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somatropin (Valtropin / somatropin, LG Chem / Eutropin Pen)

✓ Approved

Takeda · GHR · 重组蛋白

什么是 somatropin？

somatropin 是一种重组蛋白，由Takeda研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Valtropin, somatropin, LG Chem, Eutropin Pen
公司Takeda
药物类别重组蛋白
分子靶点GHR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Takeda

作用机制

分子靶点

somatropin 作用于 1 个分子靶点：

GHRgrowth hormone receptor (GHBP, GHIP)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

somatropin 针对 4 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersGrowth hormone deficiency✓ Approved
Congenital, familial and genetic disordersSex chromosome abnormality✓ Approved
Congenital, familial and genetic disordersOsteochondrodysplasia✓ Approved
Congenital, familial and genetic disordersPrader-Willi syndromePhase III

相关研究文献

PubMedJournal of comparative effectiveness research2026-09-10

Cost-effectiveness of a connected injection device for daily somatropin therapy in pediatric growth hormone deficiency in Spain: a scenario-based microsimulation analysis using real-world data.

Arriba Antonio de A, Roeder Claudia C, Nivelle Emilia E, Dommelen Paula van PV et al.

Aim: Growth hormone deficiency (GHD) in pediatric patients is characterized by impaired growth and reduced quality of life. Recombinant human growth hormone therapy requires consistent daily administration, yet adherence remains challenging. Electronic injection devices with adherence monitoring, like Easypod®, may support more consistent administration and enable more accurate assessment of treatment response. This study evaluated the cost-effectiveness of somatropin administered via a connected injection device (EasyPod) compared with nonconnected devices in pediatric patients with GHD in Spain. Materials & methods: A microsimulation model simulated 10,000 pediatric patients aged 2-13 years and incorporated adherence-dependent growth response, treatment discontinuation, costs and utilities. Outcomes included final height, height gain, cost per cm gained and incremental cost per quality-adjusted life year gained. Scenario and sensitivity analyses assessed the impact of parameter and structural uncertainty. Results: Easypod was associated with greater height gains than nonconnected devices. Projected final height at bone maturation was 163.04 cm with Easypod versus 159.21 cm with nonconnected devices, an incremental gain of 3.83 cm. Cost per cm gained was €2625 with Easypod and €3158 with nonconnected devices, a saving of €534 per cm. The incremental cost per quality-adjusted life year gained was €27,200 within Spain's willingness-to-pay threshold. Scenario and sensitivity analyses showed consistent results. Conclusion: In this model-based analysis, Easypod was associated with improved growth outcomes and was cost-effective compared with nonconnected devices in pediatric GHD patients in Spain. Continuous adherence monitoring may support treatment optimization and more efficient healthcare resource utilization.

PMID 42720214
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PubMedFunctional & integrative genomics2026-09-10

Integrated single-cell and spatial transcriptomic analyses reveal malignant epithelial glycolytic heterogeneity and spatial niche remodeling during colorectal cancer progression.

Xiao Jinyun J, Heng Shanshan S, Li Jiayu J, Xie Shaozhuo S et al.

Colorectal cancer (CRC) progression is shaped by metabolic reprogramming and complex interactions within the tumor microenvironment. However, the cellular heterogeneity, spatial organization, and clinical relevance of glycolytic activity in CRC remain incompletely understood. In this study, we integrated single-cell RNA sequencing, bulk transcriptomics, and spatial transcriptomics data to systematically characterize glycolytic heterogeneity in CRC. Glycolytic activity was quantified using five independent scoring methods, consistently showing that epithelial cells exhibited the highest glycolytic activity across the two single-cell cohorts. Stratification of CopyKAT-verified aneuploid malignant epithelial cells into high-glycolysis (HG) and low-glycolysis (LG) subgroups by glycolysis scores revealed that HG cells exhibited higher stemness scores and chromosomal copy number variations. Cell-cell communication analysis revealed that, compared with LG cells, HG cells exhibited increased interaction frequency and strength with immune and stromal populations, indicating enhanced malignant epithelial-microenvironment crosstalk. Spatial transcriptomics analyses further revealed that glycolytic activity varied across normal colorectal tissue, primary CRC, and colorectal liver metastases, accompanied by progressive remodeling of epithelial-associated spatial niches and MIF-mediated intercellular communication. Bulk transcriptomic analysis identified a glycolysis-related prognostic signature with robust predictive performance, which served as an independent prognostic factor for overall survival in CRC cohorts. Collectively, these findings indicate that glycolytic heterogeneity is a key feature of CRC malignant epithelial cells and is closely associated with tumor progression, microenvironmental remodeling, and clinical outcomes.

