北京若生智能科技有限公司
Drug Database
CI

cilostazol + ginko biloba extract (Rinexin / SID142 / SID 142)

✓ Approved

SK Chemicals · 治疗药物

什么是 cilostazol + ginko biloba extract？

cilostazol + ginko biloba extract 是一种治疗药物，由SK Chemicals研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Rinexin, SID142, SID 142
公司SK Chemicals
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, SK Chemicals

治疗适应症

cilostazol + ginko biloba extract 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersPeripheral vascular disorder✓ Approved

相关研究文献

PubMedJournal of microbiology and biotechnology2026-09-10

Ribes fasciculatum Leaf Water Extract Enhances Macrophage Immune Responses via TLR4-Mediated JNK and NF-κB Activation in RAW264.7 Cells.

Park So Jung SJ, Choi Jeong Won JW, Choi Hyeok Jin HJ, Im Gyeong Eun GE et al.

This study investigated the immunostimulatory activity and underlying mechanism of Ribes fasciculatum leaf water extract in RAW264.7 macrophages. Among extracts prepared using water or ethanol-containing solvents, only the water extract induced NO production. Further evaluation of extraction temperature and time identified the extract prepared at 20°C for 24 h (RFL-DW20) as the most active sample under the tested conditions, with NO-inducing activity increasing after 12 h of extraction and reaching a plateau by 24 h. RFL-DW20 increased NO and PGE2 production, upregulated iNOS and COX-2 expression, and enhanced IL-6 and TNF-α production without cytotoxicity. RFL-DW20 also increased IL-1β mRNA expression but did not significantly alter extracellular IL-1β levels. RFL-DW20 also increased neutral red uptake, indicating enhanced macrophage functional activity. The immunostimulatory effects of RFL-DW20 were strongly inhibited by TAK-242, SP600125, and BAY 11-7082, suggesting the involvement of TLR4, JNK, and NF-κB signaling. RFL-DW20 activated MAPK and NF-κB signaling, including rapid IκBα phosphorylation/degradation and p65 phosphorylation, while pharmacological inhibition identified JNK and NF-κB as major functional mediators of the NO response. TAK-242 markedly suppressed RFL-DW20-induced JNK and p65 phosphorylation. Ethanol precipitation further enriched its NO-inducing activity. These findings suggest that RFL-DW20 activates macrophages through the TLR4/JNK/NF-κB signaling axis and may serve as a natural immune-stimulating material.

PMID 42717697
阅读全文 →
PubMedChemistry & biodiversity2026-09-10

Combining Phytochemical and Computational Approach on Citrus hystrix DC. (Kaffir Lime) Peel Extract: Anti-Diabetic and Anti-Inflammatory Activities.

Soundara Rajan Malathy M, Palaniyandi Sankarganesh S, Sunkar Swetha S

The peel of Citrus hystrix DC. (kaffir lime), an underexploited agro-industrial by-product, may have bioactives. This work tested the ethanolic extract of C. hystrix peel's (EeChP) phytochemicals by GC-MS profiling, and the antidiabetic effect was evaluated using the alpha-amylase inhibitory test, and the anti-inflammatory activity was done using the human red blood cell (HRBC) membrane model. The antibacterial effect was determined using the agar well diffusion method against Staphylococcus aureus and Escherichia coli. Major constituents subjected to pharmacokinetic and ADMET filtering, molecular docking, Gene Ontology (GO), and KEGG pathway analysis for mechanistic plausibility. The GC-MS detected 44 phytoconstituents, including limonene, γ-sitosterol, and β-amyrin. EeChP inhibited α-amylase (IC50 = 80.97 µg/mL) and the stabilized HRBC membrane (IC50 = 64 µg/mL). The extract demonstrated substantial antibacterial action against S. aureus (IZD = 6 mm at 200 µg/well) but failed against E. coli. The β-amyrin and scoparone were found to be non-toxic. Scoparone and carbonic anhydrase 12 were connected with β-amyrin and protein tyrosine phosphatase non-receptor type 1. EeChP has anti-diabetic, multi-target, modulatory, and anti-inflammatory effects. The results recommend C. hystrix peel's bioresource potential, but enzyme kinetics, antimicrobial MIC, and in vivo research are necessary. The research has contributed to accomplishing SDG 3 and SDG 12.

