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LH

LH + FSH (Menopur / LH + FSH, Ferring / Meropur)

✓ Approved

Ferring · FSHR

什么是 LH + FSH？

LH + FSH 是一种治疗药物，由Ferring研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

商品名Menopur, LH + FSH, Ferring, Meropur
公司Ferring
分子靶点FSHR, LHCGR
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Ferring

作用机制

分子靶点

LH + FSH 作用于 2 个分子靶点：

FSHRfollicle stimulating hormone receptor (FSHRO, ODG1)
LHCGRluteinizing hormone/choriogonadotropin receptor (ULG5, LH/CGR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

LH + FSH 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersInfertility female✓ Approved

相关研究文献

PubMedChinese journal of integrative medicine2026-09-10

Transcriptomic Insights into Acupuncture Mechanisms in Protecting Ovarian Function in Mice with Premature Ovarian Insufficiency.

Luo Yu Y, Yu Meng M, Feng Shi-Yu SY, Huang Su-Ning SN et al.

To explore the molecular mechanisms underlying the protective effect of acupuncture on ovarian function in mice with cyclophosphamide-induced premature ovarian insufficiency (POI) via transcriptomic analysis. Twenty female C57BL/6 mice were divided into 4 groups: control, model, acupuncture, and non-meridian/non-acupoint (NOMA). POI was induced in the model, acupuncture, and non-meridian/non-acupoint groups via cyclophosphamide injection. The acupuncture group received acupuncture at Guanyuan (CV 4), bilateral Guilai (ST 29), and Sanyinjiao (SP 6) for 3 weeks. After the intervention, ovarian tissue weight and ovarian coefficient were calculated, serum levels of key reproductive hormones including follicle-stimulating hormone (FSH), luteinizing hormone (LH) and anti-Müllerian hormone (AMH) were detected, and ovarian histopathological changes were observed to evaluate ovarian function. Transcriptome sequencing was performed to identify differentially expressed genes (DEGs), followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to explore key functional terms and signaling pathways. Western blot was finally applied to validate the expression of core proteins related to mitochondrial function, endoplasmic reticulum stress and inflammatory pathways. The model group showed reduced ovarian weight and elevated FSH levels. The acupuncture group exhibited significantly higher ovarian weight and coefficient, lower FSH levels, and increased E2 and AMH levels compared to the model group (all P<0.01). Transcriptomic analysis revealed 4,021 DEGs between groups. GO and KEGG analyses revealed that these DEGs were mainly involved in oocyte development, steroid hormone synthesis, and pathways related to mitochondrial function, endoplasmic reticulum stress, and inflammatory signaling. Western blot analysis showed that acupuncture partially restored mitochondrial function markers cytochrome c oxidase subunit IV and NADH dehydrogenase 1 beta subcomplex subunit 8 and reduced endoplasmic reticulum stress markers (glucose-regulated protein 78 and Calnexin, P<0.01). It also downregulated pro-inflammatory proteins (IL-17R, IL-17A, NF-κB p65, p-NF-κB p65, ERK1/2, and p-ERK1/2) and upregulated proteins related to metabolic homeostasis (peroxisome proliferator-activated receptor γ, receptor-interacting protein 140, nicotinamide phosphoribosyltransferase, and sirtuin 1, P<0.01). Acupuncture effectively alleviates cyclophosphamide-induced POI in mice, improves ovarian function and follicular quality by regulating cellular functions and inflammatory pathways, suggesting a novel therapeutic approach for POI.

PMID 42717146
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PubMedHealth science reports2026-09-10

Association of Ethnicity With Ovarian Reserve: A Systematic Review and Meta-Analysis.

Raees Mahnaz M, Hussain Shahzadi Saima SS, Asif Sumayya S, Faisal Syed Suleman SS et al.

