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LH

LH + FSH (Menopur / LH + FSH, Ferring / Meropur)

✓ Approved

Ferring · FSHR

什么是 LH + FSH？

LH + FSH 是一种治疗药物，由Ferring研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

商品名Menopur, LH + FSH, Ferring, Meropur
公司Ferring
分子靶点FSHR, LHCGR
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Ferring

作用机制

分子靶点

LH + FSH 作用于 2 个分子靶点：

FSHRfollicle stimulating hormone receptor (FSHRO, ODG1)
LHCGRluteinizing hormone/choriogonadotropin receptor (ULG5, LH/CGR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

LH + FSH 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersInfertility female✓ Approved

相关研究文献

PubMedInternational journal of fertility & sterility2026-10-26

Therapeutic Potential of Bone Marrow-Derived Mesenchymal Stem Cells in A Letrozole-Induced Rat Model of Polycystic Ovary Syndrome.

M Abou-El-Naga Amoura A, Younes Elarby Nada N, El-Dusoky Sara S, Fayad Eman E et al.

Polycystic ovary syndrome (PCOS) is a prevalent metabolic and reproductive disorder and one of the leading causes of infertility. Bone marrow-derived mesenchymal stem cells (BM-MSCs) possess anti-inflammatory properties and have shown potential in alleviating PCOS manifestations in experimental models. This study aimed to evaluate the therapeutic efficacy of transplanted BM-MSCs and BM-MSC-derived culture media in a letrozole (LTZ)- induced PCOS rat model. The experimental study was conducted on 50 female Sprague Dawley rats aged (4-6 weeks) and weighing (100-120 g), using a LTZ-induced PCOS model. Animals were randomly assigned to 4 groups, including control, PCOS, BM-MSC-treated, and BM-MSC culture media-treated groups. BM-MSCs were isolated from (bone marrow) and administered via (tail vain) at a dose of (1×106 BM-MSC). Blood samples were collected to measure hormonal and metabolic parameters (insulin, androgen, progesterone, estrogen, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) using [enzyme-linked immunosorbent assay (ELISA) technique). Ovarian tissues were analyzed by for histopathological and immunohistochemical methods to assess [key markers, e.g., follicular development, tumor necrosis factor-alpha (TNF), and vascular endothelial growth factor (VEGF)]. The PCOS group exhibited hormonal imbalance, metabolic disturbance, and ovarian dysfunction. BMMSC treatment significantly reduced insulin (P=0.003) and androgen levels (P=0.040), while restoring progesterone (P=0.003), estrogen (P=0.007), FSH (P=0.009), and LH (P=0.001) to near-normal levels. BM-MSCs markedly improved both metabolic and reproductive parameters, effectively restoring fertility in the PCOS model. Treatment with BM-MSC-derived culture media produced partial improvement but did not fully reverse PCOS manifestations. BM-MSCs improved ovarian structure and function, ameliorating both metabolic and reproductive dysfunction in the PCOS rat model. BM-MSC transplantation yielded the most favorable outcomes, whereas BM-MSCderived culture media alone provided incomplete therapeutic benefits.

PMID 42929028
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PubMedBiosensors2026-10-26

HueFertility Ovulation: A Smartphone-Enabled Quantification System for Urinary Luteinizing Hormone in a Lateral Flow Assay.

Menon Nidhi N, Kara Erdi E, Sharma Prava P, Crutchfield Adrian A et al.

Luteinizing hormone (LH) is a critical biomarker for ovulation prediction and reproductive health monitoring, yet most commercially available at-home LH tests rely on qualitative or semi-quantitative visual interpretation, limiting their clinical utility. We present HueFertility Ovulation, a smartphone-enabled quantitative LH measurement system comprising a lateral flow immunoassay dipstick and a mobile application that integrates proprietary color correction algorithms with a deep learning regression model to deliver objective LH concentration estimates from strip images captured under variable real-world conditions. Color correction using the HueCard reference system substantially reduced inter-image color variability, decreasing mean ΔE00 from 11.19 to 4.02 across diverse lighting environments. When evaluated against known LH concentrations in a separately acquired independent dataset, the regression model achieved R2=0.92 and a mean absolute percentage error (MAPE) of 17.4%. The experimental limits of blank, detection, and quantitation were 0.64, 3.18, and 10.00 mIU/mL, respectively. Multi-site precision testing demonstrated %CVs within 25% across three independent locations. At a per-test cost of $0.60 with no external hardware required, HueFertility offers a low-cost, accessible platform for quantitative LH monitoring, with utility in fertility planning, hormonal health tracking, and resource-limited settings. Ultimately, the study highlights the opportunity to extend the technology to other low-cost lateral flow tests and clinical chemistry applications.

