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anti-D immunoglobulin

✓ Approved

Kedrion · 多克隆抗体 · 多克隆抗体

什么是 anti-D immunoglobulin？

anti-D immunoglobulin 是一种多克隆抗体，由Kedrion研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司Kedrion
药物类别多克隆抗体, 细胞治疗, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Kedrion

治疗适应症

anti-D immunoglobulin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersRhesus haemolytic disease of newborn✓ Approved

相关研究文献

PubMedCureus2026-10-26

Evaluation of the Cytotoxic Effect of Calcium Silicate-Based Bioceramic Sealers: An In Vitro Comparative Study.

Bagade Prashikkumar P, Borthakur Bikash Jyoti BJ, S Ganesan G, B Swathika S

Calcium silicate-based bioceramic sealers have become increasingly popular due to their biocompatibility, bioactivity, and potential for periapical tissue integration. However, evaluating their cytotoxic effects on fibroblast cell lines remains limited. The aim of this study was to compare the cytotoxic effects of two commercially available calcium silicate-based bioceramic root canal sealers on L929 mouse fibroblast cells, using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to assess cell viability following exposure to serial dilutions (100%-6.25%) of sealer extracts. Leachates were prepared by incubating for 24 hours in 2 mL of serum-free Dulbecco's Modified Eagle Medium (DMEM) through 0.2 μm polyethersulfone (PES) syringe filters from sets of specimens from both sealers. L929 mouse fibroblast cells were seeded at a density of 1×104 cells/well and treated with five serial dilutions (100%, 50%, 25%, 12.5%, and 6.25%) of sealer extracts. Cell viability was determined spectrophotometrically at 570 nm by MTT assay. Dimethyl sulfoxide (DMSO) (10%) was used as a positive control, and cells without treatment were used as a negative control. Cell viability was significantly decreased with both 100% and 50% concentrations of Bio-C Sealer (Angelus Indústria de Produtos Odontológicos S/A, Londrina, Brazil) (4.89% and 9.31%, respectively) and Prime MTA Bioceramic Root Canal Sealer (Prime Dental Products Pvt Ltd, Maharashtra, India) (5.28% and 8.30%, respectively). However, at lower concentrations, cell viability recovered significantly and approached the control level at 6.25%. At 25% concentration, a statistically significant difference (p=0.002) was observed, with Bio-C Sealer showing better cytocompatibility (92.86% vs 68.35%). Bio-C Sealer and Prime MTA Bioceramic demonstrated significant cytotoxicity at high extract concentrations with acceptable biocompatibility at clinically relevant dilute concentrations. Bio-C Sealer exhibited superior cytocompatibility at the 25% concentration and a higher IC₅₀ value, indicating better overall cytocompatibility. The comparatively favourable cytocompatibility profile of Bio‑C Sealer at intermediate concentrations suggests that material selection may be influenced by its reduced cytotoxic potential, particularly in scenarios where periapical tissue contact is likely. These findings highlight the importance of considering biological performance alongside physicochemical properties when choosing endodontic sealers.

PMID 42928799
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PubMedGels (Basel, Switzerland)2026-10-26

Conceptual Frameworks and Practice on Nano-Micro Pore Structure Design of Bio-Aerogels.

Yuan Shuai S, Yang Jiaren J, Wu Kao K, Qian Hong H et al.

Bio-aerogels have garnered significant attention due to their environmental friendliness and potential for exceptional performance. The pore structure of bio-aerogels includes both pore size and distribution, which significantly determine their functional behaviors, such as filtration, thermal insulation, and sound absorption. This review proposes several conceptual frameworks regarding the design of the pore structure of bio-aerogels, some of which are validated through practical cases. The ice crystal pore-making conceptual framework approach involves controlling the growth of ice crystals to achieve a pre-designed pore structure. The space occupying pore-making conceptual framework is the proactive addition of nano materials to occupy space prior to the formation of ice crystals, facilitating the design of the aerogel's nanoscale pore structure. The conceptual framework of blocks building involves assembling multiple aerogels to create a composite aerogel with a multi-level pore structure. These theoretical considerations contribute to the development of aerogel structural design theory to obtain aerogels with different micro-nano structures.

