北京若生智能科技有限公司
Drug Database
TK

TK-129 (TK 129 / TK129)

✓ Approved

Foshan Rexiu Biotechnology · LRP1

什么是 TK-129？

TK-129 是一种治疗药物，由Foshan Rexiu Biotechnology研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名TK 129, TK129
公司Foshan Rexiu Biotechnology
分子靶点LRP1
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Foshan Rexiu Biotechnology

作用机制

分子靶点

TK-129 作用于 1 个分子靶点：

LRP1LDL receptor related protein 1 (LRP1A, A2MR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

TK-129 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Rectosigmoid cancer✓ Approved

相关研究文献

PubMedPakistan journal of pharmaceutical sciences2026-10-26

Study on the molecular mechanism of bone marrow mesenchymal stem cells inducing epithelial-mesenchymal transition in HPV-associated cervical cancer through activation of miR-129.

Ma Nieying N, Xu Kaijie K, Wang Zhize Z

HPV-associated cervical cancer remains a leading cause of cancer-related death in women worldwide. The role of bone marrow mesenchymal stem cells (BMSCs) and miR-129 in tumor progression remains unclear. To investigate miR-129 expression and its clinical significance in HPV-associated cervical cancer and to explore whether BMSCs regulate malignant phenotypes through miR-129. miR-129 expression was measured by qRT-PCR in 77 cervical cancer and 30 normal cervical tissues. Associations with clinicopathological features and overall survival (OS) were analyzed. Diagnostic value was assessed by ROC curve. Rat BMSCs were co-cultured with SiHa and HeLa cells. Following miR-129 overexpression or knockdown, cell proliferation (CCK-8, colony formation), invasion (Transwell) and expression of E-cadherin, N-cadherin and MRP1 (Western blot) were examined. miR-129 expression was significantly higher in cervical cancer tissues than in normal controls (3.24±0.56 vs. 1.00±0.32, P<0.05). High miR-129 expression correlated with tumor size ≥3 cm (P=0.009), FIGO stage III-IV (P=0.0034) and lymph node metastasis (P=0.038). High expression was associated with shorter OS (median: 28.4 vs. 46.2 months; HR=2.944, 95%CI:1.484-5.842, P=0.002). The AUC was 0.788 (95%CI:0.693-0.884), with a cut-off of 1.85 (sensitivity:76.9%, specificity:70.4%). BMSC co-culture upregulated miR-129 expression (SiHa: 3.52±0.42 vs. 1.00±0.08, P<0.01). miR-129 overexpression promoted proliferation, colony formation and invasion, while knockdown suppressed these phenotypes. Overexpression of miR-129 reduced E-cadherin (0.42±0.05 vs. 1.00±0.08, P<0.01) and increased N-cadherin (2.85±0.22 vs. 1.00±0.10, P<0.01) and MRP1 (2.46±0.18 vs. 1.00±0.09, P<0.01). Knockdown of miR-129 partially reversed BMSC-induced changes in these proteins. miR-129 is significantly upregulated in HPV-associated cervical cancer and shows potential as a diagnostic and prognostic biomarker. BMSCs upregulate miR-129 in cervical cancer cells and miR-129 modulates proliferation, invasion, EMT marker expression and MRP1 expression. These findings suggest that the BMSCs/miR-129 axis may contribute to cervical cancer progression, but further in-vivo and mechanistic studies are needed.

PMID 42929419
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PubMedJournal of educational evaluation for health professions2026-10-26

Assessment architecture, scoring, and evidence of quality in objective structured clinical examinations in dental education: a scoping review.

