北京若生智能科技有限公司
Drug Database
IN

indometacin (IV) (Indocin IV)

✓ Approved

Merck & Co. · PTGS1 · 小分子

什么是 indometacin (IV)？

indometacin (IV) 是一种小分子，由Merck & Co.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Indocin IV
公司Merck & Co.
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Merck & Co.

作用机制

分子靶点

indometacin (IV) 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

indometacin (IV) 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersPatent ductus arteriosus✓ Approved

相关研究文献

PubMedNeurogastroenterology and motility2026-10-26

Epidemiology of Irritable Bowel Syndrome Among Chilean Adults: Differences Across Healthcare Settings and Urban-Rural Populations.

von Muhlenbrock Christian C, Pacheco Nicole N, Santos Natalia N, Carbone Florencia F et al.

Irritable bowel syndrome (IBS) is one of the most prevalent disorders of gut-brain interaction (DGBIs), with an estimated global prevalence ranging from 4.1% to 17%. However, prevalence data remain largely unknown in many countries and across different populations. The aim of this study was to characterize IBS among Chilean adults using Spanish-validated Rome diagnostic criteria across healthcare and community-based settings, including public and private gastroenterology outpatient populations and urban and rural/Mapuche community populations. IBS was assessed using standardized, Spanish-validated Rome questionnaires, with Rome IV criteria applied to available symptom data in the outpatient cohorts (public and private) and the official Spanish-language Rome IV Diagnostic Questionnaire used in the community-based populations (urban and rural/Mapuche). Data were analyzed using chi-squared, Mann-Whitney U, and multivariable logistic regression, with analyses performed using GraphPad Prism. We evaluated the proportion of gastroenterology outpatients meeting Rome IV criteria for IBS and IBS subtypes in 8717 patients, as well as IBS prevalence in 896 urban and rural/Mapuche community participants. The proportion of gastroenterology outpatients meeting Rome IV criteria for IBS was higher in the public than private hospital (36.2% vs. 23.3%; p < 0.0001) and in urban females versus males (30.5% vs. 20.5%; p = 0.0015). Rural/Mapuche and urban populations showed comparable IBS prevalence (30.9% vs. 25.7%; p = 0.26), and rural/Mapuche residence was not significantly associated with IBS after adjustment for age and sex (adjusted OR 1.18, 95% CI 0.68-2.05; p = 0.56). The rural/Mapuche population had a different subtype distribution, with a higher proportion of IBS-M. IBS symptoms compatible with Rome IV criteria were common across the evaluated Chilean adult populations, with differences observed according to healthcare setting and sex. Although IBS prevalence did not differ significantly between the urban and rural/Mapuche populations, this finding should be interpreted cautiously given differences in age and recruitment methods. Larger population-based studies are needed to confirm these findings in rural and Indigenous populations. These data provide novel insights into IBS epidemiology in a Latin American country with marked socioeconomic heterogeneity and may inform future population-based and mechanistic studies in diverse settings.

PMID 42928586
阅读全文 →
PubMedJournal of orthopaedic surgery and research2026-10-26

Clinical outcomes and surgical applications of 3D-printed patient-specific implants for traumatic bone defects: a scoping review.

Slawaska-Eng David D, Garbuz Nicholas N, Mellon Matthew M, Yan James J et al.

