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hyoscyamine sulfate

✓ Approved

Lumara Health · CHRM1 · 小分子

什么是 hyoscyamine sulfate？

hyoscyamine sulfate 是一种小分子，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Lumara Health
药物类别小分子
分子靶点CHRM1, CHRM2, CHRM3, CHRM4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Lumara Health

作用机制

分子靶点

hyoscyamine sulfate 作用于 4 个分子靶点：

CHRM1cholinergic receptor muscarinic 1 (M1, HM1)
CHRM2cholinergic receptor muscarinic 2 (HM2)
CHRM3cholinergic receptor muscarinic 3 (HM3, PBS)
CHRM4cholinergic receptor muscarinic 4 (HM4, M4R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

hyoscyamine sulfate 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersColitis ulcerative✓ Approved
Gastrointestinal disordersIrritable bowel syndrome✓ Approved
Renal and urinary disordersUrinary tract inflammation✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

Heparan Sulfate, Chondroitin Sulfate, and Keratan Sulfate as Regulators of Tumor Malignancy.

Ohkawa Yuki Y, Taniguchi Naoyuki N

All mammalian cells, which include cancer cells, express sugar chains on their cell surfaces. These sugar chains bind with proteins, lipids, and RNAs. These chains consist of as few as two or three monosaccharides in the shortest chains, and as many as several hundred to a thousand monosaccharides in the longest chains. The chains appear to have a multilayered structure, which makes cells appear to be covered in a coating of sugar. The expression patterns and levels of these sugar chains, also known as the glycocalyx, vary greatly depending on the cell or tissue, and are therefore thought to perform unique localized biological functions. Furthermore, changes in the glycocalyx changes in conjunction with the onset of disease are believed to be closely related to the development of pathological conditions. In this study, we focus on glycosaminoglycans such as heparan sulfate, chondroitin sulfate, and keratan sulfate-relatively long chains of glycans that constitute the glycocalyx-and introduce their biological functions and potential applications in cancer treatment.

PMID 42942004
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PubMediScience2026-10-27

Microbiome-dependent phytosterol sulfates production and tissue distribution in mice.

Tomita Koki K, Nakano Takeru T, Morozumi Satoshi S, Okahashi Nobuyuki N et al.

Microbial biotransformation of dietary lipids, such as cholesterol, influences host homeostasis. Despite extensive studies on animal sterols in host-microbiota interactions, the role of phytosterols in homeostasis remains unclear. In this study, we characterized phytosterol sulfates as microbiota-derived metabolites using untargeted lipidomic data mining. The levels of sitosterol sulfate (SIS), campesterol sulfate, and stigmasterol sulfate, the three major phytosterol sulfates, along with coprostanol sulfate, were reduced in the feces of germ-free mice compared with those of specific pathogen-free mice. We characterized a series of Bacteroidota species and their sterol sulfotransferases that produced phytosterol sulfates more efficiently than mammalian enzymes. Furthermore, SIS significantly accumulated in host tissues in a microbiota- and age-dependent manner, whereas unconjugated phytosterols were mostly undetectable. Our work provides insights into host-microbiome interactions via gut bacterial phytosterol metabolism.

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PubMedHuan jing ke xue= Huanjing kexue2026-10-27

[Effects of Different Treatment Methods for Printing and Dyeing Sulfate Wastewater on Microbial Structure and Sulfur Cycle Functional Genes].

Chen Jing J, Jiang Yi-Lin YL, Lü Jie J, Ma Yuan Y et al.

The advantages of Xinjiang raw cotton resources have gradually transformed into manufacturing advantages dominated by textile printing and dyeing， while the high water consumption of the textile printing and dyeing industry conflicts sharply with the water shortage in Xinjiang. The time for comprehensive utilization after the treatment of printing and dyeing wastewater in Xinjiang meets the standards is relatively short， and there is a lack of research support on whether the discharge and utilization will have an impact on the desert ecosystem. This study takes a printing and dyeing wastewater treatment system in an industrial park in Alar City， Xinjiang as the research object and comprehensively analyzes the characteristics and related driving factors of physical and chemical factors of sediment， microbial community， functional structure， sulfur cycle functional genes in drainage outlet （PSK）， constructed wetland （RGSD）， and oxidation pond （YHT）. After the printing and dyeing wastewater was treated by RGSD and YHT， the Na+， Cl-， SO42-， and electrical conductivity in the water increased significantly. PSK had higher contents of TN， SOC， SO42-， and TDS in sediment， and RGSD had higher contents of Ca2+， SO42-， TDS， and TP in sediment， while TN and SOC decreased significantly. YHT had higher contents of Na+ and Cl-， while Ca2+ and SO42- decreased significantly. The microbial community in sediment was dominated by bacteria， and its α and beta diversity varied significantly among different treatment units， with RGSD having the lowest microbial diversity. Sulfur cycle functional genes analyses showed that assimilatory sulfate reduction was the dominant pathway， dissimilatory sulfate reduction genes were the highest in RGSD， and sulfur oxidation genes were the most abundant at PSK. Structural equation and Mantel analysis indicated that nutrients in sediment promoted microbial diversity and assimilatory sulfate reduction process， while ion concentration had an inhibitory effect on them， and TP， TDS， and SO42- were the key factors driving the variation of microbial community structure. Different ions had different effects on the sulfur metabolic pathway. TN and SOC inhibited dissimilatory sulfate reduction while promoting assimilatory sulfate reduction and sulfur oxidation. Cl-， Na+， K+， and Mg2+ ions inhibited sulfur oxidation and assimilatory sulfate reduction processes. This study reveals the microbial sulfur metabolism synergy mechanism in different treatment methods of sulfate printing and dyeing wastewater from the perspectives of microbial ecology and functional genes， providing a theoretical basis for the effluent comprehensive utilization of printing and dyeing wastewater treatment and prevention and control of black and odorous water pollution in the Xinjiang Region in the future.