Ovarian reserve markers are reported to differ across ethnic groups, though the sources of this variation are unclear. We aimed to document this variation and examine the environmental, nutritional, and sociocultural factors that may explain it. Observational studies were included if they enrolled women aged 18-45 and reported ovarian reserve markers (AMH, AFC, or FSH) stratified by an explicitly defined ethnicity classification. Four databases were searched. Risk of bias was assessed with the Joanna Briggs Institute checklist. A random-effects meta-analysis estimated standardized mean differences (SMD) with 95% confidence intervals (CI) and prediction intervals; heterogeneity was assessed with τ2 and I2. The two-study FSH comparison was treated as exploratory. Ten studies (10,349 women, nine countries) were included in the narrative synthesis; six contributed to the AMH meta-analysis and two to the exploratory FSH analysis. Most studies (7/10) had a low risk of bias. Individually, most studies reported higher ovarian reserve markers in White European women than in women of Middle Eastern, South Asian, or some Latin American or African descent. The pooled estimates for Asian versus European women were not statistically significant and were accompanied by extreme heterogeneity: AMH (6 studies: SMD -0.68, 95% CI -1.84 to 0.48; p = 0.19; I2 = 99.1%) and FSH (2 studies: SMD -1.36, 95% CI -15.25 to 12.54; p = 0.43; I2 = 89.8%). The wide FSH interval reflects the fragility of pooling only two studies. The consistent, clinically relevant finding here is qualitative: individual studies repeatedly report lower ovarian reserve markers outside White European populations, most plausibly reflecting environmental, nutritional, and socioeconomic exposures rather than fixed biology. The pooled estimates are exploratory given the small number of studies and near-total heterogeneity, and should not be over-interpreted. Population-specific AMH reference ranges, informed by studies that rigorously adjust for these confounders, are needed for equitable clinical decision-making. PROSPERO Registration: CRD420251026342.

PMID 42719055
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PubMedArchivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica2026-09-09

Association of testicular MRI findings with spermatogenic status and intratesticular sperm in patients with azoospermia or cryptozoospermia.

Ogawa Soichiro S, Kirihana Yusuke Y, Yaginuma Kei K, Meguro Satoru S et al.

The pathophysiology and presence of intratesticular sperm in patients with azoospermia are usually assessed based on clinical findings, hormonal evaluation, and ultrasonography; however, assessment based on these conventional examinations does not always yield an accurate diagnosis. We focused on magnetic resonance imaging (MRI) and aimed to investigate the association between testicular MRI findings, spermatogenic status, and the presence of intratesticular sperm in patients with azoospermia or cryptozoospermia.  Methods: Thirty-three patients (45 testes) who underwent preoperative testicular magnetic resonance imaging (MRI) and intraoperative testicular biopsy during varicocelectomy or testicular sperm extraction were included in this study. Associations between the apparent diffusion coefficient (ADC) values of testes and clinical parameters were analyzed. Among the 33 patients (45 testes) included in the analysis, normalized ADC values showed significant positive correlations with serum follicle-stimulating hormone (FSH) (rs = 0.366, p = 0.015) and LH (rs = 0.414, p = 0.006), and a significant negative correlation with Johnsen's score count (JSC) (rs = -0.377, p = 0.0088). No significant correlation was observed between ADC values and total testosterone (TT) concentration or testicular volume (TV). ADC values were significantly higher in testes without intratesticular sperm (p < 0.000005). Receiver-operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.667 for predicting the presence of intratesticular sperm, using a cutoff ADC value of 0.382×10-3 mm2/s (sensitivity 0.686, specificity 0.8). These findings suggest that testicular MRI findings are associated with spermatogenic status and the presence of intratesticular sperm and may provide complementary information when combined with other clinical parameters.

PMID 42714389
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PubMedIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2026-09-09

Understanding the Endocrine Consequences of Transfusion-Dependent Thalassemia: A Detailed Exploration of Key Influences.

Shanker Addyaa A, Aggarwal Priyanka P, Kumar Ishan I, Singh S K SK et al.

Children with transfusion-dependent thalassemia (TDT) often face various endocrine complications from iron overload, extramedullary hematopoiesis, and bone marrow expansion, influenced by genetic and non-genetic factors like blood transfusions and iron chelation. This study aims to evaluate the interplay between genetic predisposition, iron overload, and endocrine dysfunction. This was a prospective cross-sectional study including children ≥ 6 year age with TDT. Hospital records were analyzed to collect patient information, blood transfusion requirements, type and duration of chelation therapy. All patients underwent estimation of serum ferritin, glucose, calcium, phosphate, alkaline phosphatase (ALP), paratharmone (PTH), vitamin D, and free T4/ thyroid stimulating hormone (TSH), whereas peripubertal children also underwent luteinizing hormone (LH), follicle stimulating hormone (FSH), estrogen, and testosterone. Only those suspected of having central cause of endocrine complications underwent growth hormone estimation. Various endocrine abnormalities were observed across 83 children (63males, 20females; aged6-20 years). Elevated mean serum ferritin levels > 3500 ng/ml was associated with increased prevalence of hypogonadism, growth retardation, hypothyroidism, impaired glucose tolerance, and hypoparathyroidism with p-values of 0.005, < 0.001, 0.02, 0.04, and 0.05, respectively. Children with β0β0 genotype had higher incidence of growth retardation (p = 0.03) and hypoparathyroidism (p = 0.02). Starting chelation therapy after 2years age resulted in hypogonadism(p = 0.003) and short stature(p = 0.04), while hypothyroidism(p = 0.04) was more prevalent in those who began transfusions after 2years age. Receiving over 20 transfusion units per year significantly resulted in glucose intolerance(p = 0.00) and osteopenia(p = 0.03). This study highlights the prevalence as well as multifactorial influences on endocrine complications in TDT, emphasizing the need for targeted interventions to improve patient outcomes.

