chlorhexidine gluconate (PerioChip)

✓ Approved

什么是 chlorhexidine gluconate？

chlorhexidine gluconate 是一种小分子，由Dexcel Pharma Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Surgical Implantation。

药物档案

商品名	PerioChip
公司	Dexcel Pharma Ltd.
药物类别	小分子
给药途径	Surgical Implantation
状态	Approved

来源： ClinicalTrials.gov, Dexcel Pharma Ltd.

治疗适应症

chlorhexidine gluconate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Infections and infestations	Periodontitis	✓ Approved

相关研究文献

PubMedThe journal of physical chemistry. B2026-09-10

Theoretical Insights into Chlorhexidine Adsorption on Polycaprolactone and Collagen Based Fibers.

Ivankova Yulia I YI, Klimchuk Darya O DO, Sorokin Pavel B PB, Antipina Liubov Yu LY

The interaction of chlorhexidine (CHX) with polycaprolactone (PCL), carboxylated PCL (PCL-COOH), and collagen-containing composite fibers was investigated using density functional tight-binding calculations (DFTB+) to elucidate the mechanisms regulating the immobilization of drugs in antibacterial polymer biomaterials. This work provides an atomistic comparison of adsorption and absorption mechanisms of chlorhexidine in pristine and functionalized PCL matrices and in collagen-PCL composite fibers. On pristine PCL, CHX exhibits moderate adsorption (-0.54 eV), while carboxylic functionalization significantly enhances binding (-1.10 eV) due to hydrogen bonding and increased electronic polarization. At the same time, the higher cohesive stability of the PCL-COOH matrix makes bulk incorporation of CHX energetically unprofitable, limiting sorption mainly by surface adsorption. In contrast, pristine PCL allows both surface adsorption and limited bulk absorption. Modeling of collagen and collagen-PCL composite fibers shows that collagen provides strong binding sites for CHX (-1.06 eV), comparable to those of PCL-COOH and stronger than those of pristine PCL. Frontier orbital analysis and charge density redistribution indicate donor-acceptor interactions in which CHX acts as an electron donor while the collagen matrix serves as the main electron-accepting component. These results suggest that collagen-rich surfaces in composite fibers may provide an effective strategy for immobilizing antibacterial agents in wound-dressing materials.

PMID 42720360

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PubMedBMC oral health2026-09-10

On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent.

Luan Mengyuan M, Gao Xiuzhi X, Cao Qianqian Q, Lv Na N

Dental caries remains a prevalent public health disorder dominated by Streptococcus mutans. Novel biocompatible antibacterial agents are urgently required for caries control. Slightly acidic electrolyzed water (SAEW), rich in endogenous hypochlorous acid, boasts broad bactericidal effects and minimal cellular toxicity, yet rapid degradation during storage limits its reproducibility. Thus, this study adopted freshly prepared SAEW to systematically assess its anti-cariogenic performance for translational reference. In vitro, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of SAEW against planktonic S. mutans were determined, and bacterial growth was monitored. Morphology was examined by scanning electron microscopy (SEM). Biofilm structure, viability, and membrane integrity were assessed by confocal laser scanning microscopy (CLSM) with live/dead staining. The cytotoxic effects of SAEW on human gingival fibroblasts (HGFs) were evaluated using the CCK-8 assay. 25 Sprague-Dawley rats were randomized into five groups: blank control, caries model, 0.12% chlorhexidine, high-concentration SAEW, and low-concentration SAEW groups. All non-blank rats received cariogenic induction and daily topical intervention. Salivary streptococcal loads were quantified, and mandibular caries severity was graded via Keyes scoring combined with radiography. Freshly prepared SAEW exhibited definitive antibacterial activity against S. mutans Its MIC and MBC against planktonic bacteria were 6.25 ppm and 12.5 ppm, respectively. SAEW compromised bacterial cell membrane integrity (activity reduced to 94.5 ± 0.8% in the high-concentration group). At its effective antibacterial concentrations, SAEW showed no significant cytotoxicity to human oral cells (Cell viability exceeded 80%). In a rat caries model, SAEW significantly reduced oral streptococcal levels and mitigated the severity of carious lesions (caries scores at superficial, moderate, and deep dentinal levels were 10.2 ± 1.30, 6.60 ± 0.89, and 1.00 ± 0.71 in the high-concentration group; all P < 0.05). No obvious histopathological alterations or systemic toxicity were induced by SAEW. Freshly prepared SAEW eliminates planktonic S. mutans primarily by disrupting cell membranes, with favorable cytocompatibility at working concentrations. It restrains cariogenic colonization and relieves caries progression in rodent models, marking a promising eco-friendly candidate for clinical caries prevention.

PMID 42717335

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PubMedMicrobiology spectrum2026-09-09

Genomic characterization of efflux pumps and putative small multidrug resistance (SMR)-like transporters in disinfectant-tolerant coagulase-negative staphylococci from a Vietnamese hospital.

Hung Dao Hai DH, Hien Le Phung LP, Oanh Pham Kieu PK, Huyen Ngo Thi Thanh NTT et al.

