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lercanidipine + valsartan (Levacalm / ZV Combi)

✓ Approved

LG Chem Ltd. · AGTR1 · 小分子

什么是 lercanidipine + valsartan？

lercanidipine + valsartan 是一种小分子，由LG Chem Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Levacalm, ZV Combi
公司LG Chem Ltd.
药物类别小分子
分子靶点AGTR1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, LG Chem Ltd.

作用机制

分子靶点

lercanidipine + valsartan 作用于 2 个分子靶点：

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lercanidipine + valsartan 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved

相关研究文献

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Differentiating therapeutic use and potential impairment in the forensic interpretation of valsartan concentrations in road traffic offenders.

Dziadosz Marek M, Marquenie Lisa L, Rosenberger Wolfgang W, Klintschar Michael M et al.

Based on the presented case, general challenges in the interpretation of cardiovascular drug concentrations in the context of active participation in road traffic are discussed. Particular emphasis is placed on the assessment of valsartan concentrations, for which no clearly defined threshold between therapeutic and toxic ranges has been established. The case of a 59‑year‑old male who experienced a medical incident while driving enabled the identification of a valsartan concentration of 12.7 µg/mL, which was well above the expected range. Potential interactions with concomitantly administered medications are also considered.

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Integrated single-cell and spatial transcriptomic analyses reveal malignant epithelial glycolytic heterogeneity and spatial niche remodeling during colorectal cancer progression.

Xiao Jinyun J, Heng Shanshan S, Li Jiayu J, Xie Shaozhuo S et al.

Colorectal cancer (CRC) progression is shaped by metabolic reprogramming and complex interactions within the tumor microenvironment. However, the cellular heterogeneity, spatial organization, and clinical relevance of glycolytic activity in CRC remain incompletely understood. In this study, we integrated single-cell RNA sequencing, bulk transcriptomics, and spatial transcriptomics data to systematically characterize glycolytic heterogeneity in CRC. Glycolytic activity was quantified using five independent scoring methods, consistently showing that epithelial cells exhibited the highest glycolytic activity across the two single-cell cohorts. Stratification of CopyKAT-verified aneuploid malignant epithelial cells into high-glycolysis (HG) and low-glycolysis (LG) subgroups by glycolysis scores revealed that HG cells exhibited higher stemness scores and chromosomal copy number variations. Cell-cell communication analysis revealed that, compared with LG cells, HG cells exhibited increased interaction frequency and strength with immune and stromal populations, indicating enhanced malignant epithelial-microenvironment crosstalk. Spatial transcriptomics analyses further revealed that glycolytic activity varied across normal colorectal tissue, primary CRC, and colorectal liver metastases, accompanied by progressive remodeling of epithelial-associated spatial niches and MIF-mediated intercellular communication. Bulk transcriptomic analysis identified a glycolysis-related prognostic signature with robust predictive performance, which served as an independent prognostic factor for overall survival in CRC cohorts. Collectively, these findings indicate that glycolytic heterogeneity is a key feature of CRC malignant epithelial cells and is closely associated with tumor progression, microenvironmental remodeling, and clinical outcomes.

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Where on Earth Are the Earth Sciences? A Mixed-Methods Study of Environmental Justice Research Trends and Roadblocks to Engagement.

Rosales Cortez Omar O, Chen Catherine C

Environmental justice (EJ) research relies on expertise from multiple disciplines to address community-specific health risks and inequities. EJ is an inherently transdisciplinary framework, yet the expansion of EJ scholarship has not occurred evenly across academic disciplines. Understanding disciplinary contributions is essential for identifying gaps in knowledge and practice. This research employed a mixed-method approach to investigate EJ research trends and roadblocks to engagement. Study 1 used a bibliometric analysis of Scopus-indexed publications and found that Environmental science and Social sciences were the leading contributors to EJ scholarship. Earth sciences ranked only seventh in EJ research volume by proportion and exhibited comparatively stagnant growth. Study 2 investigated this discrepancy through a survey of Earth scientists (N = 460) examining perceived barriers to EJ engagement. Results indicated that career stage was a significant predictor of EJ familiarity and community involvement: early-career Earth scientists were more familiar with EJ but were less involved in their communities' environmental issues than their late-career counterparts. Race and ethnicity were also associated with differences in perceived funding difficulty, with White respondents reporting fewer challenges in securing support for EJ-related projects. Taken together, these studies assess EJ engagement within the Earth sciences and identify structural and experiential factors that may limit participation. Identifying disciplinary gaps and roadblocks helps integrate Earth sciences into EJ scholarship and increase research on environmental health and equity.

