halobetasol propionate (Bryhali / Jemdel / IDP 122)

✓ Approved

什么是 halobetasol propionate？

halobetasol propionate 是一种类固醇，由Bausch + Lomb Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名	Bryhali, Jemdel, IDP 122
公司	Bausch + Lomb Corporation
药物类别	类固醇, 小分子
分子靶点	NR3C1
给药途径	Topical
状态	Approved

来源： ClinicalTrials.gov, Bausch + Lomb Corporation

作用机制

分子靶点

halobetasol propionate 作用于 1 个分子靶点：

NR3C1

nuclear receptor subfamily 3 group C member 1 (GR, GCCR)

需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

halobetasol propionate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Skin and subcutaneous tissue disorders	Psoriasis	✓ Approved

相关研究文献

PubMedJournal of phycology2026-09-10

Genome-scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta).

Lemieux Claude C, Otis Christian C, Turmel Monique M

Picocystis salinarum is an early-diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome-scale nuclear genome assembly of the type strain originally isolated from a saline pond in San Francisco Bay. The 18.5-Mb genome comprises 30 chromosomal assemblies, exhibits clear diploidy, and contains multiple copies of intact Ty3/Gypsy and Ty1/Copia long terminal repeat retrotransposons encoding polyproteins with atypical accessory domains. Phylogenomic analyses reveal strong affinity with the Nephroselmidophyceae. Comparative analyses reveal extensive metabolic streamlining, including the absence of a queuosine salvage pathway, the 2-methylcitrate cycle, β-oxidation of propionate, and branched-chain amino acid catabolism, traits retained in several marine prasinophyte lineages. In contrast, the genome preserves multiple ancestral bacterial derived systems. Notably, P. salinarum features a complete chloroplast NADH dehydrogenase-like complex, including all membrane, electron binding, and assembly components, a configuration not previously reported in sequenced chlorophyte algae. This retention implies substantial capacity for cyclic electron flow and chlororespiration, processes expected to be critical in chronically low-light and chemically extreme environments. The genome further reveals a distinctive biochemical CO2-concentrating mechanism centered on plastid-targeted phosphoenolpyruvate carboxykinase, complete plastid peptidoglycan biosynthetic and remodeling pathways, and partial retention of lipid-A-related machinery. Conversely, P. salinarum lacks canonical non-photochemical quenching proteins while retaining xanthophyll-cycle enzymes that support slower photoprotective responses. Together, these features define a coordinated genomic architecture that underpins the specialization of P. salinarum to hypersaline, alkaline, and persistently low-light ecosystems.

PMID 42717851

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PubMedTransplantation and cellular therapy2026-09-10

Early gut microbiome metabolites and diversity predict GVHD-free survival after allogeneic hematopoietic cell transplantation.

Kaundal Shaweta S, Patil Amol N AN, Khatri Pankaj P, Jana Pradipta P et al.

Disruption of the gut microbiome has been implicated in graft‑versus‑host disease (GVHD) and mortality after allogeneic hematopoietic cell transplantation (HCT). However, prior studies have focused on GVHD‑specific or mortality endpoints in isolation rather than integrated measures of transplant success. We evaluated whether early gut microbial metabolic injury and impaired ecological recovery are associated with GVHD‑free survival (GFS), a composite endpoint incorporating clinically significant GVHD and death. We conducted a prospective observational cohort study of 62 patients undergoing allogeneic HCT at a single center. Stool samples were collected before conditioning and at weeks 2 and 4 after HCT. Fecal short‑chain fatty acids (SCFAs) were quantified using liquid chromatography-tandem mass spectrometry, and microbial diversity was assessed using 16S rRNA gene sequencing. Prespecified landmark analyses were performed at day +15 (week‑2 biomarkers) and day +28 (week‑4 biomarkers). The primary endpoint was GFS at 24‑months, defined as survival without grade II-IV acute GVHD, moderate-severe chronic GVHD, or death. Multivariable Cox regression models adjusted for key clinical covariates were used, with biomarkers modeled as log₂‑transformed continuous variables. During follow‑up, 43 patients (69%) experienced GFS failure, due to acute GVHD (n=18), chronic GVHD (n=18), or death without prior GVHD (n=7). In day +15 landmark analyses, higher week‑2 concentrations of all three SCFAs were independently associated with improved GFS: butyrate (adjusted hazard ratio [aHR] per doubling 0.81, 95% CI 0.71-0.93; p=0.002), propionate (aHR 0.83, 95% CI 0.75-0.93; p<0.001), and acetate (aHR 0.85, 95% CI 0.74-0.97; p=0.018). In day +28 landmark analyses, recovery of microbial diversity at week 4 was independently associated with GFS, with each doubling of the Simpson diversity index associated with a lower hazard of GFS failure (aHR 0.53, 95% CI 0.34-0.83; p=0.005). Similar associations were observed for Shannon diversity (aHR 0.51, 95% CI 0.30-0.84; p=0.009), whereas Chao1 richness showed a concordant but borderline association (aHR 0.64, 95% CI 0.41-1.02; p=0.061). Early post‑transplant depletion of microbiome‑derived metabolites and impaired recovery of gut microbial diversity are independently associated with inferior GVHD‑free survival after allogeneic HCT. These findings are consistent with temporally distinct associations between early metabolic injury and subsequent ecological recovery and support further investigation of microbiome‑directed strategies to improve transplant outcomes.