PMID 42930136
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PubMedJSES reviews, reports, and techniques2026-10-25

Comparing outcomes of onlay humeral stem designs in reverse total shoulder arthroplasty: a systematic review.

Daher Nicholas N, Mazeh Mahdi M, Castle Joshua P JP, Nikolopoulos Christopher C et al.

Since the development of the original Grammont implant, reverse shoulder arthroplasty (rTSA) has evolved, with onlay and inlay humeral designs emerging as the 2 main options. Onlay designs have gained popularity due to modularity and adaptability, allowing conversion from anatomic total shoulder arthroplasty to rTSA. While differences in medialization and lateralization of the glenoid and humeral stem have been studied, little is known about the impact of these features in various onlay implants. This systematic review aims to compare the clinical outcomes of lateralized humeral (LH) and medialized humeral (MH) onlay designs in rTSA. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search was conducted in PubMed, Ovid MEDLINE, Embase, and Web of Science to identify studies comparing clinical outcomes of onlay designs. The primary outcomes of interest were patient-reported outcomes and shoulder range of motion. Of 1,005 studies reviewed, 14 met the inclusion criteria, including 14,427 patients. Range of motion comparisons revealed no significant difference in forward flexion between LH and MH designs (135.08° vs. 137.07°, P = .2929). Similarly, abduction did not significantly differ (113.02° vs. 116.42°, P = .1387). Both internal rotation and external rotation were significantly greater in the LH group (6.62 vs. 5.84, P = .0063) (41.21° vs. 31.94°, P < .0001), respectively. American Shoulder and Elbow Surgeons scores were higher in the LH group (77.89 vs. 75.33, P = .255), though not statistically significant. Visual analog scale pain scores were significantly lower in the LH group (0.724 vs. 1.613, P = .0015). Conversely, the MH group demonstrated significantly higher Constant scores (66.51 vs. 60.37, P < .0001). Complication rates were significantly higher in the MH group (13.8%) compared to the LH group (2.0%) (P < .001; χ2 test). The LH and MH configurations for onlay rTSA demonstrate distinct domain-specific advantages. LH implants were associated with significantly lower visual analog scale pain scores (0.724 vs. 1.613; P = .0015), superior internal rotation (6.62 vs. 5.84; P = .0063), and markedly greater external rotation (41.21° vs. 31.94°; P < .0001). However, only the external rotation difference exceeded the Minimal Clinically Important Difference. MH implants demonstrated higher Constant scores (66.51 vs. 60.37; P < .0001), though forward flexion and abduction did not significantly differ between groups. Importantly, complication rates were significantly higher in the MH group (13.8% vs. 2.0%; P < .0001). These nuanced differences underscore the importance of individualized surgical planning.

PMID 42926853
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PubMedGeriatric nursing (New York, N.Y.)2026-10-25

Handedness-dependent grip strength and asymmetries: Modulation of physical performance in healthy older adults.

Mahato Niladri Kumar NK, Davis Alexandria A

Handgrip Strength (HGS) is a reliable indicator for assessing physical performance, overall muscle strength and can provide insights into mortality risk in older adults. Although reports on handedness associated HGS are available in the literature, studies on handed related HGS asymmetries and their relationship with physical performance specifically in seniors are sparse. This report analyzed HGS data in older-adult participants who self-identified right (RH) or left (LH) hand-dominant [n=45, mean (SD)=74.04 (6.99) years, females=34, males=11; RH=30, LH=15], recorded anthropometric measurements and performed the Short Physical Performance Battery (SPPB) and 30-second chair-rise test (CRT-30) with power analysis. Cross-sectional analysis of association between HGS means, ratios (dominant/non-dominant), HGS asymmetries, % HGS differences with physical performance in older adults. Demonstrate strong within and between-group correlations (Pearson's 'r' ∼ > 0.80) for RH and LH data. No significant dominant vs. non-dominant HGS differences [mean (SD)=21.72kg (8.71) vs. 23.53kg (10.02), (95% CI = 19.86 - 27.21kg vs. 18.53 - 24.91kg), (p=0.06)] were found for the RH group. Only the LH dominant vs. non-dominant HGS presented significant differences [mean (SD)= 19.46kg (8.15) vs. 16.36kg (8.93), (p=0.03)]; the LH group presented significant dominant [95% CI= 15.12, 19.98] vs. non-dominant HGS differences (95% CI= 9.49, 9.8), (p<0.01). This group showed strong association between non-dominant HGS and SPPB (R2=0.38), 5x CRT (R2=0.48), CRT-30 chair-rise repetitions (R2=0.25) and power (R2=0.55); SSSP and 5x CRT (R2=0.67), CRT-30 power (R2=0.40); and overall left to right correlation (Pearson's 'r'=0.88). Stronger and clinically meaningful association between non-dominant HGS and physical performance in the setting of significant dominant vs. non-dominant HGS differences may exist in LH older adults.

