北京若生智能科技有限公司
Drug Database
DO

donepezil hydrochloride (Aricept jelly / donepezil jelly)

✓ Approved

Eisai Co., Ltd. · ACHE · 小分子

什么是 donepezil hydrochloride？

donepezil hydrochloride 是一种小分子，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Aricept jelly, donepezil jelly
公司Eisai Co., Ltd.
药物类别小分子
分子靶点ACHE
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

作用机制

分子靶点

donepezil hydrochloride 作用于 1 个分子靶点：

ACHEacetylcholinesterase (Cartwright blood group) (N-ACHE, ACEE)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

donepezil hydrochloride 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDementia Alzheimer's type✓ Approved
Nervous system disordersDementia with Lewy bodies✓ Approved

相关研究文献

PubMedPakistan journal of pharmaceutical sciences2026-10-26

Stability studies and characterization of nanoemulgel containing gallic acid.

Awan Hina H, Khan Hira H, Haq Rizwan Ul RU, Fatima Nighat N et al.

Gallic acid is a natural phenolic compound with excellent antioxidant, antimicrobial and anti-inflammatory activity and good skin penetration. Gallic acid demonstrates both stability and solubility problems in topical formulations. A nanoemulgel combines an emulsion for enhanced solubility with a gel base for improved physical stability. The main objective of this study is to characterize and assess the stability of a gallic acid-containing nanoemulgel. Various gallic acid nanoemulsions (GNE) were prepared using optimized ratios of oil, surfactants, gallic acid and water and evaluated for stability. Finally, stable GNE-19 was characterized for particle size and converted to nanoemulgel (GNEG-19). Nanoemulgel was subjected to short-term and accelerated stability studies and characterized for pH, viscosity, spreadability, occlusion effect, FTIR, in-vitro drug release and in-vitro pharmacological activities. The results showed that formulation GNEG-19 showed optimum thermodynamic stability, having no phase separation and color change. The droplet size of freshly prepared GNE and after 28 days was 175.43nm and 183.23nm, respectively. The pH was slightly acidic but still within the human skin range (3.9-4.5). No interaction was found between the gallic acid and other components of nanoemulgel following FTIR analysis. The viscosity of freshly prepared GNEG-19 was 2127.1 cP and after 90 days, it was 2102.3 cP, which showed its stability. The percent drug release of gallic acid from nanoemulgel after 24 hrs was 93.12%. GNEG-19 also showed effective occlusion properties when compared with gel base and petroleum jelly. In-vitro pharmacological activities showed that GNEG-19 had antioxidant activity of 63.77% and a zone of inhibition (ZOI) of 11.4 mm compared to pure gallic acid (9.5 mm). In conclusion, nanoemulgel containing gallic acid showed good physical and chemical stability and was pharmacologically active.

PMID 42929401
阅读全文 →
PubMedJournal of tropical medicine2026-10-26

Green-Synthesized Silver Nanoparticles Improve Cognitive Function and Modulate Nrf2/HO-1-BDNF-Related Gene Expression in Experimental Chronic Toxoplasmosis.

Khaksarian Mojtaba M, Khalaf Amal Khudair AK, Shojaee Saeedeh S, Shakib Pegah P et al.

