北京若生智能科技有限公司
Drug Database
IO

ior-t3 (IORt3)

✓ Approved

Center of Molecular Immunology · CD3E · 单克隆抗体

什么是 ior-t3？

ior-t3 是一种单克隆抗体，由Center of Molecular Immunology研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名IORt3
公司Center of Molecular Immunology
药物类别单克隆抗体, 抗体
分子靶点CD3E
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Center of Molecular Immunology

作用机制

分子靶点

ior-t3 作用于 1 个分子靶点：

CD3ECD3 epsilon subunit of T-cell receptor complex (TCRE, CD3epsilon)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ior-t3 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersSolid organ transplant rejection✓ Approved

相关研究文献

PubMedFrontiers in endocrinology2026-09-10

Association of static balance parameters with prediabetes: a cross-sectional study and nomogram development.

Wang Zhishan Z, Huang Liangliang L, Lin Chen C, Liang Jingran J et al.

To investigate the association between static balance function parameters and prediabetes, and to develop a nomogram integrating center-of-pressure path length, Romberg ratios, and sex, thereby evaluating its potential as a candidate functional screening tool. A cross-sectional observational design was adopted. A total of 97 patients with prediabetes and 44 age-matched healthy controls were consecutively enrolled from January 2024 to June 2025 at the Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine. General characteristics and static balance parameters under four sensory conditions were compared between groups. Variables were first screened via Least Absolute Shrinkage and Selection Operator (LASSO) regression, followed by multivariable logistic regression to identify independent associations. A nomogram was then constructed. Model discrimination and calibration were assessed using the receiver operating characteristic curve, Hosmer-Lemeshow test, and 1000-bootstrap internal validation (corrected C-statistic, calibration slope/intercept, Brier score). Effect sizes were quantified using Cohen's d. Compared with the healthy control group, the prediabetes group exhibited significantly higher values for Y-COP and COP-PL under Condition 1, RRA and RRT under Condition 2/1, as well as Y-COP, COP-EA, and COP-PL under Conditions 3 and 4 (all P < 0.05). LASSO regression retained T1 COP-PL, T3 COP-PL, T4/T3 RRA, and RRT as candidate variables. Multivariable logistic regression showed that female sex (vs. male, OR = 0.208, 95% CI: 0.044-0.973; P = 0.046), T1 COP-PL (per unit increase, OR = 0.990, 95% CI: 0.980-0.999), T3 COP-PL (per unit increase, OR = 1.016, 95% CI: 1.008-1.023), and T4/T3 RRA (per unit increase, OR = 1.013, 95% CI: 1.007-1.020) were independently associated with prediabetes. A nomogram incorporating these variables yielded an AUC of 0.972. After bootstrap internal validation, the corrected AUC was 0.964 (95% CI: 0.941-0.991), with a calibration slope of 0.806, intercept of -0.011, and Brier score of 0.075, indicating good discrimination and calibration. Cohen's dvalues for T1 COP-PL, T3 COP-PL, and T4/T3 RRA were -0.40, 1.45, and 1.39, respectively, reflecting moderate to large effect sizes. Static balance indices including T1 COP-PL, T3 COP-PL, and T4/T3 RRA are associated with prediabetes. The nomogram combining these measures with sex demonstrated robust performance in internal validation, offering a functional perspective that may aid in the auxiliary screening of prediabetes. Nevertheless, as a cross-sectional exploratory study, these associations do not imply causality, and the model requires external validation before its clinical generalizability can be determined.

PMID 42718427
阅读全文 →
PubMedCancer medicine2026-09-10

Serum Levels of Thyroid Hormones in Relation to Breast Cancer Prognosis: A Multicentre Cohort Study.

Brange Annie A, Heyman Ylva Y, Demircan Kamil K, Vallon-Christersson Johan J et al.

