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meningococcal polysaccharide AC vaccine (Mengllingkang)

✓ Approved

China National Biotec Group · 疫苗 · 疫苗

什么是 meningococcal polysaccharide AC vaccine？

meningococcal polysaccharide AC vaccine 是一种疫苗，由China National Biotec Group研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Mengllingkang
公司China National Biotec Group
药物类别疫苗
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, China National Biotec Group

治疗适应症

meningococcal polysaccharide AC vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsMeningococcal bacteraemia✓ Approved

相关研究文献

PubMedEpidemiologia (Basel, Switzerland)2026-10-26

A Carriage-Structured Model of Meningococcal Meningitis: Backward Bifurcation, Seasonal Recurrence, and the Reach of Conjugate-Vaccine Strategies in the African Meningitis Belt.

Gatyeni Siphokazi Princess SP

Epidemic meningococcal meningitis in the African meningitis belt recurs on two timescales: a sharp annual dry-season peak and irregular multi-annual epidemics five to twelve years apart, whose mechanistic origin remains unsettled. Invasive disease is a rare, dead-end outcome of asymptomatic nasopharyngeal carriage, so susceptible-infectious templates misrepresent community transmission. We ask how carriage structure shapes bifurcation, seasonal recurrence, and the reach of conjugate-vaccine strategies. We formulate a deterministic carriage-structured model in which only carriers transmit, immunity against re-acquisition is leaky, and a conjugate vaccine is imperfect and wanes. We use the Castillo-Chavez-Song centre manifold method, numerical continuation, Floquet and eigenvalue analysis, and scenario simulations of abstract rate- and pulse-type interventions parameterised from published belt ranges. The basic reproduction number R0 is a property of carriage transmission, decoupled to first order from disease incidence. Backward bifurcation at R0=1 is governed by a threshold ε∗ on carriage-blocking immunity; only the untreated fatality hazard and treatment capacity are absent from the local condition. It is impossible without vaccination and, with any positive routine coverage, persists across the plausible coverage range, giving vaccine-induced bistability. Continuation confirms a fold at R0,c≈0.946 (φ=0.12yr-1, weak carriage immunity), but not at baseline immunity. Under seasonal forcing, dynamics converge to a simple annual cycle throughout the region searched; we found no multi-annual recurrence, although damped eigenmodes of the unforced system have periods overlapping the observed interval. Within this deterministic, single-strain model, irregular recurrence likely requires additional structure, with stochastic amplification of damped cycles a natural next step. Whether sustained immunisation eliminates epidemics or merely postpones them may depend on the same carriage-efficacy threshold that governs the bistability result.

PMID 42930328
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PubMedOmics : a journal of integrative biology2026-10-26

Patient-Level Glioblastoma Recurrence Trajectories and a Candidate EGFR/NFIA-Associated Expression Module.

Alexopoulos Georgios G, Karampelas Ioannis I

Matched single-cell analyses may reveal glioblastoma recurrence changes obscured by pooled comparisons. We reanalyzed tumor-classified cells from 9 Wang primary-recurrent pairs and 59 paired CARE patients using recurrent-minus-primary program vectors. Five of nine Wang pairs were assigned an astrocytic-like (AC-like) route, but its exact 95% proportion interval was 21-86%, and an exact paired sign-flip test did not establish an excess of this route (p = 0.227). Continuous positive-program contributions indicated mixed trajectories. A 10-gene candidate expression module selected from 5 Wang AC-like pairs increased in all 11 CARE AC-like patients in the original sample-level analysis (median T2-T1 score +0.277), versus 13 of 48 other patients (median -0.125). In the CARE authors' copy-number-informed malignant-cell table, 242,702 cells from paired T1/T2 samples were scored; the mean paired score change was +0.412 in AC-like patients and -0.158 in others (between-group difference +0.570, 95% confidence interval 0.321-0.820). Enrichment implicated glutamate transport but does not establish a single pathway or EGFR/NFIA causality. These findings support a recurrence-associated candidate module in an independent cohort while leaving discovery-route frequency, mechanistic function, and spatial localization unresolved.

PMID 42928478
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PubMedBMC health services research2026-10-26

So what they do can be seen - A realist-informed evaluation of and theory refinement for a digital counseling tool to support family caregivers in Austria.

Gabl Katharina K, Clement Theresa T, Eppel-Meichlinger Jasmin J, Mayer Hanna H

Family Caregivers (FC) make a significant contribution to maintaining our care system and must be supported in their vital roles. Alles Clara (AC) is a digital service in Austria that addresses FCs, their challenges, and needs. This study aimed at evaluating the intended impact of AC and to refine its underlying program theory explaining how the impact comes about. Following a realist approach to evaluation, we considered multiple perspectives and data sources, including four online surveys (S1 n = 52, S2 n = 16, S3 n = 89, S4 n = 169), in-app tracking data, narrative interviews with FCs (n = 8) and two focus group interviews with counselors (n = 10). Quantitative data were analyzed using descriptive statistics, qualitative data were analyzed thematically and interpretatively. A confirmatory approach to theory building was chosen to test and refine the initial program theory. The theory on how AC unfolds its impact is presented in two configurational models. FCs can access the digital service anonymously and independently of time and place. In digital counseling, FCs can build a trusting relationship with the counselors and thus receive person-centred counseling. They no longer feel alone with their situation, move on from problems to next steps and exit the counseling room strengthened. AC also has an impact on counselors, especially nursing staff. The counselors are empowered to provide person-centred counseling and can recognize the quality of their actions, make an impact from a distance and see meaning in their actions. They can show what nursing is and can do and thus develop pride in their work and profession. AC reveals a way to introduce the concept of person-centredness into a digital context. In this study, we explored counseling as a nursing intervention that takes place anonymously and distantly in digital space - a space in which what they do can be seen.

PMID 42928179
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PubMedBiotech (Basel (Switzerland))2026-10-26

Application of a Halophilic Consortium for Saline Phenol Wastewater Treatment and Bioelectricity Generation in Microbial Fuel Cells: An AI-Driven Evaluation.

Alarishi Rawan Mohammed RM, Pugazhendi Arulazhagan A, Mathew Dinesh Kumar DK, Banaganapalli Babajan B et al.

High organic pollutant load and salinity pose major challenges for the biological treatment of industrial wastewater. This study evaluated an air-cathode microbial fuel cell (AC-MFC) inoculated with halophilic microorganisms for the simultaneous treatment of phenol-contaminated saline industrial wastewater and bioelectricity generation. The AC-MFC was operated at organic loads (OLs) of 1.2, 2.5, 3.2, 4.8, 6.2 and 8.6 g chemical oxygen demand (COD)/L, with optimum performance at 6.2 g COD/L. In optimal conditions, the system achieved a maximum voltage of 803 mV, power density of 460.6 mW/m2, current density of 573.6 mA/m2, and total and soluble COD removal efficiencies of 90% and 89%, respectively. Complete phenol degradation was achieved within 8 days. High-throughput sequencing revealed dominant halophilic taxa, including Ochrobactrum, Marinobacter, Bacillus and Stenotrophomonas, which may contribute to pollutant degradation and extracellular electron transfer. A Random Forest regression model implemented using Python/scikit-learn was further developed using OL and operational time as input variables to predict treatment and electrochemical performance. The model identified 6.2 gCOD/L as the optimum OL, consistent with the experimental results. Overall, inoculation of halophilic consortium coupled with AC-MFC technology demonstrates potential for simultaneous treatment of saline phenolic wastewater and bioelectricity generation, while artificial intelligence provides a useful tool for process optimization.

PMID 42930063
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PubMedACS sensors2026-10-26

Bivalent Ligand-Aptamer Binding-Cooperated Hybridization Assembly for Illuminating Ratiometric Fluorescence Biosensing of Convertible Ag Nanoclusters.

Long Min M, Chen Xiaoyu X, He Maolan M, Fu Yuchen Y et al.

To address low affinity and reaction rate in monovalent ligand-aptamer binding, herein, we propose a bivalent binding-cooperated hybridization assembly (bbHA) strategy to light up the ratiometric fluorescence of convertible Ag nanoclusters (cAgNC) for detecting adenosine triphosphate (ATP). Two identical repeats of ATP-recognizable aptamer splits (a1 and a2) are separately programmed in an aptamer templating strand (aT) and an aptamer converter strand (aC), while two pairs of cAgNC-clustering and emission-converting segments are tethered in aT (template-a1-a1-template) and aC (converter-a2-a2-converter), respectively. Two tandem red cAgNC emitters are preferably developed in aT. Upon presenting ATP, the affinity recognition by a specific aptamer (a1/a2) entity enables cooperative binding events for triggering rapid complementary hybridization of aT and aC. The other proximal a1/a2 pair is bulged and merged to speed up the second ATP affinity binding. The structurally stable aT·2ATP·aC complex is formed to orient two ended converters and clusters together, thereby modulating its red fluorescence into green through electronic interactions between Ag0 and particular nucleobases. The resulting signal ratio of dual-emissive cAgNC exhibits a linear dependence on ATP, achieving sensitive and accurate quantification via inherent built-in correction. In contrast to the monovalent mechanism, the bbHA-based strategy features superior assay performances such as higher target responsiveness, faster reaction kinetics, and more efficient transduction. Thus, this label-free method would offer a new paradigm to construct simplified, specific, robust, and cost-effective sensing platforms for applicable assay of various small-molecule analytes.

PMID 42928640
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PubMedNanoscale2026-10-26

Assembly of negatively charged gold nanoparticles induced by a negatively charged polysaccharide (gum arabic).

Zeharia Tal T, Schiltt Yael Y, Cohen Ariel A, Raviv Uri U et al.

The self-assembly of like-(negatively) charged gold nanoparticles (GNPs) into hexagonal structures was observed in salt-free, dilute solutions of negatively charged branched polysaccharide, Gum Arabic (GA). The core-shell GNPs, consisting of a gold core coated with a p-mercaptobenzoic acid (pMBA) ligand shell, were highly monodisperse. It was observed that the presence of solvated, non-adsorbing GA induced crowding of the negatively charged GNPs into strings that further assembled into finite-sized clusters of low fractal dimensions. Cryo-TEM imaging, cryo-Electron Tomography (cryo-ET), small angle X-ray scattering (SAXS) and zeta potential measurements reveal finite-sized, long-lived clusters of like-charged close-packed GNPs. Assuming that GNPs crowding and assembly are induced by depletion interactions, this would suggest that, in this system, depletion-induced crowding of like-charged GNPs occurs even though the particle diameter is comparable to the characteristic dimensions of GA. These results suggest that GA may induce crowding in seemingly stable suspensions of like-charged nanoparticles, leading to entropically driven clustering in natural and synthetic complex fluids.

PMID 42929797
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