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Sonovue (Lumason / Sonovue / BR1)

✓ Approved

Bracco · 小分子 · 小分子

什么是 Sonovue？

Sonovue 是一种小分子，由Bracco研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Lumason, Sonovue, BR1
公司Bracco
药物类别小分子, 影像药物
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bracco

治疗适应症

Sonovue 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersArteriosclerosis coronary artery✓ Approved
InvestigationsBlood pressure increased✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

相关研究文献

PubMedJournal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology2026-10-25

Contrast-enhanced echocardiographic assessment of left ventricular wall measurements in cats.

Novo Matos J J, Harding I I, Partington C C

Hypertrophic cardiomyopathy (HCM) is defined by increased left ventricular wall thickness (LVWT), making accurate measurement essential. Contrast-enhanced echocardiography (C-ECHO) improves myocardial border delineation. We aimed to evaluate whether C-ECHO provides more reliable LVWT measurements in cats than standard echocardiography (S-ECHO). Forty-five cats (32 with an LVWT <6 mm and 13 with an LVWT ≥6 mm) were prospectively enrolled in the study. Two-dimensional right parasternal short-axis images were acquired before and after contrast administration (SonoVue: 0.05 mL/kg [0.04-0.14 mL/kg]). Septal and posterior wall thickness values were measured using both modalities. Agreement and reliability were assessed using Bland-Altman analysis, Kappa statistics, and intraclass correlation coefficients. Left ventricular wall thickness was greater with S-ECHO than C-ECHO (maximal LVWT: 5.0 mm [2.8-9.5 mm] vs. 4.2 mm [2.5-8.9 mm], P < 0.0001). On average, the LVWT measured by S-ECHO was 0.61 mm greater than that obtained by C-ECHO. Agreement between S-ECHO and C-ECHO for HCM diagnosis was only moderate (Kappa: 0.50). The Bland-Altman analysis showed fixed biases and wide 95% limits of agreement (LoA) for LVWT (septum: bias: 0.8 mm, LoA: -0.7-2.3 mm; posterior wall: bias: 0.4 mm, LoA: -1.1-2.0 mm). Contrast-enhanced echocardiography demonstrated higher measurement reliability (intraclass correlation coefficient: 0.99 vs. 0.96). A low-mechanical index preset was not used, and measurements were not timed using an electrocardiogram (ECG). Standard echocardiography seems to overestimate LVWT compared to C-ECHO, consistent with findings reported in human studies. Contrast-enhanced echocardiography improves measurement reliability. These findings support its use to enhance HCM assessment in cats.

PMID 42925801
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PubMedJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026-10-15

Microbubble Timing and Vascular Geometry Are Associated With Vessel-Level Blood-Brain Barrier Opening During Focused Ultrasound.

Park Seongdong S, Lee Hyemin H, Choi Seunghwan S, Park Juyoung J et al.

To examine whether minute-scale microbubble handling and injection-to-sonication timing are associated with vessel-level focused ultrasound (FUS)-mediated blood-brain barrier opening (BBBO), and whether control normalization improves longitudinal 2-photon (2P) measurements. Cranial-windowed mice received FITC-dextran (40 kDa) and SonoVue microbubbles by retro-orbital injection, followed by 1.0 MHz FUS at 0.2-0.4 MPa. Two-photon stacks were acquired over 0-15 minutes. Frangi vesselness and Otsu thresholding defined vessel masks and a perivascular ring for extravasation analysis. Three timing conditions were compared: standard (injection within ~5 seconds of reconstitution, sonication immediately); Microbubble Floating (microbubbles held 2 minutes before injection); and Sonication Delay (sonication started 2 minutes after injection). Per-mouse AUC used 2-way ANOVA; slice-level vessel-area dependence used a linear mixed-effects model with mouse as a random intercept. Control intravascular fluorescence decreased by ~24% over 15 minutes, showing that the intravascular signal is not a stable denominator; control-normalized extravascular AUC was therefore the primary metric. Under the standard protocol, extravascular AUC peaked at 0.3 MPa, but the across-pressure difference was not significant (F(2,6) = 3.36, p = .105). Timing effects were descriptive: relative to standard, both Microbubble Floating and Sonication Delay increased extravascular AUC at 0.2 MPa but decreased it at 0.3 MPa. Vessel area was inversely associated with extravasation at the slice level (β = -0.37 per μm2, p = .010), with mouse-level intraclass correlation (ICC = 0.80) indicating dominant between-mouse variability. Microbubble handling and injection-to-sonication timing are potential protocol variables in FUS-BBBO studies. Control-normalized extravascular metrics provide a reproducible framework for vessel-level longitudinal 2-photon quantification.