PMID 42929920
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PubMedDentistry journal2026-10-26

Xenogeneic Grafts Combined with Platelet Concentrates: Effects on Bone Microarchitecture and Collagen Maturation.

Braga Wanderson Thalles de Souza WTS, Martins Ulli da Costa Cunha UDCC, Sávio Débora de Souza Ferreira DSF, Silva Lucia Moitrel Pequeno da LMPD et al.

Background: This study assessed the impact of xenogeneic bone grafts (XEN), either utilized alone or combined with autologous platelet concentrates (APCs) prepared using three different centrifugation protocols, on the healing of critical-size defects (CSDs) in rat calvaria. Methods: Forty rats were assigned to five groups (n = 8): Control, XEN, XEN + L-PRF, XEN + A-PRF, and XEN + Bio-PRF. Blood concentrates were prepared by centrifuging blood collected via cardiac puncture: L-PRF (~700 g for 12 min), A-PRF (~208 g for 14 min), and Bio-PRF (~700 g for 8 min). Defects (5 mm diameter) in the right parietal bone of each rat were filled with blood clot, XEN, or XEN combined with L-PRF, A-PRF, or Bio-PRF. Animals were euthanized 60 days post-surgery, and the calvariae were analyzed using histomorphometry and micro-CT. The percentage of mature and immature collagen fibers was analyzed using Picrosirius red staining under polarized light microscopy. Results: Groups XEN-A-PRF, XEN-L-PRF, and XEN-Bio-PRF presented higher bone volume (BV/TV) than the control group (14.35 ± 6.42%, 11.96 ± 4.68%, and 14.92 ± 3.47%, respectively, vs. 4.13 ± 2.25%; p < 0.05). These groups also presented lower bone porosity (BP) than the control group (p < 0.05). The XEN group did not show different values of BV/TV and BP compared to the control group. Only the XEN + A-PRF and XEN + Bio-PRF groups showed a higher percentage of mature collagen fibers (red color) compared to the XEN and control groups (p < 0.05). The control and XEN groups showed a higher amount of immature collagen fibers (green color) compared to the XEN + A-PRF, XEN + L-PRF, and XEN + Bio-PRF groups (p < 0.05). Conclusions: It can be concluded that CSDs treated with XEN combined with APCs presented a more favorable bone microarchitecture than untreated CSDs after a 60-day healing period. Furthermore, CSDs treated with XEN combined with A-PRF or Bio-PRF showed greater collagen maturation than those treated with XEN alone, suggesting that the centrifugation protocol used for preparing APCs may be a decisive factor for the quality of the collagen matrix in newly formed bone tissue.

PMID 42930441
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PubMedAdvanced healthcare materials2026-10-26

Recent Advances of Functional and Smart Polymeric Hydrogels Toward Cutting-Edge Applications in Ophthalmology.

Wu Yue Y, Li Meng M, Le Xiaoxia X, Chen Tao T et al.

Ophthalmic engineering is defined by a rigorous set of constraints including the need for absolute optical clarity, precise viscoelasticity, and the ability to navigate formidable physiological barriers. Polymeric hydrogels have ascended as the quintessential material class to resolve these conflicts by leveraging their high content of water to create a seamless interface with native ocular tissues. This review critically examines the transition of these materials from passive structural substitutes to dynamic and stimulus-responsive systems. The molecular strategies required to balance mechanical robustness with biodegradation are dissected alongside the integration of responsive moieties that react to physiological cues. These principles are explored through cutting-edge clinical applications including suprachoroidal drug depots, bio-integrative tissue sealants, and closed-loop biosensing contact lenses. Finally, the discussion addresses the translational gap separating laboratory innovation from industrial manufacturing. By identifying persistent hurdles such as the inherent trade-off between long-term stability and transparency as well as sterilization compatibility, a strategic roadmap is outlined for the next generation of vision-restoring technologies.

PMID 42928516
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PubMedTransfusion2026-10-26

Blocking FcγRI and FcγRIII reduces RBC phagocytosis induced by patient-derived anti-E and anti-K alloantibodies in vitro.

Cabado Yaima Tundidor YT, Gonzalez Lazaro Gil LG, Noa Yeniley Ruiz YR, Oro Alequis Pavon AP et al.