Espada-Salgado Fernando Mauricio FM, Ramirez-Mora Tatiana T, Oprea Bogdan B, Iuga María Mihaela MM

This scoping review mapped the design, scoring, implementation, and quality assurance of objective structured clinical examinations (OSCEs) in dental education. The review followed Joanna Briggs Institute guidance and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Scopus, Web of Science Core Collection, PubMed/MEDLINE, ERIC, Embase, and LILACS/BVS were searched through July 25, 2026. Of the 940 records identified, 129 full-text reports were assessed and 63 studies were included. The most frequently reported evidence concerned station design, blueprinting, scoring, examiner calibration, reliability, and psychometric performance. Fewer studies examined standard setting, fairness and potential construct-irrelevant variance, classification accuracy, economic feasibility, or the consequences of high-stakes decisions. Virtual and electronic OSCEs supported assessment continuity and structured evaluation of diagnostic reasoning, interpretation, communication, and decision-making; however, they should not be assumed to replace direct observation when technical or psychomotor performance is the main target. The dental OSCE literature now encompasses both isolated station-based examinations and broader assessment systems. Future research should establish which combinations of assessment design, scoring, examiner preparation, psychometric evaluation, fairness analysis, and decision rules provide defensible evidence for specific educational purposes.

PMID 42928548
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PubMedScandinavian journal of caring sciences2026-10-26

How Nurses Assess Interventions to Promote Patients Sleep on Hospital Wards: Results of a Self-Report Survey.

Vasse Miia M, Paala Elina E, Kangasniemi Mari M, Koivunen Marita M

The aim of this study is to describe how nurses assess interventions to promote patients' sleep on hospital wards. The study was a cross-sectional survey, and it was conducted among nurses in Finnish specialist healthcare in 2022. Out of 482 eligible participants in the sampling frame, 129 nurses returned a completed questionnaire. The open-ended question was answered by 36 participants. Data were analysed using statistical methods and inductive content analysis. In general, participants assessed that they perform well in sleep-promoting activities in a hospital ward. Participants gave the highest assessment to supporting patients' mental and emotional well-being. Minimising disturbance related to nursing interventions got the lowest scores. Based on the open-ended questions, respondents described that the realisation of patients' sleep support in the hospital related to the care environment, patient placement within the ward, resources available for nursing interventions, sleep-supporting aids, care culture and training related to supporting patients' sleep. Nurses assess that they are implementing patient sleep-promotion interventions well. Nurses realise patients' sleep promotion as a part of their daily activities. Nurses can promote patient's sleep with small activities, as long as the organisation takes care of the nurses' skills and ensures practical interventions so that the patient gets enough rest during the treatment period.

PMID 42928489
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PubMedThe Journal of craniofacial surgery2026-10-26

Quality and Reliability of Neck Wrinkle-Related Short Videos on TikTok and Bilibili: A Cross-Sectional Study.

Ren Ci C, Jin Zhoufeng Z, Zhu Ling L, Yang Jialu J et al.

Neck wrinkles are a common aesthetic concern, and patients increasingly seek information on short-video platforms. However, the quality and reliability of such content remain unclear. To evaluate the quality and reliability of neck wrinkle-related short videos on TikTok and Bilibili. On April 20-22, 2026, we searched the Chinese keyword "Jingwen" on TikTok and Bilibili. The top 150 videos per platform (default comprehensive ranking) were screened. Video characteristics and engagement metrics were recorded. Two independent reviewers assessed quality (Global Quality Score, GQS) and reliability (modified DISCERN, mDISCERN). Of 129 videos analyzed (Bilibili: 39; TikTok: 90), treatment was the dominant content category (89.7% and 95.6%, respectively), while prognostic outcomes were rarely addressed (10.3% and 0%). Bilibili videos were significantly longer (median 182.0 versus 66.5 s, P<0.001) and had higher GQS scores (mean 2.5 versus 2.0, P<0.001), whereas TikTok videos showed higher engagement. Videos by health care professionals received significantly higher GQS (P=0.012) and mDISCERN (P=0.020) scores. Engagement metrics did not correlate with quality or reliability. Neck wrinkle-related short videos have an imbalanced content structure, overemphasizing treatment and neglecting prognosis. Overall quality was moderate. Bilibili videos were of higher quality, and professional-uploaded content was more reliable. Platforms should encourage professional participation and comprehensive content strategies to improve patient education.

PMID 42929805
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PubMedCells2026-10-26

Chromosomal Radiosensitivity in Sjögren's Syndrome with and Without Concomitant Malignancy.

Strljic Elena E, Kuhlmann Lukas L, Wacker Jochen J, Geinitz Hans H et al.