PMID 42935434
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PubMedRSC advances2026-10-27

Crystallization and purification of nickel sulfate hexahydrate from agromining leach solution.

Kalakech Carla C, Sanchez Antoine Martin AM, Buch Arnaud A, Matar Naeif N et al.

The growing demand for lithium-ion batteries has intensified the need for high-purity nickel sulfate hexahydrate (NSH6), a key precursor for nickel-rich cathode materials. In this context, agromining represents a promising alternative nickel source, although the resulting leachates contain various impurities that challenge downstream purification. This study investigates the evaporative crystallization of NSH6 from a synthetic nickel-rich sulfate solution formulated to reproduce the composition of post-solvent extraction (SX) feed obtained from a bio-ore leach solution (BLS), with a particular focus on impurity partitioning, incorporation mechanisms, and post-crystallization purification. Evaporative crystallization enabled efficient nickel recovery while rejecting most impurities into the mother liquor. However, selective incorporation of Co(ii) and Fe(ii) into the crystal phase was observed, whereas K, Mg(ii), Ca(ii), and Mn(ii) were largely excluded. Controlled dissolution experiments revealed distinct impurity uptake mechanisms, including surface adsorption for Ca(ii), growth-induced inclusions for Co(ii), Fe(ii), and Mg(ii), and mixed inclusion/solution entrapment for K, while Mn(ii) was completely eliminated by crystallization. These mechanisms were corroborated by impurity distribution coefficients, incorporation ratios, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) analyses. A simple displacement washing step effectively removed surface-associated and interstitial impurities, increasing the purity of nickel sulfate hexahydrate to 99.99 wt%, with a single washing stage sufficient to meet battery-grade specifications. Overall, these findings demonstrate that the relatively low impurity-to-nickel ratio of the post-SX agromining-derived feed favors efficient impurity rejection during crystallization, highlighting the potential of agromining as an attractive alternative nickel source for the sustainable production of battery-grade nickel sulfate hexahydrate.

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PubMedMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2026-10-27

Magnesium Sulfate, Nicardipine, and Volatile Anesthetics in Severe Preeclampsia: Clinical and Mechanistic Implications for Uterine Atony and Postpartum Hemorrhage.

Bouya Mohammed Said MS, Hamdani Zakariya Z, Bouhabba Najib N

Severe preeclampsia frequently requires the concurrent administration of magnesium sulfate, intravenous nicardipine, and volatile anesthetics during the peri-delivery period, exposing the myometrium to convergent inhibition of calcium-dependent contraction. We conducted a narrative review guided by the Scale for the Assessment of Narrative Review Articles framework. We searched PubMed/MEDLINE and screened reference lists through March 2026, prioritizing mechanistic studies, human myometrial experiments, clinical cohorts, randomized trials, meta-analyses, and contemporary obstetric anesthesia guidance. The evidence indicates that convergence occurs at multiple levels of the excitation-contraction coupling machinery, including L-type calcium channel influx, inositol 1,4,5-trisphosphate-mediated intracellular calcium release, oxytocin receptor signaling, intercellular coupling through connexin-43 gap junctions, and calcium sensitization via the Ras homolog family member A (RhoA)/Rho-kinase pathway. Magnesium sulfate acts as a broad calcium antagonist, nicardipine blocks L-type calcium channels, and volatile anesthetics depress spontaneous and oxytocin-induced force generation. Clinical evidence is more heterogeneous: magnesium sulfate shows mixed hemorrhagic associations, direct postpartum hemorrhage data for nicardipine remain sparse, and general anesthesia is associated with greater hemorrhagic risk than neuraxial techniques. This "tocolytic triad" is therefore best viewed as a mechanistically grounded risk model rather than a validated clinical syndrome. We propose a graded exposure-burden care bundle, anchored in quantified blood loss assessment, to align hemorrhage preparedness with cumulative pharmacologic inhibition of postpartum uterine contraction.

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PubMedBioengineering (Basel, Switzerland)2026-10-27

Influence of a Bacteriophage Cocktail as a Biocontrol Strategy on Sulfate-Reducing Bacteria in a Pilot-Scale System.

Vieira Marcella Silva MS, Dias Roberto Sousa RS, Lima Helena Santiago HS, Sousa Maíra Paula de MP et al.

Sulfate-reducing bacteria (SRB) play crucial roles in microbiologically induced corrosion (MIC), especially in anaerobic environments where the production of hydrogen sulfide (H2S) and biofilm formation accelerate metal degradation. Conventional treatments, such as THPS-based biocides, while effective, face limitations relating to the development of resistance and poor biofilm penetration. In this study, we evaluated the use of a non-specific bacteriophage cocktail as a biological control strategy against a mixed SRB culture (AP) biofilm and related corrosion, utilizing a pilot-scale system with AISI 1020 carbon steel coupons. Over 38 days, we monitored H2S production, optical density, and ATP concentrations, along with the surface characterization of steel coupons through scanning electron microscopy (SEM) and profilometry. Metagenomic sequencing revealed changes in microbial community composition, including reductions in sulfate consumers and shifts in dominant taxa. SEM and profilometric analyses showed disrupted and less aggressive biofilms on treated surfaces, often exhibiting filamentous structures. Diversity indices indicated the modulation of microbial richness and composition over time. These findings demonstrate the potential of bacteriophage cocktails to reshape complex microbial communities and reduce MIC, providing a sustainable alternative to chemical biocides in large-scale industrial settings.

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