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sumatriptan succinate (Imigran Nasal Spray / Imitrex Nasal Spray / Suminant)

✓ Approved

GSK · HTR1D · 小分子

什么是 sumatriptan succinate？

sumatriptan succinate 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名Imigran Nasal Spray, Imitrex Nasal Spray, Suminant
公司GSK
药物类别小分子
分子靶点HTR1D
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, GSK

作用机制

分子靶点

sumatriptan succinate 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan succinate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved
Nervous system disordersCluster headache✓ Approved

相关研究文献

PubMedThe journal of poultry science2026-10-27

Effects of Cyclic High Ambient Temperature on Tricarboxylic Acid Cycle Intermediates and Orotate Levels in the Liver and Breast Muscle of Broiler Chickens.

Katafuchi Ayumi A, Shimamoto Saki S, Tomonaga Shozo S, Kamimura Miyu M et al.

Heat stress alters tricarboxylic acid (TCA) cycle metabolism in broiler chickens; however, quantitative changes in TCA cycle-related metabolites remain poorly understood. This study determined the effects of heat exposure on TCA cycle intermediate (citrate, isocitrate, α-ketoglutarate, succinate, fumarate, and malate) and orotate levels in the liver and breast muscle of broiler chickens. Twelve 14-day-old male broiler chickens were assigned to either a control group (25 ± 1 °C) or a cyclic high ambient temperature group (35 ± 1 °C for 8 h/day) and reared under these conditions for 4 days. Heat exposure increased liver levels of citrate, α-ketoglutarate, fumarate, and malate, while decreasing succinate and orotate. Heat exposure also decreased the mRNA expression of isocitrate dehydrogenase 3A (IDH3A) and oxoglutarate dehydrogenase, key TCA cycle regulatory enzymes, as well as dihydroorotate dehydrogenase and ubiquinol-cytochrome c reductase Rieske iron-sulfur protein 1 (UQCRFS1), which are involved in mitochondrial electron transport. Heat exposure increased breast muscle levels of succinate, fumarate, and malate, while reducing IDH3A and UQCRFS1 mRNA expression. These findings suggest that heat exposure impairs TCA cycle metabolism in broiler chickens, possibly by reducing the utilization of TCA cycle intermediates through impaired electron transfer in mitochondrial complex III.

PMID 42936156
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PubMedNigerian journal of clinical practice2026-10-27

Nasal Septal Swell Body is a Universal Anatomical Structure: Endoscopic Grading and CT-Based Morphometric Analysis in Patients with Nasal Obstruction.

Sivrice M E ME, Balaban M M, Yasan H H, Okur E E et al.

The nasal septal swell body (NSSB) is a structure that influences nasal airflow and may contribute to nasal obstruction when hypertrophied. To evaluate the prevalence, gender distribution, and size characteristics of NSSB, which play a role in nasal breathing physiology, endoscopically and radiologically. This cross-sectional study included 148 patients who presented with nasal congestion between January and July 2025. All patients underwent nasal endoscopic examinations. NSSB was classified using an endoscopic grading score. Width and height measurements were taken from the widest surface of the NSSB in coronal sections of paranasal sinus computed tomography (PNS CT). The obtained data were statistically analyzed in terms of age, gender, NSSB grade score, and size measurements. NSSB was detected in all patients included in the study (100%). Of the study population, 40.5% were female and 59.5% were male, with a mean age of 36.11 ± 16.76 years. No significant relationship was found between age and NSSB dimensions. A weak positive correlation was found between NSSB width and height ( P = 0.019). NSSB width, height, and endoscopic grade score were significantly higher in male patients compared to female patients ( P < 0.001). NSSB width differed significantly among NSSB grade score groups, whereas no significant difference was found in height. The detection of NSSB in all cases suggests that this structure may be more prevalent than previously reported in the literature. It is important to consider the NSSB hypertrophy in the evaluation of patients presenting with nasal obstruction due to its effect on narrowing the nasal valve.

