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immune globulin intravenous (Iveegam, Immuno / Iveegam EN)

✓ Approved

Baxter International, Inc. · 多克隆抗体 · 多克隆抗体

什么是 immune globulin intravenous？

immune globulin intravenous 是一种多克隆抗体，由Baxter International, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Iveegam, Immuno, Iveegam EN
公司Baxter International, Inc.
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Baxter International, Inc.

治疗适应症

immune globulin intravenous 针对 5 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersSelective IgG subclass deficiency✓ Approved
Infections and infestationsBorna virus infection✓ Approved
Musculoskeletal and connective tissue disordersDermatomyositisPreclinical
Musculoskeletal and connective tissue disordersPolymyositisPreclinical
Musculoskeletal and connective tissue disordersJuvenile idiopathic arthritisPreclinical

相关研究文献

PubMedIranian journal of biotechnology2026-10-26

Differential Regulation of Postoperative Gut Microbiota by Inhalation vs Intravenous Anesthesia: NF-κB/HIF-1α-Mediated Macrophage Polarization.

Chen Nami N, Hu Cixian C, Huang Xin X, Zhao Liming L

Perioperative anesthetic strategies are increasingly recognized as important modulators of postoperative immune responses and intestinal microecological homeostasis following gastrointestinal surgery. To systematically explore the differential effects of inhalational anesthesia (sevoflurane) and intravenous anesthesia (propofol) on postoperative intestinal microbiota, and to investigate the potential association between anesthetic methods, NF-κB/HIF-1α signaling pathway, and macrophage polarization using integrated bioinformatics analyses. Publicly available datasets were retrieved from NCBI SRA, GEO, and EMBL-EBI to identify three independent cohorts with clear annotations of gastrointestinal surgery and anesthetic methods. A total of 90 samples were included (30 control, 30 inhalational anesthesia, and 30 intravenous anesthesia). Intestinal microbiota profiles derived from 16S rRNA sequencing were integrated with expression data of NF-κB/HIF-1α pathway-related genes. Microbial diversity, community composition, differential taxa, functional enrichment, and microbe-gene correlations were analyzed using QIIME2, limma, vegan, and related bioinformatics tools to construct the regulatory axis of "anesthetic method-intestinal microbiota-signaling pathway-macrophage polarization." The inhalational anesthesia group exhibited significantly reduced α-diversity (Chao1 and Shannon indices) compared with both the control and intravenous anesthesia groups (P<0.05). β-diversity analysis revealed distinct microbial community structures among the three groups (PERMANOVA R2=0.27, P=0.001). Genus-level analysis demonstrated a marked enrichment of Bacteroides in the inhalational anesthesia group, whereas Lactobacillus and Bifidobacterium were predominant in the control group. LEfSe analysis identified eight significantly differential genera. Expression of pro-inflammatory NF-κB/HIF-1α pathway genes (NFKB1, IL-6, TNF-α) was significantly up-regulated in the inhalational anesthesia group, accompanied by down-regulation of anti-inflammatory markers (ARG1, IL-10). These alterations were less pronounced in the intravenous anesthesia group. Correlation analysis identified Bacteroides-NFKB1 and Lactobacillus-IL-10 as key regulatory nodes. Functional enrichment revealed inflammation-related pathways enriched under inhalational anesthesia, whereas short-chain fatty acid synthesis pathways were enriched in controls. Inhalational anesthesia is associated with greater disruption of postoperative intestinal microbiota homeostasis than intravenous anesthesia, and is correlated with NF-κB/HIF-1α-related pro-inflammatory macrophage polarization. These findings provide bioinformatics evidence supporting propofol-based intravenous anesthesia and microbiota-targeted strategies to improve postoperative outcomes.

PMID 42928741
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PubMedAdvanced healthcare materials2026-10-26

Inhalable PD-1 Exosomes Co-Delivering EP2/EP4 Antagonists Remodel the Pulmonary Tumor Microenvironment in Breast Cancer Lung Colonization.

Li Qi Q, Yang Jingyi J, Chen Xuan X, Zhao Pi P et al.

