北京若生智能科技有限公司
Drug Database
KE

ketoprofen (Ketopatch / ketoprofen, Pacific / Ketotop patch)

✓ Approved

Aestura · PTGS1 · 小分子

什么是 ketoprofen？

ketoprofen 是一种小分子，由Aestura研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

商品名Ketopatch, ketoprofen, Pacific, Ketotop patch
公司Aestura
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Aestura

作用机制

分子靶点

ketoprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen 针对 6 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsEpicondylitis✓ Approved
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved
Musculoskeletal and connective tissue disordersOsteoarthritis✓ Approved
Musculoskeletal and connective tissue disordersRheumatoid arthritis✓ Approved

注册免费账户还可查看另外 1 个适应症

免费注册查看全部适应症 →

相关研究文献

PubMedPhysical chemistry chemical physics : PCCP2026-10-26

Stereoselectivity of photoinduced interaction of nonsteroidal anti-inflammatory drug S-ketoprofen with (L/D)-Trp-Leu-Pro-Phe peptide in solution studied by NMR, CIDNP and molecular dynamics simulation.

Selyutina Olga Yu OY, Polyakov Nikolay E NE, Molokoedov Alexander S AS, Sidorova Maria V MV et al.

The stereoselectivity of chiral drug interactions with enzymatic active sites and cellular receptors is a subject of significant scientific interest. This interest is driven, firstly, by the pronounced differences in the therapeutic activity of drug enantiomers and, secondly, by the emerging role of amino acid chiral inversion in peptides associated with pathologies such as Alzheimer's, Parkinson's, and type II diabetes. To probe the fundamental steps of such biomolecular interactions, electron transfer (ET) serves as a well-defined elementary chemical process. Prior investigations of photoinduced ET in chiral donor-acceptor dyads, incorporating (S)-ketoprofen and (L/D)-tryptophan, have revealed stereoselective and spin-selective phenomena. Extending this work, the present study examines the interaction of (S)-ketoprofen with the L- and D-enantiomers of tryptophan within the tetrapeptide tryptophan-leucine-proline-phenylalanine (WLPF), in homogeneous non-aqueous solutions. Utilizing NMR spectroscopy, chemically induced dynamic nuclear polarization (CIDNP) to detect transient paramagnetic intermediates, and molecular modeling, we have demonstrated that (S)-ketoprofen exhibits stereoselective interaction with the peptide epimers. Furthermore, it was shown that the D-epimer of the peptide has a greater tendency to aggregation than the L-epimer. The stereoselective light-induced formation of the ketoprofen ketyl radicals provides a plausible mechanistic basis for ketoprofen's phototoxic side effects.

PMID 42929292
阅读全文 →
PubMedAquaculture nutrition2026-10-26

Replacement of Wheat With Barley With or Without Exogenous Carbohydrases in Pacific White Shrimp (Litopenaeus vannamei): Effects on Growth, Digestibility, and Gene Expression.

Gonzalez Jairo A JA, Singha Krishna P KP, Bruce Timothy J TJ, Davis D Allen DA

Barley can potentially replace wheat in aquaculture feed. However, barley contains relatively higher fiber and β-glucans levels, which may reduce digesta viscosity, and hinder endogenous enzyme activities. Supplementation of exogenous enzymes in barley-based diets could aid in hydrolyzing the non-starch polysaccharides (NSP). To investigate the effects of enzyme supplements in barley-based diets replacing wheat, a 5-week growth trial was conducted on Pacific white shrimp (Litopenaeus vannamei). Six isonitrogenous (~35%) and isolipidic (~8%) diets were formulated, namely, whole wheat-based (17.42%) basal diet (BW); barley-based basal diet (BB); and four enzyme-supplemented diets were BB supplemented with either xylanase (XYL) or a multienzymatic solution (MES) which contains pectinase, protease, phytase, β-glucanase, XYL, cellulase, and amylase. XYL and MES amount was determined based on manufacturers' recommended dose (low, L) (0.01 and 0.05 g/100 g diet, respectively) and double the recommended dose (high, H) (0.02 and 0.10 g/100 g diet, respectively) and denoted as BB:XYL-L, BB:XYL-H, BB:MES-L, and BB:MES-H. Shrimp (0.72 ± 0.03 g) were stocked in 108-L aquaria. Diets were randomly assigned, with six tanks per treatment. At the completion of the trial, growth performance, apparent digestibility coefficients (ADCs), and physiological gene expression in hepatopancreas were analyzed. Growth parameters showed no significant differences (p  > 0.05). However, significant differences in ADC of energy (p = 0.010) and dry matter (p = 0.001) were observed. The BB:XYL-L diet significantly increased energy digestibility compared to BB group. No significant differences in hepatopancreatic gene (tor, tghsr1l, cat, tgfβ, propo, lgbp, and hsp70) expression were detected among treatments (p  > 0.05), although clustering patterns suggested similarity between multienzyme and wheat-based diets. Overall, barley can replace wheat in Pacific white shrimp diets without impairing growth, while XYL supplementation may improve energy utilization.

