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TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

什么是 TJ-114？

TJ-114 是一种治疗药物，由Tsumura研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Sai
公司Tsumura
分子靶点IL1RN
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Tsumura

作用机制

分子靶点

TJ-114 作用于 1 个分子靶点：

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

TJ-114 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersNephritis✓ Approved

相关研究文献

PubMedApplied and environmental microbiology2026-07-27

Microencapsulation of a novel Bacteroides thetaiotaomicron strain: a promising strategy to fortify intestinal barrier fortification in a weaned pig model.

Jin Shen S, Liu Yanjiao Y, Zhang Yifang Y, Shen Yuqing Y et al.

Porcine Bacteroides thetaiotaomicron LYH5 demonstrated in vitro antimicrobial activity, suggesting probiotic potential. Due to poor gastric juice tolerance, LYH5 was encapsulated via extrusion using sodium alginate (SA) and gellan gum. Box-Behnken design optimization yielded optimal parameters: SA 1.5%, gellan gum 0.4%, CaCl2 0.9%, bacteria:glue ratio 1:4, achieving an encapsulation rate of 84.22 ± 0.17%. Its effect on weaned piglet intestinal health was evaluated using 78 piglets (7.69 ± 0.52 kg) randomly assigned to four groups for 40 days: CON (control), T (basal diet + LYH5 live bacteria, 1 × 1010 CFU/mL), TJ (basal diet + LYH5 microcapsules, 1 × 1010 CFU/mL), J (basal diet + empty capsules). The results of this experiment showed that, compared with the control group, LYH5 microcapsules can improve the intestinal barrier function without affecting the growth performance of piglets, and provide ideas and references for a promising candidate for probiotic development. This study addresses the key bottleneck of poor gastric acid tolerance of probiotics via microencapsulation and provides a practical reference for a promising candidate for probiotic development.

PMID 42505593
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PubMedJournal of neurogastroenterology and motility2026-07-27

The Effects of Physical Activity on Functional Dyspepsia: A Mendelian Randomization and Randomized Controlled Study.

Wei Zhongcao Z, Tao Zhiwei Z, Hao Yujie Y, Liu Na N et al.

: The relationship between physical activity (PA) and functional dyspepsia (FD) remains unclear due to a lack of robust evidence. We conducted a Mendelian randomization (MR) analysis to assess potential genetic associations, followed by a randomized controlled trial (RCT) assessing the therapeutic effects of moderate-intensity exercise in FD patients. : In the MR analysis, genetic variants associated with PA traits from genome-wide association studies were analyzed. For the RCT, 260 FD patients were randomized to moderate-intensity exercise intervention or a control group. The primary endpoint was the adequate relief rate of dyspeptic symptoms. : Using MR, a potential inverse association of strenuous sports activity against the development of FD was estimated (inverse variance weighte OR = 0.92, 95% CI = 0.88-0.98, P = 0.0047). Additionally, a suggestive inverse association was observed between other exercises (eg, swimming, cycling, keep fit, and fishing) (inverse variance weighte OR = 0.964; 95% CI, 0.937-0.993; P = 0.013) and FD risk. In the previous high-quality study, other exercises (eg, swimming, cycling, keep fit, and fishing) were considered moderate intensity exercise. Therefore, the MR study suggest that moderate intensity exercise may reduce the occurrence of FD. In the subsequent RCT, 114 participants in the exercise intervention group and 113 in the control group completed the study. The exercise group demonstrated a significantly higher adequate relief rate (46.9% vs 30.8%, P = 0.008) and greater reductions in symptom scores (all P < 0.05) versus controls. : PA, particularly moderate-intensity exercise, may reduce the risk of FD.

PMID 42504657
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis: Clinical Study Evaluating Antimicrobial Susceptibility Patterns and Antibacterial Regimens.

Tolbert Samantha A SA, Day Mollie V MV, Arif Aline A, Tolbert Preston H PH et al.

