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somatropin (Valtropin / somatropin, LG Chem / Eutropin Pen)

✓ Approved

Takeda · GHR · 重组蛋白

什么是 somatropin？

somatropin 是一种重组蛋白，由Takeda研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Valtropin, somatropin, LG Chem, Eutropin Pen
公司Takeda
药物类别重组蛋白
分子靶点GHR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Takeda

作用机制

分子靶点

somatropin 作用于 1 个分子靶点：

GHRgrowth hormone receptor (GHBP, GHIP)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

somatropin 针对 4 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersGrowth hormone deficiency✓ Approved
Congenital, familial and genetic disordersSex chromosome abnormality✓ Approved
Congenital, familial and genetic disordersOsteochondrodysplasia✓ Approved
Congenital, familial and genetic disordersPrader-Willi syndromePhase III

相关研究文献

PubMedThe Journal of clinical endocrinology and metabolism2026-10-26

Efficacy and Safety of Lonapegsomatropin in Children With Turner Syndrome: 52-Week Results From the New InsiGHTS Trial.

Davis Shanlee M SM, Abuzzahab M Jennifer MJ, Tryggestad Jeanie B JB, Fechner Patricia Y PY et al.

Treatment with growth hormone is effective in improving height outcomes in children with Turner syndrome. However, poor adherence-often influenced by daily injection burden-may compromise treatment outcomes. Lonapegsomatropin is a prodrug, administered once weekly, that provides sustained release of somatropin. To evaluate the efficacy and safety of lonapegsomatropin in children with Turner syndrome. New InsiGHTS is a phase 2 dose-ranging trial (ClinicalTrials.gov: NCT05690386). This trial was conducted across 19 centers in the United States. This trial enrolled and dosed 49 prepubertal children with Turner syndrome. Randomization was 1:1:1:1 to receive once-weekly lonapegsomatropin (0.24, 0.30, or 0.36 mg hGH/kg/week) or daily somatropin (0.35 mg/kg/week). The primary efficacy endpoint was annualized height velocity (AHV) at week 26. Secondary efficacy endpoints included AHV at week 52 and change from baseline in height standard deviation score (SDS) at weeks 26 and 52. At week 26, AHV was comparable between lonapegsomatropin starting dose cohorts (range: 9.23 to 10.36 cm/year) and the somatropin cohort (10.86 cm/year). At week 52, AHV was comparable between pooled lonapegsomatropin cohorts (9.05 cm/year) and the somatropin cohort (9.04 cm/year), with mean gains in height SDS of 0.60 and 0.67, respectively. Lonapegsomatropin was well tolerated with a safety profile similar to somatropin. Across evaluated doses, lonapegsomatropin treatment demonstrated comparable efficacy, safety, and tolerability to somatropin after 1 year, supporting development of lonapegsomatropin as a once-weekly treatment option for short stature in children with Turner syndrome.

PMID 42929032
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PubMedChemistry & biodiversity2026-10-26

Integrated Metabolomics and Network Pharmacology Reveal Anti-Aging and Anti-MRSA Activities of Cucumis melo Var. flexuosus.

Khalil Mohammed N A MNA, Radwan Rasha A RA, Hassan Mariam M, Ahmed Noha A NA et al.

Cucumis melo var. flexuosus is traditionally used for the management of skin ailments; however, its phytochemical composition and bioactivities remain insufficiently characterized. Hereto, three fruit genotypes (LG, SH, and WH) and the leaves of the LG genotype (LGLV) were systematically investigated. More than 100 phytochemicals were tentatively identified in the investigated extracts utilizing LC-HRMS. Chemometric tools discerned samples in three distinct clusters. LGLV cluster characterized by richness in flavonoids, LG & SH cluster were enriched in glycerol- and lyso-phospholipids while WH was enriched in cerebroside. Network pharmacology revealed that flavonoids, phenolic acids and lysophospholipids were the key phytochemicals against skin aging and MRSA (Methicillin resistant Staphylococcus aureus). LGLV had the highest antioxidant activities in different in vitro assays. LGLV had the highest antibacterial, biofilm inhibition (IC50 = 0.322 mg/mL) and detachment activities against MRSA. Antibacterial efficacy was verified by in vivo MRSA skin infection model. Moreover, LGLV halted aging in H2O2-induced aging model in vitro human fibroblast cell culture as evidenced by flow cytometry and by the effective suppression of MMP-1 and IL-6, p53 and increment in TIMP-1 levels. These findings highlighted that leaves are a better sustainable source of bioactive compounds for the development of anti-MRSA and skin-protective products.

