北京若生智能科技有限公司
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TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

什么是 TJ-114？

TJ-114 是一种治疗药物，由Tsumura研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Sai
公司Tsumura
分子靶点IL1RN
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Tsumura

作用机制

分子靶点

TJ-114 作用于 1 个分子靶点：

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

TJ-114 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersNephritis✓ Approved

相关研究文献

PubMedJournal of chemical information and modeling2026-10-26

Toward Autonomous Extraction and Building of Machine-Readable Molecular Models from Publications Using Large Language Models.

Fleckenstein Florian F, Rodin Volodymyr V, Dieudonné Isabell I, Al Machot Fadi F et al.

Force field models are one of the central pillars of molecular simulations. A large number of molecular force field models has been developed in the past decades─mostly published in scientific papers. Building machine-readable force field input files for simulation engines is a tedious and error-prone task. We developed a method for extracting and building force field files from publications using large language models (LLMs). We have tested the new method by extracting 114 force field models from 21 scientific publications. The studied force fields comprise 6-74 parameters that were automatically extracted, identified, annotated, and allocated. We have compared the performance of different LLMs, namely Gemini 2.5 Pro, Claude 4 Sonnet, Claude 3.7 Sonnet, Gemini 2.5 Flash, and GPT-4o. Overall, they yield similar performance─yet there are important differences in individual cases. The overall best performance was obtained by the Gemini 2.5 Pro LLM. The force field parameters were extracted and identified with an accuracy of 94.0% using the Gemini 2.5 Pro LLM. The new LLM-assisted extraction method drastically reduces the time required for building force field files. Nevertheless, human-in-the-loop verification is still indispensable.

PMID 42929564
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PubMedChild development2026-10-26

From naturals to strivers: How stereotypes in social and moral dimensions change with age to drive children's preference development.

Zhu Naping N, Zhou Jie J, Wang Yuhan Y, Li Yanfang Y

Children observe some people succeed through natural talent (naturals), whereas others succeed through sustained effort (strivers). Children's preference for naturals or strivers may influence the people they admire and choose as role models and may have implications for their social judgment and achievement development. However, little is known about how children's preferences for naturals versus strivers develop and the factors that explain these preferences. We examined the development of preferences for naturals versus strivers among 221 Han Chinese children (5.06-11.99 years, 114 girls), as well as associations with external perceptions of naturals and strivers (warmth, competence, and morality) and internal self-cognitions (self-concept and mindset). Results revealed an age-related pattern in children's preferences, with younger children tending to prefer naturals and a preference for strivers observed from ages 7-8 onward. These preferences can be explained by the sociomoral value of effort (viewing strivers as warmer and less likely to free-ride). These results extend previous research on the instrumental value of effort and underscore the distinct roles of external stereotypes and internal self--cognitions in shaping social preferences. This study can inform educators how to understand children's preferences for naturals versus strivers and the sociomoral significance of effort in daily interactions.

PMID 42928562
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PubMedCanadian journal of physiology and pharmacology2026-10-26

Electrocardiographic screening for left atrial enlargement in dogs: derivation and validation of an algorithm combining lead II P-wave duration and the Morris index.

Santana José Luís de Sousa J, Sanches Marina Pinto M, Moura Laecio da Silva L, Souza Yanca Bizerra Y et al.

Combining electrocardiographic measurements may improve identification of dogs requiring echocardiographic assessment. This retrospective diagnostic accuracy study derived a three-category algorithm in 150 dogs and evaluated it in 50 separate validation dogs. Three observers independently measured lead II P-wave duration and the V1 Morris index, with observer A providing the primary analysis. Left atrium-to-aorta ratio (LA/Ao) ≥ 1.6 was the primary outcome; normalized left ventricular internal diameter in diastole (LVIDDN) ≥ 1.7 was evaluated independently as a secondary outcome. Thresholds from 114 reference dogs were 48 and 52 ms for P duration and 3.04 mV·ms for Morris. Positive triage comprised intermediate and high categories. Primary-outcome sensitivity and specificity were 90.6% and 50.0% in derivation and 100% and 85.7% in validation. Validation sensitivity had a 95% confidence interval of 88.1%-100%. The ordinal algorithm area under the curve was 0.961 in validation, compared with 0.868 for P and 0.844 for Morris; paired differences were not significant after Holm adjustment. Secondary-outcome validation sensitivity and specificity were 88.0% and 60.0%. The algorithm provided complementary detection of left atrial enlargement and reproducible measurements across observers, supporting further evaluation as an adjunct to echocardiographic triage.

PMID 42929310
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PubMedLiver international : official journal of the International Association for the Study of the Liver2026-10-26

Screening for Biliary Dysplasia Using Brush Cytology in PSC: Prevalence, Risk Factors and Outcomes.

Färkkilä Martti M, Boyd Sonja S, Åberg Fredrik F, Tenca Andrea A et al.

