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sumatriptan succinate (sc) (DFN 11 / Zembrace SymTouch / DFN11)

✓ Approved

Upsher-Smith Laboratories, LLC. · HTR1B · 小分子

什么是 sumatriptan succinate (sc)？

sumatriptan succinate (sc) 是一种小分子，由Upsher-Smith Laboratories, LLC.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名DFN 11, Zembrace SymTouch, DFN11
公司Upsher-Smith Laboratories, LLC.
药物类别小分子
分子靶点HTR1B, HTR1D
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Upsher-Smith Laboratories, LLC.

作用机制

分子靶点

sumatriptan succinate (sc) 作用于 2 个分子靶点：

HTR1B5-hydroxytryptamine receptor 1B (HTR1DB, 5-HT1DB)
HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan succinate (sc) 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedDiabetic medicine : a journal of the British Diabetic Association2026-10-26

Characterising differential maturation of stem cell-derived islets in mice: Graft function and transcriptomic analysis.

Sullivan Rosie R, Gatward Lydia F Daniels LFD, Hong Tzu-Wen TW, Lyu Zekun Z et al.

Stem cell-derived islets (SC-islets) offer the potential to revolutionise type 1 diabetes treatment. However, functional maturation in vivo is variable, suggesting that specific, but as-yet undefined, environmental cues are critical. We aimed to identify pathways associated with SC-islet in vivo maturation in mice, assess early functional markers of this, and determine whether a hyperglycaemic graft environment impairs this. Mice transplanted with 800 SC-islets but exhibiting differing glycaemic outcomes (cured, semi-cured, uncured) were selected and glucose tolerance and human C-peptide concentrations over time were measured. Single-cell transcriptomic analysis of the graft from the cured mouse was compared with in vitro-maintained SC-islets. The impact of hyperglycaemia on in vivo maturation was assessed by comparing mouse recipients of SC-islet grafts which were either hyperglycaemic or normoglycaemic for 1 month post-transplantation. Superior SC-islet in vivo maturation was broadly associated with progressive improvements in C-peptide and glucose tolerance. In vivo maturation was associated with a distinct transcriptomic pattern (including increased MAFA and INS expression) compared with SC-islets maintained in vitro. Finally, a hyperglycaemic post-transplant environment did not affect long-term SC-islet maturation, with no impairment in plasma human C-peptide seen at 6 months, and no changes in gene expression of β-cell maturity markers after SC-islets were transplanted into diabetic mice. Longitudinal plasma C-peptide and glucose tolerance can be used to characterise in vivo SC-islet maturation, which is associated with transcriptomic changes not observed in vitro. Additionally, elevated blood glucose does not impair long-term functional maturation. These findings support the importance of in vivo cues for SC-islet maturation to inform future preclinical studies.

PMID 42928611
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PubMedGels (Basel, Switzerland)2026-10-26

Spunlace Cotton Nonwoven-Reinforced Sodium Alginate/Bamboo Charcoal Photothermal Hydrogel Evaporator for Solar-Driven Water Purification.

Zhang Haifeng H, Chen Guangfu G, He Hao H, Zhu Xia X et al.

Solar-driven interfacial evaporation offers a low-energy and sustainable route for seawater desalination and the purification of complex water matrices. However, freestanding hydrogel evaporators often suffer from insufficient mechanical robustness and interfacial salt accumulation under high-salinity conditions. Herein, a spunlace cotton nonwoven/sodium alginate/bamboo charcoal (SC/SA/BC) composite interfacial evaporator was fabricated through a facile impregnation-ionic crosslinking strategy, using a spunlace cotton nonwoven (SC) as the reinforcing scaffold, sodium alginate (SA) as the hydrophilic hydrogel matrix, and bamboo charcoal powder (BC) as the photothermal component. The Ca2+-crosslinked SA network immobilized the bamboo charcoal particles and formed continuous hydrated mass-transport pathways, while the spunlace fibrous network provided capillary water-supply channels and robust mechanical support. Consequently, SC/SA/BC exhibited substantially improved mechanical performance compared with the freestanding SA/BC hydrogel. Under 1 sun irradiation using a 3.5 wt% NaCl solution, SC/SA/BC achieved an evaporation rate of approximately 1.80 kg m-2 h-1 and maintained stable performance during 8 h of continuous operation. The evaporation-condensation process markedly reduced the concentrations of major ions in natural seawater and effectively retained nonvolatile dyes. Through the synergistic integration of a spunlace fibrous scaffold, a hydrated hydrogel network, and a bamboo-charcoal-based photothermal component, the proposed evaporator simultaneously achieved mechanical reinforcement, sustained water supply, efficient photothermal conversion, and salt-tolerant operation. This work provides a promising strategy for constructing structurally stable and readily fabricated solar interfacial evaporation materials.