PMID 42925792
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PubMedMicrobiology spectrum2026-10-25

Baicalin and levofloxacin exert divergent modulation on gut microbiota and metabolome crosstalk in DSS-triggered ulcerative colitis.

Wang Caixia C, Wu Weihan W, Cui Mingxi M, Zhang Shaosen S et al.

Baicalin (BA), a bioactive flavonoid, and levofloxacin hydrochloride (LH), a fluoroquinolone antibiotic, both hold potential for ulcerative colitis (UC) treatment, yet the mechanistic differences in their regulation of gut microbiota and metabolome remain elusive. This study aimed to systematically compare their therapeutic efficacy and underlying mechanisms in a dextran sulfate sodium-induced murine colitis model, with a focus on gut microbial and metabolic modulation. Mice were randomized into Control, model, BA-treated, and LH-treated groups. Disease severity was assessed via body weight changes, disease activity index, colon length, and histopathological analysis. Western blot and enzyme-linked immunosorbent assay were employed to detect NF-κB pathway activation and pro-inflammatory cytokine levels, while 16S rRNA sequencing and metabolomics profiled gut microbiota and metabolites. Both agents markedly ameliorated colitis symptoms, suppressed NF-κB activation, and cytokine expression, with BA showing superior cytokine inhibition. BA enriched beneficial Lactobacillus, regulating isoflavone/alkaloid synthesis; LH elevated Akkermansia abundance and modulated amino acid metabolism. These findings reveal distinct therapeutic mechanisms of BA and LH, laying a foundation for personalized UC therapy and validating BA's traditional medicinal utility.IMPORTANCEUlcerative colitis remains a prevalent inflammatory bowel disease with limited microbiota-targeted therapies. Baicalin and levofloxacin both alleviate dextran sulfate sodium-induced colitis, yet their gut microbiome and metabolome regulatory mechanisms have not been directly compared. This study demonstrates that baicalin and levofloxacin exert anti-colitis effects via divergent microbiota-metabolite axes: baicalin enriches Lactobacillus and modulates isoflavone/alkaloid metabolism, while levofloxacin increases Akkermansia and reshapes amino acid metabolism. These distinct mechanisms provide new evidence for developing microbiota-based personalized strategies for ulcerative colitis treatment.

PMID 42925028
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PubMedNeurobiology of stress2026-10-25

Sex-dependent cross-resilience to social defeat and learned helplessness: The role of BDNF-ERK signaling and norepinephrine.

Bairachnaya Maryia M, Penney Lucy L, Fakhfouri Gohar G, Isingrini Elsa E et al.

Major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are two of the most prevalent and disabling psychiatric conditions, both closely tied to stress exposure. While they have distinct diagnostic criteria, MDD and PTSD share considerable comorbidity, overlapping behavioral symptoms, and common neurobiological pathways. However, not all individuals exposed to chronic or traumatic stress develop these disorders, highlighting the importance of resilience, the capacity to maintain psychological and physiological stability under stress. An emerging yet incompletely understood aspect of stress adaptation is cross-resilience, defined as the extent to which resilience or susceptibility to one form of stress generalizes to subsequent stressors across contexts. While animal models have effectively captured individual differences in stress responses, few have explored whether resilience generalizes across distinct stress modalities or differs by sex. We examined cross-resilience using two validated rodent models: chronic social defeat stress (CSDS) and learned helplessness (LH). These paradigms model complementary aspects of stress vulnerability. We assessed how prior CSDS experience influenced subsequent responses to LH. We also evaluated the role of the noradrenergic system using wild-type and norepinephrine (NE)-deficient (VMAT2loxDBHcre KO) mice. Behavioral phenotyping was combined with molecular analyses in key brain regions involved in emotion, motivation, and fear processing: the ventral tegmental area (VTA), nucleus accumbens (NAc), and amygdala (AMY). We focused on BDNF and ERK/MAPK signaling pathways, known to mediate neuroplasticity and stress resilience. Our findings reveal sex-specific patterns of cross-resilience, with prior CSDS resilience predicting LH resilience in males but not females. Molecular results indicate distinct adaptations across brain regions and sexes, underscoring the biological complexity of resilience. These insights may inform personalized strategies for preventing and treating stress-related disorders.

PMID 42927174
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