PMID 42875816
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PubMedPeerJ2026-10-06

Assessment of pleural effusion using intracavitary contrast-enhanced ultrasound: a pilot study.

Tang Dachuan D, Wang Dan D, Li Zhongyu Z, Lu Bohan B et al.

To address the limitations of current imaging modalities, the present study aimed to develop and validate a novel intracavitary contrast-enhanced ultrasound (CEUS) approach for the quantitative assessment of pleural effusion (PE) volume and differentiation of exudative PE from transudative PE. This cross-sectional diagnostic accuracy study prospectively enrolled 100 patients with PE undergoing US-guided thoracentesis. Intracavitary CEUS was performed using SonoVue microbubbles, and time-intensity curve parameters (A, B, and A+B) were analyzed. PE volume was measured based on the drainage volume, and effusions were classified as exudates or transudates according to Light's criteria. Diagnostic performance was assessed by receiver operating characteristic (ROC) analysis, and a linear regression model was developed to predict PE volume. Exudative PE showed significantly higher baseline intensity parameter B (-35.18 ± 5.17 vs. -41.41 ± 8.64, p < 0.01) and lower peak intensity increment parameter A (1.20 ±  3.27 vs. 6.61 ± 6.10, p < 0.01) compared to transudative PE. The combined parameter A+B (steady-state microbubble concentration index) showed a strong correlation with PE volume (r = 0.912, R 2 = 0.831), yielding the predictive model: V(mL) = -33.345 × (A+B) - 453.071 (intraclass correlation coefficient = 0.950). The ROC analysis revealed moderate diagnostic accuracy for the A value (area under the curve (AUC) = 0.779) and B value (AUC = 0.719) in differentiating exudative PE from transudative PE. Intracavitary CEUS could serve as a reliable, minimally invasive, feasible radiation-free adjunctive technique for quantifying PE volume and differentiating exudative versus transudative PE in patients undergoing thoracentesis. The A+B-based regression model provides high predictive accuracy, while A and B values facilitate effusion classification. This quantitative CEUS workflow may facilitate clinical decision-making, and its utility for serial monitoring requires further verification in large-scale real-world cohorts.

PMID 42835785
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PubMedThoracic cancer2026-09-28

Intraoperative Contrast-Enhanced Ultrasound to Assess Lymph Node Resection and Involvement in Patients Undergoing Robotic-Assisted Thoracic Surgery Lobectomy for Management of Non-Small Cell Lung Cancer.

Gaetana Messina M, Fasano Morena M, Pica Davide Gerardo DG, Vicario Giuseppe G et al.

Mediastinal staging is crucial in patients undergoing lung resection for cancer to plan further adjuvant. Current guidelines recommend resecting at least three mediastinal lymph node stations, including Group7. Herein, we evaluated the role of intraoperative Contrast-enhanced ultrasound (CEUS) to guide lymph node resection in patients undergoing RATS lobectomy for management of non-small cell lung cancer. It was a retrospective study including 24 consecutive patients underwent RATS lobectomy for management lung cancer. The hilar and mediastinal lymph node was firstly evaluated with a CEUS and then resected. A bolus of 2.4 mL SonoVue was injected into the antecubital vein and the perfusion was scanned continuously for at least 3 min. The dynamic image obtained was used to evaluate the mediastinal and hilar lymph nodal and guide the dissection. A radical lymph-adenectomy was performed in all cases independently from the CEUS results. We evaluated 144 lymph nodes with a CEUS during RATS lobectomy. Histological examination of the lymph nodes showed five lymph nodes metastatic (3.5%); of which 3 (60%) metastatic N1 lymph nodes; 2 (40%) metastatic N2 lymph nodes. Intraoperative CEUS of hilar and mediastinal lymph nodes showed: sensitivity 83%; specificity 98%; PPV, 77%; PNV, 99% and accuracy 94%. Our preliminary results seem to confirm the value of intraoperative CEUS to assess lymph node resection during RATS lobectomy. It may help the lymph node dissection and reduce the risk of intraoperative injury. Future study should confirm our preliminary results and confirm the value of intraoperative CEUS.