PMID 42929933
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PubMedClinical ophthalmology (Auckland, N.Z.)2026-10-26

Quantitative Assessment of Schlemm's Canal Morphology and Observer Variability Using Swept-Source as-OCT in Healthy Eyes with Open and Narrow Angles.

Hatami Mohammad Mehdi MM, Doozandeh Azadeh A, Zare Mohsen M, Marandi Samaneh S et al.

This cross-sectional study assessed Schlemm's Canal (SC) morphology in healthy eyes with open and narrow angles using anterior segment optical coherence tomography (AS-OCT) and evaluated inter- and intraobserver variability in SC measurements. AS-OCT images were obtained from 97 eyes from 97 patients. Two horizontal images were captured from the nasal region and one image from the temporal region. Two observers measured the following SC parameters: cross-sectional area (CSA), width, and height. Differences between open- and narrow-angle groups were compared, and interobserver and intraobserver reproducibility were measured using Intraclass Correlation Coefficients (ICC). Pearson's correlation coefficients were used to assess linear associations between measurements. Schlemm's canal CSA values in nasal images were significantly higher in open-angle eyes (4704 ± 1859 vs 3222 ± 1084 µm2, p = 0.003). However, differences in width or height between the two groups were nonsignificant. Interobserver agreement was good for CSA (ICC = 0.85), moderate to good for width (ICC = 0.74), and moderate for height (ICC = 0.66). Intraobserver repeatability was good for CSA (ICC = 0.86) and moderate to good for width (ICC = 0.73) but poor for height (ICC = 0.41). Visibility of SC was higher in nasal images than in temporal images (65-76% vs 39%). Nasal CSA and ACA were larger in the open-angle group and demonstrated good interobserver and intraobserver reproducibility. However, the significance of CSA, its utility in glaucoma patients and its relationship with functional measures of aqueous outflow remain unclear. This calls for longitudinal studies to determine the clinical applicability of this parameter.

PMID 42928895
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PubMedInternational journal of fertility & sterility2026-10-26

Comparison of Growth Pattern in Children Conceived by Assisted Reproductive Technology with or without Gestational Diabetes Mellitus: A Prospective Cohort Study.

Bagheri-Lankarani Narges N, Madani Sedigheh S, Shahsavand Masoumeh M, Hosseini Roya R et al.

Assisted reproductive technology (ART) has been associated with an increased risk of gestational diabetes mellitus (GDM) as well as various obstetric and perinatal complications. However, the long-term growth trajectories of children conceived via ART in the context of maternal GDM remain unclear. This prospective cohort study aimed to evaluate the effect of GDM on growth parameters among children conceived through ART or spontaneous conception (SC). The prospective cohort study enrolled 420 children aged 3-5 years, who were categorized into four groups: ART, ART-GDM, SC-GDM, and SC. Growth assessments included height, weight, and body mass index (BMI), which were extracted from medical records at birth and during follow-up visits at ages 3 and 5 years. Anthropometric data were standardized using age- and sex-adjusted Z-scores. Statistical analyses were performed using SPSS and included Chi-square tests, one-way analysis of variance (ANOVA), Kolmogorov-Smirnov tests for normality, Kruskal-Wallis tests, and post hoc comparisons. Children in the GDM-exposed groups tended to be shorter at birth, with the ART-GDM group showing the highest prevalence of obesity by age 5. Children conceived by ART, particularly those exposed to GDM, were significantly heavier than their SC counterparts. At birth, mean height and weight in the ART, ART-GDM, and GDM groups approximated the 50th percentile. Catch-up growth was evident by age 3, and by age 5, all groups exhibited comparable mean height and weight, with no significant sex-based differences. Despite being shorter and lighter at birth, children conceived via ART appeared to achieve growth parameters comparable to their peers by preschool age, suggesting compensatory growth. Nonetheless, further longitudinal research is warranted to clarify these findings. Healthcare providers should prioritize the monitoring and management of pregnancies complicated by GDM following assisted conception.