This study aimed to evaluate the neuroprotective effects of silver nanoparticles (AgNPs) green-synthesized using the ethanolic extract of Muscari neglectum against Toxoplasma gondii-induced cognitive impairment and to explore the underlying Nrf2/BDNF and oxidative stress-related mechanisms. Chronic toxoplasmosis was experimentally induced in mice using the Tehran strain of T. gondii. Forty-eight mice were randomly allocated into six experimental groups, including a noninfected control group, an infected untreated control group, and four treatment groups receiving pyrimethamine (PYM, 20 mg/kg), donepezil (DON, 2 mg/kg), AgNPs (10 mg/kg), or AgNPs (20 mg/kg). Spatial learning and memory capabilities were assessed using the Morris water maze test. Post-treatment, brain cyst number and size were determined via microscopic examination. Additionally, quantitative real-time PCR was employed to evaluate the expression levels of genes associated with oxidative stress and neuroprotection, including brain-derived neurotrophic factor (Bdnf), NADPH oxidase 2 (Nox2), superoxide dismutase 2 (Sod2), catalase (Cat), glutathione peroxidase 1 (Gpx1), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (Hmox1). Treatment with AgNP resulted in a significant, dose-dependent improvement in behavioral performance, evidenced by reduced escape latency and enhanced exploration of the target quadrant (p < 0.001). Moreover, AgNP administration markedly decreased both the number and size of brain Toxoplasma cysts, with the 20 mg/kg dose demonstrating superior efficacy compared to PYM (p < 0.01). Molecular analyses indicated significant upregulation of Nrf2, Hmox1, Bdnf, Sod2, Cat, and Gpx1, accompanied by downregulation of Nox2 expression in mice treated with AgNP (p < 0.001). These findings suggest that green-synthesized AgNP exert significant, dose-dependent antiparasitic and neuroprotective effects in the context of chronic toxoplasmosis. AgNP notably reduced brain cyst burden, enhanced spatial learning and memory, and normalized oxidative stress-related gene expression. Importantly, AgNP exhibited greater efficacy than both PYM and DON, indicating their potential as a promising therapeutic approach for neurotoxoplasmosis.

PMID 42928771
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Insights into the Protonation State and Counterion Interactions of Linear Polyethyleneimine Materials.

Byrne Agustín J AJ, Vladimir Daniel D, Garro-Linck Yamila Y, Copello Guillermo J GJ et al.

Polyethyleneimine (PEI) polymers are widely used in the synthesis of nanoparticles, hydrogels and composite materials for biotechnological and environmental applications. However, the solid-state structural organization of linear PEI (L-PEI) materials, and how it is influenced by molecular weight, protonation state and counterion type, have not yet been comprehensively studied. In this work, solid-state nuclear magnetic resonance (ss-NMR), X-ray powder diffraction (XRD), small-angle X-ray scattering (SAXS) and time-domain NMR (TD-NMR) experiments were combined with theoretical calculations to analyze the local chemical environments, crystalline and nanoscale organization, and molecular mobility of L-PEI materials with different molecular weights. The analyzed materials were the free base (PEI·FB), the hydrochloride (PEI·HCl), the trifluoroacetate (PEI·TFA), and the sulfate-containing forms of L-PEI (PEI·Na2SO4 and PEI·H2SO4), as well as an intermediate protonation state obtained by the heterogeneous treatment with HCl-saturated isopropanol. Proton, 13C or 15N ss-NMR studies evidenced different chemical environments associated with changes in protonation state and counterion identity. Furthermore, XRD and SAXS showed that these variables, together with molecular weight and sample preparation conditions, influenced the crystalline arrangement and characteristic nanoscale organization of the polymer chains. Moreover, TD-NMR revealed the presence of three dynamically distinct proton populations, assigned to rigid, interfacial, and mobile domains, whose relative contributions and relaxation behavior varied among the PEI materials. Finally, high-resolution magic-angle spinning (HRMAS) NMR experiments were used to study different PEI-gel materials and films as well as the crosslinking of protonated PEI and sulfate ions.

PMID 42929946
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Dual-Drug Chitosan Hydrogel Loaded with Metformin and Cefazolin for Antibacterial, Anti-Inflammatory and Antioxidant Treatment of Drug-Resistant Bacteria-Infected Skin Wounds.

Zhang Yilin Y, Cao Jie J, Yan Yong Y, Li Zhaoyang Z et al.

