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parathyroid hormone (Natpara / NPSP558 / SHP634)

✓ Approved

AstraZeneca UK Limited · PTH1R · 重组蛋白

什么是 parathyroid hormone？

parathyroid hormone 是一种重组蛋白，由AstraZeneca UK Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Natpara, NPSP558, SHP634
公司AstraZeneca UK Limited
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, AstraZeneca UK Limited

作用机制

分子靶点

parathyroid hormone 作用于 1 个分子靶点：

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

parathyroid hormone 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersHypoparathyroidism✓ Approved
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedJournal of investigative medicine high impact case reports2026-10-26

Retropharyngeal Ectopic Parathyroid Gland Presenting as Primary Hyperparathyroidism: A Diagnostic Challenge From the Endocrine Perspective.

Alharbi Mariam S MS

Ectopic parathyroid tissue is an unusual yet clinically significant contributor of primary hyperparathyroidism (PHPT), especially when standard localization studies yield inconclusive results. Retropharyngeal ectopic parathyroid glands are uncommon and may postpone diagnosis due to their unusual anatomical location. This report details a case of a 39-year-old woman exhibiting hypercalcemia, musculoskeletal pain, constipation, a history of nephrolithiasis, and diminished bone mineral density. Biochemistry showed that parathyroid hormone (PTH) levels were always high, with occasional hypercalcemia and hypercalciuria, which is what you would expect with PHPT. Ultrasound of the neck did not show a parathyroid lesion. Cross-sectional imaging and fluorocholine PET/CT identified a retropharyngeal soft tissue nodule indicative of ectopic parathyroid tissue. Histopathology following biopsy confirmed parathyroid tissue. This case highlights the endocrine diagnostic pathway in PHPT, the importance of correlating biochemical findings with advanced imaging, and the need to consider ectopic glands when first-line imaging is negative.

PMID 42929282
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PubMedCureus2026-10-26

Paget Disease of the Calvarium: A Case Report.

Navabi Kasra K, Patel Erica E

Paget disease of bone (PDB) is a focal skeletal disorder characterized by excessive and disorganized bone remodeling. When the skull is involved, the disease may also affect the temporal bones. We present the case of a 68-year-old woman referred for evaluation of persistently elevated alkaline phosphatase (ALP), ultimately diagnosed with Paget disease of the calvarium with bilateral temporal bone involvement. The diagnosis was established through a systematic workup spanning nearly four years, including serial biochemical monitoring, exclusion of alternative causes of increased bone turnover, whole-body bone scintigraphy, skull radiographs, and computed tomography of the skull. Total ALP remained persistently elevated, and the bone-specific fraction rose progressively over the course of follow-up while calcium and parathyroid hormone remained within their reference ranges. She was treated with a single intravenous infusion of zoledronic acid. This case highlights the importance of serial monitoring of bone-specific ALP in the evaluation of persistently elevated ALP, the potential for subtle, easily overlooked bone scintigraphy findings in early or evolving Paget disease, and the role of multimodality imaging in defining the extent of calvarial and temporal bone involvement.

PMID 42928824
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PubMedCells2026-10-26

Osteochondral Cell Fate in the Mandibular Condyle: A Shared Fate Decision Across Development, Degeneration, and Regeneration.

Xu Lingfeng L, Wang Meiqing M

The mandibular condyle is highly responsive to mechanical loading, which shapes its development and maintains osteochondral homeostasis. Understanding how loading regulates osteochondral cell fate may connect developmental mechanisms with strategies to limit mechanically driven degeneration and promote repair. In this narrative review, we integrate evidence across development, degeneration, and regeneration into a framework centred on a shared cell-fate decision: coordination between progenitor renewal, chondrocyte maturation, and endochondral bone formation. We examine the reported dual modes of parathyroid hormone-related protein (PTHrP) signalling and their interactions with Indian hedgehog (IHH) and canonical Wnt/β-catenin signalling within the broader network governing this balance. Physiological loading supports the spatial and temporal coordination of these pathways, whereas persistent abnormal loading may accelerate hypertrophic differentiation and impair progenitor replenishment, contributing to cartilage damage and aberrant osteochondral remodelling. Effective regeneration may therefore depend on restoring both a favourable mechanical environment and coordinated cell-fate regulation. Accordingly, where pathological occlusal loading contributes to degeneration, correcting the mechanical environment may merit consideration alongside biological interventions tailored to the joint's residual repair capacity. Potential approaches include pathway modulation to support responsive endogenous cells and cell supplementation when progenitor reserves are insufficient.

PMID 42929885
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PubMedThe British journal of surgery2026-10-26

Use of autofluorescence and/or indocyanine green in thyroid surgery: recommendations by the European Society of Endocrine Surgeons (ESES).

Van Den Heede Klaas K, Triponez Frédéric F, Agcaoglu Orhan O, Barczynski Marcin M et al.