Traumatic bone defects are complex injuries associated with prolonged disability and limited reconstructive options. Three-dimensional printed (3DP) patient-specific implants provide anatomically matched, mechanically tailored solutions. This review synthesizes current clinical evidence regarding their use, effectiveness, and safety in trauma-related bone defects. MEDLINE, Embase, and Scopus were searched from inception to February 17, 2025. Human studies reporting clinical outcomes of custom 3DP implants for traumatic bone defects were included. Two reviewers independently screened studies, extracted data, and assessed methodological quality using the MINORS tool. Owing to heterogeneity in anatomy, defect characteristics, adjunctive procedures, and outcome definitions, a meta-analysis was not performed. Twelve studies comprising 108 patients met inclusion criteria; most were retrospective, non-comparative case series (predominantly Level IV evidence). Titanium-based implants were most common (92 patients), followed by tantalum (9) and polyetheretherketone (5). Defect sites included the humerus, forearm, femur, tibia, and calcaneus. Union assessment methods varied, but confirmed union was frequently reported. For tibial defects, union was confirmed in 13/20 patients; four had indeterminate imaging and three declined a planned second-stage procedure. Functional outcomes generally improved. Reported complications were typically manageable, and no catastrophic implant failures were described, although follow-up duration was limited. Current evidence suggests that patient-specific 3DP implants are a feasible reconstructive option for selected traumatic bone defects. However, evidence certainty remains very low, and prospective comparative studies with standardized reporting are required. IV (systematic review of primarily Level IV case series and retrospective studies).

PMID 42928195
阅读全文 →
PubMedInternational journal of women's health2026-10-26

Natural History and Risk Factors for Adverse Outcomes of Ovarian Endometrioma in Pregnancy - A 9-Year Cohort with Histopathological Confirmation.

Luo Mengyao M, Tao Quanting Q, Wang Jing J

This study aimed to characterize the natural history of ovarian endometrioma (OE) during pregnancy and identify independent risk factors for adverse outcomes. This retrospective cohort study was conducted at Hangzhou Women's Hospital and included 151 patients with OE histopathologically confirmed during cesarean section between January 2017 and December 2025. Patients were stratified according to the timing of OE detection: Group 1 (n = 86; OE detected before conception or before 14 weeks of gestation) and Group 2 (n = 65; OE first identified intraoperatively during cesarean section). The serial cyst dimensions in Group 1 were reviewed to assess gestational changes in cyst size during pregnancy. Composite adverse outcomes included cyst rupture, suspected malignant transformation, or cyst-related iatrogenic preterm birth. Risk factors were evaluated using univariable and multivariable logistic regression analyses. Among 151 patients (median age, 31 years [IQR, 29-34 years]), cyst behavior in Group 1 was heterogeneous: 17.4% decreased, 60.5% remained stable, and 22.1% increased in size. Revised American Society for Reproductive Medicine (rASRM) stage III-IV disease (61.6%) was significantly more prevalent in Group 1 (80.2% vs 36.9%; P < 0.001). Cyst rupture occurred in 20 patients (13.2%), decidualization in 26 (17.2%), and composite adverse outcomes in 22 (14.6%). rASRM stage III-IV disease (aOR = 5.784; 95% CI: 1.549-21.596; P = 0.009) and decidualization (aOR = 4.530; 95% CI: 1.541-13.316; P = 0.006) were independent risk factors for adverse outcomes, whereas absolute cyst size was not. The gestational course of OE is characterized by considerable interindividual variability; most cysts remain stable, whereas approximately one-fifth enlarge. rASRM stage III-IV disease and decidualization were independent risk factors for adverse outcomes, whereas cyst size alone was not. Increased surveillance may be warranted for patients with advanced-stage disease or sonographic features suggestive of decidualization.

PMID 42928753
阅读全文 →
PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-10-26

Arthroscopic Delivery of Particulated Juvenile Articular Cartilage Allografts Provides Durable Outcomes for Full-Thickness Chondral Lesions of the Knee.

Dragoo Jason L JL, Constantine Evangelia P EP, Whitney Kaitlyn E KE, McCartney Carolynn M CM et al.

