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(S)-atenolol (Atpure)

✓ Approved

Emcure Pharmaceuticals · ADRB1 · 小分子

什么是 (S)-atenolol？

(S)-atenolol 是一种小分子，由Emcure Pharmaceuticals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Atpure
公司Emcure Pharmaceuticals
药物类别小分子
分子靶点ADRB1
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Emcure Pharmaceuticals

作用机制

分子靶点

(S)-atenolol 作用于 1 个分子靶点：

ADRB1adrenoceptor beta 1 (B1AR, RHR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

(S)-atenolol 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedBMC infectious diseases2026-10-26

Clinical characteristics of infections due to Staphylococcus lugdunensis compared to other staphylococcal infections.

Bou Harb Souad S, Mansour Reem R, Al Zoghby Lea L, Khazzeka Alicia A et al.

Staphylococcus lugdunensis is a coagulase-negative staphylococcal species with virulence characteristics resembling those of Staphylococcus aureus. Despite its increasing recognition as a clinically significant pathogen, data comparing its clinical outcomes with other staphylococcal infections remain limited. This study aimed to compare the clinical characteristics, outcomes, and factors associated with unfavorable clinical outcomes among patients with S. lugdunensis, S. aureus, and Staphylococcus epidermidis infections. We conducted a retrospective cohort study at the American University of Beirut Medical Center between January 2019 and December 2023. Adult patients with S. lugdunensis infections were identified and matched by site of infection to patients with S. aureus and S. epidermidis infections. Demographic, clinical, microbiological, treatment, and outcome data were collected. Bivariable analyses and multivariable logistic regression were performed to identify factors independently associated with unfavorable clinical outcome, defined as a composite of in-hospital mortality and major infection-related complications. A total of 301 patients were included: 101 with S. lugdunensis, 103 with S. aureus, and 97 with S. epidermidis infections. Skin and soft tissue infections were the most common presentation of S. lugdunensis (72%), followed by urinary tract infections (16%), bacteremia (8%), and respiratory infections (4%). Compared with S. aureus, S. lugdunensis infections were associated with lower rates of persistent bacteremia (0% vs. 4.9%, p = 0.025) and higher rates of acute renal failure (8.9% vs. 1.9%, p = 0.028). No significant outcome differences were observed between S. lugdunensis and S. epidermidis infections. Overall in-hospital mortality rates were 7.9%, 5.8%, and 7.2% for S. lugdunensis, S. aureus, and S. epidermidis, respectively. In multivariable analysis, S. aureus infection was associated with lower odds of unfavorable clinical outcome than S. lugdunensis (aOR 0.31, 95% CI 0.13-0.75), whereas no significant difference was observed between S. lugdunensis and S. epidermidis. Diabetes mellitus (aOR 2.71, 95% CI 1.27-5.82) and hospitalization within the previous 30 days (aOR 1.97, 95% CI 1.26-3.06) were independently associated with unfavorable clinical outcome. S. lugdunensis demonstrates clinical characteristics and outcomes overlapping those of S. aureus and S. epidermidis. Prompt recognition and appropriate management remain essential to optimize clinical outcomes.

PMID 42928117
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PubMedInorganic chemistry2026-10-26

Flexible Transparent Scintillation Films Based on Chiral Molecular Scintillators Showing Strong Circularly Polarized Luminescence and High-Resolution X-ray Imaging.

Tan Li-Hong LH, Yin Si-En SE, Shi Jia-Ran JR, Hu Jun-Jie JJ et al.

Flexible scintillation films based on chiral molecular scintillators have considerable potential for application in advanced technologies, such as three-dimensional displays, optical information storage, and high-resolution diagnostic imaging. Herein, a pair of chiral Cd-Tb complex enantiomers [(R, R)/(S, S)-(L)2TbCd2(H2O)4] (ClO4)3 (R/S -Cd-Tb) was synthesized, and they exhibit a high PLQY of 38.40% and strong circularly polarized luminescence (CPL) with asymmetry factors of 4.69 × 10-2. R/S -Cd-Tb has strong X-ray scintillation performance with a light yield of 2136 and 2111 ph·MeV-1 based on LuAG:Ce and the X-ray detection limit of 50.6 and 52.1 nGy·s-1, respectively. Chiral flexible transparent scintillation films of R/S -Cd-Tb@PMMA were prepared using R/S -Cd-Tb, and the asymmetry factor of the R/S -Cd-Tb@PMMA film is 2.4 × 10-2. The R/S -Cd-Tb@PMMA film exhibits strong circularly polarized radioluminescence (CPRL) and circularly polarized light-emitting diode emission (CP-LEDs). Moreover, it can deliver prominent CPRL signals and achieve high-resolution X-ray imaging with a spatial resolution of 23.96 lp/mm. The results indicate that chiral lanthanide complexes represent a promising class of chiral molecular scintillator materials.

PMID 42929642
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PubMedJournal of applied toxicology : JAT2026-10-26

Large-Scale Monitoring, Biochemical Mechanism, and Fitness Cost of Resistance to Chlorfenapyr in a Near-Isogenic Strain of Spodoptera litura (Lepidoptera: Noctuidae) From China.

Liu Chenghong C, Tang Juan J, Qu Cheng C, Ma Xiaoli X et al.