Postoperative hypoparathyroidism remains the most frequent complication after total thyroidectomy. Recently, near-infrared autofluorescence (NIRAF) imaging with or without indocyanine green (ICG) was introduced to evaluate parathyroid glands during surgery. The aim of this paper is to provide recommendations by the European Society of Endocrine Surgeons (ESES) regarding its use in thyroid surgery based on a scoping review and meta-analysis. A working group of experts was created by the ESES. A systematic literature search was performed, using MEDLINE® (PubMed), up to 31 December 2024. Studies were included if a comparative group was used to evaluate short- and long-term postoperative hypoparathyroidism, autotransplantation rates, and/or inadvertent parathyroid gland removal. The results were pooled in a random-effects meta-analysis. Subgroup analyses were performed to assess the impact of NIRAF with or without ICG, as well as central lymph node neck dissection. Recommendations were created among all co-authors and discussed at the 11th ESES conference. A modified Delphi online voting process amongst all members approved all recommendations. After screening 335 abstracts, there were 34 studies, with a total of 9322 patients, that met the inclusion criteria. These were published between 2017 and 2024 and included 11 RCTs. Meta-analyses showed promising results for NIRAF and ICG with regard to immediate and permanent hypoparathyroidism, inadvertent removal proportions, and autotransplantation proportions. The quality of evidence was rated as 'moderate' for most of the recommendations with good quality of evidence for most questions. These ESES recommendations provide guidance for the use of NIRAF with or without ICG based on a scoping review of the literature, meta-analyses, and expert opinion.

PMID 42929023
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PubMedBiosensors2026-10-26

HueFertility Ovulation: A Smartphone-Enabled Quantification System for Urinary Luteinizing Hormone in a Lateral Flow Assay.

Menon Nidhi N, Kara Erdi E, Sharma Prava P, Crutchfield Adrian A et al.

Luteinizing hormone (LH) is a critical biomarker for ovulation prediction and reproductive health monitoring, yet most commercially available at-home LH tests rely on qualitative or semi-quantitative visual interpretation, limiting their clinical utility. We present HueFertility Ovulation, a smartphone-enabled quantitative LH measurement system comprising a lateral flow immunoassay dipstick and a mobile application that integrates proprietary color correction algorithms with a deep learning regression model to deliver objective LH concentration estimates from strip images captured under variable real-world conditions. Color correction using the HueCard reference system substantially reduced inter-image color variability, decreasing mean ΔE00 from 11.19 to 4.02 across diverse lighting environments. When evaluated against known LH concentrations in a separately acquired independent dataset, the regression model achieved R2=0.92 and a mean absolute percentage error (MAPE) of 17.4%. The experimental limits of blank, detection, and quantitation were 0.64, 3.18, and 10.00 mIU/mL, respectively. Multi-site precision testing demonstrated %CVs within 25% across three independent locations. At a per-test cost of $0.60 with no external hardware required, HueFertility offers a low-cost, accessible platform for quantitative LH monitoring, with utility in fertility planning, hormonal health tracking, and resource-limited settings. Ultimately, the study highlights the opportunity to extend the technology to other low-cost lateral flow tests and clinical chemistry applications.

PMID 42930136
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PubMedCurrent oncology (Toronto, Ont.)2026-10-26

[177Lu]Lu-PSMA-617 in Metastatic Hormone-Sensitive Prostate Cancer: Evidence from PSMAddition and Considerations for Treatment Sequencing.

Buonerba Carlo C, Di Lorenzo Giuseppe G

Introducing [177Lu]Lu-PSMA-617 into metastatic hormone-sensitive prostate cancer (mHSPC) raises questions about patient selection and treatment sequencing. This non-systematic narrative review examines PSMAddition alongside evidence on alternative treatments, prostate-specific membrane antigen (PSMA) imaging, safety, and subsequent therapy. In the peer-reviewed analysis, with a data cutoff of 13 January 2025, adding radioligand therapy to androgen-deprivation therapy and an investigator-selected androgen receptor pathway inhibitor improved radiographic progression-free survival (hazard ratio 0.72; 95% confidence interval 0.58-0.90). Overall survival was immature and did not meet the prespecified interim significance threshold (hazard ratio 0.84; 95% confidence interval 0.63-1.13). A subsequent non-peer-reviewed sponsor update supported the radiographic findings, although the updated analysis was not controlled for type I error and overall survival remained immature. Radioligand intensification increased grade ≥3 adverse events (51% versus 43%). Prespecified composite quality-of-life and pain endpoints showed no statistically significant differences, although their interpretation is limited by the inclusion of progression or death. Control-arm crossover after progression was optional. Direct mHSPC evidence is distinguished from contextual castration-resistant evidence. Neither a preferred hormonal partner nor superiority over docetaxel-containing triplet therapy has been established. A non-prescriptive five-domain framework integrates target expression, disease characteristics, patient fitness, subsequent treatment options, and delivery capacity to support multidisciplinary assessment.

PMID 42930191
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