Thyroid function has been suggested to be associated with breast cancer risk, but not much is known about thyroid hormones as a potential prognostic factor for breast cancer. This study investigated the relation between thyroid hormones in breast cancer patients and mortality. A total of 2000 breast cancer patients from the Swedish SCAN-B cohort were followed for 9 years. Blood samples were collected at the time of diagnosis, before surgery, and analysed for free and total T3 and T4. All-cause mortality and recurrent disease were compared between quartiles (Q) using Cox proportional hazard analysis adjusted for prognostic factors, yielding hazard ratios (HR) with 95% confidence intervals (CIs). During follow-up, 310 deaths and 167 recurrences occurred. Free T3 was associated with a lower mortality; the combined group Q2 to Q4 had an adjusted HR of 0.73 (0.58-0.93) as compared to Q1. Moreover, a high ratio of free T3/T4 was associated with a low mortality in Q2, Q3 and Q4, respectively. High levels of free and total T4 were associated with a high risk of all-cause mortality; the crude HR for free T4 Q4 vs. Q1 was 1.53 (1.14-2.07) and the corresponding HR for total T4 was 1.63 (1.20-2.22). These results did not remain in the adjusted analysis. No clear associations were found regarding recurrent disease. We conclude that high levels of free T3, and a high free T3/T4 ratio were associated with a lower risk of all-cause mortality and may be a marker of a favourable prognosis.

PMID 42717518
阅读全文 →
PubMedEuropean journal of oral sciences2026-09-10

Effect of chitosan-containing desensitizers applied prior to bleaching on the physical properties of enamel.

Barbato Júlia J, Passos Luís Otávio LO, Barbosa Carolina Meneghin CM, Benati Marcos Roberto de Lima MRL et al.

This in vitro study evaluated the effects of adding chitosan (Chi) to desensitizing agents applied before dental bleaching on enamel properties. Bovine enamel specimens were allocated to seven groups (n = 12): no treatment (negative control), 2% NaF (positive control), 2% NaF + 2% Chi, 2% NaF + 5% Chi, 2% NaF + 5% KNO3, 2% NaF + 5% KNO3 + 2% Chi, and 2% NaF + 5% KNO3 + 5% Chi. All specimens underwent three bleaching sessions with 35% hydrogen peroxide, each preceded by a 10-min application of desensitizing agents. Color change (∆L*, ∆a*, ∆b*, ∆Eab, and ∆E00), whiteness index (∆WID), surface roughness (Ra), and microhardness (SMH) were evaluated at baseline (T0) and after each session (T1-T3). Scanning electron microscopy analysis was performed at T3. Color parameters did not differ among groups (p > 0.05), indicating bleaching efficacy. Surface roughness increased in all groups (p < 0.0001), with greater increases in chitosan-containing groups. However, groups 2% NaF + 5% Chi and 2% NaF + 5% KNO3 + 5% Chi showed significantly higher microhardness values than controls at T2 and T3. Incorporation of chitosan into desensitizing agents increased enamel surface roughness but preserved microhardness without compromising bleaching efficacy. These findings suggest chitosan may represent strategy for protecting enamel during in-office bleaching.

PMID 42719982
阅读全文 →
PubMedFrontiers in pharmacology2026-09-10

Pretreatment myopia progression is associated with the response to 0.01% atropine: a post-hoc secondary analysis of a randomized controlled trial.

Wei Shi-Fei SF, Bai Wei-Ling WL, Sun Yun-Yun YY, An Wen-Zai WZ et al.

To determine which subgroup of children would best benefit from 0.01% atropine eyedrop. This post hoc secondary analysis assessed 68 subjects. Placebo for the first year and 0.01% atropine eye drops for the second year. According to the annual spherical equivalent progression (SEP) during the first year, subjects were subdivided into three groups: slow, moderate and fast (annual SEP > -0.50 D, -1.00 D < annual SEP ≤ -0.50 D, annual SEP ≤ -1.00 D, respectively). After 1 year of 0.01% atropine treatment, SEP was -0.37 ± 0.23 D, -0.57 ± 0.38 D, and -0.68 ± 0.49 D in the slow, moderate, and fast progression groups (P = 0.17). The group with faster SEP during the first year still showed faster SEP after treatment. The reduction of SEP (SEP of the second year minus SEP of the first year) in the moderate group was more than that in the slow group (0.22 ± 0.37 D vs. -0.10 ± 0.21 D, P = 0.007); the fast group was more than that in the slow group (0.57 ± 0.55 D vs. -0.10 ± 0.21 D, P < 0.001) and the moderate group (0.57 ± 0.55 D vs. 0.22 ± 0.37 D, P = 0.02). Faster SEP before treatment is related to the reduction efficiency (β = -0.5, P = 0.01). Faster SEP before treatment is associated with a better treatment response to 0.01% atropine eye drops, with greater reduction in SEP after treatment. However, no significant association was found between baseline progression and axial elongation changes. Children with slow SEP cannot get significant myopia control benefit from 1-year 0.01% atropine treatment. clinicaltrials.gov, identifier ChiCTR-IOR-17013898.

