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chlorhexidine dihydrochloride + dexamethasone + nystatin (Nystalocal)

✓ Approved

Medinova · 小分子 · 小分子

什么是 chlorhexidine dihydrochloride + dexamethasone + nystatin？

chlorhexidine dihydrochloride + dexamethasone + nystatin 是一种小分子，由Medinova研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名Nystalocal
公司Medinova
药物类别小分子
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Medinova

治疗适应症

chlorhexidine dihydrochloride + dexamethasone + nystatin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
InvestigationsDermatologic examination✓ Approved
Infections and infestationsCandida infection✓ Approved

相关研究文献

PubMedCureus2026-10-26

A Comparative Evaluation of the Effects of Three Different Mouthwashes on Salivary pH in Patients Undergoing Fixed Orthodontic Treatment: A Randomized Clinical Trial.

Jeevagan Sruthi S, Mora Sathi Rami Reddy SRR, N Mohamed Rahmankhan MR, Vijaykumar V V et al.

Introduction Orthodontic appliances have been reported to influence salivary composition and properties, including alterations in pH and buffering capacity, which may increase the vulnerability of patients to caries development. In addition to mechanical plaque control, mouthwashes and other chemical agents are frequently advised to improve oral hygiene in orthodontic patients. This randomized clinical experiment assesses and compares the effects of three distinct mouthwashes on the salivary pH level in patients receiving fixed orthodontic therapy. Methods This randomized parallel-group single-blind clinical trial involved 120 patients who attended fixed orthodontic treatment, randomly divided into three groups (n = 40 each): Hetafu CUTE, chlorhexidine, and Listerine mouthwash users. Every participant received two 10-15 mL rinses per day, each of which lasted 30-60 seconds. Saliva pH was measured using standard pH paper at baseline, directly after mouthwash use (five minutes), and one week after the beginning of the intervention. The results were analyzed using a mixed-design repeated-measures analysis of variance (ANOVA) with Greenhouse-Geisser correction, and Bonferroni-adjusted post-hoc comparisons were performed where appropriate. Statistical significance was set at p < 0.05. Results A total of 120 participants were included, with 40 in each group. Baseline salivary pH was comparable among the groups (p = 0.157). At five minutes, salivary pH was higher with Hetafu CUTE (7.75 ± 0.78) than with chlorhexidine (7.08 ± 1.00) and Listerine (7.15 ± 1.37) (p = 0.014). At one week, pH increased with Hetafu CUTE (7.93 ± 0.69) but decreased with chlorhexidine (6.78 ± 0.80) and Listerine (6.70 ± 1.34) (p < 0.001). The group × time interaction was statistically significant (p < 0.001), with Bonferroni-adjusted comparisons showing higher pH with Hetafu CUTE than chlorhexidine (p = 0.006) and Listerine (p = 0.023). Conclusion Within the scope of the study, the Hetafu CUTE mouth rinse showed a more pronounced and prolonged increase in saliva pH compared to Listerine and chlorhexidine. This characteristic may contribute to the maintenance of oral pH homeostasis and prevention of enamel demineralization and white spot lesions. However, further research, including large-scale randomized controlled trials, is warranted to validate these findings and establish the clinical efficacy of Hetafu CUTE.

PMID 42928919
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PubMedPeerJ2026-10-26

In vitro evaluation of N-acetylcysteine, calcium hydroxide, chlorhexidine digluconate and their combinations effect against five dental obligate anaerobic bacteria.

de Carvalho Lara Steffany LS, de Oliveira Júlia Andrade JA, Cezarino Gabriel Manente GM, Dos Santos Luiz Augusto Rodrigues LAR et al.