PMID 42712790
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PubMedFrontiers in immunology2026-09-09

Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis.

Luo Yujun Y, Huang Chaojie C, Lu Yanting Y, He Jieying J et al.

Pediatric central precocious puberty (CPP) is driven by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, along with immune-inflammatory imbalance, metabolic dysfunction, obesity, and gut microbiota-derived signals. According to traditional Chinese medicine (TCM) principles, kidney yin deficiency with hyperactive ministerial fire and spleen deficiency with phlegm-dampness form the basis for central pubertal activation and peripheral metabolic-inflammatory burden, thus supporting a combined approach for obesity-related or mixed-pattern CPP. Representative prescriptions include modified Zhibai Dihuang pills with Liujunzi decoction and modified Danzhi Xiaoyao powder with Erchen decoction, which integrate kidney yin-nourishment and ministerial fire-clearance with spleen qi-strengthening and phlegm resolution. Available clinical evidence suggests potential benefits in controlling secondary sexual characteristics, reducing gonadotropin and sex-steroid levels, and slowing bone-age advancement. Mechanistic studies indicate possible regulation of kisspeptin/GPR54/GnRH and LH/FSH-sex-steroid signaling, Th1/Th2/Treg homeostasis, NF-κB/NLRP3 pathways, adipokine imbalance, insulin resistance, hypothalamic inflammation, and gut microbiota-associated metabolism. However, most mechanistic links remain indirect, comparative trials are scarce, and direct correction of pathogenic MKRN3 or DLK1 variants has not been demonstrated. In this review, we have discussed the role of kidney and spleen dysfunction in CPP and explored the underlying mechanisms - particularly in the context of the neuro-endocrine-immune network that links central neuroendocrine activation with peripheral immune-metabolic signals. In addition, the application of TCM in the management of CPP, and the translational challenges of applying TCM as an adjunct to established CPP management have also been explored. Future research should prioritize CPP-specific pathway validation, identification of syndrome biomarkers, multi-omics-based stratification, multicenter trials, and long-term pediatric safety monitoring.

PMID 42713456
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PubMedIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2026-09-09

Utility of WBC Scatterplots and Suspect Flags Generated by Beckman Coulter LH-750 Hematology Analyzer in the Characterization of Leukemias and Related Hematological Malignancies.

Donald Saurabh S, Kakkar Naveen N, Mashon Ranjeet Singh RS, John M Joseph MJ et al.

Numerical data, flags and WBC scatterplots generated by automated hematology analyzers can aid in the early detection of leukemias. This study was done to assess the utility of automated data in leukemia characterization. This observational cross-sectional study included blood samples from patients with suspected or confirmed hematological malignancies. Blood samples were run on Beckman Coulter LH 750 5-part automated hematology analyzer. Routine CBC parameters, WBC suspect flags and scatterplots were studied. The study included 396 patients with leukemias and related hematological malignancies. Automated differential count showed increasing neutrophil percentage in AML subtypes according to the maturation. Mean monocyte percentage of 37.3 was seen in patients with AML M4/M5. Thirty one (79.5%) of the 39 patients with AML M4/M5 showed the monoblast (MO) flag. Patients with ALL and CLL showed variant lymphocyte and/or LY Blast flags. Ten abnormal WBC scatterplot patterns were seen. Most (80%) patients with APML showed a characteristic scatterplot pattern. Patients with AML M4/M5 showed consistent monocytic and monocytic/granulocytic patterns. WBC scatterplots showed a sensitivity of 92.5% and specificity of 91.5% to detect abnormal cell populations indicative of leukemias. Patients with ALL and CLL showed mainly lymphoid dominant scatterplot patterns. Patients with CML also showed a characteristic granulocytic predominant plot. Automated WBC data has utility in identifying abnormal leukemia WBC populations. For APML and CML, characteristic WBC scatterplots were seen. In other leukemias, overlap patterns exist which can be delineated further by flagging data and differential percentages.

PMID 42712746
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