Background: Vancomycin-resistant enterococci (VRE) Enterococcus faecalis (E. faecalis) remains largely ampicillin-susceptible, yet broad-spectrum agents are frequently used empirically (i.e., daptomycin and linezolid). Despite its frequent susceptibility to ampicillin, VRE E. faecalis is often managed with broad-spectrum antimicrobials, raising concerns about overtreatment and antimicrobial stewardship. Resistance mechanisms vary, with vancomycin resistance mediated by vanA/vanB operons and beta-lactams by altered penicillin binding proteins. These distinct mechanisms help explain why VRE E. faecalis isolates may remain susceptible to ampicillin, supporting its potential use in clinical isolates. This study aims to describe the antibacterial susceptibility results of Enterococcus faecalis VRE and assess antibiotics use in clinical settings in a tertiary medical center. Methods: This was a single-center, retrospective, descriptive study of hospitalized and outpatient adults with Enterococcus faecalis VRE isolates identified between 1 June 2018 and 15 March 2025. We excluded individuals with concomitant non-Enterococcus faecalis VRE infections and those aged <18 years. Vancomycin resistance was defined by a minimum inhibitory concentration of >32 mcg/mL per the 35th edition of the Clinical and Laboratory Standards Institution breakpoints. Results: A total of 337 patients were screened; 114 met inclusion criteria. The cohort was 54% female, 50% Black, and 48% White, with 54% having hypertension, 36% diabetes, and 19% a history of multidrug-resistant organism carriage. The most common source of infection was urinary (67%), followed by skin and soft tissue infections and bone/joint infections (11% each). All isolates were vancomycin-resistant; 82% were susceptible to ampicillin, 84% to nitrofurantoin, 61% to daptomycin, and 70% to linezolid. Antimicrobial regimens varied, with daptomycin being the most used agent (19%). No patients in the aminopenicillin group experienced 30-day mortality, whereas two patients (3%) in the non-aminopenicillin group died within 30 days. Acute kidney injury occurred in four patients (29%) in the aminopenicillin group compared with four patients (7%) in the non-aminopenicillin group, representing a significantly higher incidence in the aminopenicillin group (p = 0.037). However, myalgia, elevated creatine phosphokinase, and thrombocytopenia were more common in the non-aminopenicillin group. Conclusions: Despite higher susceptibility to ampicillin and nitrofurantoin, daptomycin was the most used agent for VRE E. faecalis infections. These findings highlight a need for improved antimicrobial stewardship and further clinical studies to guide optimal therapy.

PMID 42505635
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PubMedJournal of imaging2026-07-27

B-Mode Ultrasound Radiomics for Differentiating Benign and Malignant Small Hyperechoic Renal Masses: An Exploratory Single-Center Experience.

Urraro Fabrizio F, Giordano Nicoletta N, Patanè Vittorio V, Piscopo Marco M et al.

Introduction: Small hyperechoic renal masses are frequently detected incidentally on conventional ultrasound and are often presumed to represent benign lesions, particularly angiomyolipomas. However, malignant renal tumors, including renal cell carcinoma, may also appear hyperechoic when small, creating a diagnostic challenge at first-line imaging. This study aimed to evaluate the feasibility and exploratory diagnostic performance of B-mode ultrasound radiomics for differentiating benign and malignant small hyperechoic renal masses. Methods: This retrospective single-center study included adult patients with incidentally detected small hyperechoic renal masses measuring ≤3 cm and examined between July 2022 and April 2025. All lesions underwent standardized B-mode ultrasound assessment and multidisciplinary review. Final diagnosis was established by histopathology when available or by longitudinal ultrasound follow-up stability for lesions considered benign. Lesions were manually segmented on representative B-mode DICOM images, and original radiomic features were extracted using PyRadiomics version 3.0 according to standardized definitions compatible with the Image Biomarker Standardisation Initiative framework. A total of 114 original radiomic features were extracted from each lesion. The primary comparison was benign versus malignant lesions. Diagnostic performance was assessed using feature-level receiver operating characteristic analysis. Results: Forty-two lesions were included in the final radiomic cohort, including 26 malignant renal cell carcinomas and 16 benign angiomyolipomas. Malignant lesions included papillary renal cell carcinoma, chromophobe renal cell carcinoma, and clear-cell renal cell carcinoma. All malignant lesions were histologically confirmed. Among benign lesions, 14 angiomyolipomas were classified based on longitudinal ultrasound stability, whereas 2 were confirmed by ultrasound-guided percutaneous biopsy after mild dimensional increase during imaging surveillance. Among the extracted radiomic features, firstorder_Variance and firstorder_MeanAbsoluteDeviation showed the highest exploratory discriminatory performance, each achieving an area under the receiver operating characteristic curve of 0.837. Both features are first-order measures of gray-level dispersion within the segmented lesion. Higher values were observed in malignant lesions, suggesting greater intralesional grayscale heterogeneity compared with benign angiomyolipomas. Conclusions: B-mode ultrasound radiomics is feasible for the quantitative assessment of small hyperechoic renal masses and may provide complementary information for differentiating benign angiomyolipomas from malignant renal cell carcinomas. firstorder_Variance emerged as a representative candidate imaging biomarker of grayscale dispersion, with firstorder_MeanAbsoluteDeviation showing concordant performance as a related dispersion measure. These findings should be considered preliminary and hypothesis-generating and require validation in larger multicenter cohorts before clinical implementation.