Primary sclerosing cholangitis (PSC) is associated with significantly increased risk of cholangiocarcinoma (CCA) with a 5-year survival below 10%. Although CCA screening remains controversial, current guidelines recommend annual surveillance via ultrasound or MRI/MRCP. Brush cytology (BC) enables early detection of biliary dysplasia (BD), but its sensitivity varies widely (8%-89%). We assessed the accuracy of BC in detecting CCA, the prevalence and risk factors for BD, and the outcomes of dysplasia screening. We analysed 4017 BC samples from 984 PSC patients who underwent ERC. The exclusion criteria (n = 114) were age at diagnosis < 18 or > 65 years, early CCA diagnosis (< 1 year from PSC diagnosis), and IgG4-related cholangitis. Demographics, laboratory data and ERC scores were compared between patients with repeated BD findings (≥ 3 times) or CCA (composite endpoint) and those without. Optimal predictors were assessed using time-weighted AUC and Cox regression. BD was detected at least once in 10% of the patients. Repeated suspicion of dysplasia in BC was also strongly associated with BD in explanted livers. The negative predictive value was 0.99, and the overall accuracy was 0.91. Only the ERC score (≥ 7, AUC 0.87) and S-IgG4-twAUC (≥ 1.06, AUC 0.76) predicted the composite endpoint. Combining both improved accuracy (ERC-IgG4-score, AUC 0.88). Brush cytology has a high negative predictive value for excluding CCA development. The ERC score and S-IgG4 are key predictors of biliary dysplasia, supporting their use in PSC surveillance. The ERC-IgG4-score may help guide individualized monitoring strategies.

PMID 42929737
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PubMedBMC endocrine disorders2026-10-26

Incidence and predictors of diabetic ketoacidosis among patients with diabetes mellitus receiving follow-up care in public health centers of Lideta Sub-City, Addis Ababa: a retrospective cohort study, 2023.

Kassaw Getasew G, Molla Asressie A, Tsehay Binalfew B, Tsehay Mellese M

The most dangerous acute consequence of diabetes mellitus is diabetic ketoacidosis, which has become more prevalent in diabetic individuals. Although diabetic ketoacidosis is becoming more common in people with diabetes mellitus, little is known about its incidence and predictors. In Ethiopia, this is particularly true. To assess the incidence of diabetic ketoacidosis and its predictors among patients with diabetes mellitus attending follow-up care in public health centers of Lideta Sub-City, Addis Ababa, Ethiopia. A retrospective follow-up study was conducted among diabetic mellitus patients who were registered from January 1, 2018, to December 31, 2022, in Lideta Sub-City public health centers, Addis Ababa, Ethiopia. Sampling with probability proportional to size and the simple random sampling technique were used to select patients. Data were collected from the patient charts by using a pretested checklist. The data were entered into EPI data version 3.1 and analyzed using STATA version 14.0. The Cox proportional hazard regression model was fitted to identify the independent predictors of diabetic ketoacidosis. Out of the 419 diabetic patients included in the study, 114 (27.2%) developed Diabetic Ketoacidosis in the entire follow-up period. Hence, the cumulative incidence was 0.742 per 100-person-month of observation. Type 1 diabetes mellitus (AHR = 1.88, 95%CI: 1.12, 3.15), history of medication noncompliance (AHR = 2.7, 95% CI: 1.52, 4.8), recent six month poor glycemic control (AHR = 1.9, 95% CI: 1.07, 3.4), acute recent illness (AHR = 1.75, 95% CI: 1.02, 3.01) and talking insulin medication (AHR = 2.32, 95% CI: 1.39, 3.8) were significant predictors of DKA. The incidence of diabetic ketoacidosis was high. Uncontrolled recent six-month glycemic levels, taking insulin medication rather than OHGA, having type 1 diabetes mellitus, has a history of medication noncompliance, and acute illness were the predictors. Diabetic care should prioritize these predictors to mitigate the public health and economic impacts of diabetic ketoacidosis. Not applicable. Not applicable.

PMID 42928256
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PubMedInternational journal of emergency medicine2026-10-26

Low-volume body bag cooling for severe exertional heat stroke in the emergency department: a case report.

Ikeda Takao T, Watase Taketo T, Kondo Takashiro T, Watase Hiroko H et al.

Exertional heat stroke (EHS) is a life-threatening emergency in which delayed or inadequate cooling substantially increases the risk of death and permanent neurological injury. Core temperature reduction to below 39 °C within 30 min is the therapeutic target, and cold-water immersion achieves the fastest cooling rates (0.15-0.35 °C/min) but is frequently unavailable in emergency departments (ED) due to equipment and space limitations. Body bag-based tarp-assisted cooling with oscillation (TACO) has been proposed as an alternative using universally available materials; however, clinical evidence supporting its emergency department use remains limited. A 57-year-old immunocompromised male construction worker (acute myeloid leukemia, status post umbilical cord blood transplantation, maintained on prednisolone and tacrolimus) presented with EHS following 90 min of outdoor labor in ambient conditions of 36 °C and 65% relative humidity. On ED arrival, rectal temperature was 42.0 °C, Glasgow Coma Scale score was 4, blood pressure was 125/80 mmHg, and heart rate was 183 beats/minute. Body bag-based TACO was initiated immediately upon arrival using 15 L of tap water and 15 kg of ice. Endotracheal intubation for airway protection was performed concurrently, demonstrating patient accessibility during cooling. Target temperature (rectal temperature < 39 °C) was achieved in 39 min at a cooling rate of 0.085 °C/min. Glasgow Coma Scale score improved to 14 within 7.5 h of admission. The hospital course was complicated by bacteremia requiring prolonged antimicrobial therapy. The patient was discharged ambulatory on hospital day 42 without neurological sequelae. Body bag-based TACO required substantially less water (15 L) than the water/ice volumes reported in TACO studies (114-151 L) using materials available in any ED. Although the cooling rate achieved (0.085 °C/min) fell below published benchmarks, the patient achieved complete neurological recovery, suggesting that immediate initiation of cooling may help offset a suboptimal rate. While a single case cannot establish equivalence to cold-water immersion, body bag-based TACO offers a practical, low-cost option for initiating cooling when standard infrastructure is unavailable, and merits further comparative evaluation.

PMID 42928101
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