidism. Following medical correction of hypercalcemia, the patient successfully underwent parathyroidectomy under general anesthesia. However, at 2 months postpartum, she developed acute abdominal pain due to renal calculi and subsequently underwent lithotripsy. In summary, primary hyperparathyroidism in pregnancy is relatively rare, however, vigilant monitoring of serum calcium levels is imperative throughout the gestational period. Management strategies should be individualized based on gestational age and clinical severity to optimize maternal and fetal outcomes. For severe cases requiring surgery, precise preoperative localization of parathyroid lesions is essential. Notably, the second trimester is considered the optimal window for surgical intervention.

PMID 42718468
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PubMedFrontiers in cell and developmental biology2026-09-10

Advanced maternal age as a risk factor for endometrial receptivity in repeated implantation failure: intersectional transcriptomic analysis and gene validation.

Guo Yaping Y, Zhang Mianqiu M, Wu Zhenggang Z, Hou Xiaojing X et al.

Repeated implantation failure (RIF) remains a significant challenge in assisted reproductive technology. Endometrial receptivity (ER) plays a critical role in embryo implantation. However, the impact of advanced maternal age (AMA) on ER in this population remains unclear. The study aimed to evaluate whether maternal age is associated with displacement of the window of implantation (WOI) and explore potential endometrial transcriptomic characteristics. This retrospective observational study included 254 women with RIF who underwent evaluation of ER between January 2020 and March 2024. ER status and WOI timing were determined using a transcriptome-based receptivity assessment. Clinical characteristics were compared between women with normal receptivity and those with a 2-day pre-receptive endometrium. Endometrial biopsies were analyzed by RNA sequencing to identify differential gene expression associated with age and receptivity status. An independent small validation cohort was used for qRT-PCR validation. Women in the impaired receptivity group (2-day pre-receptive) were significantly older than those in the normal receptivity group (34.3 ± 3.1 vs. 33.0 ± 4.1, p = 0.016). Multivariate logistic regression further demonstrated maternal age as an independent risk factor for ER displacement (OR = 1.118, 95% CI: 1.013-1.234, p = 0.027). Transcriptomic analysis identified age- and receptivity-associated transcriptomic changes, with 10 overlapping differentially expressed genes (DEGs) between the two comparisons, which were further examined by qRT-PCR in a small independent cohort (n = 10). As a result, four genes, including activating transcription factor 3 (ATF3), C-X-C motif chemokine ligand 1 (CXCL1), parathyroid hormone-like hormone (PTHLH), and non-specific cytotoxic cell receptor protein 1 (NCCRP1), were significantly downregulated in the AMA-RIF group compared with controls. AMA was independently associated with an increased likelihood of WOI displacement in women with RIF, suggesting that aberrant endometrial timing may be associated with implantation failure in this population. These findings provide a rationale for further investigation of personalized embryo transfer strategies in older patients, while the identified candidate genes should be regarded as preliminary molecular associations requiring further functional validation.

PMID 42718970
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PubMedFrontiers in endocrinology2026-09-10

Pregnancy and lactation-associated osteoporosis in a postpartum woman with twin pregnancy: a 5-year follow-up case report.

Adnan Hussain Muthasim HM, Gao Xiaoyun X, Yu Xiuqi X, Zhang Chunyu C

Pregnancy and lactation-associated osteoporosis (PLO) is a rare but potentially disabling metabolic bone disorder that typically emerges in late pregnancy or the early postpartum period. Because its symptoms often present as common postpartum musculoskeletal complaints, diagnosis is frequently delayed until vertebral fractures are detected. This case report describes a postpartum woman with a twin pregnancy who developed multiple vertebral compression fractures, illustrating the diagnostic challenges, clinical features, and long-term outcomes of PLO. A 32-year-old woman presented with persistent low back pain two weeks after cesarean delivery of twins. She had been exclusively breastfeeding and reported inadequate dietary intake and recent weight loss. Thoracolumbar MRI revealed acute compression fractures at T12, L1, and L5. Laboratory evaluation demonstrated low 25-hydroxyvitamin D and parathyroid hormone levels, markedly elevated β-CTX and P1NP, and elevated prolactin. DXA showed significantly reduced lumbar bone mineral density (Z-score -3.25). Clinically significant secondary causes of osteoporosis were excluded based on available testing, and PLO was diagnosed. She was treated with calcium carbonate, calcitriol, alfacalcidol, calcitonin, and intravenous zoledronic acid (initial 5 mg dose during admission, with a second 5 mg dose administered at 1-year follow-up). Following treatment, biochemical markers normalized. At follow-up, MRI confirmed fracture healing, DXA demonstrated improved bone mineral density, and the patient reported complete resolution of symptoms. Long-term evaluation at 5 years showed sustained clinical stability and continued improvement in BMD. This case highlights the importance of considering PLO in postpartum women with severe back pain, particularly in the presence of risk factors such as low BMI, inadequate calcium intake, vitamin D insufficiency, exclusive breastfeeding, and twin pregnancy. Early recognition and management can prevent prolonged morbidity and support continued improvement in bone health.

PMID 42718481
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PubMedClinical science (London, England : 1979)2026-09-10

How lipid ingestion is sensed: the mechanisms underlying intestinal hormone secretion.

Santos-Hernández Marta M, Gribble Fiona M FM, Reimann Frank F

Dietary lipids are potent stimulators of intestinal hormone secretion, which plays a central role in the regulation of digestion, appetite, glucose homeostasis, and lipid metabolism. Following digestion in the intestinal lumen, lipid-derived molecules are detected through complementary mechanisms involving lipid transporters, nutrient-sensing receptors, intracellular metabolic pathways, and bile acid signaling. These pathways couple nutrient availability to the secretion of enteroendocrine hormones, including glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), ghrelin and serotonin, thereby coordinating local and systemic metabolic responses. In the small intestine, CD36 contributes to lipid uptake and sensing, while intracellular lipid processing and chylomicron formation influence hormone secretion. Bile acids facilitate lipid digestion and absorption and further regulate enteroendocrine function through receptor-mediated signaling pathways. This review examines the cellular and molecular mechanisms underlying intestinal lipid sensing, with particular emphasis on the roles of CD36, chylomicron formation, bile acid signaling, and nutrient-sensing receptors in the regulation of enteroendocrine hormone secretion.

PMID 42719962
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PubMedJournal of the Endocrine Society2026-09-10

Growth hormone deficiency in children: divergence between clinical/laboratory evaluation and genetic architecture.

Rogol Alan D AD

PMID 42719011
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PubMedAnnals of translational medicine2026-09-10

Screening for atrial fibrillation according to serum thyroid-stimulating hormone: an opportunity for refinement?

Mavilakandy Akash Kamalakshan AK, Lip Gregory Y H GYH

PMID 42719254
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