北京若生智能科技有限公司
Drug Database
CO

colistin methanesulfonate sodium (GW402007A / Oldoreb / Aldreb)

✓ Approved

GSK · 小分子 · 小分子

什么是 colistin methanesulfonate sodium？

colistin methanesulfonate sodium 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名GW402007A, Oldoreb, Aldreb
公司GSK
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, GSK

治疗适应症

colistin methanesulfonate sodium 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPneumonia pseudomonal✓ Approved

相关研究文献

PubMedPhysical chemistry chemical physics : PCCP2026-10-26

Sodium alginate-stabilized gold nanoparticles synthesized via solution plasma sputtering for turn-on fluorescent detection of mercury(II) ions in water.

Chantaramethakul Jidapa J, Panomsuwan Gasidit G

Sodium alginate-stabilized AuNPs synthesized via solution plasma sputtering were coupled with Rhodamine 6G to construct a turn-on fluorescent sensor for mercury(II) ion detection in water. The probe exhibited a low detection limit of 0.022 µM, excellent selectivity, and good applicability to real water samples.

PMID 42929384
阅读全文 →
PubMedNanoscale2026-10-26

Recent advances in structural and interfacial chemistry of Prussian blue analogues for sodium-ion batteries.

Jang Seunghye S, Kim Yuseul Y, Jo Changshin C

Prussian blue analogues (PBAs) have emerged as leading cathode materials for sodium-ion batteries owing to their open framework structure, low cost, and scalable synthesis. While early studies primarily focused on compositional and morphological optimization, recent advances have revealed that structural chemistry and interfacial reactions critically govern electrochemical performance, degradation behavior, and long-term stability. This mini review will highlight recent progress in understanding crystal water, structural evolution, surface degradation mechanisms, and emerging stabilization strategies. Particular attention will be given to the interplay between bulk structural characteristics and interfacial chemistry, which collectively determines the practical performance of PBA cathodes. By integrating these recent developments, we aim to provide a timely perspective on key challenges and future directions for the practical deployment of PBA cathodes in sodium-ion batteries.

PMID 42929254
阅读全文 →
PubMedCardiovascular toxicology2026-10-26

The Pesticide Pyrethroid Metabolite 3-Phenoxybenzoic Acid (3-PBA) Impairs Human Cardiac Nav1.5 and Action Potential Depolarization.

de Lima Conceição Michael Ramon MR, Marques Leisiane Pereira LP, da Silva Alcantara Fabiana F, de Morais Rafael Leite Tavares RLT et al.

Pyrethroid insecticides (PYRs) are widely used worldwide, and their primary metabolite, 3-phenoxybenzoic acid (3-PBA), serves as a near-ubiquitous biomarker of human exposure to PYRs. While epidemiological data consistently link urinary 3-PBA to increased cardiometabolic risk and coronary heart disease, the underlying electrophysiological mechanisms of its direct potential cardiotoxicity remain unexplored. Parent PYRs are known to exert cardiotoxic effects by enhancing the late sodium current (INa-L) and inducing arrhythmia, but the direct effect of 3-PBA on heart excitability has not been previously investigated. This study demonstrates that 3-PBA interacts with human cardiac Nav1.5 expressed in Human Embryonic Kidney (HEK293) cells, and significantly increases INa-L in a concentration-dependent manner with an EC50 of 51.3 ± 5.1 µM. The metabolite does not alter the voltage dependence of activation and inactivation, but it significantly delays the recovery from inactivation of the peak sodium current. In human induced pluripotent stem cell-derived cardiomyocytes (CM-hiPSCs) and adult rat ventricular myocytes, 3-PBA reduced maximal depolarization rate (dV/dt), indicating impaired depolarization dynamics and reduced peak sodium current. At the organ level, acute exposure in isolated rat hearts did not significantly alter standard ECG parameters. Collectively, these findings suggest that 3-PBA is not electrophysiologically inert but directly modulates cardiac sodium channel function, although at supraphysiological concentration. This provides new evidence of the biological activity of 3-PBA and suggests that its cardiotoxic potential may become clinically relevant under conditions of high dose and chronic exposure or in susceptible populations.

PMID 42928408
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Surimi Gel Quality Enhanced by κ-Carrageenan/Konjac Glucomannan and Sodium Caseinate-Stabilized Emulsion.

Xiong Tianzhen T, Li Lala L, Wu Guanchen G, Zhang Lihua L et al.

