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Prevalence of breast, cervical, and colorectal cancer screening among adults according to disability type and difficulty level, United States, 2021 and 2023.

Mazzitelli Natalia N, Star Jessica J, Meggett Kinsey K, Han Xuesong X et al.

Adults with disabilities face multiple barriers to cancer screening services. Few studies have examined screening receipt across multiple disability domains via standardized measures in contemporary nationally representative samples. Data were pooled from the 2021 and 2023 National Health Interview Survey. Prevalence of United States Preventive Services Task Force recommendation concordant breast, cervical, and colorectal cancer screening was estimated according to disability domain (vision, hearing, mobility, cognition, communication, and self-care) and difficulty level ("substantial," "some," and "none"), which were defined according to the Washington Group Composite Disability Indicator. A total of 1712, 1147, and 3106 sample respondents eligible for breast, cervical, and colorectal screening had disabilities, respectively, which translates to 6.02 million, 5.10 million, and 11.17 million when population weighted. Breast and cervical screening prevalence decreased with increasing difficulty level for self-care, vision, mobility, and cognition domains, with the lowest receipt among those reporting substantial versus no self-care difficulties (breast: 52% vs. 79%; adjusted prevalence ratio [aPR], 0.69; 95% CI, 0.58-0.82; cervical: 37% vs. 78%; aPR, 0.63; 95% CI, 0.51-0.78). Communication disability was associated with lower cervical screening (35% substantial vs. 78% none; aPR, 0.65; 95% CI, 0.52-0.82) but not for other screenings. Conversely, stool testing for colorectal screening was higher among adults with substantial mobility difficulties (22% vs. 16% none; aPR, 1.24; 95% CI, 1.12-1.38) and some self-care, mobility, and vision difficulties, compared to those with none. Addressing barriers for individuals with self-care limitations could improve suboptimal screening levels across multiple cancer screenings. Self-sampling modalities, including stool testing, may mitigate accessibility issues, and warrant further evaluation.

Paediatric Posterior Reversible Encephalopathy Syndrome (PRES) Induced by Ibuprofen Intake: A Case Report.

Bargiacchi Giuditta G, De Marco Oriana O, Petruzzelli Luigi Annicchiarico LA, Tucci Celeste C et al.

Severity of irritable bowel syndrome and its correlates among Middle East and North African medical students: a multicentric cross sectional study.

Abdelshafi Abdelrahman A, Abdelhamid Zeinab G ZG, Osama Belal B, Mohammed Yasmine Adel YA et al.

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder that is commonly reported among individuals experiencing high levels of stress, such as medical students. Despite its significance, data on the severity of IBS and its correlates remains scarce in the Middle East and North Africa (MENA) region. This study is a secondary analysis of a previously published multicenter study and aimed to evaluate the severity of irritable bowel syndrome (IBS) and identify the correlates of severe IBS among medical students with Rome IV-confirmed IBS. This multicentric cross-sectional study was conducted across 27 medical faculties in seven MENA countries) from March until May 2024. A bilingual (Arabic/English) online self-reported questionnaire was used to assess IBS severity via the validated IBS-Symptom Severity Scale. Data analysis was performed using SPSS, version 26. Remission, mild, moderate, and severe IBS symptoms were detected among 15.28%, 31.38%, 36.60%, and 16.73% of the participants, respectively. Students with severe IBS symptoms had a significantly higher mean age compared to other students (p = 0.019). Among students with severe IBS symptoms, the proportion of overweight/obese (18.5%) was significantly higher than that of underweight/normal weight (16.1%) (p = 0.022). Furthermore, among students with severe IBS symptoms, there were significantly higher proportions of positive depression (p < 0.001), anxiety (p < 0.001), and history of food or drug hypersensitivity (p < 0.001). In the Generalized linear model - Adjusted Poisson regression analysis for determination of the correlates of severe IBS among medical students, Anxious students [aPR = 1.87 (95% CI 1.418-2.461)] and depressed students [aPR = 1.86 (95% CI 1.512-2.284)] were significantly more likely to experience severe IBS symptoms (p < 0.001*). Similarly, students with a history of food or drug hypersensitivity were significantly more likely to have severe IBS [aPR = 1.29 (95% CI 1.079-1.546)] (p = 0.005). The present study demonstrated that more than half of students with IBS In the MENA region exhibited moderate to severe symptoms. Psychological comorbidities were predominant among students with severe IBS symptoms, highlighting the strong association between mental health conditions and IBS symptom severity in this population.

Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report.

Binidris Mutasim M, Shehata Menatalla M, Mahfouz Ahmed A, Abousaad Omar O et al.

Invasive meningococcal disease is a life-threatening infection that classically presents as meningitis or meningococcemia. Extra-meningeal manifestations, including pericarditis and septic arthritis, are uncommon and may complicate diagnosis, particularly in the absence of meningeal involvement. A previously healthy vaccinated man in his 50s presented with acute bilateral knee pain and swelling following a short history of fever, productive cough, fatigue, and dyspnea. Blood cultures grew Neisseria meningitidis serogroup W, whereas cerebrospinal fluid, synovial fluid, and pericardial fluid cultures remained negative. Cardiac magnetic resonance imaging demonstrated constrictive pericarditis with circumferential pericardial enhancement and pericardial effusion. The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations.