北京若生智能科技有限公司
Drug Database
AM

AM-87 (Difur)

✓ Approved

Cantabria Labs · LTB4R

什么是 AM-87？

AM-87 是一种治疗药物，由Cantabria Labs研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Difur
公司Cantabria Labs
分子靶点LTB4R, IL6R
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Cantabria Labs

作用机制

分子靶点

AM-87 作用于 2 个分子靶点：

LTB4Rleukotriene B4 receptor (GPR16, P2Y7)
IL6Rinterleukin 6 receptor (IL6RQ, IL-6R-1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

AM-87 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

相关研究文献

PubMedPhysiologia plantarum2026-09-11

Funneliformis mosseae Modulates Root 14-3-3 Gene Expression to Enhance Drought Tolerance in Trifoliate Orange: A Molecular-Physiological Integration.

Zheng Feng-Ling FL, Yan Ke-Xing KX, Liu Zhen Z, Zou Ying-Ning YN et al.

The 14-3-3 family proteins are involved in plant metabolism and stress signal transduction, while whether and how they contribute to the enhancement of host drought tolerance by arbuscular mycorrhizal (AM) fungi remains unclear. This study aimed to identify the 14-3-3 gene family (GRF) in trifoliate orange (Poncirus trifoliata) and analyze their responses in roots to drought and inoculation with the AM fungus Funneliformis mosseae, integrating molecular data with physiological assessments. Despite drought-inhibited AM fungal colonization and soil mycelium length, AM inoculation markedly increased plant biomass, root growth, soluble sugars, antioxidant enzyme activities, and phytohormone levels under drought. Fifteen PtGRF members were identified with variable gene structures and abscisic acid/stress-related promoter elements. Drought stress predominantly suppressed the expression of most PtGRF genes in non-AM plants, while it triggered the upregulation of a specific subset (PtGRF3, 6, 9, 13, 14) in AM plants. Inoculation with AM fungi under drought conditions dramatically modulated the host's transcriptional response, significantly upregulating 10 of the 13 detected PtGRFs, most notably PtGRF13. Principal component and correlation analyses delineated distinct functional associations among PtGRF members: PtGRF1, PtGRF2, PtGRF5, and PtGRF15 were closely linked to soluble sugar accumulation and antioxidant defense, while PtGRF3, PtGRF6, PtGRF8, PtGRF9, and PtGRF13 showed stronger integration with abscisic acid and isopentenyl adenine. In summary, inoculation with AM fungi enhanced drought tolerance in trifoliate orange by modulating the expression of drought-responsive specific PtGRF genes, which functioned as integrated signaling modules to coordinate sugars, antioxidant defense, and abscisic acid levels.

PMID 42723318
阅读全文 →
PubMedNature communications2026-09-11

Entropy-driven densification of medium-entropy alloys with laser powder bed fusion.

Luo Zairan Z, Liu Qian Q, Yi Jiang J, Wu Boyang B et al.

Anomalies inherent to laser-based additive manufacturing (AM), including porosity and structural defects, present significant barriers to fabricating high-integrity metallic structural components. These unavoidable anomalies can significantly degrade the long-term properties of metals, including fatigue, creep, and corrosion, thereby limiting their use in critical environments. In this study, we overcome this challenge with a single-step entropy engineering strategy. By integrating CoCrNi and 316 L powders and enabling temporal changes in entropy evolution during printing, we obtained a nearly void-free (density > 99.99%) medium-entropy alloy with exceptional fatigue resistance and corrosion performance, surpassing conventional PBF-LB/Med medium- and high-entropy alloys. By combining macro-scale densification analysis, micro-scale SEM/EBSD observations, and nano-scale TEM investigations, our results revealed that the increase in configurational entropy during the AM process, together with changes in microstructure, can modify the thermal history, thereby optimizing melt pool spreading. This modification promoted the formation of a uniformly distributed, subgrain-predominated microstructure with a relatively low geometrically necessary dislocation density, which is relatively stable under external loading. This work presents a single-step approach to overcoming the long-term property limitations of AM-fabricated components.

PMID 42722656
阅读全文 →
PubMedCirculation reports2026-09-11

Coronary Microvascular Dysfunction in Hemodialysis-Dependent End-Stage Renal Disease: Prevalence, Characteristics, and Prognostic Implications.

Yoshikawa Hiroshi H, Murai Tadashi T, Yonetsu Taishi T, Yamaguchi Masao M et al.

Coronary microvascular dysfunction (CMD) is an established mechanism in cardiovascular diseases and is associated with adverse outcomes. However, CMD in hemodialysis (HD) patients remains poorly characterized. This study evaluated the prevalence, physiological profiles, and prognostic implications of CMD in this high-risk population. Among 894 patients who underwent intracoronary physiological assessment of the left anterior descending artery, 87 were on HD. A control group of 87 non-HD patients was selected using propensity score matching for established CMD risk factors. Microvascular resistance reserve (MRR) and the baseline index of microvascular resistance (b-IMR) and hyperemic IMR were compared. MRR was significantly lower in HD than non-HD patients (median [interquartile range (IQR)] 2.4 [1.9-3.4] vs. 3.8 [2.6-5.0], P<0.001). This was driven primarily by lower b-IMR in the HD than non-HD group (median [IQR] 42.3 [23.6-61.0] vs. 68.7 [42.7-90.9], P<0.001); IMR was comparable between the 2 groups (18.6 [12.0-24.7] vs. 18.3 [12.7-26.0], respectively; P=0.65). In HD patients, an MRR of 2.1 was optimal for predicting the composite endpoint (all-cause mortality, heart failure, and acute myocardial infarction). Kaplan-Meier analysis showed event-free survival was significantly worse in HD patients with MRR <2.1 (log-rank P=0.001). CMD is highly prevalent in HD patients and is characterized by markedly reduced b-IMR. In this population, MRR serves as a potent prognostic indicator.

PMID 42724050
阅读全文 →
PubMedExperimental & molecular medicine2026-09-11

TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons.

An Heeyoung H, Lee Hye-Lan HL, Cho Doo-Wan DW, Hong Jinpyo J et al.

In spinal cord injury (SCI), the scar-forming reactive astrocytes with upregulated glial fibrillary acidic protein (GFAP) proliferate aberrantly near the injury site, representing a potential cellular source for transdifferentiation into neurons to replenish dead neurons. However, the conventional use of GFAP promoter to target reactive astrocytes has two inherent problems: inadvertent conversion of normal astrocytes and low efficiency due to progressive weakening of promoter activity during transdifferentiation. Here, we present TRANsCre-DIONE, a dual-promoter split-Cre system combining GFAP and Lcn2 regulatory elements with Cre-dependent Neurog2 expression under the EF1α promoter, enabling selective targeting of scar-forming reactive astrocytes. This approach achieved 87% conversion efficiency and 96% specificity in vivo. After SCI, TRANsCre-DIONE caused transdifferentiation into Isl1-positive and ChAT-positive motor neurons, reduced astrogliosis, enhanced regeneration in surrounding cells, and a significant motor recovery. These findings suggest that TRANsCre-DIONE enables efficient and selective astrocyte-to-neuron conversion and represents a promising strategy for SCI repair.

PMID 42722703
阅读全文 →
PubMedPrimary health care research & development2026-09-11

Percutaneous image-guided pain procedures for low back pain in an Australian suburban primary care centre: findings from a retrospective single-year audit.

Lesicar Jordan J, Tinnion Joshua J, Glynatsis Nik N, Yau Yun-Hom YH et al.

To describe the incidence, indications and outcomes of percutaneous image-guided pain procedures (PIGPPs) for low back pain (LBP) in an Australian suburban primary care centre. PIGPPs are widely used in secondary and tertiary care for LBP but there is little information about their use in primary care. A retrospective audit in an Australian city suburban primary care centre, during 2022. Of 2828 patients coded with terms relating to LBP 673 had a consultation for LBP and 90 (13%: 95% CI 11-16%) had a PIGPP. These patients were significantly (p < 0.001) older and more likely (p < 0.001) to have chronic lower limb pain. Outcome documentation by GPs was high (87%: 95% CI 75-95%) but subjective. Future studies of PIGPPs for LBP in primary care should address deficiencies in objective patient assessment to facilitate evaluation of their appropriateness and both clinical and cost effectiveness.

PMID 42723300
阅读全文 →
PubMedBMC medical education2026-09-11

"It's why I'm the doctor that I am": a qualitative study of the long-term outcomes of a longitudinal service-learning medical education program.

Waltrich Nichole M NM, Michel Joanna L JL, Rudd Emma E, Miranda Mayra M et al.

Service-learning (SL) is widely used in medical education to promote structural competency and engagement with underserved communities. However, most SL evaluations focus on short-term outcomes, leaving limited understanding of whether these experiences shape physicians' perspectives and practice over time. This study examined the long-term impact of the Urban Medicine (UMed) Program, a longitudinal service-learning program, on graduates' professional development and commitment to health equity. A retrospective qualitative study was conducted using semi-structured interviews with 35 UMed alumni who graduated from the University of Illinois College of Medicine between 2009 and 2020 and had at least four years of postgraduate clinical experience. Interviews were conducted via Zoom. Data were analyzed inductively using thematic coding, with codes and themes refined through iterative discussion among the research team. Graduates described UMed as having a sustained influence on their professional identity, clinical practice, and commitment to underserved communities. Three major themes emerged: (1) sustained community engagement through the longitudinal community rotation reinforced graduates' sense of purpose and accountability to underserved populations; (2) structural competency training shaped participants' approaches to patient care by increasing attention to social determinants of health, advocacy, and systemic barriers to care across specialties; and (3) cohort relationships and mentorship fostered belonging and provided ongoing professional support that helped sustain equity-oriented commitments throughout training and practice. Participants also described continued collaborations with peers and community partners that influenced career decisions and professional trajectories. Longitudinal service-learning programs may have durable effects on physicians' professional development and clinical practice. Sustained community engagement, structural competency training, mentorship, and cohort-based learning environments may help reinforce commitments to health equity and support physicians in addressing systemic barriers to care across diverse clinical settings.

PMID 42723051
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多AM-87