北京若生智能科技有限公司
Drug Database
CH

chlorhexidine dihydrochloride + dexamethasone + nystatin (Nystalocal)

✓ Approved

Medinova · 小分子 · 小分子

什么是 chlorhexidine dihydrochloride + dexamethasone + nystatin？

chlorhexidine dihydrochloride + dexamethasone + nystatin 是一种小分子，由Medinova研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名Nystalocal
公司Medinova
药物类别小分子
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Medinova

治疗适应症

chlorhexidine dihydrochloride + dexamethasone + nystatin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
InvestigationsDermatologic examination✓ Approved
Infections and infestationsCandida infection✓ Approved

相关研究文献

PubMedThe journal of physical chemistry. B2026-09-10

Theoretical Insights into Chlorhexidine Adsorption on Polycaprolactone and Collagen Based Fibers.

Ivankova Yulia I YI, Klimchuk Darya O DO, Sorokin Pavel B PB, Antipina Liubov Yu LY

The interaction of chlorhexidine (CHX) with polycaprolactone (PCL), carboxylated PCL (PCL-COOH), and collagen-containing composite fibers was investigated using density functional tight-binding calculations (DFTB+) to elucidate the mechanisms regulating the immobilization of drugs in antibacterial polymer biomaterials. This work provides an atomistic comparison of adsorption and absorption mechanisms of chlorhexidine in pristine and functionalized PCL matrices and in collagen-PCL composite fibers. On pristine PCL, CHX exhibits moderate adsorption (-0.54 eV), while carboxylic functionalization significantly enhances binding (-1.10 eV) due to hydrogen bonding and increased electronic polarization. At the same time, the higher cohesive stability of the PCL-COOH matrix makes bulk incorporation of CHX energetically unprofitable, limiting sorption mainly by surface adsorption. In contrast, pristine PCL allows both surface adsorption and limited bulk absorption. Modeling of collagen and collagen-PCL composite fibers shows that collagen provides strong binding sites for CHX (-1.06 eV), comparable to those of PCL-COOH and stronger than those of pristine PCL. Frontier orbital analysis and charge density redistribution indicate donor-acceptor interactions in which CHX acts as an electron donor while the collagen matrix serves as the main electron-accepting component. These results suggest that collagen-rich surfaces in composite fibers may provide an effective strategy for immobilizing antibacterial agents in wound-dressing materials.

PMID 42720360
阅读全文 →
PubMedHaematologica2026-09-10

Ixazomib, pomalidomide and dexamethasone in triple-class exposed multiple myeloma patients - a phase II study.

Shragai Tamir T, Lavi Noa N, Vaxman Iuliana I, Gatt Moshe E ME et al.

Multi-class upfront regimens for multiple myeloma (MM) have improved outcomes, yet many patients become either triple-class exposed (TCE) or refractory (TCR) early in their disease course. This is a phase II, investigator initiated, open-label, single-arm, prospective, multicenter study evaluating all-oral Ixazomib-pomalidomide- dexamethasone (IPd) regimen for TCE RRMM patients. Sixty-one patients were enrolled between March 1st 2021 and March 17th 2024. The median age was 74 (range: 53-89) years; 25 (41%) were ≥75 years old. Fiftyseven percent had high-risk cytogenetics (t(4;14), t(14;16), +1q21, del17p(. Twenty-six (43%) patients were frail. Refractoriness rates to bortezomib, lenalidomide and daratumumab were 51%, 85% and 96% respectively. Tripleclass refractory (TCR) rate was 39%. Ninety-seven percent of the patients had ≥1 treatment emergent adverse event (TEAE) and 67% had a TEAE grade ≥3. The rate of Gr ≥3 AE was not increased in frail vs. non-frail patients (p=0.43). Overall response rate (ORR) was 58% (22% very good partial response or better). TCR patients had an ORR of 46% vs. 68% for non-TCR patients (p=0.12). The median progression-free survival was 8.1 (95% CI 3.9-12.3) months and the median overall survival was 30.4 (95% CI 21.5-39.4) months. To conclude, the all-oral IPd regimen for TCE RRMM patients showed high response rates and a manageable safety profile, in a cohort enriched with TCR, elderly and frail patients. (NCT04790474).

PMID 42719971
阅读全文 →
PubMedTherapeutic advances in hematology2026-09-10

Fulminant extramedullary relapse of multiple myeloma with rare cardiac, vascular, and multivisceral involvement: A case report.