Bacterial-infected skin wounds, especially those caused by drug-resistant pathogens accompanied by persistent inflammation, remain a major clinical therapeutic challenge. Rising antimicrobial resistance compromises the therapeutic effect of conventional single-agent antibiotics, creating an urgent demand for novel wound therapeutics that integrate bactericidal potency, immunomodulation and tissue regeneration capacity. In this work, an injectable multifunctional chitosan-based hydrogel (C@MC) was developed, which simultaneously incorporates metformin hydrochloride (as a potential antibiotic adjuvant) and cefazolin sodium (as a β-lactam class antibacterial drug). The optimized C@MC possesses interconnected three-dimensional pores with an initial storage modulus of ~0.83 kPa (C@MC360), featuring desirable mechanical strength, injectability, tissue adhesion and dual pH/glucose-responsive sustained drug release. In vitro evaluations revealed the dose-dependent bactericidal activity of C@MC against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and New Delhi metallo-β-lactamase-1-producing E. coli (NDM-1 E. coli, resistant bacteria). The highest drug-laden group nearly eliminated all wound bacteria in vitro. It scavenged reactive oxygen species (ROS) to lower cellular MDA levels and suppress pro-inflammatory TNF-α and IL-6 in LPS-stimulated RAW 264.7 macrophages. In full-thickness mouse wounds infected with NDM-1 E. coli, C@MC360 achieved nearly complete wound closure, with only a 4.2% residual wound area on day 14, accompanied by suppressed inflammatory infiltration and accelerated wound regeneration. This dual-drug hydrogel integrates antibiotic potentiation, anti-inflammation and antioxidation, providing an intervention regimen for skin wounds infected with drug-resistant bacteria.

PMID 42929911
阅读全文 →
PubMedAmerican journal of translational research2026-10-25

Effects of butylphthalide plus donepezil on symptoms, cognitive function, and oxidative stress in patients with cognitive impairment in Parkinson's disease.

Li Ni N, Li Yuqin Y, He Xuebing X, Huang Shungui S

To investigate the effects of butylphthalide combined with donepezil on clinical symptoms, cognitive function, and oxidative stress in patients with cognitive impairment associated with Parkinson's disease (PD). A total of 119 patients with PD-associated cognitive impairment who were admitted to Chengdu Sixth People's Hospital (Donghong Branch) were retrospectively included and divided into two groups. Both groups received levodopa and benserazide hydrochloride as basic treatment. In addition, patients in the control group (n = 55) received donepezil, and those in the research group (n = 64) received butylphthalide combined with donepezil. The two groups were compared in terms of therapeutic efficacy, clinical symptoms (assessed by the Unified Parkinson's Disease Rating Scale [UPDRS]), cognitive function (Montreal Cognitive Assessment [MoCA]), activities of daily living (ADLs; ADL scale), neurotransmitter levels (dopamine [DA], gamma-aminobutyric acid [GABA], 5-hydroxytryptamine [5-HT]), neurotrophic factors (neurotrophin-3 [NT-3], nerve growth factor [NGF]), oxidative stress (superoxide dismutase [SOD], malondialdehyde [MDA]), adverse events, and quality of life (QoL; the 36-Item Short Form Health Survey [SF-36]). Furthermore, exploratory subgroup analyses were performed according to Hoehn-Yahr staging (H-Y staging) and baseline MoCA scores. Compared to the control group, patients in the research group exhibited much higher overall response rate, lower post-treatment UPDRSII, UPDRSIII, and MDA levels, and higher MoCA scores, ADL scores, DA, GABA, 5-HT, NT-3, NGF, SOD levels, and SF-36 scores. The overall incidence of adverse events was comparable between groups. Neither H-Y staging nor baseline MoCA scores significantly affected the efficacy of the combination therapy. Butylphthalide combined with donepezil may exert beneficial effects on symptom improvement, cognitive function enhancement, and oxidative stress regulation in patients with PD-associated cognitive impairment.

PMID 42923556
阅读全文 →
PubMedPharmaceutical science advances2026-10-25

Corrigendum to "Protective effect of lycorine hydrochloride against diabetic nephropathy in high-fat diet and streptozotocin-induced diabetic mice" [Pharm. Sci. Adv. 2 (2024) 100035].

Fang Kai-Li KL, Qi Xin-Yu XY, Han Qing-Tong QT, Chen Lu-Zhou LZ et al.

[This corrects the article DOI: 10.1016/j.pscia.2024.100035.].

PMID 42926922
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多donepezil hydrochloride