PMID 42929016
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PubMedDalton transactions (Cambridge, England : 2003)2026-10-26

Unravelling average, local and magnetic structure in Sr-Sc-M-O oxides (M = Co, Fe) by neutron scattering.

Ceretti Monica M, Cuello Gabriel J GJ, Sheptyakov Denis D, Ritter Clemens C et al.

Oxygen-deficient Sr-Sc-M-O oxides (M = Fe, Co) were synthesized and characterized in cubic and brownmillerite forms, with the brownmillerite phase Sr2ScCoO5 reported here for the first time. The cubic phases, described as SrSc0.5M0.5O3-x, and the brownmillerite phases, Sr2ScMO5, exhibit different oxygen contents and distinct degrees of structural ordering. Neutron diffraction and pair distribution function analysis reveal short-range oxygen-vacancy and B-cation ordering at the local scale within the cubic structure. In contrast, the brownmillerite phases exhibit long-range oxygen-vacancy and cation ordering, adopting Imma and I2mb symmetries for Sr2ScFeO5 and Sr2ScCoO5, respectively. Magnetic measurements indicate weak antiferromagnetic interactions, with brownmillerite Sr2ScFeO5 showing only short-range magnetic correlations. In contrast, Sr2ScCoO5 exhibits long-range magnetic ordering at 1.5 K, with the Co magnetic moment aligned along the stacking axis. This represents the first observation of coexisting cation and three-dimensional magnetic ordering in this system, despite the large Co-Co distances of 7.63 Å. These findings highlight the role of oxygen content in driving structural ordering and underscore the need for a multiscale approach to understanding the complex structure-property relationships of oxygen-deficient perovskites.

PMID 42929422
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PubMedArchiv der Pharmazie2026-10-26

TPGS-Transferrin Functionalized Polydopamine Nanocarriers Potentiate the Pharmacokinetics, Antioxidant, and Anti-Inflammatory Activity of Carvacrol.

Mahata Rumi R, Modak Mrinmoyee M, Malakar Rimpa R, Karan Gouri G et al.

Poor aqueous solubility and rapid systemic clearance limit the therapeutic translation of carvacrol (CVC). Herein, we report the fabrication of carvacrol loaded, transferrin (Tf) and d-α-tocopheryl polyethylene glycol succinate (TPGS) functionalized polydopamine nanoparticles (PDA NPs). We recently demonstrated the therapeutic efficacy of CVC-PDA-TPGS-Tf against breast cancer. In the present study, we evaluated the in vivo pharmacokinetic (PK) and biodistribution analysis of this nanoconjugate in Swiss albino female mice. The results of PK and biodistribution analyses revealed markedly increased area under the curve (AUC) (1858 vs. 31,797 ng·min/mL) and maximum serum concentration (Cmax) (318 vs. 715 ng/mL), compared with free CVC. Biodistribution studies demonstrated preferential accumulation in the liver and kidneys with minimal penetration into the brain and spleen. The nanoconjugate displayed superior in vitro free radical scavenging activity against hydroxyl, superoxide, and nitric oxide species and an in vivo antioxidant effect relative to free CVC, and significantly attenuated inflammation in a murine paw edema model. Molecular docking suggested strong interactions of CVC with inflammation- and oxidative stress-related protein targets, consistent with the observed bioactivity. Collectively, these results demonstrate that TPGS-Tf-modified PDA nanocarrier effectively modulates the biological behavior of CVC, offering a promising nanoplatform for improving the pharmacological performance of hydrophobic phenolic therapeutics.

PMID 42929738
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