PMID 42717115
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PubMedGeoHealth2026-09-10

Where on Earth Are the Earth Sciences? A Mixed-Methods Study of Environmental Justice Research Trends and Roadblocks to Engagement.

Rosales Cortez Omar O, Chen Catherine C

Environmental justice (EJ) research relies on expertise from multiple disciplines to address community-specific health risks and inequities. EJ is an inherently transdisciplinary framework, yet the expansion of EJ scholarship has not occurred evenly across academic disciplines. Understanding disciplinary contributions is essential for identifying gaps in knowledge and practice. This research employed a mixed-method approach to investigate EJ research trends and roadblocks to engagement. Study 1 used a bibliometric analysis of Scopus-indexed publications and found that Environmental science and Social sciences were the leading contributors to EJ scholarship. Earth sciences ranked only seventh in EJ research volume by proportion and exhibited comparatively stagnant growth. Study 2 investigated this discrepancy through a survey of Earth scientists (N = 460) examining perceived barriers to EJ engagement. Results indicated that career stage was a significant predictor of EJ familiarity and community involvement: early-career Earth scientists were more familiar with EJ but were less involved in their communities' environmental issues than their late-career counterparts. Race and ethnicity were also associated with differences in perceived funding difficulty, with White respondents reporting fewer challenges in securing support for EJ-related projects. Taken together, these studies assess EJ engagement within the Earth sciences and identify structural and experiential factors that may limit participation. Identifying disciplinary gaps and roadblocks helps integrate Earth sciences into EJ scholarship and increase research on environmental health and equity.

PMID 42719559
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PubMedAdvances in medical education and practice2026-09-10

A Systematic Review of Psychosocial Interventions for Enhancing Resilience in Medical Sciences Students.

Ghanbari Sahar S, Hosseini Sara S, Zamiran Sara S, Kavousipor Somaye S

Undergraduate medical sciences students experience substantial psychological distress due to demanding academic workloads and early clinical exposure, increasing their vulnerability to anxiety, depression, and burnout. This systematic review evaluates randomized controlled trials (RCTs) examining psychosocial interventions-including mindfulness-based programs, cognitive-behavioral strategies, acceptance-based therapies, and structured stress-management training-designed to enhance resilience among undergraduate medical sciences students. A comprehensive search of PubMed, Scopus, ISI Web of Science, ProQuest, Google Scholar, and Semantic Scholar identified studies published between January 2000 and April 2025. 11 RCTs met inclusion criteria. Data extraction included participant characteristics, intervention type and duration, delivery format, and outcome measures. Methodological quality was assessed using the PEDro scale, and risk of bias was evaluated using the Cochrane RoB 2 tool. Across the included trials, psychosocial interventions demonstrated consistent positive effects on resilience, perceived stress, coping flexibility, and psychological well-being. Mindfulness-based programs-ranging from brief sessions to full 8-week MBSR courses-generally reduced distress, though shorter or peer-led formats produced mixed results. Cognitive-behavioral and stress-management interventions improved coping skills, emotional regulation, and self-efficacy. Acceptance and Commitment Therapy enhanced psychological flexibility, and structured resilience curricula such as the Penn Resilience Program yielded significant gains in resilience scores. Variability in intervention design, duration, and measurement tools limited comparability across studies. Overall, psychosocial interventions appear effective in enhancing resilience among undergraduate medical sciences students. Integrating structured, theory-based approaches into medical education may strengthen students' psychological health and academic functioning. Future research should prioritize standardized protocols, culturally sensitive adaptations, and long-term follow-up.

