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halobetasol propionate (Bryhali / Jemdel / IDP 122)

✓ Approved

Bausch + Lomb Corporation · NR3C1 · 类固醇

什么是 halobetasol propionate？

halobetasol propionate 是一种类固醇，由Bausch + Lomb Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名Bryhali, Jemdel, IDP 122
公司Bausch + Lomb Corporation
药物类别类固醇, 小分子
分子靶点NR3C1
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Bausch + Lomb Corporation

作用机制

分子靶点

halobetasol propionate 作用于 1 个分子靶点：

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

halobetasol propionate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

相关研究文献

PubMedPhysiologia plantarum2026-10-26

Unraveling the Chemical Dialogue: The Impact of Volatiles on the Interaction Between PGPR and Verticillium dahliae in Pepper Plants.

Triantafyllou Aikaterini A, Kamou Nathalie N, Mellidou Ifigeneia I, Testempasis Stefanos S et al.

Plant growth-promoting rhizobacteria (PGPR) have attracted increasing scientific interest due to their potential to enhance crop productivity and alleviate plant stress. An important trait of PGPR is the production of volatile organic compounds (VOCs), which can play crucial roles in plant-microbe and interspecies communication. This study investigates the volatilome composition of a novel PGP strain, Chryseobacterium sp. SAESo14, and its impact during interactions with the soilborne pathogen Verticillium dahliae and pepper plants. First, volatiles from SAESo14 and V. dahliae co-inoculated in dual cultures were analyzed by Gas chromatography-mass spectrometry (GC-MS). A diverse set of VOCs, including alcohols, ketones, esters, and sulfur-containing compounds, was detected. Among these, VOCs with known antifungal activity, such as 2-heptanone, ethyl propionate, and ethyl acetate, were identified. To further investigate the role of VOCs in tripartite interactions, volatilomes of a pepper-V. dahliae pathosystem treated with SAESo14 were analyzed. Seedlings treated with SAESo14 showed viable root cells and enhanced terpenoid metabolism, leading to the emission of 1,8-cineole, β-elemene, and sclarene, whereas V. dahliae-inoculated seedlings released 4,5-di-epi-aristolochene. When tested in planta, pepper plants treated with SAESo14 exhibited increased net photosynthesis and improved growth, along with a 25% reduction in disease index compared to pathogen-inoculated plants, in which distinct metabolic and transcriptomic reprogramming was observed. Collectively, these findings highlight the importance of VOC-mediated signaling in plant-microbe-pathogen interactions in a tripartite system and support the potential of a novel Chryseobacterium strain and its derived VOCs as sustainable alternatives for improving plant performance and disease management.

PMID 42928643
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PubMedbioRxiv : the preprint server for biology2026-10-25

Nutrient-sensitive histone propionylation regulates T cell fate and function.

Jaccard Alison A, Rome Kelly K, Yang Qihua Q, Zhang Shuo S et al.

Tissue microenvironments differ widely in nutrient composition; yet how local nutrient conditions shape epigenetic programs that direct immune cell fate is poorly understood. We identify histone lysine propionylation (Kpr) as a chromatin mechanism linking nutrient availability to T cell fate decisions. Proteomic analysis reveals that Kpr is broadly reduced in exhausted T cells. H3K18pr is enriched at stemness-associated loci in effector T cells and depleted upon exhaustion. Isoleucine and propionate supply propionyl-CoA in T cells, and restricted nutrient availability within the tumor microenvironment limits histone Kpr, promoting T cell exhaustion. Disrupting isoleucine catabolism in T cells further suppresses Kpr, without altering histone acetylation, and impairs T cell function and antitumor immunity in a manner rescued by propionate. Dietary supplementation of isoleucine and propionate increases Kpr in tumor infiltrating lymphocytes, limits exhaustion, and improves tumor control. These findings establish a microenvironment-chromatin axis crucial for antitumor immunity and amenable to nutritional intervention.

PMID 42926507
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PubMedbioRxiv : the preprint server for biology2026-10-25

Microbial valerate is associated with CAR T dysbiosis and its supplementation enhances CAR T function in B-cell lymphoma.

Rehman Lubna L, Song Wenting W, Rehman Abdur A, Singh Kamini K et al.