Coagulase-negative staphylococci (CoNS) are common inhabitants of healthcare environments and can serve as reservoirs of antimicrobial resistance determinants. However, the relationship among disinfectant tolerance, efflux-associated phenotypes, and multidrug resistance in environmental CoNS remains incompletely defined. Here, 51 staphylococcal isolates were recovered from high-touch hospital surfaces in Hanoi, Vietnam, and 14 isolates showed elevated MICs to at least one disinfectant, including benzalkonium chloride, chlorhexidine gluconate, or hydrogen peroxide, relative to Staphylococcus aureus ATCC 25923. These isolates also displayed multidrug-resistant phenotypes. Moreover, ethidium bromide accumulation assays revealed a clear efflux-associated phenotype, and representative isolates exhibited biofilm-forming ability. Whole-genome sequencing of three representative isolates reclassified SDH.B1 and SDH.B3 as Staphylococcus nepalensis-a CoNS species rarely documented in hospital AMR surveillance-and confirmed SDH.B7 as Staphylococcus haemolyticus. To our knowledge, this is among the first reports of S. nepalensis carrying mecA together with the disinfectant efflux gene qacG, and a set of putative small multidrug resistance (SMR)-like transporters in a hospital environment from Southeast Asia. In addition, six putative SMR-like proteins were identified. Phylogenetic and structural analyses suggested relatedness to YkkC/YkkD-like systems, although their transport activity remains to be experimentally verified. These findings identify environmental CoNS as reservoirs of disinfectant tolerance and multidrug resistance in hospital settings and provide a basis for future functional investigation of putative SMR-like transporters.IMPORTANCEHospital environmental CoNS are often dismissed as low-priority contaminants, yet they may persist under disinfectant pressure and carry clinically relevant resistance determinants. Here, disinfectant-tolerant CoNS recovered from a Vietnamese hospital combined multidrug resistance, efflux-associated phenotypes, and biofilm-related traits. Genome analysis further revealed known qac genes and six putative SMR-like proteins that merit functional testing. These findings support inclusion of environmental CoNS in infection-prevention surveillance and disinfectant stewardship programs.

PMID 42714170

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PubMedNano letters2026-09-09

Synergistic Antibacterial Behavior of Carbon Dots via Both Contact-Dependent and -Independent Mechanisms.

Xu Guopeng G, Zhang Wenyan W, Lu Hui H, Zhang Tingting T et al.

Antibiotic-resistant infections remain a major barrier to wound care, motivating antimicrobial biomaterials that are effective and locally activatable. Here, we report infection-responsive iron-doped carbon dots (FeCDs) synthesized via a one-pot hydrothermal route using biocompatible iron(II) gluconate. FeCDs eradicate bacteria through synergistic dual pathways: (i) a contact-independent mechanism in which iron doping confers peroxidase-like activity to catalyze reactive oxygen species (ROS) generation in H2O2-rich infection microenvironments, amplifying localized oxidative stress; and (ii) a contact-dependent mechanism where FeCDs electrostatically bind to bacteria and drive material-bacteria interfacial electron transfer, disrupting respiratory chains and energy production. Combined experiments and molecular dynamics simulations substantiate this synergistic coupling between catalytic and bioelectronic kinetics. Consequently, FeCDs exhibit broad-spectrum antibacterial ability with a high bactericidal rate (98.91%), and significantly accelerate infected wound healing with excellent biosafety. This work advances scalable carbon-based nanozymes, and highlights respiratory electron disruption as a powerful and complementary modality for anti-infective therapy.

PMID 42715070

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PubMedThe journal of sexual medicine2026-09-08

Chlorhexidine gluconate irrigation used at implantation lowers culture positivity in non-infected prosthesis revisions.

Nose Brent B, Sarantos Nicklas N, Grimaud Logan L, Sury Kiran K et al.

PMID 42708449

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PubMedJournal of veterinary emergency and critical care (San Antonio, Tex. : 2001)2026-09-08

Successful Treatment of a Dog With Polyethylene Glycol Electrolyte and Activated Charcoal Solution Aspiration Pneumonitis With Bronchoalveolar Lavage and Mechanical Ventilation.

Pollak Claire R O CRO, Ruys Laura J LJ

To describe a dog with aspiration pneumonitis resulting from administration of polyethylene glycol (PEG) electrolyte and activated charcoal (AC) solution into the airway that was successfully treated using bronchoalveolar lavage and mechanical ventilation (MV). A young female Chihuahua-Pomeranian crossbreed initially presented with constipation to the primary care clinician. The dog was sedated for the placement of a nasoesophageal tube, after which the PEG and AC solution wer administered. The administration of this solution into the airways led to aspiration pneumonitis, causing respiratory distress and coughing. Initial treatment involved bronchoscopic suction and airway lavage and medical support, including an antimicrobial and a bronchodilator. Due to increasing respiratory effort and hypoxemia, MV was needed. Pressure-controlled synchronized intermittent mandatory ventilation mode, which allows spontaneous breathing and the administration of mandatory breaths, was initiated. Two complications occurred during MV. The first was hyperkalemia of unknown origin, which was treated with glucose, calcium gluconate, insulin, and terbutaline. The second complication involved severe clogging of the heat-moisture exchanger filters by the PEG and AC solution, resulting in hypercapnia. After 4 days, the dog was successfully weaned from the ventilator and eventually made a full recovery. To the authors' knowledge, this is the first report describing successful treatment of a dog using bronchoalveolar lavage and MV for the inadvertent administration of PEG electrolyte and AC solution into the airways.

PMID 42706485

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chlorhexidine gluconate (PerioChip)

什么是 chlorhexidine gluconate？

药物档案

治疗适应症

相关研究文献

Theoretical Insights into Chlorhexidine Adsorption on Polycaprolactone and Collagen Based Fibers.

On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent.

Genomic characterization of efflux pumps and putative small multidrug resistance (SMR)-like transporters in disinfectant-tolerant coagulase-negative staphylococci from a Vietnamese hospital.

Synergistic Antibacterial Behavior of Carbon Dots via Both Contact-Dependent and -Independent Mechanisms.

Chlorhexidine gluconate irrigation used at implantation lowers culture positivity in non-infected prosthesis revisions.

Successful Treatment of a Dog With Polyethylene Glycol Electrolyte and Activated Charcoal Solution Aspiration Pneumonitis With Bronchoalveolar Lavage and Mechanical Ventilation.

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