Developing effective nanomedicines for pulmonary metastasis remains challenging because of systemic clearance and local stromal barriers. Guided by single-cell transcriptomic profiling, we characterized a compartmentalized immunosuppressive network involving PGE2 and provide a biological rationale for coordinated EP2/EP4 antagonism. We therefore engineered an inhalable biomimetic platform (PD-1@E2/4 Exo) comprising PD-1-displaying exosomes co-loaded with EP2 and EP4 antagonists. Compared with intravenous administration, nebulized delivery increased pulmonary exposure of the engineered vesicles. Within the pulmonary tumor setting, surface PD-1 is intended to interfere with PD-1/PD-L1 signaling, while the co-delivered antagonists target the EP2/EP4 immunosuppressive axis. Treatment was associated with macrophage reprogramming, increased oxidative stress, and enhanced ICD-related responses in tumor cells. In the experimental breast-cancer lung-colonization model, the inhaled formulation reduced established pulmonary tumor burden and was accompanied by systemic immune-memory responses. These findings provide a preclinical study for integrating local pulmonary delivery with coordinated metabolic and immune modulation in breast cancer lung disease.

PMID 42929240
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PubMedAnaesthesia and intensive care2026-10-26

Safety and efficacy of volatile sedatives in critically ill patients receiving mechanical ventilation: A systematic review and meta-analysis.

Lee Jong Min JM, Chang Youjin Y, Kim Seok Chan SC, Lee Jongmin J

Volatile sedatives are increasingly utilised for sedation in critically ill patients receiving invasive mechanical ventilation. Despite numerous randomised controlled trials and observational studies comparing volatile sedation to intravenous sedation, questions regarding its safety and efficacy persist. A systematic search was performed in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science databases for studies published up to July 2025. The analysis included randomised controlled trials and observational studies that compared the use of volatile sedation with intravenous sedation in patients admitted to the intensive care unit for mechanical ventilation. Eligible studies involved adults aged ⩾18 years, requiring mechanical ventilation, and utilising either volatile or intravenous sedatives. They also needed to report at least one outcome of interest: incidence of delirium, mortality, intensive care unit length of stay, or duration of mechanical ventilation. From 3182 identified publications, fifteen studies were included in the systematic review. Volatile sedation was not associated with a significant difference in the incidence of delirium compared to intravenous sedation (risk ratio 0.72; 95% confidence interval 0.38-1.34), mortality (risk ratio 0.97; 95% confidence interval 0.80-1.17), intensive care unit length of stay (mean difference 0.28 days; 95% confidence interval -1.74 to 2.30), or duration of mechanical ventilation (mean difference -37.20 h; 95% confidence interval -78.60 to 4.20). Volatile sedation was not associated with significant differences in mechanical ventilation duration, delirium incidence, intensive care unit length of stay, or mortality compared to intravenous sedation. Further large-scale, high-quality randomised trials are needed to clarify its clinical benefit in critical care settings.

PMID 42929360
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PubMedCureus2026-10-26

Persistent Type B Hyperlactataemia as a Diagnostic Clue to Occult Diffuse Large B-cell Lymphoma-Associated Haemophagocytic Lymphohistiocytosis.

Hassan Nasiba N, Khatib Kavish K

Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory disorder characterised by excessive immune activation. It may be primary or secondary, with secondary HLH associated with a range of triggers; the most common are infections, autoimmune and autoinflammatory conditions, haematological malignancies and other immune‑dysregulatory states. We present a case of a man in his 70s who presented with a two-week history of exertional dyspnoea, profound fatigue and anorexia. Initial investigations demonstrated marked hyperferritinaemia, thrombocytopenia, mild anaemia, cholestatic liver dysfunction and disproportionately elevated lactate without acidosis. Despite intravenous fluids, lactate remained persistently elevated, consistent with type B hyperlactataemia. Computed tomography (CT) of the abdomen and pelvis demonstrated appearances suggestive of hepatitis but no organomegaly, significant lymphadenopathy or biliary obstruction. Despite empirical antibiotics and fluid resuscitation, he developed progressive pancytopenia, worsening liver dysfunction and rising lactate. Further investigations supported secondary HLH, with an HScore of 186, hypertriglyceridaemia and markedly elevated lactate dehydrogenase. Initial treatment with corticosteroids and anakinra resulted in limited response. An autoimmune trigger was initially considered given his Raynaud's phenomenon and ongoing connective tissue disease investigation. However, bone marrow biopsy subsequently confirmed diffuse large B-cell lymphoma (DLBCL). Reduced-dose rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone (R-mini-CHOP) was commenced, resulting in the resolution of hyperlactataemia, normalisation of blood counts and liver function and improvement in performance status. PET-CT after two cycles demonstrated a complete metabolic response. This case highlights the importance of considering secondary HLH in patients with unexplained cytopenias, hyperferritinaemia, liver dysfunction and persistent hyperlactataemia. Persistent hyperlactataemia despite adequate fluid resuscitation should prompt the consideration of systemic causes beyond tissue hypoperfusion. Bone marrow biopsy is crucial for identifying occult malignancy when conventional imaging fails to show overt malignancy. The early recognition of HLH and investigation for an underlying aetiology may facilitate timely definitive treatment.