This study aimed to evaluate the antibacterial action of N-acetylcysteine (NAC), calcium hydroxide Ca(OH)2, chlorhexidine digluconate (CHX), and their combinations against five obligate anaerobic bacteria including Fusobacterium nucleatum, Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, and Parvimonas micra in planktonic and biofilm forms. Eight experimental groups were evaluated in this study including saline solution (SS) (control group), Ca(OH)2, CHX, NAC, NAC + Ca(OH)2, NAC + CHX, Ca(OH)2 + CHX, and NAC + Ca(OH)2 + CHX. The anti-planktonic evaluation was performed by determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) following Clinical and Laboratory Standards Institute guidelines (CLSI M11). The antibiofilm was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet (CV) assays. Data were analyzed statistically considering a significant level of (α ≤ 0.05). It was found that the MIC and MBC values of the tested intracanal medications ranged from 1.95-500 mg/mL. MTT and CV assays showed significant, species-dependent antibiofilm activity. CHX was most effective against F. nucleatum; NAC-based medications, especially combined with Ca(OH)2 and/or CHX, were superior against P. endodontalis, P. intermedia, and P. micra. Ca(OH)2-containing groups were particularly effective against P. gingivalis. Therefore, NAC + Ca(OH)2 and NAC + Ca(OH)2 + CHX can be considered as effective combinations of intracanal medication against different obligate anaerobic bacteria.

PMID 42928779
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PubMedDentistry journal2026-10-26

Alternative Strategies for Managing Dental Black Stains: A Systematic Review.

Boukhancha Omaima O, Amimer Manal M, Chala Sanaa S

Background/Objectives: Dental black stains (BSs) are a form of extrinsic tooth discoloration of bacterial origin, with a prevalence ranging from 2.4% to 20%. As scaling and polishing remain the standard of care, recurrence is frequent. Therefore, this systematic review assessed alternative or adjunctive treatments, such as probiotics, chemical agents, and photodynamic therapy, for managing BSs. The primary objective was to evaluate clinical changes in BS recurrence and severity, while the secondary objective was to analyze microbiological changes. Methods: Conducted following PRISMA 2020 guidelines and registered on PROSPERO (CRD420261357137), this review searched PubMed, Cochrane Library, Scopus, Web of Science, and Dentistry & Oral Sciences Source through EBSCOhost as well as clinical trial registers (ClinicalTrials.gov and ISRCTN) and grey literature, up to 30 April 2026, with no language or date restrictions. We included randomized and non-randomized clinical trials. Two independent reviewers performed study selection and data extraction; a third resolved disagreements. We assessed risk of bias using RoB 2 and ROBINS-I V2, and quality of evidence using GRADE. Results: Of 716 records identified, eight clinical trials (five randomized clinical trials and three non-randomized clinical trials were included), with 250 patients enrolled and 227 assessed at follow-up. Four intervention categories were investigated: probiotics, antimicrobial mouthwashes (0.1%, 0.12% chlorhexidine and 0.1% chlorine dioxide), enzyme-containing toothpaste, and antimicrobial photodynamic therapy (aPDT). Probiotics may reduce BS indices, though the effect was inconsistent over time. In a single small, randomized study, chlorine dioxide showed a short-term reduction in bacterial viability greater than chlorhexidine. aPDT and enzyme-containing toothpaste did not show a significant benefit in the included studies. High risk of bias, heterogeneity, and the small sample prevented quantitative synthesis. Conclusions: Evidence supporting alternative strategies for managing recurrent dental BSs or reducing chromogenic bacterial load remains insufficient. Larger RCTs with standardized outcomes and longer follow-up are needed.

PMID 42930404
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PubMedDentistry journal2026-10-26

Implant-Abutment Interface Gels in Two-Piece Implant Systems: The "Guardian-Hazard" Paradigm-A Scoping Review.

Anastasiadis Konstantinos K, Kokoti Maria M, Bakopoulou Athina A, Romanos Georgios G