Connective tissue diseases have long been hypothesized to confer increased radiosensitivity and radiotherapy-related toxicity, although findings vary between disease entities. In a previous institutional study, we found increased radiosensitivity in patients suffering from systemic lupus erythematosus (SLE), primarily in patients with concomitant malignancy. We therefore investigated Sjögren's syndrome, an autoimmune disease for which evidence has been limited. Ex vivo chromosomal radiosensitivity was assessed in 45 patients with Sjögren's syndrome (27 non-oncological, 18 oncological) by three-color fluorescence in situ hybridization after 2 Gy irradiation of G0 peripheral blood lymphocytes. Results were compared with 211 healthy controls, 129 breast cancer patients, and the previously characterized SLE cohorts (37 non-oncological, 33 oncological). Demographic, clinical, serological, and treatment-related associations were explored in 31 deeply phenotyped patients. Radiosensitivity was significantly increased in non-oncological Sjögren patients (0.527 breaks per metaphase (B/M)) compared with healthy controls (0.411 B/M; p < 0.001) and non-oncological SLE patients (0.404 B/M; p = 0.001), and it remained similarly elevated in oncological Sjögren patients (0.527 B/M), whereas in SLE increased radiosensitivity was predominantly associated with concomitant malignancy. High-grade anti-SSB positivity was associated with increased radiosensitivity in the unadjusted analysis (p = 0.016), but did not withstand correction for multiple testing (q = 0.124). Sjögren's syndrome is associated with increased ex vivo chromosomal radiosensitivity, with no further apparent increase in patients with concomitant malignancy. This pattern differs from SLE and may suggest a stronger contribution of disease-associated factors. High-grade anti-SSB positivity may represent a relevant serological signal in relation to radiosensitivity, but requires validation in larger cohorts. These findings support closer consideration of individual radiosensitivity in Sjögren's syndrome and highlight the need for prospective studies integrating ex vivo radiosensitivity with radiotherapy-related toxicity and treatment outcomes in this patient population.

PMID 42929827
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PubMedInternational journal of general medicine2026-10-26

Development and Internal Validation of a Clinical Prediction Model for Coronary Slow Flow Phenomenon in Type 2 Diabetes: A Retrospective Observational Study.

Hu Su S, Yan Chang-Shun CS, Xu Tong T, Li Yao Y et al.

Patients with type 2 diabetes mellitus (T2DM) may exhibit coronary slow flow phenomenon (CSFP) despite the absence of obstructive epicardial coronary stenosis. Dedicated prediction tools remain limited. This study aimed to develop and internally validate a model for estimating the probability of TIMI frame count (TFC)-defined CSFP in patients with T2DM. Among 501 patients with T2DM undergoing coronary angiography at a single center in Xinjiang, China (2021-2025), 429 met eligibility criteria. CSFP was defined as maximum coronary stenosis <40% and TFC >27 frames in at least one major coronary artery. Patients were randomly divided into training (n = 300) and validation (n = 129) cohorts. Predictors selected by penalized regression were entered into multivariable logistic regression. Performance was assessed using area under the receiver operating characteristic curve (ROC-AUC), area under the precision-recall curve (AUC-PR), calibration, bootstrap-corrected concordance index, and decision curve analysis; additional analyses were complementary. CSFP occurred in 44 patients (14.7%) in the training cohort and 16 (12.4%) in the validation cohort. The final model included smoking history, systolic blood pressure, hemoglobin A1c, lymphocyte count, and uric acid. ROC-AUC was 0.832 (95% confidence interval [CI]: 0.774-0.889) in the training cohort and 0.840 (95% CI: 0.733-0.946) in the validation cohort; AUC-PR was 0.467 and 0.542, respectively. Calibration was acceptable (Brier scores 0.101 and 0.084); bootstrap-corrected concordance indices were 0.827 and 0.846. Decision curve analysis suggested net benefit across clinically relevant thresholds. Given the limited number of CSFP events in the validation cohort, validation estimates should be interpreted cautiously. We developed and internally validated a five-variable model for estimating the probability of TFC-defined CSFP in patients with T2DM. The model was translated into a nomogram and web-based calculator as a complementary tool for individualized risk characterization. External validation is required before broader clinical application.

PMID 42928914
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