PMID 42928750
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PubMedThe British journal of radiology2026-10-26

Intravenous oxycodone versus morphine patient-controlled analgesia (PCA) after uterine artery embolisation: A propensity matched case-control study.

Clements Warren W, Markakis Demi D, Koukounaras Jim J, Venn Georgina G et al.

The use of intravenous oxycodone is still limited in the Interventional Radiology setting. This study aimed to assess the safety and efficacy of intravenous oxycodone used in patient-controlled analgesia (PCA) after uterine fibroid embolisation (UFE), compared to morphine. Retrospective case-control study. The study group consisted of patients treated with UFE between March and December 2024, using an oxycodone protocol. The control group consisted of a previously published dataset using morphine protocol. Primary outcomes were safety and the incidence of severe nausea. There were 57 patients in the oxycodone group compared to 69 in the morphine group. After propensity score matching, this left 43 in the oxycodone group and 60 in the morphine group. Groups were similar in terms of background demographics, however the use of smaller 355-500 micrometre polyvinyl alcohol particles were higher in the oxycodone group (100% vs 18%, p < 0.001).No analgesic-related adverse events were observed in either group. The incidence of severe nausea was lower in the oxycodone group (43.3% vs 37.2%, p = 0.533) despite a higher rate of post-embolisation syndrome (65.1% vs 48.3%, p = 0.091). After multiparametric logistic regression, oxycodone was associated with a 64% reduced odds of severe nausea (OR 0.36, p = 0.217). Intravenous oxycodone PCA is safe and showed a trend towards a lower incidence of severe nausea compared with morphine PCA. There is limited evidence of the use of oxycodone PCA to treat post-embolisation syndrome. This study showed it was safe and resulted in reduced nausea compared to morphine.

PMID 42928627
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PubMedJournal of medical case reports2026-10-26

High-dose regular insulin as a potential rescue therapy in severe aluminum phosphide poisoning: a case report.

Sedaghattalab Moslem M, Akbari Ghaidafeh G

Aluminum phosphide (rice tablet) can cause cardiocirculatory collapse and has negative cardiac inotropic effect. Positive inotropic effect of insulin on the cardiac myocytes is through calcium flux. Insulin increases the intramyocytes calcium concentration by increasing conductance of calcium through the L-type calcium channels and by increasing intramyocytes concentration of cyclic adenosine monophosphate. In addition to increasing the intramyocytes calcium level, insulin also enhances the responsiveness of the cardiac cells to calcium. High-dose insulin is a potential therapy for hypodynamic and hypotensive septic shock due to its positive inotropic qualities. In this paper, a critical aluminum phosphide poisoning patient (a 25-year-old Iranian young woman), presented with mixed severe metabolic acidosis and respiratory alkalosis, tachypnea, tachycardia, and hypotension. In contrast to our previous experiences that ingestion of aluminum phosphide tablets associated with multiple organ failure and severe shock in approximately all critical poisoning patients, early initiation of high-dose intravenous regular insulin for this patient prevented multiorgan dysfunction and death. Treatment with high-dose intravenous insulin associated with IV fluids, sodium bicarbonate, hydrocortisone, potassium, dextrose therapy and supportive care resolved completely signs and symptoms of patient after 3 days in ICU. High-dose intravenous regular insulin may be act as a rescue therapy for aluminum phosphide poisoning patients. While this single case suggests a potential benefit, further studies are required to confirm these findings.

PMID 42928247
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