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colistin methanesulfonate sodium (GW402007A / Oldoreb / Aldreb)

✓ Approved

GSK · 小分子 · 小分子

什么是 colistin methanesulfonate sodium？

colistin methanesulfonate sodium 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名GW402007A, Oldoreb, Aldreb
公司GSK
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, GSK

治疗适应症

colistin methanesulfonate sodium 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPneumonia pseudomonal✓ Approved

相关研究文献

PubMedFrontiers in cellular and infection microbiology2026-09-10

α-Terpineol reverses mcr-mediated colistin resistance and potentiates colistin's antibacterial activity in multidrug-resistant Escherichia coli.

Li Yujuan Y, Yang Yi Y, Zhou Ting T, Zhou Jing J et al.

Amid the growing antibiotic resistance crisis, colistin remains a last-line therapeutic option for multidrug-resistant (MDR) Gram-negative bacterial infections. However, the emergence and rapid dissemination of plasmid-mediated colistin resistance gene (mcr) have markedly reduced its clinical effectiveness. Utilizing colistin adjuvants to restore its antibacterial potency is a promising strategy to combat this threat. In this study, we aimed to investigate the synergistic effects of α-terpineol in combination with colistin against colistin-resistant MDR Escherichia coli (E. coli) and to elucidate the underlying mechanisms of this synergy. In vitro synergistic activity was evaluated using checkerboard microdilution assays, time-kill curve analyses, and resistance development studies. Mechanistic insights were obtained through transcriptomic analysis and fluorescence-probe based assays. In vivo efficacy was validated using Galleria mellonella and mouse acute peritonitis infection models. The results showed that the combination of α-terpineol and colistin exhibited synergistic bactericidal activity and suppressed the development of colistin resistance. α-Terpineol increased inner- and outer-membrane fluidity in E. coli, thereby enhancing colistin uptake. Furthermore, it inhibited superoxide dismutase (SOD) activity, preventing the conversion of O2 ·- to H2O2 and causing superoxide accumulation. Elevated O2 ·- levels damaged iron-sulfur clusters and impaired respiratory function. Together with the proton motive force (PMF) dissipation, these effects severely impaired ATP synthesis, ultimately sensitizing MDR E. coli to colistin. The combination also showed significant therapeutic efficacy in animal models. Our findings identify α-terpineol as a promising colistin adjuvant that restores antibacterial activity by disrupting membrane integrity and impairing antioxidant defenses, offering a viable strategy for treating MDR Gram-negative bacterial infections.

PMID 42718814
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PubMedHypertension research : official journal of the Japanese Society of Hypertension2026-09-10

Effects of sodium reduction interventions on home and morning home blood pressure: a systematic review and meta-analysis of randomized controlled trials.

Sakima Atsushi A, Arima Hisatomi H, Arakawa Kimika K, Hirohama Daigoro D et al.

Excessive sodium chloride (salt) intake significantly contributes to hypertension and cardiovascular diseases, and reducing sodium is a cornerstone of non-pharmacological management of hypertension. Although the antihypertensive effects of sodium reduction are well established, most existing evidence is from office blood pressure (BP) measurements, with limited data available on home BP. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of sodium reduction on home BP. We searched PubMed and the Cochrane Library from inception to September 2025 and included 23 RCTs comprising 4110 participants. Sodium reduction significantly reduced home systolic BP (SBP) (mean difference [MD], -3.66 mmHg; 95% confidence interval [CI], -4.86 to -2.45; P < 0.001) and home diastolic BP (MD, -1.40 mmHg; 95% CI, -2.08 to -0.71; P < 0.001). Nine studies that reported morning home BP also showed reduced morning home SBP (MD, -4.06 mmHg; 95% CI, -6.60 to -1.52; P = 0.002). Greater reductions in home SBP were observed in predominantly hypertensive populations than in non-hypertensive populations (P for heterogeneity = 0.003). No significant differences were detected across other predefined subgroups. Sodium reduction interventions were also associated with significant reductions in salt intake, urinary sodium excretion, and the urinary sodium-to-potassium ratio. Quantitative synthesis was not feasible because only a few included studies reported cardiovascular or adverse events. In conclusion, sodium reduction interventions effectively lower home BP, including morning home BP, with a greater impact in hypertensive populations. Thus, reducing sodium is a practical strategy for improving home BP control, particularly in hypertensive populations. This systematic review and meta-analysis of randomized controlled trials showed that sodium reduction interventions significantly lowered home systolic blood pressure (SBP), including morning SBP. No significant differences in BP-lowering effects were detected across various sodium reduction strategies, and digital health approaches may support implementation and adherence. Sodium reduction interventions were also associated with reductions in salt intake, urinary sodium excretion, and the urinary sodium-to-potassium ratio. These findings support major hypertension guidelines, including the Japanese Society of Hypertension Guidelines for managing elevated blood pressure and hypertension 2025 (JSH2025) and the JSH Morning Hypertension Eradication Program Project (Asakatsu BP Action Plan-the Morning Blood Pressure 130 Campaign).

PMID 42716956
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PubMedJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2026-09-10

Implications of European Union Sodium Perborate Restrictions for Intracoronal Bleaching Procedures: A Narrative Review.