PMID 42928866
阅读全文 →
PubMedOpen access rheumatology : research and reviews2026-10-26

The Burden and Temporal Trends of Rheumatoid Arthritis in High-Income Countries and Territories, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023.

Mak Tsui Chi TC, Tang Celine Cinlin CC, Choi Jenny Man Chik JMC, Law Karlen Ka Pui KKP et al.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing progressive joint damage, disability, and excess mortality. Evaluating long-term epidemiological trajectories across high-resource health systems is essential for optimizing rheumatology care. This study analyzes the burden and 33-year temporal trends of RA across high-income countries and territories using Global Burden of Disease (GBD) Study 2023 estimates. We analyzed incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) across 36 high-income countries and territories (5 GBD regions: Australasia, High-income Asia Pacific, High-income North America, Southern Latin America, and Western Europe) from 1990 to 2023. To distinguish clinical risk from population growth and aging, we prioritized age-standardized rates (ASRs per 100,000) alongside absolute metrics. We present all estimates with 95% uncertainty intervals (UIs). In 2023, high-income settings accounted for 0.26 million incident cases, 4.98 million prevalent cases, 0.80 million DALYs, and 10,190 deaths. From 1990 to 2023, absolute prevalent cases (+72%) and DALYs (+49%) grew substantially due to demographic aging. Conversely, underlying age-standardized incidence (17.12 [95% UI: 15.69-18.83]) and prevalence (282.80 [95% UI: 256.24-314.48]) increased modestly (+9% and +10%), while age-standardized DALY rates (44.14 [95% UI: 32.63-56.59]) fell by 7% and age-standardized death rates (0.39 [95% UI: 0.34-0.45]) decreased markedly by 41%. Australasia exhibited the highest ASRs across all metrics in 2023, whereas Southern Latin America demonstrated the sharpest ASR increases (+54% incidence, +62% prevalence, +34% DALYs). High-income Asia Pacific achieved the largest ASR reductions (-14% incidence, -12% prevalence, -26% DALYs, -49% deaths). Females and adults aged over 60 years consistently bore the primary disease burden. While age-standardized mortality has dropped substantially, reflecting improved management of RA and its comorbidities, the non-fatal disability burden continues to expand alongside population aging. Rheumatology health services must shift toward long-term disability management, early treat-to-target intervention, and addressing persistent regional disparities.

PMID 42928873
阅读全文 →
PubMedPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2026-10-26

Tropospheric Ozone Assessment Report II: Ozone distribution and variability in the oceanic and polar regions.

Sommariva Roberto R, Koenig Theodore K TK, Sekiya Takashi T, Badia Alba A et al.

Oceanic and polar regions are critical for global atmospheric processes, but an evaluation of ozone distributions and trends in these regions has been missing. In this assessment, part of the TOAR-II project, we report lower atmosphere ozone concentrations over open oceans and polar regions: with data from ships, buoys, aircraft and ground sites from 1975 to 2023, this is the most comprehensive dataset yet. Ozone trends were determined using Linear Mixed-effects Modelling (LMM). In most regions, trends have been modest since the mid-1970s (<1 nmol mol-1 per decade), positive in the mid-latitudes and tropical regions (with medium-low certainty), negative in the North and Tropical Pacific (with low and high certainty, respectively), increasing in Antarctica and decreasing in the Arctic. Seasonal effects often influence the long-term trends in extra-tropical regions. Five global and one hemispheric models were used to aid the interpretation of the sparse observations. The seasonal cycles are reasonably well reproduced, although models disagree with each other and with the observations on the distribution of ozone, especially in the tropics and in the Arctic. Changes in methane, iodine, shipping emissions, nitrogen oxides emissions, and terrestrial and marine volatile organic compound are likely to be important drivers for ozone over the oceans, although specific attributions are uncertain owing to insufficient data. This article is part of the theme issue 'Tropospheric Ozone Assessment Report II'.

