AMEGA Biotech · IFNB1 · 重组蛋白
Human recombinant interferon beta-1a 是一种重组蛋白，由AMEGA Biotech研发。该药已获批，用于治疗相关适应症，给药途径：Intramuscular (IM) Injection。
| 商品名 | Megavex |
| 公司 | AMEGA Biotech |
| 药物类别 | 重组蛋白 |
| 分子靶点 | IFNB1 |
| 给药途径 | Intramuscular (IM) Injection |
| 状态 | Approved |
Human recombinant interferon beta-1a 作用于 1 个分子靶点：
| IFNB1 | interferon beta 1 (IFN-beta, IFNB) |
Human recombinant interferon beta-1a 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Nervous system disorders | Multiple sclerosis | ✓ Approved |
Najafi Soroosh S, Jojani Maryam M, Najafi Kianoosh K, Roviello Giovanni N GN
In the original publication [...].
Khisamieva Guzel G, Sologova Diana D, Svitich Oxana O, Diachkova Ekaterina E et al.
Background/Objectives: Oral potentially malignant diseases (OPMDs) with signs of epithelial dysplasia are characterized by a high risk of malignancy. However, there are still no algorithms for their early diagnosis and prediction, due to the many possible predisposing factors, including human papillomavirus (HPV) infection and decreased immunity. There is a need to assess the relationship between the manifestations of oral epithelial dysplasia (OED), HPV invasion in the oral cavity, and interferon status to improve the identification and characterization of patients with different degrees of dysplasia. Methods: This study was designed and reported with reference to the STROBE checklist. The study aimed to assess the association between interferon status and HPV invasion in patients with OED. As per the inclusion and exclusion criteria, this observational study included 180 patients with histologically confirmed oral epithelial dysplasia associated with leukoplakia or oral lichen planus. Interferon (IFN) status was assessed by measuring serum interferon activity, spontaneous interferon production, IFN-α/β, and IFN-γ activity in peripheral blood. HPV DNA was detected and genotyped in biopsy specimens using polymerase chain reaction. Results: HPV-positive patients demonstrated significantly lower IFN-α/β and IFN-γ activity compared with HPV-negative patients (p < 0.001). Severe OED was more frequently observed in HPV-positive individuals, whereas mild dysplasia predominated among HPV-negative patients (p < 0.05). Interferon activity progressively decreased with increasing dysplasia severity, with the lowest IFN-α/β and IFN-γ activity detected in patients with severe dysplasia (p < 0.001 and p < 0.05, respectively). A significant positive correlation between IFN-α/β and IFN-γ activity was identified in patients with moderate dysplasia (p = 0.003). Multivariate binary logistic regression analysis demonstrated that HPV positivity (adjusted OR = 4.62, 95% CI: 2.18-9.79; p < 0.001) and reduced IFN-α/β activity (adjusted OR = 1.34 per 10-unit decrease, 95% CI: 1.14-1.58; p < 0.001) were independently associated with severe dysplasia. The multivariable model demonstrated acceptable discriminatory ability for identifying patients with severe dysplasia (AUC = 0.736), with a sensitivity of 89.4% and a specificity of 56.1%. Conclusions: The findings suggest that HPV-associated OED is linked to reduced interferon status, particularly lower IFN-α/β and IFN-γ activity in more severe dysplastic lesions. Combined assessment of interferon status and HPV detection may help identify patients at higher risk of severe OED.
Liu Yang Y, Guo Hua H
In hyperthermal chemistry, electronically excited cyano radicals (CN) are considered as a key radiative source in the shock boundary layer in front of supersonic (re)entry vehicles. To correctly model radiative heating in such extreme environments, it is necessary to understand collisional excitation and quenching rates. Although quenching of CN(A2Π) to CN(X2Σ+) with various collision partners has been investigated experimentally, a quantitative understanding of the nonadiabatic transitions in such electronically inelastic scattering has not been achieved. In this work, a full-dimensional diabatic potential energy matrix (DPEM) for the three lowest-lying singlet A' states of HCN, namely the 1 1A', 2 1A', and 3 1A' states, is developed based on multi-reference configuration interaction calculations. The DPEM provides valuable insights into the quenching/excitation of CN(X2Σ+/A2Π) via collisions with H in the singlet manifold.
