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triamcinolone acetonide (Triesence)

✓ Approved

Novartis AG · NR3C1 · 小分子

什么是 triamcinolone acetonide？

triamcinolone acetonide 是一种小分子，由Novartis AG研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraocular Injection。

药物档案

商品名Triesence
公司Novartis AG
药物类别小分子
分子靶点NR3C1
给药途径Injectable (Others), Intraocular Injection
状态Approved
来源： ClinicalTrials.gov, Novartis AG

作用机制

分子靶点

triamcinolone acetonide 作用于 1 个分子靶点：

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

triamcinolone acetonide 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved
Eye disordersUveitis✓ Approved
Injury, poisoning and procedural complicationsVascular access site inflammation✓ Approved

相关研究文献

PubMedFrontiers in medicine2026-09-10

Case Report: Occult ocular toxocariasis revealed during vitrectomy in a child with chronic vitritis and vitreoretinal traction.

Chen Jing J, Zhang Ling L

This report describes an 11-year-old girl who presented with a 6-month history of decreased visual acuity in the left eye without ocular pain or redness. She had a history of exposure to cats and dogs. Initial ophthalmic examination showed dense vitreous inflammatory opacities and diffuse fibroproliferative traction involving the posterior pole, but no typical granulomatous lesion was visible before surgery. The patient underwent 25-gauge pars plana vitrectomy with membrane peeling, and periocular triamcinolone acetonide (40 mg) was administered at the end of surgery for residual intraocular inflammation. During surgery, a peripheral grayish-white granulomatous lesion with associated retinal traction was identified. Paired serum and undiluted vitreous fluid testing showed elevated anti-Toxocara IgG levels, and the Goldmann-Witmer coefficient was markedly increased to 63.67, supporting local intraocular anti-Toxocara antibody production. Together with the intraoperative identification of a peripheral granulomatous lesion, these findings strongly supported the diagnosis of ocular toxocariasis. The postoperative course was uneventful, with no recurrent vitritis, new retinal lesion, retinal detachment, clinically evident macular edema, or progression of the peripheral granuloma during 12 months of follow-up. Anatomical stabilization was achieved, although visual recovery remained limited, likely because of long-standing tractional macular distortion and chronic structural damage. This case highlights that ocular toxocariasis should be considered in children with unilateral chronic vitritis and tractional vitreoretinal changes, even when a typical granuloma is not visible before surgery. Paired serum and undiluted vitreous antibody testing, together with calculation of the Goldmann-Witmer coefficient, can provide important diagnostic evidence, while vitrectomy may have both diagnostic and therapeutic value in advanced tractional cases.

PMID 42718488
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PubMedAmerican journal of ophthalmology2026-09-10

Cystoid Macular Edema After Cultured Human Corneal Endothelial Cell Injection: Frequency, Associated Factors, and Visual Outcomes.

Ogino Rintaro R, Shirane Mariko M, Yagi-Yaguchi Yukari Y, Akasaki Yasutsugu Y et al.

To evaluate the frequency, timing, factors associated with, and visual impact of cystoid macular edema (CME) detected after cultured human corneal endothelial cell (cHCEC) injection therapy. Multicenter retrospective clinical cohort study. Fifty-seven eyes of 57 patients who underwent cHCEC injection therapy at 3 tertiary ophthalmic institutions in Japan. Clinical records were reviewed retrospectively. CME was defined as the presence of intraretinal cystoid spaces with or without macular thickening detected by spectral-domain optical coherence tomography. Clinical factors associated with postoperative CME were evaluated using univariate analyses. Kaplan-Meier analysis was performed to assess time to postoperative detection of CME according to preoperative prostaglandin analog use. Postoperative detection of CME, time to CME detection, and postoperative best-corrected visual acuity (BCVA) at 6 months. CME was detected postoperatively in 15 of 57 eyes (26.3%). Preoperative prostaglandin analog use was significantly associated with postoperative CME detection (9/15 [60.0%] vs 6/42 [14.3%], P=.001). Glaucoma (P=.006), use of topical glaucoma medications (P=.006), and worse preoperative BCVA (P=.003) were also associated with CME detection. Kaplan-Meier analysis demonstrated that CME was detected predominantly in the early postoperative period and was significantly more frequent in eyes treated with prostaglandin analogs than in those without prostaglandin analog use (log-rank P=.002). All CME cases resolved following treatment with topical nonsteroidal anti-inflammatory drugs or sub-Tenon triamcinolone acetonide injection. Six-month postoperative BCVA did not differ significantly between eyes with and without CME (logMAR, 0.44 vs 0.60; P=.52). Lens status was not significantly associated with postoperative CME (P=.325). Preoperative macular status was undetermined in 50 of 57 eyes; therefore, pre-existing CME could not be definitively excluded in these eyes. CME was detected postoperatively in approximately one-quarter of eyes after cHCEC injection therapy and was associated with preoperative prostaglandin analog use. Most cases were detected during the early postoperative period and resolved with treatment without adversely affecting 6-month visual outcomes. Careful perioperative management of prostaglandin analogs and routine postoperative optical coherence tomography may facilitate early detection and management of CME.