PMID 42929035
阅读全文 →
PubMedBioinformatics (Oxford, England)2026-10-26

SomatiX: accurate and efficient somatic SNV detection from matched tumor-normal long-read DNA sequencing.

Liu Zelin Z

Accurate somatic single-nucleotide variant (SNV) calling from matched tumor-normal long-read DNA sequencing remains challenging because sequencing errors, variable tumor purity, tumor-in-normal contamination, and low variant allele fractions (VAFs) can obscure tumor-specific signals. Although recent deep-learning methods have improved long-read somatic variant calling, robust low-VAF detection and efficient genome-scale analysis remain important methodological challenges. We present SomatiX, a deep-learning method for somatic SNV detection from matched tumor-normal long-read DNA sequencing data, built on an allele-aware pileup representation. In comprehensive cancer benchmark analyses across diverse cell-line datasets, sequencing contexts, VAF bins, and minimum variant-supporting read thresholds, SomatiX outperformed DeepSomatic and ClairS in F1 score across most Oxford Nanopore Technologies (ONT) benchmark conditions and achieved competitive performance on Pacific Biosciences (PacBio) data. Across the held-out chromosome 1 cancer cell-line benchmarks, at the threshold of ≥ 3 variant-supporting reads and VAF ≥0.05, SomatiX achieved mean F1 scores of 0.986 for ONT data and 0.988 for PacBio data. SomatiX showed particularly strong performance for low-VAF SNVs in ONT data while using a compact model and achieving the fastest runtime among the evaluated tools. SomatiX is available at https://github.com/colinliuzelin/SomatiX and archived at Zenodo under DOI: https://doi.org/10.5281/zenodo.22062438. The repository includes source code, trained models, and benchmarking scripts. Supplementary data are available at Bioinformatics online.

PMID 42928626
阅读全文 →
PubMedBMC medicine2026-10-26

Prenatal COVID-19 pandemic-related traumatic stress and risk of child neurodevelopmental disorders: a cohort study.

Grosvenor Luke P LP, Anderson Meredith M, Qian Yinge Y, Alexeeff Stacey E SE et al.

The COVID-19 pandemic was a prolonged period of traumatic stress with potentially lasting health impacts, especially for vulnerable groups including pregnant individuals. Prenatal stress has been associated with greater risk of neurodevelopmental disorders (NDD), warranting investigation of prenatal pandemic-related traumatic stress (PTS) as a risk factor for NDD. We surveyed Kaiser Permanente Northern California (KPNC) members who were ≥ 12 weeks pregnant between June 2020 and September 2022. PTS was measured using the 10-item PTS Scale and modeled as a continuous total symptom score (range: 0-10) and binary exposure (high, ≥ 9; low, < 9). We prospectively followed children through July 2025 and linked to sociodemographic and medical characteristics, including NDD diagnoses, in KPNC electronic records. We fit Cox regression models adjusted for maternal age, race and ethnicity, insurance type, SARS-CoV-2 infection, pre-pregnancy BMI, pre-pregnancy depression, child birthyear and sex to estimate hazard ratios (HR) for any NDD and separately for autism spectrum disorder (ASD) associated with PTS and evaluated effect modification by child sex. Of 13,859 mothers, 21.1% identified as Asian, 3.0% as Black, 19.6% as Hispanic, 4.6% as Multiracial, < 1.0% as Native American or Pacific Islander, 49.0% as White, and 1.7% were of Unknown race. The mean (SD) PTS score was 3.9 (2.6) and 722 (5.2%) mothers had high PTS (≥ 9); 2,750 (19.8%) children were diagnosed with any NDD and 651 (4.7%) with ASD. Higher PTS symptom score was associated with significantly greater risk of any NDD (HR = 1.02, 95% CI = 1.01-1.04) and ASD (HR = 1.04 [1.01-1.07]) per 1-point increase in continuous score. High compared to low PTS was associated with greater risk of NDD diagnoses (HR = 1.18 [1.01-1.37]) and ASD (HR = 1.20 [0.89-1.62]), although not statistically significant for ASD. Associations did not differ by sex for NDD (HRFemales= 1.20 [0.92-1.56], HRMales= 1.17 [0.96-1.41]; interaction P = 0.78) or ASD (HRFemales= 1.31 [0.73-2.34], HRMales= 1.17 [0.82-1.65]; interaction P = 0.60). Among this cohort of mothers who were pregnant during the COVID-19 pandemic, higher PTS was associated with greater risk of child NDD diagnoses. Further research is needed to investigate the potential biologic mechanisms underlying this association.

PMID 42928291
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多ketoprofen