PMID 42722156

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PubMedAdvances in laboratory medicine2026-09-09

When rare diseases do not appear as a single entity.

Solares Isabel I, Alegre Estibaliz E, Colina Inmaculada I, Gavira Juan Jose JJ et al.

The coexistence of multisystemic involvement in a young adult raises the need to consider rare metabolic and mitochondrial disorders. We report a case of late-onset propionic acidemia (PPA) that may have contributed to unmasking Leber hereditary optic neuropathy (LHON), an extremely infrequent association. A 43-year-old woman presented with acute biventricular heart failure following a viral infection. Evaluation revealed severe dilated cardiomyopathy, newly diagnosed type 2 diabetes mellitus, and bilateral sensorineural hearing loss. Genetic testing for cardiomyopathy was unremarkable. Two months later, she developed sudden bilateral blindness due to optic neuropathy. Extended genetic analysis identified a pathogenic RDH12 variant consistent with LHON and two POLG variants. Progressive renal dysfunction and long QTc interval prompted metabolic investigation. Urine organic acids showed marked accumulation of propionate-related metabolites, and plasma acylcarnitines revealed elevated C3 and low free carnitine, confirming late-onset PPA. The pattern of cardiac dysfunction, renal impairment, and hearing loss was consistent with chronic multisystem toxicity of PPA. In this patient, mitochondrial dysfunction from PPA may have precipitated the clinical expression of LHON, a condition with incomplete penetrance. This exceptional coexistence highlights that rare diseases may overlap and that unexplained multisystem findings warrant comprehensive metabolic and genetic evaluation.

PMID 42713573

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PubMedFrontiers in microbiology2026-09-09

Integrative analysis of rumen microbiome and host metabolism reveals adaptive strategies of Boer goats to high-altitude environments.

Xu Huifen H, Niu Huidong H, Liu Jiapei J, Cuoji Awang A et al.

The transition to high-altitude environments presents significant metabolic challenges for livestock, primarily due to hypoxia and altered dietary resources. Understanding the adaptive strategies involving the rumen microbiome and host metabolism is crucial for improving animal health and productivity in these regions. This study investigated the adaptive responses of Boer goats to high-altitude exposure by integrating ruminal fermentation, ruminal and fecal microbiota, and serum metabolomics. The results demonstrated that high-altitude exposure markedly reshaped ruminal fermentation, microbiota composition, and serum metabolome of Boer goats. Concomitant with the elevational shift, the ruminal pH increased, whereas acetic acid concentration and the acetate-to-propionate ratio decreased; however, fecal volatile fatty acid concentrations remained unchanged. Microbial alpha diversity was reduced in both ruminal and fecal samples. The high-altitude rumen of Boer goats was characterized by an enrichment of fiber-degradation-associated taxa, accompanied by significantly elevated relative abundances of Firmicutes_A, Ruminococcus_E, as well as a heightened Firmicutes-to-Bacteroidetes ratio; in contrast, the relative abundances of fecal Patescibacteria, Faecousia, and Phocaeicola_A were decreased. Serum metabolomics profiling revealed that the acclimatization of Boer goats to high altitudes was characterized by profound alterations in energy and amino acid metabolism, coupled with hydromineral regulation and neuroactive metabolite pathways. Notably, energy-related metabolites, including 2-oxoglutaric acid, 3-hydroxybutyric acid, and L-malic acid, were elevated in the high-altitude cohort and positively correlated with fibrolytic taxa such as Fibrobacterota, Fibrobacter and Ruminococcus_E. In summary, the metabolic synergy between the rumen microbiome and the host likely contributes to maintaining energy homeostasis in Boer goats in high-altitude environments. These findings provide a useful reference for developing targeted nutritional strategies to improve goat farming in plateau regions.

PMID 42713482

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PubMedBMC veterinary research2026-09-08

Analysis of reproductive behavior in male pigeons in the White Mirthys and Egyptian Baladi breeds injected with testosterone propionate.