PMID 42506161
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PubMedGenetics in medicine open2026-07-26

Genome and transcriptome sequencing reveal pathogenic activation of a pseudoexon in PKD1 via a de novo-common variant complex allele.

Han Sangwoo T ST, Rehman Atteeq U AU, Srinivasa Sowmya Thirumalai ST, Lam Alicia A et al.

Despite improvements in and access to clinical genetic testing, many patients with classic phenotypes remain without a molecular diagnosis. Such cases may reflect variants in noncoding regions or complex alleles made up of disparate sequence variants. In this article, we report a patient with autosomal dominant polycystic kidney disease caused by a deep intronic de novo single-nucleotide substitution forming a dinucleotide variant, with an adjacent common single-nucleotide variant (formerly single-nucleotide polymorphism) inherited from an unaffected parent. Although neither variant alone was predicted to be pathogenic, together as a dinucleotide variant, they created a novel splice donor site that activated a pseudoexon within intron 16 of the PKD1 gene. Genome sequencing was paired with transcriptome sequencing to evaluate the dinucleotide variant within intron 16 of PKD1. Evaluation of RNA from patient cells confirmed the inclusion of a 114-bp pseudoexon and an in-frame premature termination codon into the PKD1 messenger RNA transcript. This case identified a rare scenario in which the combination of 2 independently predicted benign nucleotide substitutions immediately adjacent to one another generated a pathogenic allele. This case highlights the diagnostic utility of genome sequencing coupled with RNA sequencing to clarify the effects of a deep intronic variant, confirming a molecular diagnosis for a patient with a clear clinical diagnosis who had undergone years of inconclusive testing. Furthermore, this case cautions that similar events may underlie unsolved cases across other genes and disorders.

PMID 42502691
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PubMedMovement disorders : official journal of the Movement Disorder Society2026-07-26

Pre-Diagnostic Factors Associated with Coding-Based Incident Multiple System Atrophy: A Nested Case-Control Study of the UK Biobank.

Zhao Charlie Weige CW, Robbins Nathaniel N, Krolewski Richard R, Liu Jennifer J et al.

Multiple system atrophy (MSA) is a rare neurodegenerative synucleinopathy whose epidemiological risk factors remain poorly characterized. To characterize pre-diagnostic features and identify candidate risk factors for coding-based incident MSA in the UK Biobank (UKB), compared with Parkinson's disease (PD) and healthy controls. Iterative logistic regression models were used to derive risk factors from sociodemographic, lifestyle, environmental, and medical factors, adjusting for baseline age and sex, with Benjamini-Hochberg correction in the fully adjusted model. Candidate risk factors were evaluated in multivariate models at baseline and using 5- and 10-year latency windows to assess reverse causation. We identified 114 coding-based incident MSA diagnoses, 1139 age- and sex-matched incident PD cases, and 1075 matched controls. We identified several baseline associations that attenuated with latency windows, including antihistamine use, alcohol use, and reduced physical activity, suggesting reverse causation. Statin use was associated with reduced risk at baseline (odds ratio [OR] 0.34, 95% confidence interval [95% CI] 0.17-0.69) and 5 years' latency but attenuated at 10 years, and was discordant with findings of reduced risk with moderately elevated cholesterol (OR 0.41, 95% CI 0.24-0.72). Rural living was the only candidate exposure whose effect strengthened with longer latency windows (5-year OR 2.73, 95% CI 1.32-5.65). Coding-based incident MSA in the UKB exhibits a long pre-diagnostic phase consistent with autonomic and lifestyle changes several years prior to the diagnosis of an autonomic or parkinsonian disorder. Rural living may be an environmental signal warranting further investigation. © 2026 International Parkinson and Movement Disorder Society.

PMID 42502215
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