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glimepiride + metformin SR (Amaryl Mex / Amaryl M SR)

✓ Approved

Sanofi S.A · KCNJ11 · 小分子

什么是 glimepiride + metformin SR？

glimepiride + metformin SR 是一种小分子，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Amaryl Mex, Amaryl M SR
公司Sanofi S.A
药物类别小分子
分子靶点KCNJ11, ABCC8
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

作用机制

分子靶点

glimepiride + metformin SR 作用于 2 个分子靶点：

KCNJ11potassium inwardly rectifying channel subfamily J member 11 (BIR, HHF2)
ABCC8ATP binding cassette subfamily C member 8 (MRP8, SUR1delta2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

glimepiride + metformin SR 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

相关研究文献

PubMedRapid communications in mass spectrometry : RCM2026-10-26

TIMS Techniques for Measuring Strontium Isotope Ratios in Apatite Grains and Application to Igneous Rock Petrology.

Neto Carla C, de Morisson Valeriano Claudio C, Paravidini Gabriel G, Bruno Henrique H et al.

This study evaluates the potential of Sr isotopic compositions in apatite grains from magmatic rocks as a proxy for initial 87Sr/86Sr ratios, addressing the need for alternative approaches to conventional whole-rock analyses in isotopic studies of granitoid systems. Chemical and spectrometric procedures were optimized and validated for the determination of Sr isotopic ratios in apatite by TIMS. Three representative samples from the Ribeira Orogen, Brazil, were selected, and apatite Sr isotopic compositions were compared with initial whole-rock 87Sr/86Sr ratios calculated from U-Pb zircon crystallization ages, whole-rock isotopic ratios, and Rb and Sr concentrations. The reliability of the analytical approach was evaluated using the EN-1 and Durango apatite reference materials. Apatite grains yielded Sr concentrations ranging from 80 to 950 μg g-1, with total Sr masses between 0.5 and 50 ng. Comparisons between apatite-derived and whole-rock initial 87Sr/86Sr ratios show isotopic variability below 0.05%, indicating high analytical precision. Validation results demonstrate consistent agreement between methods, with uncertainties within 0.5%. The proposed TIMS-based method for Sr isotope analysis in apatite grains provides a potential approach for investigating the initial Sr isotopic compositions of granitoid magmatic systems. This approach represents a cost-effective and time-efficient alternative to traditional whole-rock analyses, with strong potential for large-scale isotopic applications in orogenic terrains.

PMID 42928975
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PubMedStrabismus2026-10-26

A case of highly myopic strabismus with large exotropia after Yokoyama procedure.

Simpao Juan Lorenzo JL, Goseki Toshiaki T, Onouchi Hiromi H

Highly myopic strabismus (heavy eye syndrome) is characterized by superotemporal prolapse of the elongated globe, resulting in nasal displacement of the superior rectus (SR) muscle and inferior displacement of the lateral rectus (LR) muscle. This abnormal extraocular muscle configuration can result in restrictive esotropia, limitation of abduction, and progressive binocular diplopia. The Yokoyama procedure restores the extraocular muscle paths by uniting the SR and LR muscle bellies and generally provides excellent ocular alignment. Persistent postoperative exotropia is uncommon and its management has rarely been described. We report a case of persistent large-angle exotropia following an uncomplicated bilateral Yokoyama procedure despite satisfactory postoperative muscle repositioning on orbital magnetic resonance imaging (MRI). A 72-year-old woman with high myopia and progressive horizontal diplopia underwent ophthalmologic and strabismus evaluation, including orbital MRI before and after bilateral Yokoyama procedures. Ocular alignment, axial length, and SR-LR displacement angles were assessed. Following development of persistent postoperative exotropia, the patient was observed for six months. Because the deviation did not improve spontaneously and postoperative MRI demonstrated satisfactory SR and LR repositioning, bilateral medial rectus (MR) plication was subsequently performed while preserving the SR-LR union. Preoperatively, the patient had 35 prism diopters (PD) of esotropia at distance with limitation of bilateral abduction and elevation. Axial lengths were 27.19 mm in the right eye and 26.91 mm in the left eye. Orbital MRI demonstrated nasal displacement of the SR and inferior displacement of the LR, with SR-LR displacement angles of 142° and 144°, respectively. Following bilateral Yokoyama procedures, approximately 55 PD of exotropia developed on the first postoperative day and persisted with little spontaneous improvement over three months. Repeat MRI demonstrated restoration of the normal SR-LR relationship, with displacement angles improving to 97° and 95°, confirming successful anatomical correction despite persistent exotropia. After six months of observation, bilateral 7-mm MR plication was performed. One month later, ocular alignment improved to near orthotropia, with resolution of diplopia and recovery of stereopsis. Persistent large-angle exotropia may occur despite successful anatomical correction following the Yokoyama procedure. Postoperative orbital MRI can help distinguish persistent muscle malposition from successful SR and LR repositioning. When satisfactory muscle positioning is confirmed and spontaneous improvement does not occur, preserving the SR-LR union and addressing the residual horizontal deviation with MR plication may provide an effective secondary surgical strategy. This case highlights the value of postoperative imaging in guiding management of unexpected overcorrection after the Yokoyama procedure.