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A Systematic Review of Psychosocial Interventions for Enhancing Resilience in Medical Sciences Students.

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College students face significant challenges in their physical and psychological well-being, potentially affecting their perception of social status. This study examines the association between health perception and perceived social status among college students and investigates the potential mediating roles of self-esteem and life satisfaction. Data from 5,966 participants (50.8% female, 49.2% male) were analyzed from the 2016 Korean Education and Employment Panel Survey (KEEP). Analyses were conducted using SPSS 21.0, AMOS 22.0, and the PROCESS macro. The research model examined the direct relationships between health perception, self-esteem, life satisfaction, and perceived social status, as well as the potential mediating roles of self-esteem and life satisfaction. Health perception was positively associated with self-esteem (β = 0.232, p < 0.001), life satisfaction (β = 0.273, p < 0.001), and perceived social status (β = 0.120, p < 0.001). Self-esteem showed positive associations with life satisfaction (β = 0.359, p < 0.001) and perceived social status (β = 0.078, p < 0.001). Life satisfaction was significantly related to perceived social status (β = 0.419, p < 0.001). The indirect association of health perception with perceived social status through self-esteem was 0.018 (95% CI [0.011, 0.025]), through life satisfaction was 0.115 (95% CI [0.101, 0.129]), and through both mediators sequentially was 0.035 (95% CI [0.029, 0.041]). Results suggest that college students' health perception may be associated with their perceived social status both directly and indirectly through potential mediating roles of self-esteem and life satisfaction. Because these findings are based on cross-sectional secondary data, they represent statistical associations rather than confirmed causal mechanisms. Health awareness, self-esteem, and life satisfaction were associated with more positive perceived social status; however, longitudinal research is needed before implications for educational interventions can be drawn.

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Beyond the coach: contextual, community, and organizational predictors of coaches' perceived impact on athlete life skill development.

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Youth sport is widely regarded as a context for promoting positive youth development (PYD) and life skill development; however, inequities in the youth sport system can limit coaches' perceived ability to foster these outcomes. Guided by an integrated youth sport system perspective, this study examined how contextual factors, community-level resource access, and organizational training and support were associated with coaches' perceived impact on athlete life skill development. Using data from the U.S. National Coach Survey (N = 4,964), hierarchical linear regression analyses were conducted with predictors entered in three blocks: (1) context (school vs. community setting, urbanicity, proportion of athletes experiencing poverty, proportion of athletes identifying as Black, Latino, Asian/Pacific Islander, or multiracial), (2) access to community-level resources (e.g., equipment, transportation, safe practice spaces), and (3) organizational support and training [coaching certification, life skills training, administrative support, peer support, compensation (paid vs. unpaid), and having been evaluated last season]. Context accounted for 5.4% of the variance in perceived impact. Access to community-level resources accounted for an additional 1.7% of the variance, with equipment availability emerging as a significant predictor. Organizational support and training variables accounted for the largest increase in variance (ΔR 2 = 6.5%, p < .01), with training in life skill development through sport, peer support, coaching certification, paid status, and prior evaluation associated with greater perceived impact on life skill development (R 2 = .136). Findings suggest that coaches' capacity to support life skill development can be shaped by factors within youth sport organizations and the broader youth sport context. More research is needed to understand drivers of coaching to support life skill development. Implications for practice, policy, and coach education are discussed.

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