Herz Marco M MM, Meller Christian C, Klein Christian C, Österreicher Johannes J

To critically evaluate current and emerging intracoronal bleaching agents and to provide an evidence-informed framework for clinical decision-making in the postsodium perborate era. The declining availability of sodium perborate, particularly within the European Union, has substantially altered contemporary intracoronal bleaching practice. A narrative review was conducted using a structured PubMed/MEDLINE literature search and manual reference screening. Evidence regarding bleaching efficacy, biological safety, peroxide diffusion, cervical root resorption, dentin-related effects, restorative implications, regulatory developments, and emerging bleaching materials was critically synthesized. Hydrogen peroxide, carbamide peroxide, and sodium percarbonate all achieve clinically relevant whitening but differ in biological characteristics and the strength of supporting evidence. Hydrogen peroxide remains effective but raises greater concerns regarding peroxide diffusion and concentration-dependent biological effects. Carbamide peroxide is supported by extensive contemporary clinical evidence and long-term outcome data, whereas sodium percarbonate represents a promising borate-free alternative currently supported primarily by laboratory and ex vivo studies. Among currently available intracoronal bleaching agents, carbamide peroxide is supported by one of the largest bodies of contemporary clinical literature and represents one of the most extensively documented contemporary alternatives to sodium perborate. Sodium percarbonate shows considerable potential but requires prospective clinical validation before more definitive clinical recommendations can be made. This review provides an evidence-informed framework for selecting contemporary intracoronal bleaching agents to achieve predictable esthetic outcomes in the postsodium perborate era while identifying priorities for future clinical research.

PMID 42717716
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PubMedThe journal of physical chemistry letters2026-09-10

From Small Data to High Capacity: Symbolic Learning of Sodium-Ion Cathode Materials.

Meng Kong K, Vasenko Andrey S AS, Chulkov Evgueni V EV, Long Run R

Data-driven discovery of sodium-ion cathodes is often limited by small data sets and the poor interpretability of graph neural networks (GNNs). Here, we developed Symbol_ETR, an interpretable framework combining symbolic regression with ensemble learning. By constructing explicit nonlinear descriptors, symbolic regression extra trees regression (Symbol_ETR) achieves a test R2 of 0.90 for average voltage prediction and outperforms representative GNN models in the small-data regime. High-throughput screening of the Materials Project database identified Na5Co2S5 as a promising cathode candidate with a theoretical capacity of 340.86 mAh/g. First-principles calculations indicate a metallic electronic character and reveal weakly hybridized S 3p states near the Fermi level at Na-rich sulfur sites. Their evolution during desodiation supports sulfur-dominated charge compensation and anion redox activity. This work establishes an accurate and interpretable strategy for small-data material screening and the discovery of high-capacity sodium-ion cathodes.

PMID 42720337
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PubMedInnovation (Cambridge (Mass.))2026-09-10

Erratum: Sodium-ion-responsive injectable supramolecular hydrogel delivers engineered Salmonella for safer and enhanced tumor immunotherapy.

Yu Wenliang W, Tang Wei W, Zhang Tao T, Gao Mengyue M et al.

[This corrects the article DOI: 10.1016/j.xinn.2026.101363.].

PMID 42719758
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PubMedEpidemiology (Cambridge, Mass.)2026-09-10

Association between high fat, sugar, and sodium diet and adverse pregnancy outcomes, modified by fruit and vegetable intake density.

Yu Ya-Hui YH, Bodnar Lisa M LM, Kirkpatrick Sharon I SI, Parisi Sara M SM et al.

We aimed to examine whether fruit and vegetable intake densities modify the association between a periconceptional high-fat, sugar, and sodium diet and adverse pregnancy outcomes. We analyzed data from 8,259 participants in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (2010-2013). Periconceptional diet was assessed via food frequency questionnaire. The outcome was a composite of preeclampsia, gestational diabetes, preterm birth, or small-for-gestational-age birth; individual outcomes were also examined. Effect modification by vegetable and fruit intake densities was evaluated using a doubly robust learner with ensemble machine learning. Approximately 23% of participants experienced an adverse outcome, and 29% consumed a high-fat, sugar, and sodium diet. This dietary pattern was associated with 1.0-2.9 excess cases per 100 pregnancies for the composite outcome and most individual outcomes (except preterm birth), compared with other diets. For the composite outcome, associations varied across levels of vegetable but not fruit intake density, although estimates were imprecise. For example, risk differences decreased from 3.7 (95% CI, -0.7 to 8.0) to 2.6 (95% CI, -1.4 to 6.6) excess cases per 100 pregnancies at 0.5 versus 1.25 cups of vegetables per 1,000 kcal. Attenuation of risk at higher vegetable intake was slightly greater when combined with higher fruit intake density, but estimates remained imprecise, limiting interpretation of joint effect modification. Patterns of associations differed across individual outcomes. We did not find evidence that the risk of adverse pregnancy outcomes associated with a high-fat, sugar, and sodium dietary pattern was meaningfully different across vegetable and/or fruit intake densities.

PMID 42720229
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