PMID 42937382
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PubMedBiomedicines2026-10-27

A Synbiotic for the Oral-Nasal Gateway: The Mechanistic Rationale, Pathogen-Targeting Profile, and Implications for Gut and Pulmonary Health.

Peldyak John N JN, Reynolds Paul P, Pineda César Alas CA, Ferrer Gustavo G et al.

The oral cavity and the nasal passage form a single, continuously mixed ecological gateway rather than two independent niches: saliva is swallowed roughly once every one to two minutes while awake, and nasal mucus is transported posteriorly into the nasopharynx on a cycle of roughly ten to twenty minutes, so oral and nasal microbial communities are in near-constant fluid exchange with each other and with the gut. This narrative review examines the mechanistic rationale for a proposed formulation containing Streptococcus salivarius M18, Lactobacillus plantarum HEAL9, Lacticaseibacillus paracasei 8700:2, and Bifidobacterium longum subsp. infantis, with 2 g/day xylitol and vitamins C and D3. We assess component-level evidence for bacteriocin-mediated antagonism, immune modulation, colonization resistance, and airway-surface effects and relate these findings to oral-gut translocation, lung microbiome seeding, and gut-lung immune signaling. The strongest clinical support concerns caries-related and upper respiratory outcomes for individual components or strain pairs. Gut effects depend on strain identity, age, diet, and substrate availability; pulmonary benefits remain indirect hypotheses. No trial has tested the complete formulation, and evidence from topical nasal xylitol cannot establish nasal efficacy after oral administration. Cardiovascular findings involving circulating xylitol and experimental platelet activation warrant dose-specific safety evaluation; their relevance to 2 g/day remains uncertain. Trials should establish strain identity, compatibility, viability, and safety, then pair clinical endpoints with longitudinal oral, nasal, and intestinal sampling. The proposed formulation offers a testable approach to the oral-nasal-gut-pulmonary axis, but its efficacy and safety require product-specific confirmation.

PMID 42940073
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PubMedOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026-10-27

Outpatient Nasal Bone Fractures: An Under-Recognized Marker for Domestic Violence.

Rock Jenna J, Katragadda Rishi R, Hayden Jamil J, Crafton Christopher L CL et al.

To assess the risk of a new domestic violence (DV) diagnosis following outpatient presentation for a nasal bone fracture. Retrospective cohort study. Multicenter analysis using the TriNetX research database. Female patients aged 18 to 60 years were identified by ICD-10 codes. Propensity-matched analyses compared the risk of subsequent DV diagnosis among patients with nasal bone fractures versus (1) patients with other facial fractures and (2) the general population. Among 24,757 patients with nasal bone fractures, 3.55% were later diagnosed with DV compared with 0.57% in the general population and 2.66% in patients with other facial fractures. Relative risk of DV was 6.18 (95% CI, 5.18-7.38) compared with the general population and 1.34 (95% CI, 1.21-1.48) compared with other facial fractures (P < .001). Black and Hispanic women with nasal bone fractures had the highest rates of DV diagnosis (6.85% and 4.20%, respectively) and relative risk compared with the general population (8.55 and 6.88, respectively). Outpatient presentation with a nasal bone fracture is associated with more than a sixfold increased risk of subsequent DV diagnosis. Early DV screening and referral protocols in outpatient settings may help identify at-risk individuals and provide timely support.

PMID 42934832
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PubMedLife (Basel, Switzerland)2026-10-27

Beyond Cartilage Grafting in Rhinoplasty: Biopharmaceutical and Biomaterial Strategies for Nasal Cartilage Regeneration.

Yi Kyu-Ho KH, Lee Han Earl HE, Kim Hongseok H, Choi Wonseok W et al.