To evaluate patient outcomes after arthroscopic particulated juvenile articular cartilage implantation for full-thickness cartilage lesions in the knee with a minimum 24-month follow-up. This was a retrospective case series of patients aged ≥15 years with International Cartilage Repair Society grade IV chondral lesions with exposed subchondral bone treated with primary arthroscopic particulated juvenile articular cartilage implantation between 2016 and 2023. All included patients had a minimum of 24 month follow-up. Knee Injury and Osteoarthritis Outcome Score and Western Ontario and McMaster Universities Osteoarthritis Index subscales were compared between baseline and a minimum of 24 months postoperatively using Wilcoxon signed-rank tests. Linear mixed-effects models with random intercepts for patients were constructed a priori to evaluate longitudinal associations between outcomes and prespecified covariates (age, sex, body mass index [BMI], smoking exposure, lesion area and compartment, and common concomitant procedures). Thirty-four patients (16 women, 18 men; mean age 43.5 ± 10.2 years; mean BMI 27.9 ± 5.2) with mean lesion area of 2.98 ± 1.50 cm2 were included. Mean follow-up was 3.9 years (range: 2.1-9.5). All outcome subscales improved significantly from baseline to 24 months (all P < .003), with 71% to 82% of patients achieving clinically meaningful improvements (54% for Western Ontario and McMaster Universities Osteoarthritis Index Stiffness). In mixed-effects models, higher BMI was the only covariate associated with worse outcomes, with approximately 1.2-point lower Knee Injury and Osteoarthritis Outcome Score scores for each 1 increase in BMI. No acute graft displacements occurred, and 1 patient (2.9% of the cohort) experienced late graft delamination requiring revision 2.3 years postoperatively. Arthroscopic particulated juvenile articular cartilage transplantation provided significant 24-month improvements across all outcome domains for high-grade knee lesions. Outcomes were not associated with lesion size, location, or demographics, though higher BMI was associated with worse results. No acute graft complications occurred. Level IV, retrospective case series.

PMID 42928438
阅读全文 →
PubMedJournal of cataract and refractive surgery2026-10-26

Ophthalmologists' Perspectives on Cataract Surgery Sedation: A National Survey Study.

Bao Phuong H PH, Luo Yanting Y, Schwartz Rachel R, Huang Alison J AJ et al.

In this national survey assessing US cataract surgery sedation practices, among 659 of 3,406 (19.3%) respondents, 578 (87.7%) routinely performed cataract surgery with anesthesia care. For sedation, 534 (81.0%) routinely used light-to-moderate IV sedation; 69 (10.5%) routinely used oral or no additional sedation. Forty-two (6.4%) performed cataract surgery in office-based surgery (OBS) suites. For future consideration of OBS, 76.0% (n=501), 76.0% (n=501) and 77.2% (n=509) indicated it was "moderately" or "very important" for Medicare to establish physician payment policies for OBS; to maintain access to ambulatory surgery center or hospital outpatient department privileges for complex cases; and for Medicare to continue allowing anesthesia services in the office when needed, respectively. Ophthalmologists nationwide rely heavily on anesthesia care for cataract surgery sedation. With appropriate training and favorable Medicare policies to make OBS financially viable and safe, ophthalmologists may be willing to assume additional, selected sedation roles traditionally performed by anesthesia teams.

PMID 42929220
阅读全文 →
PubMedCase reports in surgery2026-10-26

Combined Bouveret and Type IV Mirizzi Syndromes Treated by One-Stage Biliary and Gastrointestinal Reconstruction: A Case Report.

Ryu Madeline M, Chang Ching-Kuo CK, Le Sidney T ST

Bouveret syndrome is a rare condition that occurs due to migration of a gallstone into the duodenum through fistula formation between the gallbladder and duodenum, leading to gastric outlet obstruction. Mirizzi's syndrome is a rare condition where cholelithiasis leads to external compression or even erosion into the common hepatic duct (CHD). Here, we present a unique case that showcases severe presentations of both phenomena in a male presenting with sudden-onset pain and vomiting for 3 h. The decision for a one-stage approach of fistula takedown, cholecystectomy, duodenectomy, Roux-en-Y, and hepaticojejunostomy was made given the patient's young age and good health status after failure of stone retrieval through esophagogastroduodenoscopy (EGD). Beyond anatomic necessity, simultaneous stone clearance and cholecystectomy avoid the recurrent lithiasis, interval cholecystitis, and ongoing erosion into adjacent structures associated with a staged approach. This case underscores that operative planning should be guided by anatomic complexity rather than age or ASA class alone, provided patient selection is appropriate.

PMID 42928823
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多indometacin (IV)