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AS

AS0-3B (AS03B1 / AS03B)

✓ Approved

GSK · 治疗药物

什么是 AS0-3B？

AS0-3B 是一种治疗药物，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名AS03B1, AS03B
公司GSK
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, GSK

治疗适应症

AS0-3B 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedInternational journal of urology : official journal of the Japanese Urological Association2026-09-10

Validation of the Japanese Association for the Surgery of Trauma Type 3 Subclassification of Renal Trauma Using the Japan Trauma Data Bank.

Yanagi Masato M, Nakae Ryuta R, Takeda Hayato H, Endo Yuki Y et al.

The Japanese Association for the Surgery of Trauma (JAST) renal trauma classification is widely used in Japan but has not been validated using nationwide multicenter data. This study aimed to assess its clinical validity in blunt renal trauma. We conducted a retrospective cohort study using 2019-2024 data from the Japan Trauma Data Bank (JTDB), a nationwide multicenter trauma registry. Among 1256 renal trauma patients in the JTDB, we included those with isolated JAST Type 3 blunt renal trauma (severe parenchymal renal trauma) and classified them as Type 3a or 3b. Multivariable logistic regression was used to identify factors associated with operative management (OM). Among 219 patients (Type 3a trauma, n = 136; Type 3b trauma, n = 83), OM was more frequent in Type 3b (14.5% vs. 2.9%, p = 0.002). In multivariable analysis, shock on arrival (odds ratio [OR], 7.96; 95% confidence interval [CI], 2.11-30.08; p = 0.002) and Type 3b trauma (OR, 4.49; 95% CI, 1.35-14.96; p = 0.023) were independently associated with OM. This nationwide multicenter cohort study demonstrated that JAST Type 3b trauma was independently associated with OM in patients with blunt renal trauma. The JAST Type 3 subclassification provides clinically relevant information for predicting the need for OM.

PMID 42717256
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PubMedScientific reports2026-09-10

Molecular divergence and genomic composition of B chromosomes in the fish Cyphocharax modestus (Characiformes, Curimatidae).

Dos Santos Natalia N, Sassi Francisco de Menezes Cavalcante FMC, Dos Santos Rodrigo Zeni RZ, Goes Caio Augusto Gomes CAG et al.

B chromosomes are supernumerary elements that evolve from standard A chromosomes and are primarily composed of repetitive DNAs, yet their origin, diversification, and molecular composition remain poorly understood in most vertebrates. We investigated two allopatric populations of Cyphocharax modestus (Curimatidae) combining classical cytogenetics, comparative genomic hybridization (CGH), and comparative satellitomics to characterize the repetitive DNA landscape of its B chromosomes. While both populations exhibited a conserved karyotype of 2n=54 biarmed chromosomes, five individuals from the Batalha River (BR) carried supernumerary chromosomes, comprising two distinct variants: a C-positive B1 and an C-negative B2. Comparative satellitome analysis between 3B-carrying and B-lacking individuals identified 116 satellite DNAs (CmoSatDNAs), with the 3B library showing higher abundances of specific sequences. Fluorescence in situ hybridization (FISH) revealed that both B variants share two centromeric satellites (CmoSat01-192 and CmoSat02-108) with the A complement, while CmoSat58-47 was exclusively to B2. Minimum spanning tree analysis of CmoSat58-47 revealed B-exclusive haplotypes alongside haplotypes shared with B-lacking individuals, suggesting a recent origin for these chromosomes. CGH experiments further confirm the sequence sharing between the A and B chromosomes, supporting an intraspecific origin, and revealing substantial genomic differentiation among B variants.

PMID 42717220
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PubMedAJP reports2026-09-10

A Novel Rectal Propranolol Strategy in Neonatal Supraventricular Tachycardia Complicated by Surgical Necrotizing Enterocolitis.

Siddharth M M, Banpurkar Ashishkumar A, Benare Abhijit A, Rao Anusha A et al.

Objective Surgical necrotizing enterocolitis (NEC, Bell stage 3B) complicating neonatal supraventricular tachycardia (SVT) is exceedingly rare. We describe a novel per-rectal propranolol strategy to maintain antiarrhythmic prophylaxis during mandatory nil per oral (NPO) status imposed by NEC. Study Design This study includes a single case report at a tertiary neonatal unit in Western India. Results A 35-week neonate with antenatal fetal tachyarrhythmia (>300 beats per minute [bpm]) developed postnatal SVT at 6 h of life (280-300 bpm), requiring adenosine cardioversion and oral propranolol. On day of life (DOL) 4, hematochezia, abdominal distension, and portal venous gas indicated Bell stage 3A NEC, mandating NPO status. With enteral routes contraindicated, propranolol was continued per rectum, to our knowledge the first reported neonatal antiarrhythmic use of this route. Deterioration to pneumoperitoneum by DOL 8 necessitated laparotomy with jejuno-jejunal and ileo-caecal resection and anastomosis. No SVT recurred during NPO. The infant was discharged on DOL 25 on oral propranolol. Conclusion This first Indian report of SVT-associated surgical NEC highlights two novelties: Bell stage 3B NEC requiring surgery and per-rectal propranolol as a novel antiarrhythmic bridge during NPO. Clinicians should maintain vigilance for NEC in neonates with SVT regardless of hemodynamic stability, and consider the rectal route for propranolol when NPO.

PMID 42719918
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PubMedFrontiers in plant science2026-09-10

Dissecting the genetics of forage quality traits in soft red winter wheat in the U.S. southeast region.

Ali Maria M, Missaoui Ali A, Brown-Guedira Gina G, Saha Uttam U et al.