PMID 42802416
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PubMedUltrasonics sonochemistry2026-09-25

Microbubble-assisted pLIFU enhances riboflavin delivery and corneal cross-linking in an in vivo rabbit keratoconus-like model.

Wang Qiao Q, Guo Shifang S, Sun Youjia Y, Wu Yaojie Y et al.

Epithelium-off corneal collagen cross-linking (CXL) slows keratoconus progression but disrupts the epithelial barrier, whereas epithelium-on CXL is constrained by limited stromal riboflavin loading and insufficient evidence that physical delivery enhancement improves CXL outcomes in vivo keratoconus-like ectasia. Here, we developed microbubble-assisted pulsed low-intensity focused ultrasound (pLIFU) to enhance riboflavin transport through cavitation and evaluated its therapeutic effect in a collagenase-induced rabbit keratoconus-like model. Passive cavitation detection and temperature monitoring identified a treatment condition of 1 Hz pulse repetition frequency, 20 % duty cycle, 1.43 MPa focal-zone peak negative pressure, and 200 μl SonoVue solution, with maximum temperature rise limited to 1.5 °C. Hydrophone measurements showed low posterior-segment acoustic action, with a retinal-position mechanical index of approximately 0.076. Confocal fluorescence imaging showed that pLIFU with microbubbles increased peak stromal riboflavin fluorescence by 9.27 ± 2.16-fold (p < 0.0001) and effective penetration depth by 4.09-fold (p < 0.001) relative to control. In vivo, pLIFU-microbubble-enhanced CXL produced greater corneal flattening and a larger shear-wave-speed response than the US group. One month after treatment, central corneal curvature decreased by 45.85 ± 6.32 % and shear-wave speed (cs) increased by 52.50 ± 12.89 % relative to pretreatment in the USMB group. Short-term histology and inflammatory cytokine assays showed no sustained inflammatory elevation or overt retinal laminar disruption within the observation window. These findings support the early feasibility of pLIFU cavitation-enhanced riboflavin delivery as a physical augmentation strategy for epithelium-on CXL in keratoconus-like ectasia, with favourable short-term ocular tissue tolerance for the assessed endpoints; they do not establish non-inferiority to epithelium-off CXL or long-term safety and durability.

PMID 42790152
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PubMedIEEE transactions on ultrasonics2026-09-24

Implementation of subharmonic imaging on a clinical scanner for optimal ambient pressure sensitivity with SonoVue microbubbles.

De Koninck Lance H LH, Michaelis Hanna H, Babu Gautam G, Powers Jeffry E JE et al.

Subharmonic imaging for ambient pressure estimation is a noninvasive alternative to catheter pressure measurements currently used to diagnose multiple disease processes. However, current implementations of subharmonic imaging settings lack important attributes necessary for accurate generation and detection of the subharmonic component. Some implementations employ frequencies near the resonance frequency of microbubbles, requiring high acoustic pressure to generate subharmonic signals. Others utilize short pulses (2-6 cycles) resulting in scattered spectra where the fundamental and subharmonic frequencies overlap. We investigated longer pulses at twice the resonance frequency of SonoVue microbubbles and detected the subharmonic component as a method sensitive to ambient pressure changes. We used an in-vitro pressure chamber filled with SonoVue to vary the ambient pressure (0-140 mmHg) while collecting subharmonic images. We considered multiple frequencies, pulse lengths, acoustic pressures (0-900 kPa), pulsing schemes, imaging arrays, and microbubble concentrations. Native linearized image data and radiofrequency data were used to accurately measure the subharmonic signal. Transmitting at twice the resonance frequency (4.2 MHz) results in the greatest change in subharmonic signal with ambient pressure, a 16 dB increase from 0-80 mmHg (+0.2 dB/mmHg) at 70 kPa acoustic pressure. At low acoustic pressures the sensitivity of subharmonic imaging to ambient pressure changes was not impacted by variation in microbubble concentration or image depth. Higher ambient pressures (> 100 mmHg) resulted in microbubble destruction that reduced image intensity without a change in subharmonic sensitivity. The findings in this work provide evidence of the utility of SonoVue for ambient pressure sensing at low acoustic pressures.

PMID 42784473
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