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measles (Tresivac)

✓ Approved

Serum Institute of India Pvt. Ltd. · 疫苗 · 疫苗

什么是 measles？

measles 是一种疫苗，由Serum Institute of India Pvt. Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Tresivac
公司Serum Institute of India Pvt. Ltd.
药物类别疫苗
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Serum Institute of India Pvt. Ltd.

治疗适应症

measles 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsMeasles✓ Approved

相关研究文献

PubMedInternational journal of fertility & sterility2026-10-26

Viral Infections and Ovarian Reserve: Mechanistic Insights into Ovarian Aging- A Review.

Haratian Kaveh K, Borjian Boroujeni Parnaz P, Zarei Moradi Shabnam S, Mohseni Meybodi Anahita A

Ovarian aging, marked by the progressive loss of follicular reserve and decline in oocyte quality, is a principal determinant of female reproductive lifespan. While genetic and environmental factors are well-established contributors, viral infections, including both DNA and RNA viruses, are increasingly recognized as significant extrinsic modulators of ovarian function. This review synthesizes current evidence on the mechanisms and clinical outcomes by which key viral pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), hepatitis B virus (HBV), human immunodeficiency virus (HIV), cytomegalovirus (CMV), human papillomavirus (HPV), mumps virus, herpes simplex virus (HSV), and rubella virus, affect ovarian aging and reserve. The discussion highlights those viral infections can impact ovarian function through inflammation, cytopathic effects, oxidative stress, and immune-mediated mechanisms, although the magnitude and clinical relevance vary. Current evidence for viruses such as SARS-CoV-2 and HBV is limited and inconsistent, highlighting the need for individualized assessment when considering fertility interventions. Further longitudinal and mechanistic studies are essential to clarify long-term reproductive outcomes and to guide evidence-based fertility counseling.

PMID 42929014
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PubMedInfection control and hospital epidemiology2026-10-26

Estimating the incidence and duration of diagnostic delays for measles.

Arakkal Alan T AT, Miller Aaron C AC, Cavanaugh Joseph E JE, Herwaldt Loreen A LA et al.

Although measles was declared eliminated in the United States in 2000, cases have increased in recent years. Our goal was to estimate the incidence and duration of diagnostic delays for measles and identify factors associated with delays. Case-crossover. We used the Merative MarketScan Research Databases (2001-2023). We identified measles cases and evaluated prior healthcare encounters for potential missed diagnostic opportunities. Using a bootstrapping approach, we estimated the number of healthcare visits representing possible missed opportunities to diagnose measles during a two-week period preceding the index diagnosis. We utilized Firth logistic regression to assess factors associated with delays. We identified 4,651 measles cases. During the two-week period prior to diagnosis, 426 (9.2%) patients had healthcare visits with signs or symptoms commonly associated with measles. We estimated 381 (95%CI: 330-440) missed opportunities to diagnose measles. Delays occurred most frequently in outpatient settings (81.0%). Approximately 6.9% (95%CI: 6.1-8.0%) of patients experienced at least one missed opportunity, with a mean delay of 4.05 days (95%CI: 3.48-4.51) (median delay = 2.94 days [95%CI: 2.00-3.00]). An estimated 1.7% (95%CI: 1.1-2.2%) of patients experienced a diagnostic delay lasting a week or longer. Factors associated with an increased likelihood of delays included age <2 years and receiving antibiotic prescriptions. Diagnostic delays for measles are not uncommon and may facilitate transmission, especially in outpatient settings.

PMID 42929400
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PubMedNEJM evidence2026-10-26

Domestic Measles Importations in Washington State, January 2026.

Bennett Julia C JC, Hartman Daniel A DA, Lewis James W JW, Melnick Alan A et al.

AbstractMeasles outbreaks are increasing in frequency and size in the United States. Within 2 weeks, there were five distinct out-of-state measles importations into Washington State epidemiologically connected to an outbreak in South Carolina, resulting in a total of 26 measles cases during January-February 2026. Genomic analyses supported epidemiologic conclusions regarding exposure sources of imported cases and independence among importations. Adherence to isolation and quarantine likely limited onward transmission in undervaccinated communities. Combining timely genomic data analysis with epidemiologic information can strengthen understanding of measles outbreaks as public health jurisdictions prepare to respond to increases in imported measles cases.

PMID 42929740
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PubMedNature communications2026-10-26

Extended dosing intervals enhance the durability of a self-amplifying mRNA vaccine against pandemic H5N1 influenza: a randomized, observer-blind, dose-finding Phase I study.