Anaerobe-depleting antibiotic exposure is associated with inferior progression-free survival after CD19 CAR T-cell therapy in large B-cell lymphoma, yet the cellular mechanisms linking gut dysbiosis to the CAR T-cell product and whether this imprint is reversible have remained undefined. In two independent CAR-T candidate cohorts, low stool valerate at the time of CAR-T eligibility identified a multi-metabolite-deficient dysbiotic gut microbiome state marked by depletion of fiber-fermenting commensals and loss of carbohydrate-fermentation, SCFA-biosynthesis, and amino-acid metabolism pathways. Reanalysis of single-cell RNA sequencing from 42 lymphoma patients stratified by piperacillin-tazobactam/imipenem/meropenem (PIM) exposure revealed that PIM-exposed CAR T-cell products were CD4-skewed, with significantly elevated AP-1/immediate-early gene (IEG) and cellular activation signatures that together predicted inferior progression-free survival. Ex vivo conditioning of CAR T-cells with valerate produced a chromatin and transcription factor program distinct from butyrate or propionate, characterized by KLF/SP/EGR family engagement, KLF4 promoter opening, and broad induction of AP-1/IEG and MHC class II transcripts, whereas butyrate drove broader chromatin remodeling with TBX21/EOMES/NF-κB gains and KLF2 promoter closure, and propionate induced an NFY-centered program with preferential commitment to low-mitochondrial-content states. Untargeted metabolomics confirmed valerate uptake and mitochondrial β-oxidation in CAR T-cells, while dietary sodium valerate supplementation in meropenem-treated mice bearing A20 lymphoma significantly reduced tumor burden and extended survival compared with CAR T-cells alone. These findings identify stool valerate as a bedside-deployable biomarker of dysbiosis-imprinted CAR T-cell dysfunction and support ex vivo or dietary valerate supplementation as a clinically tractable strategy to improve CAR-T anti-tumor function in patients with disrupted gut microbiomes.

PMID 42922635
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PubMedVeterinary and animal science2026-10-25

Zeolite supplementation modulates ruminal ammonia and methane production without compromising animal performance: A meta-analysis of in vitro and in vivo studies.

Muzadi Akbar Dicky AD, Azzahra Farisha Rachma FR, Abdelbagi Mohammed M, Ridwan Roni R et al.

Zeolite has potential to improve nitrogen utilization and modulate rumen fermentation through its ion-exchange and adsorption properties; however, reported responses in ruminants remain inconsistent. This meta-analysis quantified the effects of dietary zeolite supplementation on rumen fermentation, nutrient digestibility, productive performance, milk characteristics, and blood metabolites. Data were obtained from 34 eligible articles identified through Scopus, PubMed, and Semantic Scholar. Effect size was calculated as natural logarithm of response ratio using a random-effects model and converted to relative mean difference (RMD). Zeolite supplementation reduced ruminal NH₃-N concentration under both in vitro (RMD = -11.13%; P < 0.001) and in vivo conditions (RMD = -11.40%; P = 0.009). Methane production was also reduced in vitro (RMD = -14.53%; P = 0.035) and in vivo (RMD = -9.70%; P = 0.001). Both in vitro and in vivo, zeolite increased total VFA (mmol/L), acetate (%), propionate (%), while decreasing butyrate concentration, the acetate-to-propionate ratio. In vivo, zeolite improved the digestibility of dry matter, organic matter, crude protein, ether extract, total digestible nutrients, neutral detergent fiber, and hemicellulose. Dry matter intake, average daily gain, milk yield, and milk composition were affected, whereas growth (RMD = 12.52%; P = 0.011) and milk efficiency (RMD = 13.66; P = 0.05) increased. Zeolite reduced blood urea nitrogen (RMD = -7.96%; P = 0.003), although aspartate aminotransferase activity increased modestly. Meta-regression indicated a dose-dependent reduction in ruminal NH₃-N, while subgroup responses varied according to zeolite type and animal species. In conclusion, Zeolite supplementation at inclusion levels of 0.1-5% showed beneficial effects on ruminal fermentation, including reductions in ruminal NH₃-N and methane production, improved nutrient digestibility, and maintained or improved animal productive performance, with responses in fermentability being more evident in small ruminants. However, an optimum inclusion level could not be definitively established, and further studies are needed to clarify the underlying microbial, enzymatic, and post-ruminal mechanisms, which were insufficiently addressed in the available literature.

PMID 42926997
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PubMedPsychoneuroendocrinology2026-10-25

Multi-layer analysis of gut metagenomic functional potential in major depressive disorder.

Yasen Gulinuer G, Ma Liya L, Yan Ping P, Xie Rui R et al.