Wei Yuhui Y, Yang Xuejiao X, Zheng Yulan Y, Zhang Dongdong D

Multiple myeloma (MM) is a plasma cell malignancy that typically follows a protracted clinical course. Extramedullary disease (EMD) represents an aggressive manifestation of MM with a relatively low incidence, traditionally involving the skin and soft tissues. While MM usually progresses indolently, fulminant disease progression characterized by extensive multivisceral and vascular infiltration is exceptionally rare and seldom documented in the medical literature. This case illustrates a 64-year-old woman who presented with left chest wall mass and pain and was diagnosed with high-risk IgG-λ-type MM (R-ISS Stage II), harboring 1q21 amplification and IGH/FGFR3 translocation. Following 12 cycles of VCD (bortezomib, cyclophosphamide, and dexamethasone) induction, she achieved partial remission and proceeded to maintenance therapy with bortezomib and ixazomib. Fifteen months post-diagnosis, the patient presented with a rapidly enlarging abdominal wall mass. 18F-FDG PET-CT revealed widespread hypermetabolic activity involving the heart, major blood vessels, liver, spleen, lungs, and multiple soft tissue sites, indicating extensive EMD. Bone marrow examination showed only 1% plasma cells, demonstrating a marked dissociation between systemic EMD and medullary involvement. Despite salvage therapy with carfilzomib, liposomal doxorubicin, and dexamethasone, the patient's condition deteriorated rapidly. Compounded by severe hypoproteinemia, electrolyte disturbances, and respiratory infection, the disease followed a fulminant course, ultimately leading to the patient's death. This case represents a catastrophic transition of genetically high-risk MM from initial medullary involvement to widespread multivisceral and cardiovascular infiltration upon relapse. It highlights a rare phenotype of relapsed/refractory MM where aggressive extramedullary proliferation occurs independently of bone marrow progression. Such patients face a dismal prognosis and present a formidable challenge for current salvage therapeutic strategies.

PMID 42719364
阅读全文 →
PubMedJournal of medicinal chemistry2026-09-10

Design and Synthesis of Anemoside B4 Derivatives as Pyruvate Carboxylase-Targeting Therapeutic Agents for Atopic Dermatitis.

Li Heng H, Du Yexin Y, Li Qiurong Q, Zhang Junlei J et al.

Although injectable anemoside B4 (AB4) has therapeutic potential for atopic dermatitis (AD), its clinical use is restricted by safety and pharmacokinetic issues. Therefore, we designed 42 AB4 derivatives, established a preliminary SAR for anti-inflammatory and antiallergic activities, and selected three promising compounds for in vivo evaluation in an AD mouse model, leading to the identification of B4-39 as the lead compound. In a DNCB-induced AD mouse model, topical B4-39 (6.6 mg/kg) was more effective than dexamethasone and free from its side effects, while matching the efficacy of crisaborole at a much lower dose and providing better skin barrier repair. Mechanistically, B4-39 targets pyruvate carboxylase (PC)─a novel therapeutic target in AD─modulating the TCA cycle to suppress dendritic cell activation and concurrently inhibiting NF-κB and NLRP3 inflammasome signaling. Given its enhanced efficacy, steroid-sparing safety, novel PC-targeted action, and favorable topical delivery, B4-39 is a highly promising candidate for AD treatment.

PMID 42720484
阅读全文 →
PubMedRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie2026-09-10

Alternative cutoffs for cortisol post-Dexamethasone suppression testing: is there a practical point for the bone health evaluation?

Ionovici Nina N, Trandafir Alexandra Ioana AI, Manda Dana D, Gheorghe Ana Maria AM et al.