PMID 42719907
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PubMedFrontiers in psychology2026-09-10

The sequential mediating roles of self-esteem and life satisfaction in the relationship between health perception and perceived social status among college students.

Kim Eun Bee EB, Kim Jhong Yun JY

College students face significant challenges in their physical and psychological well-being, potentially affecting their perception of social status. This study examines the association between health perception and perceived social status among college students and investigates the potential mediating roles of self-esteem and life satisfaction. Data from 5,966 participants (50.8% female, 49.2% male) were analyzed from the 2016 Korean Education and Employment Panel Survey (KEEP). Analyses were conducted using SPSS 21.0, AMOS 22.0, and the PROCESS macro. The research model examined the direct relationships between health perception, self-esteem, life satisfaction, and perceived social status, as well as the potential mediating roles of self-esteem and life satisfaction. Health perception was positively associated with self-esteem (β = 0.232, p < 0.001), life satisfaction (β = 0.273, p < 0.001), and perceived social status (β = 0.120, p < 0.001). Self-esteem showed positive associations with life satisfaction (β = 0.359, p < 0.001) and perceived social status (β = 0.078, p < 0.001). Life satisfaction was significantly related to perceived social status (β = 0.419, p < 0.001). The indirect association of health perception with perceived social status through self-esteem was 0.018 (95% CI [0.011, 0.025]), through life satisfaction was 0.115 (95% CI [0.101, 0.129]), and through both mediators sequentially was 0.035 (95% CI [0.029, 0.041]). Results suggest that college students' health perception may be associated with their perceived social status both directly and indirectly through potential mediating roles of self-esteem and life satisfaction. Because these findings are based on cross-sectional secondary data, they represent statistical associations rather than confirmed causal mechanisms. Health awareness, self-esteem, and life satisfaction were associated with more positive perceived social status; however, longitudinal research is needed before implications for educational interventions can be drawn.

PMID 42719160
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PubMedFrontiers in sports and active living2026-09-10

Beyond the coach: contextual, community, and organizational predictors of coaches' perceived impact on athlete life skill development.

Bates Samantha S, Anderson-Butcher Dawn D, Ault-Baker Kylee J KJ, Nothnagle Emily A EA

Youth sport is widely regarded as a context for promoting positive youth development (PYD) and life skill development; however, inequities in the youth sport system can limit coaches' perceived ability to foster these outcomes. Guided by an integrated youth sport system perspective, this study examined how contextual factors, community-level resource access, and organizational training and support were associated with coaches' perceived impact on athlete life skill development. Using data from the U.S. National Coach Survey (N = 4,964), hierarchical linear regression analyses were conducted with predictors entered in three blocks: (1) context (school vs. community setting, urbanicity, proportion of athletes experiencing poverty, proportion of athletes identifying as Black, Latino, Asian/Pacific Islander, or multiracial), (2) access to community-level resources (e.g., equipment, transportation, safe practice spaces), and (3) organizational support and training [coaching certification, life skills training, administrative support, peer support, compensation (paid vs. unpaid), and having been evaluated last season]. Context accounted for 5.4% of the variance in perceived impact. Access to community-level resources accounted for an additional 1.7% of the variance, with equipment availability emerging as a significant predictor. Organizational support and training variables accounted for the largest increase in variance (ΔR 2 = 6.5%, p < .01), with training in life skill development through sport, peer support, coaching certification, paid status, and prior evaluation associated with greater perceived impact on life skill development (R 2 = .136). Findings suggest that coaches' capacity to support life skill development can be shaped by factors within youth sport organizations and the broader youth sport context. More research is needed to understand drivers of coaching to support life skill development. Implications for practice, policy, and coach education are discussed.

PMID 42719736
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