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amphotericin B (Ampholip)

✓ Approved

Bharat Serums and Vaccines Limited · 小分子 · 小分子

什么是 amphotericin B？

amphotericin B 是一种小分子，由Bharat Serums and Vaccines Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Ampholip
公司Bharat Serums and Vaccines Limited
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bharat Serums and Vaccines Limited

治疗适应症

amphotericin B 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersEndocardial disease✓ Approved
Infections and infestationsCandida infection✓ Approved
Infections and infestationsAspergillus infection✓ Approved

相关研究文献

PubMedChemical Society reviews2026-10-26

Transition metal-catalyzed carborane cage B-H activation and functionalization: a mechanistic view.

Jing Hui-Xian HX, Li Shi-Jun SJ, Li Haoran H, Liu Shihan S et al.

Icosahedral carboranes have extensive potential applications across diverse research fields because these compounds have distinctive properties, including high stability, three-dimensional aromaticity, and high boron density. However, selective cage B-H modification among 10 or 11 chemically similar B-H vertices is an intriguing challenge. Experimental progress in cage B-H functionalization has inspired numerous mechanistic studies of the underlying activation mechanisms and factors dictating selectivity. This review summarizes recent mechanistic studies of transition metal-catalyzed selective functionalization of carboranes, focusing on the activation mechanism of specific B-H bonds and the factors governing regio- and enantioselectivities. Concerted metalation-deprotonation, σ-complex-assisted metathesis, oxidative addition, and metal-carbene insertion are discussed in detail as typical models for B-H bond activation. The transition metal oxidation state and proton acceptor determine the favored activation model. The stability of the B-metal species generated via B-H activation affects the energy level of further functionalization, and thus the selectivity is determined by B-H activation or subsequent functionalization. Therefore, the factors dictating selectivity can be identified by analyzing the transition state properties, providing insights into improving regio- or chiral-at-cage selectivities. The opportunities and challenges for future research are discussed. We highlight strategies of exploiting the unique characteristics of carboranes based on C-H bond activation protocols and single-electron transfer approaches including photo- and electrocatalysis. We expect that this review will provide a framework for understanding the catalytic mechanism, rational catalyst design, and exploration of precise functionalization strategies.

PMID 42929296
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PubMedMagnetic resonance in medicine2026-10-26

The b-Value Dependence for Higher-Degree Spherical Harmonic Powers of the Diffusion MRI Signal Follows Stick Model Predictions in White Matter.

Moss Hunter G HG, Jensen Jens H JH, Benitez Andreana A

To compare the dependence on b-value of the spherical harmonic powers for the diffusion MRI signal in white matter to theoretical predictions from the stick model of water diffusion within axons. Diffusion MRI data were acquired at 3 T in three healthy adults with 10 b-value shells (b = 1000-10 000 s/mm2) and 64 directions per shell. For every b-value, the signal was expanded in spherical harmonics for all even degrees l up to l = 6, and the harmonic power for each degree was calculated. These were compared in selected white matter regions of interest to the theoretical predictions of the stick model, which depend on just two adjustable parameters: the intra-axonal diffusivity and an amplitude factor for each degree. The intra-axonal diffusivity was estimated independently using triple diffusion encoding MRI, leaving the amplitude factor as the sole fitting parameter. Close agreement between experiment and theory was found for b  ≳  4000 s/mm2, the threshold where extra-axonal water signal is expected to be strongly suppressed, for total cerebral white matter as well as separately within the genu, body, and splenium of the corpus callosum. These findings extend prior studies that either considered only the l = 0 harmonic power or treated the intra-axonal diffusivity as a fitting parameter. In white matter, the b-value dependence of the diffusion MRI signal's even degree spherical harmonic powers up to l = 6 are relatively well-described by the stick model of axons for b  ≳  4000 s/mm2.

PMID 42928508
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PubMedAnnals of hematology2026-10-26

Successful treatment of B-cell acute lymphoblastic leukemia with SET-NUP214 rearrangement using venetoclax: A first case report and literature review.

Chen Gang G, Min Chao C, Xu Jing J, Zheng Jifu J et al.

B-cell acute lymphoblastic leukemia (B-ALL) harboring the SET-NUP214 fusion constitutes an exceedingly rare and aggressive subtype. While this genetic aberration is a well-recognized hallmark of T-cell acute lymphoblastic leukemia (T-ALL), its clinical implications and therapeutic landscape in the B-cell lineage remain largely elusive. Herein, we report the first documented case of relapsed/refractory SET-NUP214-positive B-ALL achieving a successful response to a salvage regimen combining venetoclax with Hyper-CVAD chemotherapy.A 25-year-old male presented with profound cytopenias and 95.5% bone marrow blasts. Flow cytometric analysis characterized the malignant population as pro-B-ALL, with immunophenotypic expression of CD34, CD38, HLA-DR, CD7, and CD58, alongside partial CD19 and cCD79a, and myeloid co-expression (CD13/CD33). Molecular profiling identified the SET-NUP214 fusion transcript, accompanied by concurrent JAK3, PHF6, and PTPN11 mutations. The patient experienced a short-term relapse following induction remission with the VDLP regimen, and subsequent re-induction with the VDEP regimen failed. Subsequently, MRD-negative remission was achieved after adding venetoclax during the mid-course of Hyper-CVAD-A chemotherapy. This deep response facilitated a successful bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT), with the patient maintaining sustained remission for 24 months post-transplant. Our findings suggest that venetoclax-based combinations may provide a potent reinduction strategy for refractory SET-NUP214-positive ALL, underscoring BCL-2 inhibition as a pivotal therapeutic intervention for this high-risk genomic subset.