Mohamed Omar A OA, Reyad Albert R AR, Elkomy Alaa E AE, Khattab Ibrahim M IM

In pigeons, reproductive success is driven primarily by male courtship and copulatory behavior, both of which require threshold levels of circulating testosterone. This study investigated the effects of exogenous testosterone propionate (TP) injection on serum testosterone levels, aggressive behaviors, sexual displays, nest defense, parental care, reproductive cycles, and squab mortality in two pigeon breeds (Columba livia): White Mirthys and Egyptian Baladi. A total of 27 adult pairs of White Mirthys pigeons and 27 adult pairs of Egyptian Baladi pigeons were randomly assigned to three experimental groups (n = 9 pairs per breed per group; total N = 54 cages). Treatments consisted of male-directed subcutaneous injections of either a vehicle control (CON; ethanol and sesame oil mixture) or TP at doses of 1 mg/kg (T1) or 2 mg/kg of body weight (T2). Baseline serum testosterone was 47.9% higher in White Mirthys than Egyptian Baladi pigeons (P < 0.001). Repeated-measures analysis showed a significant Time×Treatment interaction (P < 0.001) as TP induced dose-dependent elevations in both lineages. TP heightened aggression; female and squab pecking increased uniformly (P < 0.001), while a significant Breed×Treatment interaction (P < 0.001) governed squab predation, which surged exclusively in White Mirthys high-dose groups but remained suppressed in Baladi. For sexual behavior, strutting showed a significant interaction (P = 0.003), suppressing earlier in White Mirthys (T1) before converging at T2, whereas vocal nesting and courtship feeding followed identical quadratic trajectories (P < 0.001). Brood care feeding exhibited a significant interaction (P < 0.001); TP entirely abolished the Baladi breed's superior baseline, suppressing provisioning to a near-zero floor across both lines. Defense metrics plateaued uniformly (P < 0.001). Offspring survival was compromised via a significant Breed×Treatment interaction (P = 0.002); mortality rose from 5.6% (CON) to 15.2% (T2), peaking at 23.1% in White Mirthys due to neglect and aggression, but remained insulated at 5.6% in Baladi. The hatching-to-laying interval shortened exclusively in Baladi T2 pairs to 25.6 days (P = 0.021). In conclusion, exogenous testosterone propionate administration was associated with increased nest defense but reduced visual courtship, suppressed paternal provisioning, and higher squab mortality. Furthermore, these behavioral shifts were significantly modulated by breed background, with the White Mirthys lineage demonstrating marked vulnerability compared to the insulated resilience of the native Egyptian Baladi breed.

PMID 42706552

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PubMedEnvironmental science & technology2026-09-08

Zero-Valent Iron as a Sustainable Regulator for Anaerobic Digestion of MPs-Contaminated Organic Substrates: Performance Enhancement and Environmental Significance.

Ao Guoxu G, Wang Zhaoxuan Z, Shi Yueqi Y, Liu Yuantong Y et al.

Under the "double carbon" goal, anaerobic digestion (AD) is irreplaceable for organic solid waste resource utilization, but ubiquitous microplastics (MPs) in substrates severely impair AD performance. Studies on regulating PE-MP-containing AD systems via zero valent iron (ZVI) remain scarce, so this study incorporated ZVI into such systems to elucidate its regulatory mechanisms through batch experiments. PE-MPs reduced substrate-microbe contact, inhibited key acid-methane enzymes, and disrupted microbial networks, lowering the acetate/propionate ratio to 0.269 (stable threshold: 1.50), decreasing CH4 production by 34.23%, and enhancing oxidative stress and virulence factors. ZVI-released bioavailable Fe irons promoted hydrolysis, with protease and cellulase activities increasing by 112.87% and 97.24%, respectively, and COD removal reaching 61.27%; optimized the acid-methane balance (acetate kinase increased by 100%, and the ratio was restored to 2.66); increased Methanosarcina abundance to 20.64% and CH4 production by 74.47%; and restored microbial communities by enriching functional bacteria and network modularity to alleviate oxidative stress, as indicated by a 63.85% decline in lactate dehydrogenase activity. CB-SEM further clarified that ZVI systematically improved the performance of AD by enhancing the stability, metabolic activity, and antioxidant capacity of microbial communities and by promoting key processes such as acetic acid methanation. This study clarified the core regulatory role of ZVI in enhancing the AD performance of PE-MP-containing organic substrates, thereby providing a feasible technical strategy for improving the stability and efficiency of AD systems in MP-contaminated environments.

PMID 42708940

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halobetasol propionate (Bryhali / Jemdel / IDP 122)

什么是 halobetasol propionate？

药物档案

作用机制

分子靶点

治疗适应症

相关研究文献

Genome-scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta).

Early gut microbiome metabolites and diversity predict GVHD-free survival after allogeneic hematopoietic cell transplantation.

When rare diseases do not appear as a single entity.

Integrative analysis of rumen microbiome and host metabolism reveals adaptive strategies of Boer goats to high-altitude environments.

Analysis of reproductive behavior in male pigeons in the White Mirthys and Egyptian Baladi breeds injected with testosterone propionate.

Zero-Valent Iron as a Sustainable Regulator for Anaerobic Digestion of MPs-Contaminated Organic Substrates: Performance Enhancement and Environmental Significance.

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