PMID 42720104
阅读全文 →
PubMedRSC advances2026-09-10

Biogenic synthesis of Ag-ZnO nanocomposites via sumac (Rhus coriaria L.) extract for synergistic photocatalytic degradation of Congo red and broad-spectrum antimicrobial activity.

Qasim Amin K AK, Mustafa Lawand L LL, Faris Adar Jamal AJ, Hamad Samir M SM

In this study, Ag ZnO nanocomposites were prepared by a plant mediated synthesis using an aqueous extract of Sumac (Rhus coriaria L.) seeds. The extract served as a source of phytochemical functional groups involved in metal ion complexation, reduction, and surface stabilization. The resulting material was characterized by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, UV visible spectroscopy, and Fourier transform infrared spectroscopy. SEM showed irregular aggregates with dimensions of approximately 50 to 200 nm, whereas XRD gave crystallite sizes of 13.85 to 44.51 nm, indicating that the larger SEM features can contain several smaller crystalline domains. The photocatalytic activity was evaluated using Congo red in aqueous solution under a 5 W LED source. Under the reported optimum conditions of 4 mg L-1 dye, pH 7, 35 °C, and 0.01 g catalyst per 20 mL solution, the degradation efficiency reached approximately 83% after 20 min. Scavenger experiments showed strong suppression of degradation in the presence of reactive species scavengers, supporting the participation of superoxide radicals, hydroxyl radicals, and photogenerated holes in the reaction pathway. The material retained 52.4% degradation efficiency after four reuse cycles. Antibacterial testing by the disk diffusion method showed concentration dependent inhibition, with Staphylococcus aureus giving the largest inhibition zones of 12 to 16 mm. These results indicate that the activity of the composite is more appropriately associated with interfacial charge transfer, reactive oxygen species generation, and defect related surface reactivity than with a large reduction in the intrinsic ZnO band gap. The study demonstrates the potential of an aqueous Sumac mediated route for preparing multifunctional Ag ZnO NCs for pollutant degradation and antibacterial applications.

PMID 42719775
阅读全文 →
PubMedFrontiers in bioengineering and biotechnology2026-09-10

Verbascoside-rich Buddleja davidii extract in liposomal systems: modulation of release behavior for topical wound treatment.

Yasmin Adeela A, Casula Luca L, Pittiu Alessio A, Massoni Claudia C et al.

Introduction: Chronic wounds represent a major clinical challenge due to their complex pathophysiology, characterized by persistent inflammation, excessive production of reactive oxygen species (ROS), high risk of microbial contamination, and impaired tissue regeneration. Despite several plant extracts offering antioxidant, anti-inflammatory, and antibacterial properties, their therapeutic use is limited by poor stability and rapid clearance of the active compounds from the wound site, particularly in the case of hydrophilic molecules. In this study, a verbascoside-rich extract obtained from Buddleja davidii was encapsulated into liposomes for potential wound healing applications. Methods: The formulations were characterized in terms of vesicle size, polydispersity index, and zeta potential using dynamic and electrophoretic light scattering. Encapsulation efficiency and verbascoside release profiles were assessed by HPLC, while antioxidant activity was evaluated by the DPPH assay. Formulation stability was monitored for two months, and in vitro biocompatibility and antioxidant protective effects were investigated in human keratinocytes, while antimicrobial activity was tested against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Results: The liposomal formulations modulated the release kinetics of verbascoside, showing a prolonged release of the encapsulated fraction, limiting its rapid dispersion in aqueous environments and enabling sustained availability over time. Encapsulation preserved the antioxidant activity of the extract and ensured excellent in vitro biocompatibility across a wide concentration range. Finally, liposomes showed strong and concentration-dependent antimicrobial activity against MRSA, as well as bacteriostatic responses against E. coli. Discussion: Collectively, these findings highlight liposomal encapsulation as a solid strategy to prolong the release-and thus the residence time-of hydrophilic plant-derived actives while maintaining or potentiating their biological activities in the context of wound healing.