PMID 42928399
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PubMedChemical communications (Cambridge, England)2026-10-26

Aqueous [3+2] annulation for modular access to thieno/selenolo[2,3-b]quinolines.

Xu Wenhao W, Leng Yuting Y, Xu Hao H, Xu Yunpeng Y et al.

A novel thermal [3+2] cycloaddition strategy enables the metal-free, atom-economical synthesis of thieno/selenopheno[2,3-b]quinolines in water, featuring broad substrate scope, gram-scale synthesis, diverse product transformations, and a sequential oxidation/6π electrocyclization/rearrangement mechanism.

PMID 42929373
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PubMedBMC health services research2026-10-26

Empathy as a catalyst in patient-physician communication: a moderated-mediation analysis of shared decision-making and diabetes outcomes.

Peimani Maryam M, Stewart Anita L AL, Nasli-Esfahani Ensieh E

To examine a moderated mediation model in which shared decision-making (SDM) mediates the association between patient-physician communication (PPC) and two key diabetes outcomes-medication adherence and diabetes distress- while physician empathy moderates the pathways from PPC to SDM and from SDM to outcomes. A cross-sectional survey of 1300 adults with diabetes was conducted at a specialty clinic in Tehran, Iran. Participants completed validated measures of PPC, SDM, physician empathy, medication adherence, and diabetes distress. Analyses used latent moderated structural equation modeling in Mplus to test direct, indirect, and conditional indirect effects. SDM significantly mediated the effects of both 'hurried communication' and 'explained results' (two aspects of PPC) on adherence and distress (all 95% CIs excluded zero). Empathy significantly moderated these indirect effects. The negative indirect effect of hurried communication on adherence through SDM was weaker at high empathy (B= -0.83, p < 0.001) than at low empathy (B= -1.13, p < 0.001). A similar pattern was found for distress, where the positive indirect effect of hurried communication was weaker at high empathy (B = 0.29, p < 0.001) than at low empathy (B = 0.39, p < 0.001). Conversely, the positive indirect effect of explained results on adherence through SDM was stronger at high empathy (B = 2.95, p < 0.001) than at low empathy (B = 1.35, p = 0.001). Physician empathy may act as a relational resource that sustains SDM when communication is hurried and enhances its benefits when treatment rationales are clearly explained. These findings have important implications for the design of communication and empathy-training interventions, suggesting that enhancing physician empathy may be a key target for improving self-management and emotional well-being in diabetes care.

PMID 42928226
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PubMedAntibodies (Basel, Switzerland)2026-10-26

Antibody-Related Mechanisms in Ocular Diseases: Autoimmunity, Malignancy, and Therapeutic Targeting.

Xiao Yehan Y, Zou Yaru Y, Yang Mingming M, Gu Wendong W et al.

Antibodies in ocular disease have heterogeneous biological meanings: they may act as direct pathogenic effectors, systemic diagnostic biomarkers, indicators of B-cell clonality, or therapeutic agents. This distinction is particularly important in the eye, where immune privilege and the blood-ocular barrier restrict tissue access, whereas inflammation may permit entry of immunoglobulins, complement, and immune cells or support local humoral responses. This narrative review integrates antibody and B-cell biology across autoimmune and paraneoplastic retinopathies, aquaporin-4-immunoglobulin G-positive neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, ocular mucous membrane pemphigoid, ocular myasthenia gravis, thyroid eye disease, systemic autoimmune and fibroinflammatory disorders with ocular involvement, and B-cell malignancies including vitreoretinal and ocular adnexal lymphoma. We distinguish the evidence for direct antibody pathogenicity from disease association and emphasize that a positive result is interpretable only in relation to the ocular phenotype, assay platform, titer, specimen compartment, and orthogonal confirmation. Serum testing, ocular-fluid analysis, electrophysiology, multimodal imaging, cytology, histopathology, immunophenotyping, immunoglobulin clonality, and molecular testing have complementary roles. Therapeutic strategies include B-cell or B-lineage depletion, complement inhibition, cytokine- or receptor-directed monoclonal antibodies, insulin-like growth factor-1 receptor blockade, and emerging FcRn- or plasma-cell-directed approaches; however, regulatory status and ocular-specific evidence vary substantially among diseases. A mechanistically stratified framework may reduce overdiagnosis, improve recognition of malignant masquerade syndromes, and support more precise selection of targeted therapy.

PMID 42930036
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