北京若生智能科技有限公司
Drug Database
DE

delivery technology (CEFORM EA / CEFORM RA / CEFORM)

✓ Approved

Bausch Health Companies Inc. · 治疗药物

什么是 delivery technology？

delivery technology 是一种治疗药物，由Bausch Health Companies Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名CEFORM EA, CEFORM RA, CEFORM
公司Bausch Health Companies Inc.
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Bausch Health Companies Inc.

治疗适应症

delivery technology 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedCancer biotherapy & radiopharmaceuticals2026-10-26

Ultrasound-Mediated Modulation of circRNA hsa_circ_0004870 as a Prognostic and Therapeutic Biomarker in Pancreatic Cancer.

Lv Chunyang C, Fan Xiaodong X, Wang Gaoyuan G, Sun Haijian H et al.

Pancreatic cancer remains one of the most fatal tumors, with a 5-year survival rate of less than 10%, owing mostly to late-stage detection and inadequate treatment efficiency. The pressing need for novel diagnostic and therapeutic approaches has sparked interest in genetic biomarkers and ultrasound-based precision therapies. Circular RNAs (circRNAs) have recently been identified as intriguing regulatory molecules with diagnostic, prognostic, and therapeutic applications. A comprehensive study of transcriptome and clinical datasets revealed that hsa_circ_0004870 is significantly elevated in pancreatic cancer tissues and is linked with poor patient outcomes. Functional tests, including colony formation, cell counting kit-8, flow cytometry, wound healing, and Transwell invasion studies, were used to evaluate its biological roles. Bioinformatic predictions, along with dual-luciferase reporter assays, revealed the hsa_circ_0004870/miR-3124-3p/TRIM24 regulatory axis. In vivo xenograft research and immunohistochemistry analyses supported these findings. In addition, the authors developed an ultrasound-mediated biophysical modulation model to investigate the potential therapeutic control of this axis. hsa_circ_0004870 was highly overexpressed in pancreatic cancer cells, which increased proliferation, migration, and invasion. It acts as a competitive endogenous RNA, sequestering miR-3124-3p, resulting in increased TRIM24 and tumorigenic behavior. In vivo, silencing hsa_circ_0004870 reduced tumor development significantly. Combining these findings with developments in ultrasound-targeted gene and molecular delivery technology suggests that ultrasound-mediated manipulation of the hsa_circ_0004870 axis might provide a precise and noninvasive therapeutic method to overcome resistance and enhance localized cancer management. hsa_circ_0004870 was overexpressed in pancreatic cancer cells, resulting in enhanced proliferation, migration, and invasion. It works as a competitive endogenous RNA, sequestering miR-3124-3p, leading to enhanced TRIM24 and tumorigenic behavior. In vivo, suppressing hsa_circ_0004870 dramatically decreased tumor growth. Combining these findings with advances in ultrasound-targeted gene and molecular delivery technology, it appears that ultrasound-mediated manipulation of the hsa_circ_0004870 axis could provide a precise and noninvasive therapeutic method for overcoming resistance and improving localized cancer management.

PMID 42928620
阅读全文 →
PubMedBiomimetics (Basel, Switzerland)2026-10-26

Inkjet and Related Printing Technologies for Plant Systems: From Physiological Monitoring to Functional Biofabrication.

Wang Xiukun X, Zhang Xing X, Wang Guanghui G, Feng Bokai B et al.

Featuring non-contact, high-precision, and multi-material deposition, inkjet and related printing technologies offer a new alternative technique for plant systems. However, the spatial heterogeneity, continuous growth, and sensitivity of plant tissues to external perturbations make it difficult for conventional methods to target specific sites on living organs. This review evaluates thermal and piezoelectric inkjet printing, together with aerosol jet and electrohydrodynamic printing for plant applications. Moreover, it relates the jetting behavior of the printhead to interfacial processes between droplets and plant surfaces. Practical performance is assessed across four dimensions: effective feature size, organ-scale throughput, potential biological damage, and the physiological compatibility of printing inks with plants. Applications are then organized within a framework comprising five tiers: monitoring, delivery, sensing, biofabrication, and intelligent systems. Specifically, recent studies have demonstrated that these printing approaches can be employed for surface labeling and growth tracking of plant organs, localized delivery of agricultural inputs, fabrication of flexible sensors, and construction of living materials (e.g., plant cells). Combined with artificial intelligence technology, these capabilities could form a closed-loop system spanning sensing to feedback, with printing as the precision actuator, potentially shifting plant management from passive observation to active regulation. Finally, this review discusses the challenges of living-interface dynamics, ink biocompatibility, multiscale integration, and data intelligence. It further outlines the prospects of these technologies for programmable plants and living agricultural interfaces. By bridging printing technologies, plant systems, and functional biofabrication, this review provides a unified framework to guide the development of intelligent and sustainable agricultural systems.