Background/Objectives: Antiseptic gels applied at the implant-abutment interface (IAI) aim to reduce microbial leakage and peri-implant inflammation. However, introducing viscous media into a precision screw joint may affect tribology, preload maintenance, mechanical stability and corrosion-related processes. This scoping review mapped evidence on chlorhexidine (CHX) and other IAI gels, considering their biological, mechanical and electrochemical effects. Methods: Following PRISMA-ScR and a Population-Concept-Context framework, in vitro, in vivo and clinical studies of two-piece implant systems were eligible if they evaluated CHX or another sealing gel at the IAI and reported microbial, mechanical or electrochemical outcomes. English-language full texts published between 2015 and 2025 were identified through PubMed/MEDLINE, Scopus, ScienceDirect and reference screening. Findings were synthesised qualitatively within "Guardian" (biological protection) and "Hazard" (mechanical or electrochemical effects) domains. Results: Of 241 records, 16 met the inclusion criteria. CHX gels reduced intra-implant bacterial counts, although their sealing effect was limited and time-dependent. Silicone-based sealants generally achieved better microbial leakage control and, in several studies, maintained or increased reverse torque values compared with dry controls. Conversely, aqueous or oil-based antiseptic agents frequently reduced reverse torque, suggesting lubrication-related effects on screw-joint stability. No study directly quantified tribocorrosion associated with specific gels. Conclusions: IAI gels may provide biological protection, but their effects depend on formulation and are not exclusively antimicrobial. Silicone-based materials demonstrated the most favourable combined microbial and mechanical performance. Tribocorrosion remains insufficiently investigated, highlighting the need for integrated microbial, mechanical and electrochemical studies.

PMID 42930437
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PubMedGels (Basel, Switzerland)2026-10-26

Optimization of Hydrophobic Group Structures Covalently Incorporated into Gelatin Hydrogels for Efficient Adsorption and Release of Hydrophobic Drugs.

Nishimura Ko K, Matsumoto Takanori T, Kanamaru Kazunori K, Kobaru Saki S et al.

Hydrophobically modified gelatin (HMG) hydrogels are promising proof-of-concept drug delivery carriers. However, the structural effects of incorporated hydrophobic groups remain systematically unexamined. Here, twelve linear fatty and aromatic hydrophobic groups with varying carbon numbers were incorporated into gelatin to identify optimal structures for hydrophobic drug loading. Adsorption behaviors of three drug models were quantitatively evaluated per mole of incorporated carbon atoms. Linear fatty aldehydes with 11 and 12 carbon atoms (F-CHO-C11 and C12) achieved maximum adsorption efficiency, with equilibrium adsorption capacities of 0.35×10-3 and 0.34×10-3 mol-rhodamine B/mol-carbon atoms, respectively. Thermodynamic calculations (COSMO-SAC) and quantum chemical simulations (Gaussian MP2) supported the idea that longer alkyl chains enhance affinity, yielding higher interaction energy (-11.8kcal/mol for C12 vs. -5.73kcal/mol for C4). Furthermore, F-CHO-C12 HMG hydrogel achieved a substantial dexamethasone loading capacity of approximately 2.8×10-6 mol/g-dry polymer (unmodified gelatin showed negligible loading <0.08×10-6 mol/g-dry polymer) and sustained release at 37 °C (∼95% cumulative release without initial burst). These findings establish quantitative design guidelines for hydrophobically modified polymer hydrogels.

PMID 42929975
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PubMedVeterinary ophthalmology2026-10-26

Novel Therapy for Severe Bilateral Pyogranulomatous Blepharitis Secondary to Hyaluronic Acid Filler in a Dog.

Dacanay-DeFebo Samantha S, Putra Andhika A, Gemensky-Metzler Anne A, Davis Amanda A et al.

A 9-year-old female spayed mixed breed dog was initially examined for severe bilateral entropion secondary to enophthalmos from chronic oral steroid use for immune-mediated thrombocytopenia as well as potential historic masticatory muscle myositis. Surgical intervention with entropion surgery was pursued; however, trichiasis secondary to laxity of the periocular muscles, eyelid tissues, and tarsal plate developed several months later. Hyaluronic acid (HA) filler (Alayna SG 24 Distinct, BSC Medical Devices GmbH, Munich, Germany) was injected into the superior and inferior eyelids of both eyes to correct recurrent ocular irritation. One month later, the patient developed severe, presumed pyogranulomatous blepharitis in both eyes suspected to be a delayed hypersensitivity reaction to the HA filler. The condition worsened despite medical management. Due to the patient's previous, chronic history of oral steroid use, the owners declined administration of oral steroids at that time. Oral Zenrelia (ilunocitinib) and topical neomycin-polymyxin-dexamethasone ointment were instituted, which resulted in a rapid resolution of the patient's clinical signs. This is the first known report of a dog experiencing a severe hypersensitivity reaction to hyaluronic acid used as an eyelid filler and successful treatment with Zenrelia for this purpose.

PMID 42928512
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