Red blood cell (RBC) alloantibodies can cause hemolytic transfusion reactions and complicate compatible blood provision. Although antibody-opsonized RBCs are thought to be cleared partly through macrophage Fcγ receptor-mediated phagocytosis, the Fcγ receptors involved in phagocytosis induced by non-D alloantibodies remain incompletely defined. RBCs were sensitized with WHO anti-E or anti-C typing sera, or with plasma/serum from patients alloimmunized against RhE or K. Phagocytosis was assessed using THP-1-CD16A macrophages expressing FcγRI, FcγRIIA, and FcγRIII. Receptor involvement was evaluated using receptor-specific deglycosylated blocking monoclonal antibodies. RBCs sensitized with WHO anti-E or anti-C sera, or with patient-derived anti-E or anti-K alloantibodies, were phagocytosed by THP-1-CD16A macrophages. FcγRI or FcγRIII blockade reduced phagocytosis, although the magnitude of inhibition varied by antibody source and individual patient sample. FcγRIIA blockade produced little or no significant reduction across the conditions tested. Combined FcγRI and FcγRIII blockade produced the greatest inhibition with WHO reference sera, although inhibition was not fully additive. Patient-derived anti-E and anti-K samples showed a similar pattern. These findings support a functional contribution of FcγRI and FcγRIII to alloantibody-mediated RBC phagocytosis in this in vitro macrophage model, while suggesting a limited role for FcγRIIA under these experimental conditions.

PMID 42928980
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PubMedActas espanolas de psiquiatria2026-10-26

Association Among Systemic Immune-Inflammation Index, Vitamin D Status and Clinical Subtypes of ADHD: A Retrospective Investigation.

Lu Tingting T, Chen Yingying Y, Hu Feiping F, Zhu Yingping Y

Attention-deficit/hyperactivity disorder (ADHD) has been linked to immune dysregulation and nutritional imbalance. The systemic immune-inflammation index (SII) is a composite inflammatory marker, while serum 25-hydroxyvitamin D (25(OH)D) reflects vitamin D status. Their joint association with paediatric ADHD remains incompletely characterised. In this retrospective case-control study, 78 treatment-naïve children with ADHD and 40 non-ADHD outpatient comparison children selected using frequency matching by age and sex were included. The most recent laboratory results available in the outpatient record were extracted. Given that some 25(OH)D values were derived from reports obtained outside our hospital, all available 25(OH)D records were manually re-checked against source documents and standardised to ng/mL prior to analysis. Group comparisons, whole-sample Spearman correlation analyses, logistic regression models including an interaction term between standardised SII and standardised 25(OH)D and exploratory receiver operating characteristic (ROC) analyses were performed. Sensitivity analysis and Firth penalised logistic regression were additionally conducted. Compared with the comparison group, children with ADHD had significantly higher SII, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels, together with lower serum 25(OH)D. The ADHD group was more likely to fall into lower clinically defined 25(OH)D categories, whereas the comparison group was more frequently in the ≥30 ng/mL category; this pattern remained directionally consistent after stratification by season of blood draw. In the whole study sample, SII was positively correlated with attention, impulsivity and oppositional scores, whereas serum 25(OH)D was inversely correlated with these symptom dimensions; SII was also inversely correlated with 25(OH)D. In the parsimonious model, the interaction term between standardised SII and standardised 25(OH)D was statistically significant (odds ratio (OR) = 3.06, 95% confidence interval (CI) 1.59-6.80, p = 0.002), and it remained significant in the broader sensitivity model and Firth penalised regression. In exploratory within-sample analysis, ROC curves yielded area under curves (AUCs) of 0.808 for SII, 0.781 for serum 25(OH)D and 0.836 for the parsimonious multivariable model. Paediatric ADHD was associated with high inflammatory burden and low serum 25(OH)D status in this retrospective outpatient sample. The statistically significant interaction between SII and 25(OH)D suggests a stable pattern of effect modification on the logistic model scale. These findings support a potentially relevant immuno-nutritional pattern in ADHD, but prospective validation is needed before causal interpretation or clinical implementation can be considered.

PMID 42928691
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