Current guideline-based stratification in the non-secretory adrenal tumors (ADTs) involves the second-day (post-Dexamethasone testing) plasma cortisol (D-C) threshold of <1.8 μg∕dL to determine a non-functional profile and another one for a mild cortisol secretion (cortisol between 1.8 and 5 μg∕dL). To analyze the bone status in terms of mineral metabolism, circulating biomarkers of bone turnover and bone mineral density in menopausal women with ADTs by comparing two population subgroups, according to distinct thresholds for D-C, which are out of the current guidelines (1.4 μg∕dL and 0.9 μg∕dL, respectively). A retrospective analysis was conducted in ADT-positive menopausal women. Final analysis included 109 adults: ADT-1 group (52.3%; D-C: ≤1.4 μg∕dL) vs. ADT-2 group (47.7%; D-C: 1.4-5 μg∕dL) and ADT-3 group (20.2%; D-C: ≤0.9 μg∕dL) vs. ADT-4 group (79.8%; D-C: 0.9-5 μg∕dL), respectively. ADT-1 group vs. ADT-2 group was at similar age (60.14±8.56 vs. 60.08±11.85 years), menopause duration (13.85±7.41 vs. 14.19±8.54 years), body mass index (30.78±6.20 vs. 29.23±6.73 kg∕m²), and obesity rate (56% vs. 35.9%). Mineral metabolism assays showed no between-group difference. Both groups experienced a vitamin D deficiency according to 25-hydroxyvitamin D (23.69±10.42 vs. 25.35±9.98 ng∕mL, p=0.481). Except for femoral neck T-score within ADT-1 group (-1.22±1.11), all the other dual energy X-ray absorptiometry (DXA) categories were normal. The prevalence of osteoporosis diagnosis was similar: 24.5% vs. 35.4%, with lower fracture rate (3.5% compared to 21.2%, p=0.005). ADT-3 group compared to ADT-4 group showed a similar bone health status. Half of patients suffered from obesity (50% vs. 46.4%, p=0.775). A borderline significance was attributed to a higher total hip T-score in ADT-3 group vs. ADT-4 group (-0.23 vs. -0.87, p=0.06), both with intra-normal values, and a lower fracture rate (0% vs. 14.9%, p=0.053). Osteoporosis diagnosis displayed a statistically significant decrease in the prevalence in ADT-3 group vs. ADT-4 group: 5.6% vs. 35.4% (p=0.042). Menopausal adults with D-C >0.9 μg∕dL should be mandatory tested for osteoporosis, and those with D-C >1.4 μg∕dL should be additionally screened for osteoporotic fractures, while age is not different among the subgroups with different cutoffs.

PMID 42717460
阅读全文 →
PubMedBMC oral health2026-09-10

On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent.

Luan Mengyuan M, Gao Xiuzhi X, Cao Qianqian Q, Lv Na N

Dental caries remains a prevalent public health disorder dominated by Streptococcus mutans. Novel biocompatible antibacterial agents are urgently required for caries control. Slightly acidic electrolyzed water (SAEW), rich in endogenous hypochlorous acid, boasts broad bactericidal effects and minimal cellular toxicity, yet rapid degradation during storage limits its reproducibility. Thus, this study adopted freshly prepared SAEW to systematically assess its anti-cariogenic performance for translational reference. In vitro, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of SAEW against planktonic S. mutans were determined, and bacterial growth was monitored. Morphology was examined by scanning electron microscopy (SEM). Biofilm structure, viability, and membrane integrity were assessed by confocal laser scanning microscopy (CLSM) with live/dead staining. The cytotoxic effects of SAEW on human gingival fibroblasts (HGFs) were evaluated using the CCK-8 assay. 25 Sprague-Dawley rats were randomized into five groups: blank control, caries model, 0.12% chlorhexidine, high-concentration SAEW, and low-concentration SAEW groups. All non-blank rats received cariogenic induction and daily topical intervention. Salivary streptococcal loads were quantified, and mandibular caries severity was graded via Keyes scoring combined with radiography. Freshly prepared SAEW exhibited definitive antibacterial activity against S. mutans Its MIC and MBC against planktonic bacteria were 6.25 ppm and 12.5 ppm, respectively. SAEW compromised bacterial cell membrane integrity (activity reduced to 94.5 ± 0.8% in the high-concentration group). At its effective antibacterial concentrations, SAEW showed no significant cytotoxicity to human oral cells (Cell viability exceeded 80%). In a rat caries model, SAEW significantly reduced oral streptococcal levels and mitigated the severity of carious lesions (caries scores at superficial, moderate, and deep dentinal levels were 10.2 ± 1.30, 6.60 ± 0.89, and 1.00 ± 0.71 in the high-concentration group; all P < 0.05). No obvious histopathological alterations or systemic toxicity were induced by SAEW. Freshly prepared SAEW eliminates planktonic S. mutans primarily by disrupting cell membranes, with favorable cytocompatibility at working concentrations. It restrains cariogenic colonization and relieves caries progression in rodent models, marking a promising eco-friendly candidate for clinical caries prevention.

PMID 42717335
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多chlorhexidine dihydrochloride + dexamethasone + nystatin