Tsumura · 治疗药物
TJ-15 是一种治疗药物，由Tsumura研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。
| 商品名 | OGT |
| 公司 | Tsumura |
| 给药途径 | Oral (PO) |
| 状态 | Approved |
TJ-15 针对 5 个适应症，涉及 5 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Skin and subcutaneous tissue disorders | Eczema | ✓ Approved |
| Gastrointestinal disorders | Gastritis | ✓ Approved |
| Vascular disorders | Hypertension | ✓ Approved |
| Psychiatric disorders | Obsessive-compulsive disorder | ✓ Approved |
| Nervous system disorders | Cerebral cyst haemorrhage | ✓ Approved |
Najafi Soroosh S, Jojani Maryam M, Najafi Kianoosh K, Roviello Giovanni N GN
In the original publication [...].
Ikeda Takao T, Watase Taketo T, Kondo Takashiro T, Watase Hiroko H et al.
Exertional heat stroke (EHS) is a life-threatening emergency in which delayed or inadequate cooling substantially increases the risk of death and permanent neurological injury. Core temperature reduction to below 39 °C within 30 min is the therapeutic target, and cold-water immersion achieves the fastest cooling rates (0.15-0.35 °C/min) but is frequently unavailable in emergency departments (ED) due to equipment and space limitations. Body bag-based tarp-assisted cooling with oscillation (TACO) has been proposed as an alternative using universally available materials; however, clinical evidence supporting its emergency department use remains limited. A 57-year-old immunocompromised male construction worker (acute myeloid leukemia, status post umbilical cord blood transplantation, maintained on prednisolone and tacrolimus) presented with EHS following 90 min of outdoor labor in ambient conditions of 36 °C and 65% relative humidity. On ED arrival, rectal temperature was 42.0 °C, Glasgow Coma Scale score was 4, blood pressure was 125/80 mmHg, and heart rate was 183 beats/minute. Body bag-based TACO was initiated immediately upon arrival using 15 L of tap water and 15 kg of ice. Endotracheal intubation for airway protection was performed concurrently, demonstrating patient accessibility during cooling. Target temperature (rectal temperature < 39 °C) was achieved in 39 min at a cooling rate of 0.085 °C/min. Glasgow Coma Scale score improved to 14 within 7.5 h of admission. The hospital course was complicated by bacteremia requiring prolonged antimicrobial therapy. The patient was discharged ambulatory on hospital day 42 without neurological sequelae. Body bag-based TACO required substantially less water (15 L) than the water/ice volumes reported in TACO studies (114-151 L) using materials available in any ED. Although the cooling rate achieved (0.085 °C/min) fell below published benchmarks, the patient achieved complete neurological recovery, suggesting that immediate initiation of cooling may help offset a suboptimal rate. While a single case cannot establish equivalence to cold-water immersion, body bag-based TACO offers a practical, low-cost option for initiating cooling when standard infrastructure is unavailable, and merits further comparative evaluation.
Yuan Pengtao P, Su Peng P, Ma Rundong R, Ma Yitian Y et al.
Fat metabolism plays a pivotal role in determining meat quality and economic value in domestic pigs, yet its underlying genetic mechanisms remain poorly understood. To clarify the molecular basis of adipose deposition, this study integrated whole-genome resequencing data from 226 individuals across 61 Eurasian pig breeds and applied population genetic and selective sweep analyses to identify and validate candidate genes involved in fat metabolism. Significant genetic divergence was observed between Asian and European domestic pigs, with higher linkage disequilibrium (LD) levels in domestic breeds likely driven by artificial selection during domestication. High-fat groups (backfat thickness: 39 mm; fat percentage: 35%) exhibited substantially greater fat deposition than low-fat groups (backfat thickness: 15 mm; fat percentage: 15%). Combined analyses of Pi-ratio, XP-EHH, and FST revealed 13 key candidate genes, including SDR16C5 and CPE, functionally enriched for lipid metabolism pathways such as fatty acid metabolism and insulin signaling. Cellular assays further confirmed that SDR16C5 promotes adipogenesis by enhancing preadipocyte proliferation and lipid accumulation. This study identifies SDR16C5 as a candidate regulator of adipogenesis and fat metabolism in pigs. These findings establish a genetic framework that may facilitate targeted breeding strategies to improve fat composition and enhance premium pork production.
Vaidya Poorva P, Azenkot Tali T, Bliamptis John J, Victor Mitchell Toby MT et al.
There exists an unmet clinical need to define definitive management strategies for patients with locally advanced non-melanoma skin cancers (NMSC), particularly if not amenable to surgical resection. We retrospectively reviewed a case series of locally advanced unresectable NMSC treated with induction systemic treatment followed by response-adapted consolidative radiation. We identified 15 patients who met study criteria, including seven with basal cell carcinoma (BCC), six with cutaneous squamous cell carcinoma (CSCC), and two with Merkel cell carcinoma (MCC). Clinical complete response (CR) by physical examination was observed in all 15 patients. No locoregional or distant recurrences were observed in any histologic subtype after completion of radiation (median follow-up from completion of radiation: 18.1 months BCC, 22.5 months CSCC, 22.7 months MCC). The median duration of observed response (DOOR), measured from first clinical response was 26.9 months (26.2 BCC, 29.4 CSCC, 27.1 MCC). Radiation treatment volumes were response-adapted with median gross tumor volume reduction of 55.3% (15.3%-100%). Median treatment-free response was 20.5 months. No unexpected systemic therapy related toxicities were identified. In this single-institution retrospective case series, induction systemic therapy followed by response-adapted consolidative radiation was feasible and associated with durable disease control in selected patients with locally advanced unresectable NMSC.