PMID 42930315
阅读全文 →
PubMedTechnology and culture2026-10-26

Focus: Kranzberg's Paradoxes, Education, and Social Movements.

Sousa M Luísa ML, Valentines-Álvarez Jaume J

In our experience teaching the history of technology, Kranzberg's laws have been useful for introducing humanistic perspectives on scientific matters and challenging standard conceptions of technology. Yet this usefulness presents a paradox. While these laws are effective as introductory tools, they are too simple, binary, ethnocentric, and politically conservative to capture the complexities of technology and contemporary historiography. Set against specific case studies, global perspectives, or debates on agency and power, the laws quickly reveal their limitations and their historical situatedness. Taking Kranzberg's call to contextualize technology seriously, this essay contextualizes the laws themselves, reading them as historically situated responses to challenges from within and beyond the history of technology, particularly those posed by social movements, including environmental and antinuclear activism. Four decades after their publication, Kranzberg's laws invite not reverence but critical reassessment, a process that allows us-and our students-to reconsider their pedagogical value through a broader understanding of their historical context.

PMID 42929117
阅读全文 →
PubMedTechnology and culture2026-10-26

Focus: When Kranzberg's Laws Traveled.

Choi Hyungsub H

This essay reflects on the afterlife of Melvin Kranzberg's "six laws of technology" and their place in the disciplinary culture of the history of technology. By the early 2000s, the laws had become familiar points of reference within SHOT: rarely treated as a research agenda, yet regularly invoked as a shared language of disciplinary affiliation. Their most famous formulation-that "Technology is neither good nor bad, nor is it neutral"-resonated with a field shaped by efforts to displace technological determinism and to foreground social construction, contingency, and human agency. The subsequent globalization of the history of technology, however, has unsettled the geographical and historiographical assumptions on which that shared language rested. The essay reads them as historically situated formulations that reveal the intellectual and geographical boundaries of the field's formation. Their enduring value lies less in prescribing how technology should be understood than in prompting historically grounded questions about how technologies acquire meaning across interconnected but diverse contexts.

PMID 42929114
阅读全文 →
PubMedAudiology research2026-10-26

Prescriptive Target Matching Across Hearing Aid Technology Generations: A Real-Ear Insertion Gain Analysis.

Kruger Megan M, Manchaiah Vinaya V, Taddei Steve S, Bailey Abram A et al.

Background: Advances in hearing aid technology may improve prescriptive target matching, but whether newer devices better match targets remains unclear. This study compared prescriptive target matching across hearing aid technology generations. Methods: This secondary analysis included 29 flagship prescription hearing aids grouped into older (2021-2022; n = 8), mid (2023; n = 11), and newest (2024-2025; n = 10) technology generations. Root Mean Square Error (RMSE) between measured Real Ear Insertion Gain (REIG) and NAL-NL2 targets was calculated across six frequencies (500-6300 Hz) for soft (55 dB SPL), conversational (65 dB SPL), and loud (75 dB SPL) speech levels under Initial Fit and Tuned Fit conditions. Kruskal-Wallis tests and linear mixed-effects models accounting for manufacturer clustering were used to evaluate prescriptive target matching across technology generations. Results: No significant technology-generation differences were observed at Initial Fit. Following tuning, group comparisons showed differences at conversational (p = 0.006; ε2 = 0.321) and loud (p = 0.004; ε2 = 0.347) levels, with a directionally consistent but non-significant difference at soft speech (p = 0.055; ε2 = 0.146). After accounting for manufacturer clustering, release year remained a significant predictor of closer target matching only at conversational speech (β = -0.15 dB/year, 95% CI [-0.29, -0.01], p = 0.048). Sensitivity analyses supported the robustness of this finding. Conclusions: Newer hearing aids showed closer prescriptive target matching following tuning at conversational speech, although effects at soft and loud speech did not survive adjustment. Technological advances may improve prescriptive target matching at conversational input levels during fitting.

PMID 42930343
阅读全文 →
PubMedTechnology and culture2026-10-26

Focus: The Trap of Neutrality and Kranzberg's Laws.

Hicks Mar M

Kranzberg's laws are a classic approach to the history of technology rooted in specific mores of the mid-twentieth-century United States. This essay updates them for the early twenty-first century, discussing how changes in technological systems, and in the United States itself, have surfaced different concerns and possible new "laws." It argues that the trap of viewing technological systems as though they might be neutral-or at least more flexible than they are-is of primary concern today, not only for scholars of the history of technology but also for technology workers and users.

PMID 42929120
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多delivery technology