PMID 42929265
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PubMedClinics and practice2026-10-26

Correction: Bujdei-Tebeică et al. Myoprotective Fat-Loss Phenotypes in Obesity-Associated Type 2 Diabetes: A 12-Month Real-World Cohort Study of Metformin-Based Treatment Regimens. Clin. Pract. 2026, 16, 141.

Bujdei-Tebeică Ioana I, Pantea-Stoian Anca Mihaela AM, Mihai Doina Andrada DA, Ștefan Simona Diana SD et al.

In the original publication [...].

PMID 42930381
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PubMedRevista espanola de enfermedades digestivas2026-10-26

Spontaneous complete regression of hepatocellular carcinoma with histopathological confirmation.

Jiménez González Laura L, Velasco Martínez Elena E, Jordán de la Fuente María M, Lillo Díez Jorge J et al.

Spontaneous regression (SR) of hepatocellular carcinoma (HCC) is an exceptional phenomenon, with an estimated incidence of 0.4% (1,2). Although various mechanisms have been proposed, including tumor ischemia and immune activation, its pathogenesis remains uncertain. Most published cases lack histological confirmation of tumor disappearance and have insufficiently documented follow-up. We present a case of SR with histopathological confirmation of complete tumor necrosis following exploratory laparoscopy, suggesting a possible ischemic mechanism and highlighting the challenges in therapeutic decision-making and in assessing the indication for liver transplantation.

PMID 42929260
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PubMedEnvironmental geochemistry and health2026-10-26

HDL-C as a mediator of PPCP-related kidney function decline in community-dwelling elderly: a mixture analysis approach.

Zhao Yutong Y, Wang Sheng S, Zhou Luoling L, Xu Yuanyuan Y et al.

Pharmaceuticals and personal care products (PPCPs) are widespread environmental contaminants, but their associations with kidney function and lipid metabolism remain incompletely understood. This study included 2758 adults aged ≥ 60 years in Anhui Province, China, during 2022-2023 and used a cross sectional design. Urinary concentrations of 48 PPCPs and two metabolites were measured using high-performance liquid chromatography-tandem mass spectrometry. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Individual associations were assessed using logistic and linear regression, and mixture associations using weighted quantile sum (WQS) regression and Bayesian kernel machine regression. Restricted cubic splines examined nonlinear associations, and exploratory mediation analyses assessed the statistical contribution of high-density lipoprotein cholesterol (HDL-C). Among nine PPCPs with detection frequencies > 50%, doxycycline, enrofloxacin, acetaminophen, metformin, and cotinine were associated with lower eGFR after full adjustment and Benjamini-Hochberg correction. Coefficients ranged from - 3.00 to - 0.93 mL/min/1.73 m2 per tenfold increase in urinary concentration. Tylosin and caffeine were positively associated with eGFR. The WQS index was inversely associated with eGFR, with metformin receiving the largest weight. HDL-C showed a positive nonlinear association with eGFR. Under the mediation model assumptions, HDL-C statistically accounted for 12.21-29.30% of the associations involving enrofloxacin, metformin, and acetaminophen, and 13.78% of the mixture association. The indirect association for cotinine was nonsignificant. These findings remain exploratory. Prospective studies are needed to clarify temporal relationships and address possible reverse causation.

PMID 42928303
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PubMedDalton transactions (Cambridge, England : 2003)2026-10-26

Unravelling average, local and magnetic structure in Sr-Sc-M-O oxides (M = Co, Fe) by neutron scattering.

Ceretti Monica M, Cuello Gabriel J GJ, Sheptyakov Denis D, Ritter Clemens C et al.

Oxygen-deficient Sr-Sc-M-O oxides (M = Fe, Co) were synthesized and characterized in cubic and brownmillerite forms, with the brownmillerite phase Sr2ScCoO5 reported here for the first time. The cubic phases, described as SrSc0.5M0.5O3-x, and the brownmillerite phases, Sr2ScMO5, exhibit different oxygen contents and distinct degrees of structural ordering. Neutron diffraction and pair distribution function analysis reveal short-range oxygen-vacancy and B-cation ordering at the local scale within the cubic structure. In contrast, the brownmillerite phases exhibit long-range oxygen-vacancy and cation ordering, adopting Imma and I2mb symmetries for Sr2ScFeO5 and Sr2ScCoO5, respectively. Magnetic measurements indicate weak antiferromagnetic interactions, with brownmillerite Sr2ScFeO5 showing only short-range magnetic correlations. In contrast, Sr2ScCoO5 exhibits long-range magnetic ordering at 1.5 K, with the Co magnetic moment aligned along the stacking axis. This represents the first observation of coexisting cation and three-dimensional magnetic ordering in this system, despite the large Co-Co distances of 7.63 Å. These findings highlight the role of oxygen content in driving structural ordering and underscore the need for a multiscale approach to understanding the complex structure-property relationships of oxygen-deficient perovskites.

PMID 42929422
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