sumatriptan succinate (Imigran Nasal Spray / Imitrex Nasal Spray / Suminant)

Subcutaneous Hemangioma on Nasal Dorsum Treated With Rhinoplasty: Literature Review.

Alzamil Abdullah A, Almutairi Abdulaziz B AB, Alsudays Ali M AM, Almuhaya Reham R

Vascular anomalies, including hemangiomas, which have slow blood flow, can develop anywhere on the body. They are mostly isolated lesions and are more common in women. The deformity does not regress on its own. A rare variety, known as subcutaneous hemangioma, grows aggressively and occasionally recurs after excision. In this report, we present a case of a 44-year-old female who experienced a slowly growing, painful nasal hump as a result of nasal trauma she sustained 7 years ago. She denied any associated symptoms apart from pain. Physical examination revealed a palpable, soft, nonmobile mass measuring ∼1 cm by 0.5 cm over the nasal dorsum. There was mild tenderness, and the skin appeared normal. Imaging workup with a CT scan showed a destructive process in the cortex of the left nasal bone, with soft-tissue density noted in the anterior left nasal cavity abutting the anterior nasal septum. Furthermore, an MRI study showed a well-defined, rounded, isointense lesion on T1 FSE images under the nasal bridge and hyperintense on T2 FSE images. Ultimately, the patient underwent open rhinoplasty. According to the histopathology results, there was reactive bone with skeletal muscle fibers, fibrosis, and dilated vascular channels. Atypia, mitosis, and necrosis were not present. The patient was doing well postoperatively with no complications and was scheduled for routine clinic follow-ups.

Anatomical Feature of Nasal Cavity for Endoscopic Endonasal Skull Base Surgery in Patients With GHoma.

Suzuki Tomoharu T, Komune Noritaka N, Miyamoto Yusuke Y, Kuga Daisuke D et al.

Endoscopic endonasal skull base surgery (EESS) is widely performed for pituitary tumors. In growth hormone-secreting adenomas (GHomas), the procedure is technically more demanding than for other pituitary neuroendocrine tumor (PitNET) subtypes due to restricted instrument maneuverability. Few studies have evaluated the influence of nasal cavity morphology on this difficulty. To identify anatomical factors contributing to the technical challenges of EESS for GHomas by comparing nasal cavity structures between GHoma and non-GHoma PitNET patients. Retrospective chart review. Tertiary referral center with a collaborative skull base team of neurosurgery and otolaryngology. Computed tomography (CT) images of 28 GHoma and 104 non-GHoma PitNET patients who underwent EESS between August 2018 and April 2024 were analyzed. Measurements included inter-vidian canal distance, nasolacrimal duct opening width, inferior turbinate width, piriform aperture width, sphenopalatine foramen width, inter-carotid artery distance, skull base-to-hard palate distance, anterior nasal spine-to-clivus distance, and anterior sphenoid wall-to-clivus distance. Comparisons were performed using Student's t-test. GHoma patients showed significantly greater nasolacrimal duct opening width, piriform aperture width, and anterior nasal spine-to-clivus distance (P < .05). Vertical-to-horizontal ratios did not differ significantly. However, the inter-carotid artery distance and the ratios of inter-carotid distances to the anterior nasal spine-to-clivus distance were significantly smaller in GHomas. GHoma patients possess generally larger sinonasal dimensions, yet a narrower paraclival inter-carotid space limit surgical maneuverability. These CT-based anatomical differences may have potential implications for preoperative anatomical assessment in patients with GHomas. IV.

Reference Equations for Peak Nasal Inspiratory and Expiratory Flow: A Cross-Sectional Study.

de Oliveira Gardênia Maria Martins GMM, Laporta Gabriel Zorello GZ, Sabiá Joao Paulo Duarte JPD, Ferreira Joao Marcos JM et al.

To develop reference equations for peak nasal inspiratory flow (PNIF) and peak nasal expiratory flow (PNEF) in healthy adults using easily measurable anthropometric variables. This cross-sectional study included 239 clinically healthy adults (123 women and 116 men) aged 20-55 years with normal spirometry and no clinically relevant nasal obstruction symptoms. PNIF and PNEF were measured using standardized techniques. Generalized linear models were constructed using sex, height, weight, and age as candidate predictors. Model selection was based on the corrected Akaike information criterion (AICc). Model m14 demonstrated the best fit and parsimony for both PNIF and PNEF. The final reference equation for PNIF was PNIF (L/min) = exp (3.370356 + 0.633324 × height (m) + 0.004086 × weight (kg) + 0.130967 × sex). The reference equation for PNEF was PNEF (L/min) = exp (2.799532 + 1.062786 × height (m) + 0.005143 × weight (kg) + 0.133738 × sex). Sex was coded as 0 for female and 1 for male. Height and weight showed significant positive associations with both outcomes. Age did not improve model performance. Reference equations for PNIF and PNEF were established in clinically healthy adults. Compared with PNEF, PNIF demonstrated greater homogeneity and lower residual variability, suggesting potential value as a complementary tool for interpreting objective nasal airflow measurements. These internally validated equations require external validation before broader clinical application. N/A.

Nasal vaccines could stop pandemics before they begin.

King Anthony A