Zivkovic Stefan S SS, Misevic Vojko V VV, Krupnikovic Kosta S KS, Obradovic Aleksa D AD et al.
Acute ST-segment elevation myocardial infarction (STEMI) remains a major cause of cardiovascular morbidity and mortality. Despite successful primary percutaneous coronary intervention (pPCI), early myocardial injury and stress may contribute to left ventricular dysfunction. The optimal timing of biomarker assessment after STEMI remains uncertain. To characterize the early kinetics of soluble suppression of tumorigenicity-2 (sST2), galectin-3 (Gal-3), mid-regional pro-adrenomedullin (MR-proADM), and growth differentiation factor 15 (GDF-15) during the first 96 h after STEMI and identify potentially informative sampling time points for future prognostic assessment. Secondary, exploratory objectives were to evaluate differences in biomarker concentrations according to symptom duration, left ventricular ejection fraction (LVEF), and infarct-related artery. In this prospective, single-center, exploratory pilot study, patients aged 18-75 years with first STEMI treated with pPCI within 6 h of symptom onset were enrolled between September 2024 and November 2025. Blood samples were collected at admission and 12 ± 4, 24 ± 4, 48 ± 8, and 96 ± 8 h after pPCI. Biomarkers were measured by ELISA, with high-sensitivity cardiac troponin I (hs-cTnI) as a reference marker of myocardial injury. Of 46 enrolled patients, 16 were excluded, mostly due to early discharge, and 30 patients with complete samples at all five time points were included in the analysis (mean age 57.9 ± 11.1 years; 66.7% male). sST2, MR-proADM, and hs-cTnI showed significant temporal variation (all p < 0.001), with the highest measured concentrations of sST2 at 12 h and of MR-proADM at 24 h. No significant change over time was found for Gal-3 and GDF-15. In exploratory analyses, sST2 and MR-proADM concentrations were higher in patients with LVEF < 40%, and sST2 concentrations were higher in patients with left anterior descending artery (LAD) infarction. Symptom duration was not associated with biomarker concentrations. sST2 and MR-proADM show distinct early post-STEMI kinetics, suggesting potentially informative sampling windows for future prognostic studies. Larger prospective studies are needed to confirm these kinetics and the exploratory differences according to left ventricular function and infarct location, and to evaluate the prognostic value of these sampling windows with echocardiographic and clinical follow-up.
Kalita Himanjali H, Dey Dr Paramita DP
Menstrual material deprivation, also known as period poverty, is a complex public health issue that includes poor sanitation, restricted access to menstrual goods, and a lack of awareness regarding safe menstruation management. Women from lower socio-economic background are disproportionately affected which is associated with reduced participation in social life, employment, and education. Assam, a predominantly rural state in Northeast India marked by socio-economic inequality and uneven access to sanitation and health infrastructure, provides an important context for examining menstrual material deprivation and its implications for women's participation. Evidence from India indicates substantial regional variation in menstrual material use, with northeastern states, including Assam, showing higher reliance on reusable materials compared to southern states. This study adopts a cross-sectional secondary analysis of National Family Health Survey (NFHS-5, 2019-2021) data for women aged 15-24 years in Assam. The analytic sample included women aged 15-24 years in Assam with complete information on menstrual material use and participation-related variables. Menstrual material deprivation was approximated using type of menstrual absorbent (cloth/other vs. disposable pads), while socio-economic characteristics such as wealth, education, residence, and sanitation access were analysed as structural determinants. Women's well-being was examined through behavioural and participation outcomes, specifically restricted mobility and absenteeism from school or work. Descriptive statistics were used to estimate the prevalence of menstrual material use across socio-economic groups. Survey-adjusted Rao-Scott chi-square tests were conducted to examine associations between menstrual material type and socio-economic characteristics. Survey-weighted multivariable logistic regression models were used to estimate adjusted associations between menstrual material use, sanitation access, and participation constraints. Participation restriction was coded "1" if respondents reported either restricted mobility during menstruation or absenteeism from school/work, and "0" otherwise. Overall, 48% of women reported using cloth or other reusable materials, while 52% used disposable sanitary pads. Cloth use was highest among women in the lowest wealth quintile (70%), those with no schooling (58%), and rural residents (53%) (p < 0.001). Participation restrictions were significantly higher among cloth users (42%) compared to pad users (15%) (p < 0.001), and among women without improved sanitation (45% vs. 20%, p < 0.001). In multivariable analysis, cloth users were nearly four times more likely to experience participation restrictions (AOR = 3.85; 95% CI: 3.45-4.30), as did women lacking improved sanitation (AOR = 2.64; 95% CI: 2.31-3.02). Menstrual material deprivation in Assam reflects broader socio-economic and infrastructural inequalities rather than individual preference. Integrated interventions addressing menstrual product access, sanitation, education, and social norms are essential to enhance women's well-being and enable them to fully participate in daily life.
注册免费账户还可查看另外 9996 篇文献
免费注册查看全部文献 →