Pragalos Antoinette A AA, Pacciarini Filippo F, Jin Hongfan H, Hopkins Terri T et al.

Avian influenza poses a persistent pandemic threat, yet traditional vaccines face production delays. Self-amplifying mRNA (sa-mRNA) technology offers potential advantages, including rapid development, dose sparing, and enhanced, durable immunity. We evaluated ARCT-2304, a bicistronic sa-mRNA vaccine encoding H5N1 hemagglutinin (HA) and neuraminidase (NA), in a Phase 1 randomized, observer-blind trial (NCT06602531). Healthy adults (N = 212) received two doses of ARCT-2304 (1.5, 5, or 12 mcg) or control/placebo on a 4- or 8-week schedule. Primary outcomes evaluated safety and reactogenicity (solicited/unsolicited/serious adverse events [AEs]) and immunogenicity (HA inhibition and NA enzyme-linked lectin assays 28 days post-second dose). Immunogenicity results were benchmarked using serum from a prior study supporting licensure of an H5N1 vaccine. ARCT-2304 was well-tolerated, displaying mostly mild-to-moderate, transient, dose-dependent solicited AEs, with no safety concerns identified. Two doses elicited robust HA and NA humoral responses. An 8-week interval yielded higher magnitude and greater durability than a 4-week schedule, with neutralizing and anti-NA antibodies remaining significantly elevated 6-7 months post-second dose. ARCT-2304 also induced dose-dependent, Th1-polarized T-cell responses peaking at Day 29. These findings support advancing sa-mRNA platforms for pandemic influenza preparedness.

PMID 42928290
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PubMedTechnology and culture2026-10-26

Rethinking the Green Revolution: Continuity and the Japanese Method in Postcolonial India.

George Sujeet S

Histories of agrarian modernization in postcolonial India have largely treated the Green Revolution as a decisive technological rupture centered on the introduction of high-yielding seeds in the mid-1960s. Recovering the earlier adoption of the Japanese method of rice cultivation reveals a different trajectory. Many practices later associated with the Green Revolution-including improved rice varieties, intensive fertilizer use, and assured irrigation-were first assembled and tested through this Japanese-inspired technological package. As these techniques moved through experimental stations, government programs, and village communities, they were selectively adapted, recombined, and absorbed into subsequent agricultural interventions. The history of the Japanese method thus uncovers a longer genealogy of agrarian modernization, one in which continuity, rather than rupture, shaped the making and diffusion of agricultural technology in postcolonial India.

PMID 42929125
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PubMedDentistry journal2026-10-26

Proteomic Alterations in Hypomineralised Enamel: A Systematic Review.

Balixa Gabriela G, Ganss Bernhard B, Bandeira Lopes Luísa L

Background: Developmental enamel hypomineralisation is characterised by qualitative defects in enamel mineralisation that affect both primary and permanent dentitions. Proteomic studies have provided novel insights into the molecular mechanisms underlying these conditions; however, an updated critical appraisal integrating the available evidence across both Molar-Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM) is needed. Methods: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA 2020 guidelines. PubMed/MEDLINE, Embase, Scopus, and Web of Science were searched from inception until 30 July 2026. Observational and laboratory studies examining proteomic changes in enamel, saliva, or other oral biological samples from individuals diagnosed with MIH or HSPM were included. Risk of bias was assessed using the revised Joanna Briggs Institute (JBI) tool and the Quality Assessment Tool for In Vitro Studies (QUIN). Results: Ten reports satisfied the inclusion criteria, representing nine independent primary datasets. Consistent findings included increased retention of serum-derived proteins, particularly albumin, alongside enrichment of protease inhibitors and inflammatory proteins within hypomineralised enamel. Additionally, alterations in proteins involved in enamel matrix processing and maturation, including matrix metalloproteinase-20 (MMP20) and kallikrein-related peptidase 4 (KLK4), were identified. Salivary analyses revealed quantitative differences in proteins involved in immune, inflammatory and mineralisation-related pathways. Both shared and distinct proteomic features were observed across hypomineralised enamel in the primary and permanent dentitions. Conclusions: Current evidence indicates recurrent proteomic alterations in developmental enamel hypomineralisation, particularly impaired enamel maturation, abnormal retention of serum-derived proteins, and alterations in inflammatory pathways. Further standardised proteomic studies are needed to validate these findings and assess their potential as biomarkers.

PMID 42930447
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