PMID 42928631
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PubMedJournal of diabetes and metabolic disorders2026-10-26

Investigation of the relationship between exposure to secondhand smoke and quality of life and life satisfaction among new students at Tehran University of Medical Sciences.

Tabatabaeian Fatemeh Sadat FS, Khojasteh Mohanna M, Rezaei Nazila N, Razi Farideh F et al.

Secondhand smoke (SHS) exposure is associated with numerous adverse health outcomes, posing a substantial public health burden. Despite well-documented physical and psychological harms of SHS, based on our search, no previous research has examined its association with Quality of Life (QoL) and Life Satisfaction (LS) in university students; therefore, this study aimed to investigate these relationships in this vulnerable population. This study utilized baseline data from a prospective cohort of newly enrolled students at Tehran University of Medical Sciences. SHS exposure, QoL, LS, and demographic characteristics were assessed using standardized and validated questionnaires. Descriptive statistics and chi-square tests were used to compare groups. Linear regression models were used as the primary analyses to examine associations between SHS exposure and continuous QoL and LS scores, while logistic regression models were conducted as secondary analyses for categorized outcomes: poor/moderate versus good QoL and low versus high LS. Among the 372 participants included in the analysis, SHS exposure at home or outside was significantly associated with a 1.37-point lower QoL score (95% CI: -2.32, - 0.42; p = 0.005), while exposure in both settings was associated with a 1.80-point lower QoL score (95% CI: -3.08, - 0.52; p = 0.006). For life satisfaction, only exposure in both settings remained significantly associated with lower scores in the adjusted model (adjusted β = -2.12; 95% CI: -3.92, - 0.32; p = 0.021), while exposure at home or outside was not significantly associated with the continuouse LS score (p = 0.305). In adjusted logistic regression models, exposure at home or outside significantly increased the odds of poor/moderate QoL (AOR = 1.87; 95% CI: 1.16 to 3.01; p = 0.010), as did exposure in both settings (AOR = 1.97; 95% CI: 1.18, 3.30; p = 0.009). However, no significant associations were observed between any SHS exposure level and low life satisfaction in the adjusted logistic models. The findings indicated that SHS exposure was associated with lower QoL scores and higher odds of poor/moderate QoL among university students. Exposure in both settings was also associated with lower continuous LS scores; however, no statistically significant association was observed between SHS exposure and low LS in the adjusted logistic regression models.

PMID 42928715
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PubMedBMC medical education2026-10-26

Are health sciences students prepared for pharmacovigilance? A nationwide study of knowledge and suspected adverse drug reaction reporting.

Kopciuch Dorota D, Wach Julia J, Kus Krzysztof K

Pharmacovigilance and suspected adverse drug reaction (ADR) reporting are key components of patient safety and post-marketing drug surveillance. Spontaneous reporting systems concern suspected reactions, because causality is not established at the time of reporting. Despite their importance, suspected ADRs remain widely underreported, commonly due to limited knowledge, insufficient procedural competence, and inadequate training of healthcare professionals. Undergraduate education is therefore important for future pharmacovigilance capacity, yet comparative evidence across health sciences disciplines remains limited. A nationwide, cross-sectional survey was conducted among health sciences students enrolled in long-cycle or first- or second-cycle programmes in Poland between October 2024 and October 2025. An anonymous online questionnaire, distributed via academic and student networks, assessed pharmacovigilance knowledge, attitudes toward suspected ADR reporting, perceived barriers, and educational needs. Associations between categorical variables were analysed using Pearson's chi-square or likelihood ratio tests, with effect sizes expressed as Cramér's V. Multiple comparisons were adjusted using the Benjamini-Hochberg false discovery rate procedure. A total of 648 complete questionnaires were analysed. Significant disparities in pharmacovigilance knowledge and regulatory competence were observed across fields of study. Pharmacy students demonstrated higher awareness, more accurate conceptual understanding, and greater ability to correctly identify the competent authority for suspected ADR reporting compared with medical, nursing/midwifery, and other health sciences students (all q < 0.001, large effect sizes). While attitudes toward reporting were generally positive, they were not consistently supported by adequate procedural knowledge, particularly outside pharmacy curricula. Pharmacovigilance competence showed a non-linear relationship with year of study, with lower levels observed among sixth-year students in selected disciplines. Key barriers, including lack of remuneration and reluctance to assume additional workload, were already apparent at the undergraduate stage. Support for expanding pharmacovigilance education was high across all disciplines. The findings indicate important gaps in pharmacovigilance preparedness among health sciences students, especially in procedural and regulatory aspects of suspected ADR reporting. Undergraduate curricula should include more consistent, longitudinal, and practically focused pharmacovigilance training.