Kawase Yuria Y, Ito Kanta K, Omi Cocoro C, Ota Kei K et al.
The bulky Eind-substituted diphosphene, (Eind)P═P(Eind) (1a), reacted with an excess of elemental sulfur (S8) in solution at elevated temperatures to produce an isolable monomeric P(V) species, dithioxophosphorane, (Eind)P(═S)2 (4a), along with cleavage of the P═P double bond (Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl). A three-membered P2S ring compound with formally P(II) centers, thiadiphosphirane, (Eind)P(S)P(Eind) (2a), was isolated as an intermediate in this solution-phase reaction. In contrast, mechanochemical treatment of 1a with S8 by ball milling under solid-state conditions afforded a P(I)/P(III) mixed-valent diphosphorus species, diphosphene sulfide, (Eind)(S═)P═P(Eind) (3a), which gradually isomerized to 2a at room temperature. The sulfurized products 2a, 3a, and 4a were characterized by 31P NMR spectroscopy, and the molecular structures of 2a and 4a were confirmed by single-crystal X-ray diffraction (SC-XRD) analysis. The structural and electronic properties of these sulfurized products were further investigated using density functional theory (DFT) calculations.
Antonov Daniil O DO, Loguinova Marina Yu MY, Fan Hui H, Sazonova Elena V EV et al.
Allogeneic chimeric antigen receptor (CAR)-based cell products and induced pluripotent stem cell (iPSC)-derived regenerative grafts increasingly use multilayer immune engineering. Current strategies are strongest against direct human leukocyte antigen (HLA)-dependent recognition but incompletely address natural killer (NK)-cell counter-pressure, priming by recipient antigen-presenting cells, humoral and complement-mediated injury, inflammatory remodeling, blood- and tissue-interface damage, and terminal cell killing. Poxvirus research has characterized diverse immunomodulatory mechanisms relevant to these barriers. We review poxviral control of interferon signaling, antigen processing and presentation, T-cell activation, NK-cell surveillance, cytokine and chemokine networks, complement, inflammatory signaling, and regulated cell death, integrating viral mechanisms with human perturbation, cell-engineering, and transplantation evidence. A qualitative Tier 1-3 framework distinguishes mechanisms close to current cell-therapy practice from those requiring greater product-specific validation or control. The resulting design rules favor graded antigen-presentation control with paired NK validation, local or transient inflammatory buffering, interface-restricted complement protection, and survival enhancement only when independent eliminability is preserved. Selected poxviral proteins can act autonomously outside productive infection, but direct viral-protein expression remains a selective rather than default option. We propose a conditional defense-in-depth framework in which modules are added only when a residual barrier is demonstrated in the final therapeutic product.
Martinović Lovre L, Šantić Roko R, Kuliš Ena E, Martinović Dinko D et al.
Endogenous stimuli-responsive gels are designed to alter drug release or matrix behavior in periodontal sites, but their responsiveness is often demonstrated under conditions that may not represent the biological compartment encountered after placement. This comprehensive review examined whether proposed periodontal triggers have been biologically calibrated. Targeted searches of PubMed/MEDLINE, publisher websites, and backward and forward citations identified human studies measuring periodontal pH, proteases, redox conditions, oxygen tension, microbial metabolites, and glucose, together with gel studies using the same cues. Human pH measurements ranged from mildly acidic to alkaline and did not support a universal activation window. Protease-responsive systems had the strongest mechanistic rationale, although recombinant-enzyme testing was not equivalent to native-fluid cleavage. Hydrogen peroxide-responsive gels were generally evaluated under challenge conditions above the limited direct gingival crevicular fluid evidence and without physiological antioxidant buffering. Oxygen-generating systems did not directly sense local oxygen tension. Some glucose challenges overlapped reported human GCF measurements, but calibration to defined periodontal sites and treatment conditions remained unverified. Across trigger classes, preclinical efficacy seldom isolated responsiveness from payload and carrier effects. Future studies should use compartment- and treatment-matched measurements, realistic input-output testing under flow and buffering, patient-derived fluids, and controls that isolate cue-dependent material behavior.
注册免费账户还可查看另外 9996 篇文献
免费注册查看全部文献 →