This study investigated the effects of a combination of κ-carrageenan (CRG), konjac glucomannan (KGM) and a sodium caseinate-stabilized camellia oil emulsion on the quality attributes of surimi. The results demonstrated that adding the emulsion alone enhanced the textural properties but failed to increase the water-holding capacity (WHC) or reduce cooking loss. In contrast, incorporating both polysaccharides with the emulsion reduced cooking loss to 7.3% of that of the control (2.3 ± 1.0% vs. 31.4 ± 1.4%) and increased the WHC to 97.7 ± 1.3%, representing a 47.8% improvement over the control (66.1 ± 1.2%). Furthermore, this ternary composite system yielded substantial enhancements in the textural profile of the gels. These improvements were attributed primarily to the formation of hydrogen bonds between the polysaccharides and surimi proteins, which strengthened intermolecular interactions. Microstructural observations corroborated this mechanism, revealing that the composite system promoted the formation of a denser and more uniform network, which improved the freeze-thaw stability of the surimi. Sensory evaluation indicated that the combined treatment enhanced the flavor profile and acceptability of surimi gels. Thus, KGM and CRG can be combined with sodium caseinate-stabilized camellia oil emulsion to improve the quality of surimi gels. These results offer valuable theoretical guidance for advancing surimi-based foods.

PMID 42929941
阅读全文 →
PubMedActas espanolas de psiquiatria2026-10-26

Effects of Psychological Counselling Combined With Tolvaptan on Depression, Anxiety, and Quality of Life in Patients With Traumatic Brain Injury and Hyponatremia.

Wang Yu Y, Wang Zhiwei Z, Xiong Zhang Z, Xu Hanyun H

To explore the effects of psychological counselling model combined with tolvaptan on depression, anxiety, and quality of life in patients with traumatic brain injury (TBI) and hyponatremia. This retrospective study included 150 patients with TBI complicated by hyponatremia admitted to the First Affiliated Hospital of Wannan Medical College between May 2022 and May 2024. Based on the treatment methods provided in their medical records, the patients were divided into a combined treatment group (n = 75), receiving psychological counselling combined with tolvaptan, and a traditional treatment group (n = 75), receiving tolvaptan alone. Serum sodium levels, depression and anxiety status, quality of life, and self-efficacy were compared between the two groups before and after counselling. Compared with the traditional treatment group, the combined treatment group showed better stability in serum sodium recovery, significantly lower depression and anxiety scores, and significantly higher scores in quality of life, self-efficacy, and social functioning than the traditional treatment group (all p < 0.05). Among patients with TBI and hyponatremia, psychological counselling combined with tolvaptan was associated with more stable serum sodium recovery, better emotional state and improved quality of life compared with tolvaptan alone. However, due to the retrospective nature of this study, these findings should be interpreted as correlational rather than causal. Prospective controlled studies are needed to further validate these findings.

PMID 42928690
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Spunlace Cotton Nonwoven-Reinforced Sodium Alginate/Bamboo Charcoal Photothermal Hydrogel Evaporator for Solar-Driven Water Purification.

Zhang Haifeng H, Chen Guangfu G, He Hao H, Zhu Xia X et al.

Solar-driven interfacial evaporation offers a low-energy and sustainable route for seawater desalination and the purification of complex water matrices. However, freestanding hydrogel evaporators often suffer from insufficient mechanical robustness and interfacial salt accumulation under high-salinity conditions. Herein, a spunlace cotton nonwoven/sodium alginate/bamboo charcoal (SC/SA/BC) composite interfacial evaporator was fabricated through a facile impregnation-ionic crosslinking strategy, using a spunlace cotton nonwoven (SC) as the reinforcing scaffold, sodium alginate (SA) as the hydrophilic hydrogel matrix, and bamboo charcoal powder (BC) as the photothermal component. The Ca2+-crosslinked SA network immobilized the bamboo charcoal particles and formed continuous hydrated mass-transport pathways, while the spunlace fibrous network provided capillary water-supply channels and robust mechanical support. Consequently, SC/SA/BC exhibited substantially improved mechanical performance compared with the freestanding SA/BC hydrogel. Under 1 sun irradiation using a 3.5 wt% NaCl solution, SC/SA/BC achieved an evaporation rate of approximately 1.80 kg m-2 h-1 and maintained stable performance during 8 h of continuous operation. The evaporation-condensation process markedly reduced the concentrations of major ions in natural seawater and effectively retained nonvolatile dyes. Through the synergistic integration of a spunlace fibrous scaffold, a hydrated hydrogel network, and a bamboo-charcoal-based photothermal component, the proposed evaporator simultaneously achieved mechanical reinforcement, sustained water supply, efficient photothermal conversion, and salt-tolerant operation. This work provides a promising strategy for constructing structurally stable and readily fabricated solar interfacial evaporation materials.

PMID 42929933
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多colistin methanesulfonate sodium