Winter wheat plays a viable role in agriculture, not only as a primary grain crop but also as a valuable forage source that bridges fall-spring forage gaps in many regions, including the southeastern (SE) U.S. Despite its nutritive potential, genetic basis of forage-quality traits remains insufficiently understood, limiting breeding efforts for dual-purpose cultivars. This study aimed to dissect the genetic architecture of forage quality in 182 soft red winter wheat (SRWW) genotypes adapted to the SE U.S. using genome-wide association study (GWAS). Field experiments were carried out in randomized complete block design across three Georgia locations over two growing seasons (2023-2025), with forage sampled at the end of tillering and evaluated using near-infrared reflectance spectroscopy. Significant phenotypic variation was observed for dry matter (DM), crude protein (CP), acid and neutral detergent fiber (ADF, NDF), acid detergent lignin (ADL), total digestible nutrients (TDN), sugars (SUG), and relative forage quality (RFQ). Heritability estimates ranged from low-to-moderate in combined environments and from low-to-high within individual locations. Correlation analysis revealed strong positive associations among fiber-related traits and negative associations with TDN, RFQ, and SUG, while CP declined with increasing fiber. Genome-wide association analysis identified 282 significant marker-trait associations (P < 1×10-4) across 19 chromosomes, which were consolidated into 121 QTLs, including 27 major-effect QTLs. Three QTLs QRfq.uga-3B.1, QRfq.uga-3B.2 (RFQ) and QDm/Sug.uga-7A (DM, SUG) were stable across locations while QAdf/Adl.uga-2A (ADF, ADL) and QDm/Sug.uga-7A (DM, SUG) indicated multi-trait control. Notably, 25 of the 27 major QTLs were putatively novel, highlighting substantial untapped allelic diversity for forage-quality improvement in SE SRWW. Favorable allele accumulation resulted in an overall improvement in forage quality, increasing desirable nutritive traits (DM, RFQ, SUG, CP) while reducing undesirable traits (ADF, ADL). Candidate gene analysis linked six major QTLs with genes implicated in abiotic stress response, plant development, and metabolic regulation, supporting their functional relevance in forage-quality determination. Incorporating these loci into breeding programs provides a robust genetic framework for marker-assisted selection, enabling the development of dual-purpose wheat cultivars with enhanced forage quality, thereby strengthening wheat's utility as a reliable forage resource during periods of seasonal feed scarcity in SE production systems.

PMID 42718753
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PubMedThe journal of physical chemistry. A2026-09-10

Density Functional Analysis of Noncovalent 2- and 3-Body Interactions in Trimolecular Clusters.

Massafra Davide D, Li Hanwei H, Brémond Eric E, Sancho-García Juan Carlos JC et al.

The performance of several density functionals for the description of 3-body interactions was evaluated on three benchmark data sets: 3B-69, S22(3), and 3BHET. Only a few DFT methods achieve consistent accuracy, notably B97-based functionals (ωB97X-V, ωB97X-D, and B97M-V) and double hybrids such as PBE-QIDH-D3(BJ) and B2-PLYP-D3(BJ). If dispersion corrections are essential for describing 2-body interactions, accurate 3-body energies require the presence of a significant fraction of Hartree-Fock exchange. Among dispersion models, those casting information from the electron density, like VV10, XDM, and MBD, provide the best performance. These last models also provide a qualitative agreement with the classical Axilrod-Teller-Muto model for trimers in the S22(3) data set, an indication that they provide a reasonable description of the long-range dispersion component of the 3-body interactions. Overall, these data sets remain more challenging than standard noncovalent benchmarks due to the subtle electronic effects governing many-body interactions.

PMID 42720384
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PubMedCureus2026-09-10

A Collision Tumour Phenomenon: Dual Metastatic Deposits From Melanoma and Adrenal Carcinoma Causing Small Bowel Intussusception.

Toquero Mikaella M, Waddon Joseph J, Mohamed Hussam K HK, Hawkins Charlotte C et al.

Adult intussusception is rare and is usually associated with an underlying pathological lead point, often malignancy. While melanoma commonly metastasises to the gastrointestinal tract, melanoma-related intussusception remains uncommon, and small bowel metastasis from adrenal cortical carcinoma is exceptionally rare. This case describes synchronous metastatic melanoma and adrenal carcinoma causing jejunal intussusception. A 43-year-old male with stage 3B melanoma and an oligometastatic right adrenal lesion presented with two days of bilious vomiting and reduced oral intake, with minimal abdominal symptoms and no significant examination findings. CT imaging, prompted by his oncological history, revealed high-grade small bowel obstruction secondary to jejunal intussusception. He underwent laparoscopic-assisted reduction and small bowel resection, with a 5 cm melanoma deposit identified as the lead point. Histopathology demonstrated a rare collision tumour comprising metastatic melanoma and metastatic adrenal cortical carcinoma. The patient recovered well postoperatively and was discharged home. This case highlights the diagnostic challenge of malignant adult intussusception, particularly in patients with complex oncological histories and subtle clinical presentations. The coexistence of metastatic melanoma and adrenal cortical carcinoma as dual pathological lead points represents an exceptionally rare finding. It emphasises the importance of maintaining clinical suspicion, early cross-sectional imaging and multidisciplinary management in oncology patients presenting with gastrointestinal symptoms. Synchronous metastatic melanoma and adrenal cortical carcinoma causing small bowel intussusception is an exceptionally rare presentation. A low threshold for imaging and timely intervention is essential to avoid diagnostic delay and optimise outcomes in patients with metastatic malignancy.

PMID 42719884
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