PMID 42722115
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PubMedRetina (Philadelphia, Pa.)2026-09-10

Incidence and Management of Ocular Hypertension Following the 0.18 mg Fluocinolone Acetonide Implant for Non-infectious Uveitis affecting the Posterior Segment.

Farrell Lily C LC, Gomes Isabella V Y IVY, Zafar Sidra S, Woods Madison M MM et al.

To investigate the real-world incidence and management of ocular hypertension (OHT) following intravitreal 0.18mg fluocinolone acetonide implant (FAi, Yutiq) for non-infectious uveitis affecting the posterior segment (NIU-PS). Retrospective review of eyes treated with 0.18 mg FAi (2019-2025) with ≥1 month follow-up. Primary outcome was OHT (IOP >24 mmHg). Secondary outcomes included IOP ≥30 mmHg, >12 mmHg IOP increase from baseline, and OHT treatment. A total of 275 FAi-treated eyes (178 patients, mean age: 62.87 years) were included. Patients received an average of 1.05 FAi (range:1-2), with mean follow-up of 20.59 ± 0.72 months. Mean baseline IOP was 14.30 ± 3.90 mmHg. Glaucoma and OHT were present in 28.4% and 32.4% of eyes, respectively and 38.5% were on IOP-lowering therapy. Supplemental corticosteroid injections were required in 31.3%. The OHT rate after FAi was 10.5%. Elevated IOP ≥30 mmHg occurred in 5.82%. IOP >12 mmHg from baseline occurred in 7.3%. Among OHT eyes, 41.4% resolved with observation, 44.8% required topical therapy (mean 1.78 agents), and 10.3% required incisional surgery. Higher baseline IOP (adjusted OR 1.41 per 1 mmHg increase, 95% CI:1.19-1.67) and baseline IOP-lowering medication use (OR 8.56, 95% CI:2.61-28.11) were the strongest predictors of rise in IOP. FAi for the treatment of NIU-PS was associated with low rates of OHT, reinforcing its safety. Eyes with higher baseline IOP and those on prior IOP-lowering medications had a substantially increased risk of OHT, highlighting the need for closer IOP monitoring in this subgroup.

PMID 42720983
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PubMedClinical ophthalmology (Auckland, N.Z.)2026-09-10

Intraoperative Quantification of Incision-Site Descemet Membrane Detachment During Phacoemulsification: A Paired-Eye Comparison of Longitudinal and Torsional Ultrasound.

Bulir Petr P, Studeny Pavel P

To quantify the extent of clinically non-significant Descemet membrane detachment (DMD) at the clear corneal incision (CCI) during phacoemulsification and to compare its extent between longitudinal and torsional ultrasound modulation as a morphological marker of local tissue-instrument interaction. In this prospective contralateral-eye comparative randomized study, 14 patients (28 eyes) undergoing bilateral cataract surgery were included. One eye received longitudinal and the fellow eye torsional ultrasound (Constellation system, Alcon). DMD was assessed intraoperatively using microscope video recordings under red reflex illumination. Still images were analyzed, and DMD area (mm2) at the internal wound was measured. Correlations with cumulative dissipated energy (CDE) was evaluated. Incision-site DMD was detected in all analyzed cases (100%) using intraoperative red reflex-based visualization. Mean DMD area was 1.33 ± 0.43 mm2 (longitudinal) and 2.37 ± 0.67 mm2 (torsional), with a mean difference of 1.04 mm2 ± 0.74 mm2 (95% CI, 0.60-1.48). The paired analysis demonstrated a highly significant difference (p < 0.001). No correlation was found between DMD extent and CDE. Clinically non-significant incision-site DMD appears to be a frequent intraoperative morphological phenomenon during phacoemulsification when assessed using sensitive visualization techniques. Torsional ultrasound was associated with a significantly greater DMD extent than longitudinal modulation. Rather than indicating greater clinical damage, DMD area may serve as a sensitive quantitative morphological marker of local tissue-instrument interaction at the corneal incision. Its potential value therefore lies primarily in the comparative evaluation and future refinement of phacoemulsification technologies, while the clinical significance of these subtle morphological differences remains to be established.