Major depressive disorder (MDD) is associated with gut microbiota dysbiosis, but previous studies have mostly focused on species composition and are subject to confounding factors such as age and diet. Robust differences at the functional pathway level remain unclear. We included 98 indigenous residents of Xinjiang, China, whose families had resided there for three or more generations (49 MDD patients and 49 healthy controls) and performed shotgun metagenomic sequencing. Functional profiles were annotated with HUMAnN3 across seven levels: GBM, GMM, KO, EC, Module, Pathway, and PathAbundance. Features were transformed using the centered log-ratio (CLR) method. After controlling for 10 covariates (age, sex, BMI, bowel movement frequency, diet, gastrointestinal symptoms, years of smoking, alcohol consumption, physical activity, and sleep), OLS regression was performed with Benjamini-Hochberg FDR correction (q < 0.05). Complementary analysis was conducted using MaAsLin2, together with age caliper matching (52 participants), recurrent/first-episode subgroup analyses, and sensitivity analyses for treatment history. Overall functional profiles were evaluated by PERMANOVA based on Aitchison distance. After covariate adjustment, overall functional profiles did not differ significantly between groups (PERMANOVA R²=1.9%, p = 0.071; PERMDISP p = 0.98). After FDR correction, 33 significant features were detected across five levels: EC, Pathway, Module, GMM, and PathAbundance (no significant signals at the GBM or KO levels). Key biologically meaningful signals included: propionate CoA-transferase (EC 2.8.3.1, β=-1.42, q = 0.022)↓, teichoic acid biosynthesis (map00552, β=-0.34, q = 0.045)↓, vancomycin resistance module (M00651, β=-1.28, q = 0.014)↓, galacturonate degradation II (MF0023, β=+1.82, q = 0.048)↑, and heme b biosynthesis I (PathAbundance, β=+0.93, q = 0.033)↑. MaAsLin2 effect sizes were correlated with the main OLS results at the Pathway level (R²=0.84) with consistent direction. GRSA independently confirmed downregulation of the phosphotransferase system (map02060, padj<0.001) and teichoic acid biosynthesis. The propionate CoA-transferase and teichoic acid biosynthesis signals were directionally consistent in the main model and recurrent subgroup, but did not survive correction in the matched subset; the first-episode subgroup (n = 11) was underpowered and its results are reported as exploratory. Gut microbiota functional potential in MDD patients shows a mild but directionally consistent shift after controlling for confounders, involving short-chain fatty acid production, Gram-positive bacterial cell wall metabolism, and cofactor metabolism. This study measures functional potential and requires validation by metabolomics.

PMID 42925575
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PubMedFrontiers in microbiology2026-10-25

Soluble prebiotic fiber and glucono-δ-lactone blends integrate compatible effects to modulate microbiota composition and metabolism ex vivo.

Truffin Damien D, Perreau Caroline C, Jenkins Sánchez Liam L, Heyse Jasmine J et al.

Prebiotics modulate the gut microbiome toward health-associated states. Because distinct candidate prebiotic compounds selectively stimulate microbial taxa and metabolic pathways, combining complementary ingredients may broaden or enhance beneficial outcomes. To investigate this concept, we evaluated the effects of microbiome-modulating blends of glucono-δ-lactone (GDL) and the resistant dextrin NUTRIOSE® (NUTR). The validated ex vivo SIFR® technology pipeline (systemic intestinal fermentation research) was used to assess how GDL, NUTR and their blends impacted the composition and metabolic activity of the gut microbiota of a small cohort of healthy adults (n = 6), while effects on gut barrier integrity (transepithelial electrical resistance, TEER) were evaluated via an in vitro co-culture of epithelial/immune (Caco-2/THP-1) cells. GDL and NUTR induced distinct yet compatible shifts in microbial composition and metabolite output. GDL was rapidly fermented and specifically promoted Bifidobacterium adolescentis, while boosting butyrate-related taxa (Faecalibacterium prausnitzii, Anaerobutyricum hallii) and health-associated amino acid derivatives (e.g., indole-3-propionic acid). In contrast, NUTR gradually and strongly promoted propionate through stimulating Bacteroides and Parabacteroides, as well as specific Lachnospiraceae taxa. GDL/NUTR blends displayed ratio-dependent intermediate effects of the individual ingredients. Moreover, GDL/NUTR blends enhanced gut barrier integrity under LPS-induced inflammatory stress, with increases in TEER up to +24.5%. Overall, GDL and NUTR blends compatibly integrate divergent effects, supporting their combined use for enhancing gut health through microbiome modulation.

PMID 42922965
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