PMID 42718759
阅读全文 →
PubMedFrontiers in dental medicine2026-09-10

Phytic acid and grape seed extract in dentin biomodification: effects on bond strength and interface integrity.

Gomes Astrid Ana AA, Devadiga Darshana D, M Roma R, Chandramouli Darshan Madihalli DM et al.

Hybrid layer degradation, driven by residual matrix metalloproteinase (MMP) activity and hydrolytic attack at the resin-dentin interface, remains a primary cause of adhesive restoration failure. Dentin biomodification using natural cross-linking agents represents a promising strategy to enhance collagen stability and inhibit enzymatic degradation of the bonded interface. To evaluate and compare the effect of collagen cross linking agents, phytic acid (IP6) and grape seed extract (GSE), to reinforce the shear bond strength (SBS) of resin composite to dentin. Enamel of 34 human maxillary premolars was eliminated and each tooth was sectioned to make a total sample size of 68 which was divided into four groups (n = 17) for surface treatment: G1-PA:37% Phosphoric acid (control), G2-IP6:1% phytic acid, G3-PA + GSE:37% phosphoric acid+6.5% GSE and G4-IP6 + GSE:1% phytic acid+6.5% GSE. A hybrid resin composite material was bonded and subjected to 1,000 cycles of thermocycling followed by SBS testing and analysis of fracture mode by Scanning Electron Microscopy. The data was statistically analysed using one-way Analysis of Variance (ANOVA) followed by Tukey's Honestly Significant Difference (HSD) post hoc test. G4-IP6 + GSE showed the highest SBS (23.44 ± 4.28 MPa), followed by G2-IP6 (21.51 ± 6.00 MPa) and G3-PA + GSE (21.01 ± 4.35 MPa), while G1-PA had the lowest values of 15.40 ± 4.60 MPa. FTIR analysis showed that phytic acid exhibited a broad peak at 3311.77 cm⁻1 while GSE showed peaks 3266.37 cm⁻1 and 1602.93 cm⁻1 corresponding to hydroxyl and carbonyl functional groups. Phytic acid and grape seed extract significantly improved the composite-dentin shear bond strength of dentin. Their application appears to enhance the structural integrity of demineralized collagen at the resin-dentin interface, thereby supporting their potential incorporation into adhesive restorative protocols as a promising strategy to enhance dentin bond strength.

PMID 42718430
阅读全文 →
PubMedFood science & nutrition2026-09-10

Optimization of Onion Peel Bioactive Compounds Using Eco-Friendly Natural Deep Eutectic Solvent Based Ultrasound-Assisted Extraction.

Rasool Izza Faiz Ul IFU, Arshad Muhammad Umair MU, Imran Ali A, Siddiqa Ayesha A et al.

The current study aimed to extract bioactive compounds from onion peel using ultrasound-assisted extraction combined with natural deep eutectic solvents. Response surface methodology (RSM) design was applied to target the maximum extract yield of bioactive compounds. The extraction (UAE-NADES) method was optimized using RSM design with varying parameters including water contents (A: 35%-55%), extraction time (B: 15-35 min), and solid-to-liquid ratio (C: 10-30 g/mL) as independent variables. Study findings showed that the highest total phenolic content (TPC) of 105.06 mg GAE/g and DPPH radical scavenging activity of 50.06 mg TE/g were observed highest at the 14th run [Conditions: Water: 35%, Extraction Time: 25 min, Solid-to-solvent ratio: 30 g/mL]. Comparison analysis of design runs also showed that factors like extraction time have a significant impact on phenolic content followed by water %. 3D response results also revealed that the set variables in the solvent mixtures significantly enhanced the extraction efficiency of phenolics and their antioxidant activities from source material (peel). Conclusively, study focused on emerging green extraction technologies for bioactive compounds recovery, gained lot of interest due to their efficiency as sustainable and environment-friendly approach and for potential use in functional/nutraceutical food industries.

PMID 42719065
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多cilostazol + ginko biloba extract