PMID 42719804
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PubMedPharmaceutical development and technology2026-09-09

Sustained Intravitreal Delivery of Triamcinolone Acetonide via In Situ Forming Lipid Liquid Crystals: In-vitro and In-vivo evaluations.

Asgharian Rezae Fatemeh F, Karimi Malihe M, Abrishami Mojtaba M, Kamali Hossein H et al.

Posterior segment disorders represent a leading cause of vision impairment worldwide and remain challenging to manage due to limitations in ocular drug delivery. Although intravitreal injections of triamcinolone acetonide (TA) are effective, they are invasive and require repeated administration, highlighting the need for sustained-release systems. This study aimed to develop in situ sustained-release formulations of TA using lipid liquid crystals (LLCs). Formulations were prepared with glyceryldioleate (GDO), phosphatidylcholine (PC), and 28% w/w N-methyl pyrrolidone (NMP) at PC:GDO ratios of 50:50, 40:60, and 60:40. Additionally, a TA-hydroxypropyl-β-cyclodextrin (HPβCD) complex was prepared. The formulations were characterized for rheological properties, morphology, degradation behavior, and water uptake. In-vitro release was assessed in phosphate-buffered saline (pH 7.4), while in-vivo pharmacokinetics were evaluated in rabbits, comparing a selected LLC formulation (right eye) with a TA suspension (left eye). The F5 formulation (40:60 PC: GDO) achieved sustained release of 35.4% over one month and exhibited superior stability, with 24.9% less degradation compared to F6 (60:40 PC: GDO), which showed undesirable drug crystallization. The TA-HPβCD complex demonstrated an even slower release (28%). F4 (50:50 PC: GDO) was selected as optimized formulation, demonstrated the lowest water absorption and degradation with consistent release profile. In-vivo studies further confirmed that LLCs provided a more controlled and prolonged release compared with conventional TA suspension. In conclusion, LLC-based formulations of TA offer a promising strategy for sustained intravitreal drug delivery. Their biodegradability, ease of preparation, and ability to provide prolonged therapeutic levels highlight their potential for improving the management of posterior ocular diseases.

PMID 42713735
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PubMedJournal of cataract and refractive surgery2026-09-09

Dropless cataract surgery using intraoperative subconjunctival triamcinolone: a multicentre comparative analysis of 22,000 eyes.

Stuart Alastair A, Jones Nabila N, O'Donnell Clare C, Naylor Steven S

To compare postoperative inflammatory and visual outcomes between dropless cataract surgery using intraoperative subconjunctival triamcinolone and conventional postoperative topical steroid therapy. Optegra UK, a private eye hospital providing NHS-funded cataract surgery across 17 centres. Non-randomised retrospective multicentre audit. Two postoperative regimens were compared: a dropless pathway incorporating intraoperative subconjunctival triamcinolone acetonide (Kenalog®) 40 mg administered as a visible subconjunctival depot using a 30-gauge needle, and conventional postoperative topical steroid therapy. Patients with glaucoma and young high myopes (<50 years of age with axial length ≥27 mm) were excluded. Primary outcomes assessed were cystoid macular oedema (CMO), postoperative uveitis, and intraocular pressure (IOP) elevation. Eyes with a minimum of 12 weeks (84 days) of follow-up were included. IOP analysis was restricted to eyes with ≥14 days of postoperative follow-up. A total of 34,846 eyes were included (17,423 per group). Statistical significance was defined p value <0.05. CMO occurred in 3.3% of the topical group and 3.1% of the dropless group (RR 0.95, p=0.411). Postoperative uveitis occurred in 2.5% and 2.4% of eyes, respectively (RR 0.95, p=0.508). Steroid-related IOP elevation occurred in 0.6% in both groups (RR 1.00, p=1.00). Visual acuity and refractive outcomes were similar between groups. Dropless cataract surgery was associated with comparable rates of CMO, uveitis, and steroid-related IOP elevation compared with topical steroid regimens, with similar visual outcomes and no increase in adverse safety events. These findings support dropless pathways as an effective and safe alternative to conventional postoperative drop regimens.

PMID 42715220
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