Spodoptera litura is a globally important polyphagous herbivore that has developed resistance to many widely used insecticides. Chlorfenapyr is a pyrrole insecticide with demonstrated efficacy against lepidopteran pests, but the susceptibility baseline and field-evolved resistance in S. litura remain poorly characterized. In this study, we built a near-isogenic strain (JZ-NIL) based on one field-collected chlorfenapyr-resistant population of S. litura and characterized patterns of cross-resistance, fitness costs, and mechanism of metabolic resistance. In comparison with the susceptible Lab-S strain, the field-sampled JZ population displayed approximately 225.0-fold resistance to chlorfenapyr. The JZ-NIL strain was built and showed 124.2-fold chlorfenapyr resistance, with no apparent cross-resistance to broflanilide, chlorpyrifos, chlorantraniliprole, emamectin benzoate, indoxacarb, and spinetoram. Assays of enzyme activity and tests of synergism showed that diethyl maleate (DEM) made a synergistic ratio of 1.9 against chlorfenapyr, and glutathione S-transferase (GST) activity in JZ-NIL was 1.8-fold significantly higher than in the strain of Lab-S, indicating that GST-mediated metabolism contributes to chlorfenapyr resistance. In addition, pupation rate, fecundity, and hatchability were significantly lower in JZ-NIL than in Lab-S. The relative fitness of JZ-NIL was 0.54 compared with Lab-S. Overall, these results indicate that GST-mediated detoxification contributes to chlorfenapyr resistance in S. litura and that this resistance is associated with significant fitness costs. Further studies are needed to clarify the metabolic and target-site mechanisms underlying chlorfenapyr resistance.

PMID 42928584
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PubMedInorganic chemistry2026-10-26

Terminal Oxygen as a Proton Acceptor: S-H Activation via Proton-Coupled Electron Transfer in Decavanadate-Catalyzed P(O)-S Coupling.

Wang Li Li LL, Shu Wei-Xuan WX, Wang Ya Y, Zhong Rong-Lin RL et al.

Polyoxometalates-catalyzed P-S oxidative coupling under mild conditions has emerged as a promising sustainable route to thiophosphates for pharmaceuticals and agrochemicals. This work reveals that the decavanadate cluster-catalyzed oxidative coupling between phosphine oxide and thiophenol involves four elementary steps, in which the rate-determining step is S-H bond activation via proton-coupled electron transfer (PCET). The polyoxovanadate cluster acts as a proton relay station, stabilizing the key proton in the transition state and facilitating its transfer. Interestingly, the proton preferentially transfers to a terminal oxygen rather than a bridging oxygen, with simultaneous electron transfer to the adjacent vanadium center. The terminal oxygen atom is more reactive than the bridging one because the [H3V10VO28]3- skeleton incurs a smaller electronic reorganization penalty for electron transfer in the terminal oxygen via a PCET pathway. On the other hand, the preferential activation of the S-H bond over the P-H bond in the [H3V10VO28]3--catalyzed reaction arises from both the smaller S-H bond dissociation energy and the better orbital energy match with the thiol substrate. These findings provide a theoretical foundation for understanding PCET in polyoxometalate catalysis and expanding the application of POMs in organic synthesis.

PMID 42929611
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PubMedInorganic chemistry2026-10-26

Solvent-Directed Self-Assembly of Chiral Metal-Organic Cages and Coordination Polymers from Identical Components and Their Circularly Polarized Luminescence.

Zhang Xu-Zong XZ, Zhou Chuang-Wei CW, Lai Ya-Liang YL, Xie Mo M et al.

This work reports the solvent-directed synthesis, structures, and chiroptical properties of enantiomeric Zn(II) metal-organic cages (MOCs) and coordination polymers (CPs) assembled from identical subcomponents under the same conditions. Varying the DMF/MeOH ratio selectively produces either a discrete cubic cage (1-R/S) or a chain polymer (2-R/S). Both materials exhibit blue emission, with the MOCs demonstrating higher solid-state quantum yields. MOCs 1-R/S in poly(methyl methacrylate) films exhibit clear circularly polarized luminescence (CPL) (|glum| ≈ 4.0 × 10-4), whereas CPs 2-R/S display very weak CPL signals (|glum| ≈ 1.0 × 10-5). This work highlights that the supramolecular structure determines the CPL performance of excited-state chirality.

PMID 42929619
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PubMedJournal of virology2026-10-26

Early innate immune signatures correlate with Ad26.COV2.S vaccine immunogenicity and protective efficacy.

Colarusso Alessandro A, Stephenson Kathryn E KE, Collier Ai-Ris Y A-RY, Wegmann Frank F et al.

The innate immune system is rapidly activated following antigen exposure and plays a critical role in shaping the ensuing adaptive immune responses. In this study, we performed bulk RNA sequencing and proteomic profiling in a cohort of 25 rhesus macaques following Ad26.COV2.S immunization to characterize early innate correlates of vaccine immunogenicity and protection. Our results show that innate immune activation occurred as early as day 1 post-vaccination and demonstrated a systemic enrichment of antiviral interferon pathways, cytokine signaling, and activation of innate immune cell signatures. These early transcriptomic signatures correlated positively with humoral and cellular immune responses at 6 weeks following vaccination and correlated inversely with viral loads following SARS-CoV-2 challenge. Similar correlates of immunogenicity were observed in a cohort of 25 adult healthy participants vaccinated with Ad26.COV2.S. Taken together, these findings highlight the importance of early activation of the innate immune responses following Ad26.COV2.S vaccination in shaping the protective adaptive immune response.IMPORTANCEEarly innate immune responses may shape vaccine immunogenicity and protection. We evaluated responses to Ad26.COV2.S vaccination in rhesus macaques and humans and found that day 1 innate immune signatures correlated with subsequent adaptive responses. These findings suggest that early post-vaccination immune programming influences immunogenicity and protective efficacy months later.

PMID 42929544
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