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lercanidipine + valsartan (Levacalm / ZV Combi)

✓ Approved

LG Chem Ltd. · AGTR1 · 小分子

什么是 lercanidipine + valsartan？

lercanidipine + valsartan 是一种小分子，由LG Chem Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Levacalm, ZV Combi
公司LG Chem Ltd.
药物类别小分子
分子靶点AGTR1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, LG Chem Ltd.

作用机制

分子靶点

lercanidipine + valsartan 作用于 2 个分子靶点：

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lercanidipine + valsartan 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved

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Cucumis melo var. flexuosus is traditionally used for the management of skin ailments; however, its phytochemical composition and bioactivities remain insufficiently characterized. Hereto, three fruit genotypes (LG, SH, and WH) and the leaves of the LG genotype (LGLV) were systematically investigated. More than 100 phytochemicals were tentatively identified in the investigated extracts utilizing LC-HRMS. Chemometric tools discerned samples in three distinct clusters. LGLV cluster characterized by richness in flavonoids, LG & SH cluster were enriched in glycerol- and lyso-phospholipids while WH was enriched in cerebroside. Network pharmacology revealed that flavonoids, phenolic acids and lysophospholipids were the key phytochemicals against skin aging and MRSA (Methicillin resistant Staphylococcus aureus). LGLV had the highest antioxidant activities in different in vitro assays. LGLV had the highest antibacterial, biofilm inhibition (IC50 = 0.322 mg/mL) and detachment activities against MRSA. Antibacterial efficacy was verified by in vivo MRSA skin infection model. Moreover, LGLV halted aging in H2O2-induced aging model in vitro human fibroblast cell culture as evidenced by flow cytometry and by the effective suppression of MMP-1 and IL-6, p53 and increment in TIMP-1 levels. These findings highlighted that leaves are a better sustainable source of bioactive compounds for the development of anti-MRSA and skin-protective products.

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Secondhand smoke (SHS) exposure is associated with numerous adverse health outcomes, posing a substantial public health burden. Despite well-documented physical and psychological harms of SHS, based on our search, no previous research has examined its association with Quality of Life (QoL) and Life Satisfaction (LS) in university students; therefore, this study aimed to investigate these relationships in this vulnerable population. This study utilized baseline data from a prospective cohort of newly enrolled students at Tehran University of Medical Sciences. SHS exposure, QoL, LS, and demographic characteristics were assessed using standardized and validated questionnaires. Descriptive statistics and chi-square tests were used to compare groups. Linear regression models were used as the primary analyses to examine associations between SHS exposure and continuous QoL and LS scores, while logistic regression models were conducted as secondary analyses for categorized outcomes: poor/moderate versus good QoL and low versus high LS. Among the 372 participants included in the analysis, SHS exposure at home or outside was significantly associated with a 1.37-point lower QoL score (95% CI: -2.32, - 0.42; p = 0.005), while exposure in both settings was associated with a 1.80-point lower QoL score (95% CI: -3.08, - 0.52; p = 0.006). For life satisfaction, only exposure in both settings remained significantly associated with lower scores in the adjusted model (adjusted β = -2.12; 95% CI: -3.92, - 0.32; p = 0.021), while exposure at home or outside was not significantly associated with the continuouse LS score (p = 0.305). In adjusted logistic regression models, exposure at home or outside significantly increased the odds of poor/moderate QoL (AOR = 1.87; 95% CI: 1.16 to 3.01; p = 0.010), as did exposure in both settings (AOR = 1.97; 95% CI: 1.18, 3.30; p = 0.009). However, no significant associations were observed between any SHS exposure level and low life satisfaction in the adjusted logistic models. The findings indicated that SHS exposure was associated with lower QoL scores and higher odds of poor/moderate QoL among university students. Exposure in both settings was also associated with lower continuous LS scores; however, no statistically significant association was observed between SHS exposure and low LS in the adjusted logistic regression models.

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