Autologous septal, auricular, and costal cartilage remain the reference materials for structural and aesthetic rhinoplasty, yet each source is constrained by finite availability, donor-site morbidity, variable geometry, and the risks of warping, resorption, or revision. Nasal cartilage regeneration therefore represents more than a conventional tissue-engineering problem: a clinically useful product must recreate region-specific extracellular matrix, survive in a diffusion-limited environment, tolerate suturing and cyclic deformation, preserve the nasal airway, and maintain patient-specific contour under a thin soft-tissue envelope. This narrative review evaluates next-generation biopharmaceutical and biomaterial strategies for meeting those requirements. Direct evidence from human nasal chondrocytes and engineered nasal constructs is integrated with mechanistic evidence from broader cartilage regeneration, with explicit separation of nasal, auricular, and articular data. Chondrogenic proteins and small molecules, including transforming growth factor-beta, bone morphogenetic proteins, fibroblast growth factor 18, and kartogenin, can initiate matrix-forming programs but require spatial and temporal control to avoid fibrocartilage, hypertrophy, or mineralization. Polydeoxyribonucleotide and polynucleotide formulations have plausible anti-inflammatory and matrix-supportive actions, but evidence remains predominantly in vitro or articular; no direct clinical proof currently supports injection-only regeneration of structural nasal cartilage. Extracellular vesicles provide a cell-free signaling platform, whereas expanded nasal chondrocytes presently have the strongest tissue-specific translational lineage. Injectable collagen, fibrin, alginate, hyaluronic-acid, chitosan, gelatin-methacryloyl, and decellularized-matrix systems can localize these cargos, although biologic permissiveness often conflicts with immediate mechanical strength. Three-dimensional bioprinting and reinforced hybrid constructs offer patient-specific geometry, but clinical translation requires validated potency assays, suture retention, flexural testing, orthotopic safety, Good Manufacturing Practice-compatible production, and long-term objective assessment of shape and airflow. The most credible near-term applications are biologic enhancement of existing grafts, repair of small contained defects, and patient-specific partial-framework replacement rather than minimally invasive reshaping by regenerative injection alone. A stage-gated translational framework is proposed to align molecular potency, material performance, surgical usability, aesthetic precision, and durable nasal function.

PMID 42942299
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PubMedBMC oral health2026-10-27

Aerodynamic and anatomical changes of the upper airway after maxillary skeletal expansion in adults.

Li Zhicun Z, Zhu Sirui S, Xu Yang Y, Hou Wei W et al.

To quantify anatomical and aerodynamic changes of the adult upper airway after maxillary skeletal expansion (MSE) using computational fluid dynamics (CFD) with in vitro validation, and to assess whether expansion magnitude correlates with aerodynamic improvement. Thirty-one skeletally mature adults treated with MSE were retrospectively included. CBCT scans at baseline (T1) and after stabilization (T2) were used to reconstruct and segment airway models into nasal and pharyngeal regions. Steady inspiratory CFD was performed at a bilateral flow rate of 30 L/min and validated in 10 patient-specific 1:1 3D-printed models. Mean expansion magnitude was 4.09 mm. Nasal cavity volume increased (Δ=+3.10 cm³, P < 0.001), whereas pharyngeal MCA showed no significant change (P = 0.083). Total pressure drop decreased (Δ=-13.95 Pa, P < 0.001), mainly due to a reduction in nasal pressure drop (Δ=-12.81 Pa, P < 0.001); the pharyngeal pressure drop change was not significant (P = 0.087). Expansion magnitude correlated with nasal pressure-drop reduction (r = - 0.412, P = 0.021) and nasal volume increase (r = 0.470, P = 0.008), but not with total pressure-drop reduction (P = 0.074). MSE yields region-specific aerodynamic improvement predominantly in the nasal airway, with limited pharyngeal aerodynamic change. Aerodynamic improvements after MSE should not be assumed to extend uniformly to the pharyngeal airway; patients with marked pharyngeal narrowing may require individualized airway evaluation and adjunctive management beyond expansion alone.

PMID 42934694
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