PMID 42719043
阅读全文 →
PubMedSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026-09-10

Network temperature and stability of symptom clusters in colorectal cancer patients undergoing adjuvant chemotherapy: a prospective longitudinal study.

Cao Chenxi C, Liu Shiyu S, Shan Shengnan S, Qi Xiang X et al.

Postoperative colorectal cancer patients receiving adjuvant chemotherapy often experience a high symptom burden that compromises quality of life, yet evidence on the stage-specific stability of symptom clusters remains limited. We applied network temperature to characterize temporal changes in the configurational stability of symptom states during chemotherapy and to examine whether these patterns differed among symptom clusters. This prospective longitudinal observational study was conducted at three chemotherapy stages. Symptoms with prevalence of at least 20% at all assessments were included in multigroup Ising network models. Symptom clusters were identified using the Spinglass community detection algorithm. Temperature estimates and their 95% confidence intervals were obtained using 1000 patient-level nonparametric bootstrap resamples. Among 380 patients, three clusters emerged: emotional distress, somatic-gastrointestinal, and fatigue-neuropathy. Overall relative network temperature decreased across chemotherapy stages. The fatigue-neuropathy cluster showed a marked reduction in temperature from the initial reference level (T1 = 1.00; T2 = 0.60 [0.49-0.74]; T3 = 0.45 [0.36-0.55]), whereas the emotional distress cluster showed an increasing temperature trajectory over time (T1 = 1.00; T2 = 1.06 [0.96-1.19]; T3 = 1.12 [1.01-1.25]). Among colorectal cancer patients receiving adjuvant chemotherapy, overall symptom-network temperature decreased across stages, indicating a more constrained distribution of symptom-state configurations. The fatigue-neuropathy cluster showed progressive concentration of symptom-state configurations, whereas the emotional distress cluster maintained greater configurational variability throughout chemotherapy. These findings highlight the importance of longitudinal, cluster-informed symptom assessment during chemotherapy.

PMID 42717059
阅读全文 →
PubMedFrontiers in medicine2026-09-10

Single-center retrospective feasibility and implementation analysis of dynamic Caprini assessment-based graded nursing for in-hospital VTE risk management in a meniscoplasty-dominant arthroscopic meniscus surgery cohort.

Li Xiaomei X, Ma Jimin J, Dong Yan Y

To evaluate the feasibility and implementation outcomes of dynamic Caprini assessment-based graded nursing for in-hospital venous thromboembolism (VTE) risk management in a meniscoplasty-dominant arthroscopic meniscus surgery cohort. This single-center, retrospective, observational implementation analysis included 90 adult patients who underwent arthroscopic meniscus surgery between January 2024 and December 2025. Caprini assessments were completed at admission (T1), postoperative day 1 (T2), and discharge (T3), and nursing/prophylaxis delivery was assigned according to dynamic risk stratification. Feasibility endpoints included completion of serial assessments, risk-concordant prophylaxis delivery, documentation completeness, and discharge satisfaction. The primary clinical outcome was clinically detected in-hospital deep vein thrombosis (DVT), confirmed by symptom-triggered lower-extremity duplex ultrasonography; pulmonary embolism (PE) was assessed when clinically suspected. Results: Serial Caprini assessment and risk classification were completed in all 90 patients. Basic preventive nursing was delivered to 90/90 patients, mechanical prophylaxis to 73/73 T2 moderate/high-risk patients, and low-molecular-weight heparin (LMWH) to 26/26 T2 high-risk patients. The mean Caprini score increased from T1 (1.87 ± 1.11) to T2 (3.84 ± 1.34, P < 0.001) and decreased at T3 (2.68 ± 1.51, P < 0.001 vs. T2). Moderate-to-high risk classification increased from 26.7% at T1 to 81.1% at T2. Clinically detected in-hospital DVT occurred in 2/90 patients (2.2%; exact 95% CI, 0.3-7.8%), both distal; PE occurred in 0/90 patients (0%; 95% CI, 0.0-4.0%); and minor bleeding occurred in 1/90 patient (1.1%; 95% CI, 0.0-6.0%). No major bleeding was observed. Mean satisfaction was 98.5 ± 1.2 points. Dynamic Caprini assessment-based graded nursing was feasible to implement within this single-center meniscoplasty-dominant cohort. The findings describe protocol delivery and clinically detected in-hospital outcomes only and do not establish causal efficacy or total perioperative DVT incidence.

PMID 42718576
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多ior-t3