PMID 42928234
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PubMedEuropean journal of investigation in health, psychology and education2026-10-26

Measurement Heterogeneity and Pooled Prevalence of Academic Procrastination Among Health Sciences Students: A Systematic Review and Meta-Analysis.

Vera-Ponce Víctor Juan VJ, Zuzunaga-Montoya Fiorella E FE, Cómina-Tamayo María Julia MJ, León-Figueroa Darwin A DA et al.

In health sciences students, academic procrastination can affect performance, mental health, and professional development. This systematic review and meta-analysis aimed to estimate the pooled prevalence of study-defined elevated academic procrastination among health sciences students and to describe the methodological and measurement characteristics of the instruments used to assess it. A systematic review with meta-analysis was conducted. We included observational studies reporting the prevalence of academic procrastination among undergraduate students enrolled in health sciences programs, including medicine, nursing, dentistry, psychology, and related health professions. The reported measurement characteristics of the instruments used to assess academic procrastination, including validity, reliability, and cut-off criteria, were reviewed and systematized. The meta-analysis was performed employing a random-effects model and the double arcsine transformation (Freeman-Tukey) to stabilize variance. Subgroup analyses and meta-regressions were calculated to explore possible sources of variation. Twenty-six studies were included with a total of 8211 students. The pooled prevalence of study-defined elevated academic procrastination was 55.35% (95% CI: 46.55-63.98%, I2 = 98%). The prevalence was higher in nursing students (62.60%), followed by psychology (61.67%), medicine (52.62%), and dentistry (45.76%). The most commonly used instruments were the Procrastination Assessment Scale for Students (38.5%), Academic Procrastination Scale (23.1%), Tuckman's Procrastination Scale or its adaptations (15.4%), Academic Procrastination Scale by McCloskey and Scielzo or related APS versions (11.5%), Lay's Procrastination Scale (7.7%), and MHCA (3.8%). Most studies used non-probabilistic sampling, and only 8% validated instruments specifically for their target populations. Reliability coefficients were generally adequate (α = 0.75-0.95). The meta-regression revealed a slight upward trend in prevalence as a function of publication year, although this was not statistically significant. Academic procrastination appears to be frequent among health sciences students; however, the pooled estimate should be interpreted as a descriptive summary of study-defined prevalence rather than as a universal prevalence estimate, given the very high between-study heterogeneity and the variability in instruments, cut-off criteria, and population-specific validation. Educational institutions should implement prevention and support strategies, while research should prioritize instrument validation, measurement standardization, and transparent case definition criteria.

PMID 42930217
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PubMedClinical pharmacology and therapeutics2026-10-26

Quantitative Sciences in the Model-Informed Era: From Parallel Functions to a Shared Decision System.

McIntosh Avery A, Elmeliegy Mohamed M, Palmer Jeffrey P JP, Tsamandouras Nikolaos N et al.

Model-informed drug development increasingly depends on collaboration among clinical pharmacology, statistics, pharmacometrics, and quantitative systems pharmacology. Yet functional silos, distinct leadership structures, and divergent goals can reduce collaboration to late, parallel deliverables that constrain decision architecture. This Perspective defines a shared decision system as an operating model in which quantitative and clinical disciplines jointly define the question, context of use, evidentiary role, uncertainty standards, and accountability for model-informed evidence.

PMID 42928410
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